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  1. Book: Behavioral neurobiology of chronic pain

    Taylor, Bradley K. / Finn, David

    (Current topics in behavioral neurosciences ; 20)

    2014  

    Author's details Bradley K. Taylor ; David P. Finn ed
    Series title Current topics in behavioral neurosciences ; 20
    Collection
    Keywords Pain ; Translational ; Neuronal plasticity ; Emerging pre-clinical models ; Pharmacology ; Physiology ; Chronischer Schmerz ; Neurobiologie ; Verhalten
    Subject Mensch ; Menschliches Verhalten ; Schmerzsyndrom ; Schmerzkrankheit
    Language English
    Size VIII, 372 S. : Ill., graph. Darst., 25 cm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT018514671
    ISBN 978-3-662-45093-2 ; 3-662-45093-3 ; 9783662450949 ; 3662450941
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 249 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Contribution of µ Opioid Receptor-expressing Dorsal Horn Interneurons to Neuropathic Pain-like Behavior in Mice.

    Qi, Yanmei / Nelson, Tyler S / Prasoon, Pranav / Norris, Christopher / Taylor, Bradley K

    Anesthesiology

    2023  Volume 139, Issue 6, Page(s) 840–857

    MeSH term(s) Rats ; Mice ; Animals ; Receptors, Opioid ; Rats, Sprague-Dawley ; Neuralgia/metabolism ; Spinal Cord Dorsal Horn ; Interneurons/metabolism ; Mice, Transgenic
    Chemical Substances Receptors, Opioid
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch.

    Nelson, Tyler S / Taylor, Bradley K

    Progress in neurobiology

    2020  Volume 196, Page(s) 101894

    Abstract: An accelerating basic science literature is providing key insights into the mechanisms by which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the ... ...

    Abstract An accelerating basic science literature is providing key insights into the mechanisms by which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the G
    MeSH term(s) Animals ; Chronic Pain/drug therapy ; Chronic Pain/metabolism ; Interneurons/drug effects ; Interneurons/metabolism ; Neuropeptide Y/drug effects ; Neuropeptide Y/metabolism ; Pruritus/drug therapy ; Pruritus/metabolism ; Receptors, Neuropeptide Y/drug effects ; Receptors, Neuropeptide Y/metabolism ; Spinal Cord/drug effects ; Spinal Cord/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2020.101894
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  4. Article ; Online: Experiences with Medications for Addiction Treatment Among Emergency Department Patients with Opioid Use Disorder.

    Goldfine, Charlotte E / Chapman, Brittany P / Taylor, Melissa M / Bradley, Evan S / Carreiro, Stephanie P / Rosen, Rochelle K / Babu, Kavita M / Lai, Jeffrey T

    The western journal of emergency medicine

    2023  Volume 24, Issue 2, Page(s) 236–242

    Abstract: Introduction: Medications for addiction treatment (MAT) are the evidence-based standard of care for treatment of opioid use disorder (OUD), but stigma continues to surround their use. We conducted an exploratory study to characterize perceptions of ... ...

    Abstract Introduction: Medications for addiction treatment (MAT) are the evidence-based standard of care for treatment of opioid use disorder (OUD), but stigma continues to surround their use. We conducted an exploratory study to characterize perceptions of different types of MAT among people who use drugs.
    Methods: We conducted this qualitative study in adults with a history of non-medical opioid use who presented to an emergency department for complications of OUD. A semi-structured interview that explored knowledge, perceptions, and attitudes toward MAT was administered, and applied thematic analysis conducted.
    Results: We enrolled 20 adults. All participants had prior experience with MAT. Among participants indicating a preferred treatment modality, buprenorphine was the commonly favored agent. Previous experience with prolonged withdrawal symptoms upon MAT discontinuation and the perception of "trading one drug for another" were common reasons for reluctance to engage in agonist or partial-agonist therapy. While some participants preferred treatment with naltrexone, others were unwilling to initiate antagonist therapy due to fear of precipitated withdrawal. Most participants strongly considered the aversive nature of MAT discontinuation as a barrier to initiating treatment. Participants overall viewed MAT positively, but many had strong preferences for a particular agent.
    Conclusion: The anticipation of withdrawal symptoms during initiation and cessation of treatment affected willingness to engage in a specific therapy. Future educational materials for people who use drugs may focus on comparisons of respective benefits and drawbacks of agonists, partial agonists, and antagonists. Emergency clinicians must be prepared to answer questions about MAT discontinuation to effectively engage patients with OUD.
    MeSH term(s) Adult ; Humans ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Buprenorphine/therapeutic use ; Emergency Service, Hospital ; Substance Withdrawal Syndrome/drug therapy ; Analgesics, Opioid/therapeutic use
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-9018
    ISSN (online) 1936-9018
    ISSN 1936-9018
    DOI 10.5811/westjem.2022.9.57821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Resolvin D1: A New Path to Unleash the Analgesic Potential of Peroxisome Proliferator-activated Receptor-γ for Postoperative Pain in Patients with Diabetes.

