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Article: [A 87-year-old woman with mineralocorticoid excess due to 11 beta-HSD2 deficiency].

Inada, Mitsuo

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

2007 Volume 44, Issue 4, Page(s) 513–516

Abstract: A 87-year-old woman presented with hypertension and motor disturbance in upper and lower extremities due to severe muscle weakness. As she had a history of licorice administration, laboratory data was obtained approximately 3 months after the drug ... ...

Abstract	A 87-year-old woman presented with hypertension and motor disturbance in upper and lower extremities due to severe muscle weakness. As she had a history of licorice administration, laboratory data was obtained approximately 3 months after the drug cessation. She showed hypokalemia (2.7 mEq/l), metabolic alkalosis and reduced plasma renin activity (PRA). Despite the mineralocorticoid excess, plasma aldosterone concentration (PAC) and 24-hour urine aldosterone were markedly diminished (32 pg/ml and 1.1 microg/day, respectively). Thyroid function was normal, and plasma ACTH and serum cortisol levels were within normal limits. Serum potassium levels was elevated (3.9 mEq/l) and blood pressure returned to normal by cortisol suppression with dexamethasone, 1.5mg per day. Moreover, administration of spironolactone, 50-75 mg per day, caused additional elevation of serum potassium level (4.7 mEq/l) with clinical improvement. These results revealed that the mineralocorticoid excess, found in the present patient, was responsible to dexamesathone and spironolactone, suggesting 11 beta-HSD2 deficiency. Serum cortisol/cortisone ratio (0.95) was also elevated, as compared with age-matched female control (0.28-0.72). The active component of licorice, glycyrrhetinic acid, has a mineralocorticoid-like side effect. However, in the present patient, diminution in serum potassium level and PAC were still found approximately 1 year after stopping licorice. Recently, elderly patients with 11 beta-HSD2 deficiency are often reported, therefore further investigations in relation to the changes caused by aging are needed to elucidate this abnormality.
MeSH term(s)	Aged, 80 and over ; Aldosterone/blood ; Female ; Glycyrrhiza/adverse effects ; Humans ; Mineralocorticoid Excess Syndrome, Apparent/diagnosis ; Potassium/blood
Chemical Substances	Aldosterone (4964P6T9RB) ; Potassium (RWP5GA015D)
Language	Japanese
Publishing date	2007-09-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604107-3
ISSN	0300-9173
ISSN	0300-9173
DOI	10.3143/geriatrics.44.513
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Article ; Online: Diffuse

Higashiyama, Akira / Komori, Tsuyoshi / Inada, Yuki / Nishizawa, Mitsuo / Nakajima, Hideto / Narumi, Yoshifumi

European journal of nuclear medicine and molecular imaging

2017 Volume 44, Issue 9, Page(s) 1609–1610

Language	English
Publishing date	2017
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-017-3735-z
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Zs.A 1227: Show issues

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Article: A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery.

Hashimoto, Hikaru / Yoshida, Naohisa / Inoue, Ken / Kobayashi, Reo / Tomita, Yuri / Sugino, Satoshi / Dohi, Osamu / Hirose, Ryohei / Inada, Yutaka / Murakami, Takaaki / Morinaga, Yukiko / Kishimoto, Mitsuo / Itoh, Yoshito

Case reports in gastroenterology

2022 Volume 16, Issue 1, Page(s) 37–43

Abstract: Case report: A 65-year-old man without any symptoms received colonoscopy for cancer screening and underwent cold snare polypectomy (CSP) for a 3-mm rectal lesion at a local clinic. A histopathological examination revealed neuroendocrine tumor (NET) G1 ... ...

Abstract	Case report: A 65-year-old man without any symptoms received colonoscopy for cancer screening and underwent cold snare polypectomy (CSP) for a 3-mm rectal lesion at a local clinic. A histopathological examination revealed neuroendocrine tumor (NET) G1 with a positive margin. The patient was referred to our hospital for further treatment. Then, the post-CSP scar was removed by endoscopic submucosal dissection (ESD), with a sufficient endoscopically normal margin. Histopathology showed 4 NETs and endocrine cell micronests (ECMs) distant from the post-CSP scar, with a positive lateral margin. We considered that the possibility of other NETs was high. Additional surgery was performed. After a histopathological examination, 11 NETs and ECMs were found in the whole rectum, without lymph node metastasis. The patient had no recurrence at 24 months after surgery. In the past 10 years, we have experienced 4 cases (including the present case) of multiple rectal NETs among 56 cases of rectal NETs of ≤10 mm (7.1%). None of our 4 cases showed any recurrence (follow-up period: 12-32 months). Conclusions: We herein report a case involving a patient with 15 rectal NETs and ECMs. We reviewed our experience with multiple rectal NETs, and the rate of multiple rectal NETs was 7.1%. Endoscopists should consider that multiple lesions may be present in cases of rectal NET and be aware that some cannot be detected endoscopically.
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000521522
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Article ; Online: The usefulness of combining the pocket-creation method with a traction device using a scissor-type knife for colorectal endoscopic submucosal dissection.

