Article ; Online: Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-κB pathway in AD model rats.
Aging
2023 Volume 15, Issue 22, Page(s) 13239–13264
Abstract: The purpose of this study is to investigate the therapeutic effect of Qi Fu Yin (QFY ...
Abstract | The purpose of this study is to investigate the therapeutic effect of Qi Fu Yin (QFY) on Alzheimer's disease (AD) both computationally and experimentally. Network pharmacology analysis and molecular docking were conducted to identify potential targets and signaling pathways involved in QFY treating AD. Streptozotocin-induced AD rat model was used to verify important targets and predicted pathways. The components of QFY were identified using liquid chromatography-tandem mass spectrometry. The results indicate that the potential targets of QFY are highly enriched for anti-inflammatory pathways. Molecular docking analysis revealed stable structures formed between QFY's active compounds, including stigmasterol, β-sitosterol, and isorhamnetin, and the identified targets. |
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MeSH term(s) | Rats ; Animals ; NF-kappa B/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Neuroinflammatory Diseases ; Molecular Docking Simulation ; Tumor Necrosis Factor-alpha/metabolism |
Chemical Substances | NF-kappa B ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha |
Language | English |
Publishing date | 2023-11-22 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 1945-4589 |
ISSN (online) | 1945-4589 |
DOI | 10.18632/aging.205238 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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