    Taylor, Bradley K

    Anesthesiology

    2015  Volume 123, Issue 6, Page(s) 1231–1232

    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/complications ; Docosahexaenoic Acids/pharmacology ; Inflammation/drug therapy ; Male ; PPAR gamma/agonists ; Pain, Postoperative/drug therapy ; Thiazolidinediones/pharmacology
    Chemical Substances PPAR gamma ; Thiazolidinediones ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000000893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 199: Show issues

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  6. Article ; Online: Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo.

    Gabel, Austin M / Belleville, Andrea E / Thomas, James D / McKellar, Siegen A / Nicholas, Taylor R / Banjo, Toshihiro / Crosse, Edie I / Bradley, Robert K

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 959

    Abstract: Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few have been ... ...

    Abstract Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few have been functionally studied. Here, we address this gap by developing a CRISPR-Cas9-based screen to manipulate endogenous polyadenylation and systematically quantify how APA events contribute to tumor growth in vivo. Our screen reveals individual APA events that control mouse melanoma growth in an immunocompetent host, with concordant associations in clinical human cancer. For example, forced Atg7 3' UTR lengthening in mouse melanoma suppresses ATG7 protein levels, slows tumor growth, and improves host survival; similarly, in clinical human melanoma, a long ATG7 3' UTR is associated with significantly prolonged patient survival. Overall, our study provides an easily adaptable means to functionally dissect APA in physiological systems and directly quantifies the contributions of recurrent APA events to tumorigenic phenotypes.
    MeSH term(s) Animals ; Mice ; Humans ; 3' Untranslated Regions/genetics ; Polyadenylation ; Melanoma/genetics ; Early Detection of Cancer
    Chemical Substances 3' Untranslated Regions
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44931-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A mixed method analysis of student satisfaction with active learning techniques in an online graduate anatomy course: Consideration of demographics and previous course enrollment.

    Bradley, Libby J / Meyer, Kimberly E / Robertson, Taylor C / Kerr, Marcel Satsky / Maddux, Scott D / Heck, Amber J / Reeves, Rustin E / Handler, Emma K

    Anatomical sciences education

    2023  Volume 16, Issue 5, Page(s) 907–925

    Abstract: Online learning has become an essential part of mainstream higher education. With increasing enrollments in online anatomy courses, a better understanding of effective teaching techniques for the online learning environment is critical. Active learning ... ...

    Abstract Online learning has become an essential part of mainstream higher education. With increasing enrollments in online anatomy courses, a better understanding of effective teaching techniques for the online learning environment is critical. Active learning has previously shown many benefits in face-to-face anatomy courses, including increases in student satisfaction. Currently, no research has measured student satisfaction with active learning techniques implemented in an online graduate anatomy course. This study compares student satisfaction across four different active learning techniques (jigsaw, team-learning module, concept mapping, and question constructing), with consideration of demographics and previous enrollment in anatomy and/or online courses. Survey questions consisted of Likert-style, multiple-choice, ranking, and open-ended questions that asked students to indicate their level of satisfaction with the active learning techniques. One hundred seventy Medical Science master's students completed the online anatomy course and all seven surveys. Results showed that students were significantly more satisfied with question constructing and jigsaw than with concept mapping and team-learning module. Additionally, historically excluded groups (underrepresented racial minorities) were generally more satisfied with active learning than non-minority groups. Age, gender, and previous experience with anatomy did not influence the level of satisfaction. However, students with a higher-grade point average (GPA), those with only a bachelor's degree, and those with no previous online course experience were more satisfied with active learning than students who had a lower GPA, those holding a graduate/professional degree, and those with previous online course experience. Cumulatively, these findings support the beneficial use of active learning in online anatomy courses.
    MeSH term(s) Humans ; Problem-Based Learning ; Anatomy/education ; Students, Medical ; Personal Satisfaction ; Demography
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483491-9
    ISSN 1935-9780 ; 1935-9772
    ISSN (online) 1935-9780
    ISSN 1935-9772
    DOI 10.1002/ase.2276
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    Zs.A 6787: Show issues Location:
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  8. Article: Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias.