Tomita, Yuri / Yoshida, Naohisa / Inoue, Ken / Hashimoto, Hikaru / Sugino, Satoshi / Yasuda, Ritsu / Hirose, Ryohei / Dohi, Osamu / Naito, Yuji / Murakami, Takaaki / Inada, Yutaka / Morinaga, Yukiko / Kishimoto, Mitsuo / Itoh, Yoshito

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2022 Volume 41, Issue 2, Page(s) 149–159

Abstract: Introduction: Technical issues and long procedure time still remain a concern in colorectal endoscopic submucosal dissection (ESD). We examined the usefulness of combining the pocket-creation method (PCM) with a traction device (S-O clip; SO) using a ... ...

Abstract	Introduction: Technical issues and long procedure time still remain a concern in colorectal endoscopic submucosal dissection (ESD). We examined the usefulness of combining the pocket-creation method (PCM) with a traction device (S-O clip; SO) using a scissor-type knife (Clutch Cutter 3.5 mm; CC) for decreasing ESD procedure time. Methods: We retrospectively analyzed 95 ESD cases of PCM + SO + CC managed from August 2017 to April 2020 and 103 cases of PCM + CC treated from July 2016 to July 2017. We compared these two groups through propensity score matching. The main outcome was the analysis of the ESD procedure times under various conditions in each group. Results: After matching, 52 cases in the PCM + SO + CC and PCM + CC groups were analyzed. The PCM + SO + CC group showed a significantly shorter ESD procedure time than the PCM + CC group (57.8 ± 31.4 vs. 81.7 ± 33.5 min, p < 0.01). Additionally, the ESD procedure time was significantly shorter in the PCM + SO + CC group than in the PCM + CC group: tumor size (tumor size < 40 mm: 45.6 ± 15.8 vs. 72.7 ± 22.9 min, p < 0.01; tumor size ≥ 40 mm: 83.1 ± 40.1 vs. 111.8 ± 45.3 min, p = 0.04), tumor location (right side: 64.7 ± 33.3 vs. 81.0 ± 29.7 min, p = 0.03; left side: 50.5 ± 28.0 vs. 82.3 ± 36.9 min, p < 0.01), tumor morphology (polypoid: 39.2 ± 18.6 vs. 74.7 ± 28.6 min, p < 0.01; nonpolypoid: 62.3 ± 32.3 vs. 84.5 ± 35.2 min, p < 0.01), endoscopist (expert: 67.3 ± 41.2 vs. 91.9 ± 40.2 min, p = 0.02; nonexpert: 50.4 ± 18.3 vs. 73.6 ± 24.9 min, p < 0.01), and fibrosis (severe fibrosis: 82.0 ± 20.5 vs. 99.8 ± 40.4 min, p = 0.169; non-severe fibrosis: 52.1 ± 23.8 vs. 75.6 ± 29.0 min, p < 0.01). Conclusions: The combination of the PCM and SO using CC achieved a reduction in the colorectal ESD procedure time.
MeSH term(s)	Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection/methods ; Fibrosis ; Humans ; Retrospective Studies ; Traction ; Treatment Outcome
Language	English
Publishing date	2022-02-24
Publishing country	India
Document type	Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-021-01222-3
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Article: Effects of the combined use of a scissor-type knife and traction clip on endoscopic submucosal dissection of colorectal tumors: a propensity score-matched analysis.

Inoue, Ken / Yoshida, Naohisa / Dohi, Osamu / Sugino, Satoshi / Matsumura, Shinya / Kitae, Hiroaki / Yasuda, Ritsu / Nakano, Takahiro / Terasaki, Kei / Hirose, Ryohei / Naito, Yuji / Murakami, Takaaki / Inada, Yutaka / Ogiso, Kiyoshi / Morinaga, Yukiko / Kishimoto, Mitsuo / Yoshito, Itoh

Endoscopy international open

2021 Volume 9, Issue 11, Page(s) E1617–E1626

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2021-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1535-0786
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Article ; Online: The Impact of Mitral Regurgitation on Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Obayashi, Yuki / Shiomi, Hiroki / Morimoto, Takeshi / Miyake, Makoto / Inoko, Moriaki / Nishikawa, Ryusuke / Kaneda, Kazuhisa / Yamamoto, Ko / Takeji, Yasuaki / Tada, Tomohisa / Nagao, Kazuya / Uegaito, Takashi / Ehara, Natsuhiko / Sakai, Hiroshi / Suwa, Satoru / Tamura, Toshihiro / Sakamoto, Hiroki / Inada, Tsukasa / Matsuda, Mitsuo /

Sato, Yukihito / Furukawa, Yutaka / Ando, Kenji / Kadota, Kazushige / Nakagawa, Yoshihisa / Kimura, Takeshi

The American journal of cardiology

2023 Volume 203, Page(s) 384–393

Abstract: It is important to clarify the precise impact of mitral regurgitation (MR) on long-term outcomes in acute myocardial infarction (AMI) patients who underwent percutaneous coronary intervention (PCI). In the Coronary Revascularization Demonstrating Outcome ...

Abstract	It is important to clarify the precise impact of mitral regurgitation (MR) on long-term outcomes in acute myocardial infarction (AMI) patients who underwent percutaneous coronary intervention (PCI). In the Coronary Revascularization Demonstrating Outcome study in Kyoto Acute Myocardial Infarction (CREDO-Kyoto AMI) Registry Wave-2, the study population consisted of 5,266 patients with AMI who underwent PCI. The clinical outcomes of all-cause death, cardiovascular death, and hospitalization for heart failure (HF) were compared according to the severity of MR. Mild and moderate/severe MR were identified in 2,112 (40%) and 531 patients (10%), respectively. Patients with greater severity of MR were more likely to be old, had more co-morbidities, and more often presented with large myocardial infarction with HF. During median follow-up duration of 5.6 (interquartile range: 4.2 to 6.6) years, as the MR severity increased from no, mild, to moderate/severe MR, the cumulative 5-year incidences of all-cause death, cardiovascular death and hospitalization for HF incrementally increased ([15.3%, 19.6%, 33.3%], [8.9%, 11.7%, 21.0%] and [5.9%, 12.4%, 23.9%], respectively, P for all<0.001). After adjusting for confounders, however, mild and moderate/severe MR were not independently associated with the higher risks for all-cause death (hazard ratio [95% confidence interval]:1.05 [0.92 to 1.19], p = 0.51, and 1.10 [0.92 to 1.32], p = 0.28) and cardiovascular death (1.01 [0.85 to 1.21], p = 0.89, and 0.93 [0.73 to 1.18], p = 0.54) as compared with no MR. Both mild and moderate/severe MR were independently associated with the higher risks for hospitalization for HF (1.73 [1.42 to 2.11], p <0.001, and 2.23 [1.73 to 2.87], p <0.001). In a large population of patients with AMI who underwent PCI, MR was not independently associated with higher long-term mortality risk but was independently associated with higher risk for hospitalization for HF.
MeSH term(s)	Humans ; Percutaneous Coronary Intervention/adverse effects ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/epidemiology ; Mitral Valve Insufficiency/surgery ; Myocardial Infarction/epidemiology ; Myocardial Infarction/surgery ; Myocardial Infarction/complications ; Hospitalization ; Comorbidity ; Treatment Outcome ; Registries
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.07.038
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Article ; Online: Cold snare polypectomy for large sessile serrated lesions is safe but follow-up is needed: a single-centre retrospective study.

Yoshida, Naohisa / Inoue, Ken / Tomita, Yuri / Hashimoto, Hikaru / Sugino, Satoshi / Hirose, Ryohei / Dohi, Osamu / Naito, Yuji / Morinaga, Yukiko / Kishimoto, Mitsuo / Inada, Yutaka / Murakami, Takaaki / Itoh, Yoshito

United European gastroenterology journal

2021 Volume 9, Issue 3, Page(s) 370–377

Abstract: Background and aim: Cold snare polypectomy (CSP) is growing in popularity due to its safety and convenience. Its indication is benign tumours such as adenoma and sessile serrated lesions (SSLs) <10 mm in size. CSP for SSLs ≥10 mm in size has not been ... ...

Abstract	Background and aim: Cold snare polypectomy (CSP) is growing in popularity due to its safety and convenience. Its indication is benign tumours such as adenoma and sessile serrated lesions (SSLs) <10 mm in size. CSP for SSLs ≥10 mm in size has not been well examined. In this study, we aimed the feasibility of this treatment regarding therapeutic results and local recurrence. Methods: This was a single-centre retrospective cohort study. We reviewed SSLs with or without dysplasia of 10-20 mm that were resected by CSP from 2014 to 2020. All tumours were diagnosed endoscopically as SSLs without dysplasia before CSP with the help of magnifying narrow band imaging or blue laser imaging. We analysed the lesion characteristics, en bloc resection, histopathological diagnosis, adverse events and local recurrence. We analysed risk factors for recurrence, comparing recurrent lesions to non-recurrent lesions. We also compared risk factors for lesions 10-14 mm in size to those for lesions 15-20 mm in size. Results: We analysed 160 lesions in 100 patients (M Conclusion: CSP of SSLs ≥10 mm in size according to magnifying endoscopic diagnosis was safe and promising, but the rate of recurrence was slightly high, meaning that close follow-up is required.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Colonic Polyps/diagnostic imaging ; Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy/adverse effects ; Colonoscopy/methods ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Intestinal Perforation/epidemiology ; Intraoperative Complications/epidemiology ; Male ; Middle Aged ; Narrow Band Imaging ; Postoperative Hemorrhage/epidemiology ; Recurrence ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1177/2050640620964641
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Article ; Online: Post-contrast Acute Kidney Injury After Emergent and Elective Percutaneous Coronary Intervention (from the CREDO-Kyoto PCI/CABG Registry Cohort 3).