    Yamaguchi, Tomoki / Salavatian, Siamak / Kuwabara, Yuki / Hellman, Abigail / Taylor, Bradley K / Howard-Quijano, Kimberly / Mahajan, Aman

    Biomedicines

    2023  Volume 11, Issue 10

    Abstract: Background: A myocardial ischemia/reperfusion (IR) injury activates the transient receptor potential vanilloid 1 (TRPV1) dorsal root ganglion (DRG) neurons. The activation of TRPV1 DRG neurons triggers the spinal dorsal horn and the sympathetic ... ...

    Abstract Background: A myocardial ischemia/reperfusion (IR) injury activates the transient receptor potential vanilloid 1 (TRPV1) dorsal root ganglion (DRG) neurons. The activation of TRPV1 DRG neurons triggers the spinal dorsal horn and the sympathetic preganglionic neurons in the spinal intermediolateral column, which results in sympathoexcitation. In this study, we hypothesize that the selective epidural administration of resiniferatoxin (RTX) to DRGs may provide cardioprotection against ventricular arrhythmias by inhibiting afferent neurotransmission during IR injury.
    Methods: Yorkshire pigs (
    Results: The RTX mitigated IR-induced ARI shortening (-105 ms ± 13 ms in IR vs. -65 ms ± 11 ms in IR + RTX,
    Conclusions: The administration of RTX locally to thoracic DRGs reduces ventricular arrhythmia in a porcine model of IR, likely by inhibiting spinal afferent hyperactivity in the cardio-spinal sympathetic pathways.
    Language English
    Publishing date 2023-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11102720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Postsurgical Latent Pain Sensitization Is Driven by Descending Serotonergic Facilitation and Masked by µ-Opioid Receptor Constitutive Activity in the Rostral Ventromedial Medulla.

    Cooper, Andrew H / Hedden, Naomi S / Prasoon, Pranav / Qi, Yanmei / Taylor, Bradley K

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 30, Page(s) 5870–5881

    Abstract: Following tissue injury, latent sensitization (LS) of nociceptive signaling can persist indefinitely, kept in remission by compensatory µ-opioid receptor constitutive activity ( ... ...

    Abstract Following tissue injury, latent sensitization (LS) of nociceptive signaling can persist indefinitely, kept in remission by compensatory µ-opioid receptor constitutive activity (MOR
    MeSH term(s) Analgesics, Opioid ; Animals ; Female ; Hyperalgesia/metabolism ; Male ; Medulla Oblongata/physiology ; Mice ; Narcotic Antagonists/pharmacology ; Pain, Postoperative/metabolism ; Receptors, Opioid, mu/metabolism ; Serotonin/metabolism
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Receptors, Opioid, mu ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2038-21.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice.

    Nelson, Tyler S / Santos, Diogo F S / Prasoon, Pranav / Gralinski, Margaret / Allen, Heather N / Taylor, Bradley K

    PNAS nexus

    2023  Volume 2, Issue 8, Page(s) pgad261

    Abstract: Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G-protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) or neuropeptide Y Y1 ... ...

    Abstract Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G-protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) or neuropeptide Y Y1 receptor (Y1R) activity, persist in the spinal cord dorsal horn (DH) for months, even after the resolution of normal pain thresholds. Here, we demonstrate that following recovery from surgical incision, a potent endogenous analgesic synergy between MOR and Y1R activity persists within DH interneurons to reduce the intensity and duration of latent postoperative hypersensitivity and ongoing pain. Failure of such endogenous GPCR signaling to maintain LS in remission may underlie the transition from acute to chronic pain states.
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad261
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