Kaneda, Kazuhisa / Shiomi, Hiroki / Abe, Mitsuru / Morimoto, Takeshi / Yamamoto, Ko / Obayashi, Yuki / Nishikawa, Ryusuke / Tamura, Akinori / Kadota, Kazushige / Domei, Takenori / Nakatsuma, Kenji / Yokomatsu, Takafumi / Imai, Masao / Taniguchi, Tomohiko / Nawada, Ryuzo / Toyofuku, Mamoru / Tamura, Toshihiro / Inada, Tsukasa / Matsuda, Mitsuo /

Sato, Yukihito / Furukawa, Yutaka / Ando, Kenji / Nakagawa, Yoshihisa / Kimura, Takeshi

The American journal of cardiology

2023 Volume 202, Page(s) 58–66

Abstract: Post-contrast acute kidney injury (PC-AKI) is a common complication after percutaneous coronary intervention (PCI). However, it is unclear whether or not the effects of PC-AKI on long-term clinical outcomes were different between emergent and elective ... ...

Abstract	Post-contrast acute kidney injury (PC-AKI) is a common complication after percutaneous coronary intervention (PCI). However, it is unclear whether or not the effects of PC-AKI on long-term clinical outcomes were different between emergent and elective procedures. Among patients enrolled in the CREDO-Kyoto PCI/CABG (Coronary Revascularization Demonstrating Outcome Study in Kyoto Percutaneous Coronary Intervention/Coronary Artery Bypass Grafting) registry cohort 3, we identified 10,822 patients treated using PCI (emergent PCI stratum: n = 5,022 [46%] and elective PCI stratum: n = 5,860 [54%]). PC-AKI was defined as ≥0.3 mg/100 ml absolute or 1.5-fold relative increase of serum creatinine within 72 hours after PCI. The incidence of PC-AKI was significantly higher after emergent PCI than after elective PCI (10.5% vs 3.7%, p <0.001). In the multivariable logistic regression model, emergent PCI was the strongest independent risk factor for PC-AKI in the entire study population. The excess adjusted risk of patients with PC-AKI relative to those without remained significant for all-cause death in both the emergent and elective PCI strata (hazard ratio 1.87, 95% confidence interval 1.59 to 2.21, p <0.001 and hazard ratio 1.31, 95% confidence interval 1.03 to 1.68, p = 0.03, respectively). There was a significant interaction between the PCI setting (emergent and elective) and the effect of PC-AKI on all-cause death, with a greater magnitude of effect in the emergent PCI stratum than in the elective PCI stratum (p for interaction = 0.01). In conclusion, the incidence of PC-AKI was 2.8 times higher after emergent PCI than after elective PCI. The excess mortality risk of PC-AKI relative to no PC-AKI was greater after emergent PCI than after elective PCI.
MeSH term(s)	Humans ; Coronary Artery Bypass/methods ; Percutaneous Coronary Intervention/methods ; Follow-Up Studies ; Treatment Outcome ; Risk Factors ; Registries ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/complications ; Coronary Artery Disease/complications
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.06.031
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Article ; Online: Critical Diamond-Blackfan anemia due to ribosomal protein S19 missense mutation.

Ozono, Shuichi / Mitsuo, Miho / Noguchi, Maiko / Nakagawa, Shin-Ichiro / Ueda, Koichiro / Inada, Hiroko / Ohga, Shouichi / Ito, Etsuro

Pediatrics international : official journal of the Japan Pediatric Society

2016 Volume 58, Issue 9, Page(s) 930–933

Abstract: Diamond-Blackfan anemia (DBA) is a rare congenital disorder characterized by pure erythrocyte aplasia, and approximately 70% of patients carry mutations in the genes encoding ribosomal proteins (RP). Here, we report the case of a male infant with DBA who ...

Abstract	Diamond-Blackfan anemia (DBA) is a rare congenital disorder characterized by pure erythrocyte aplasia, and approximately 70% of patients carry mutations in the genes encoding ribosomal proteins (RP). Here, we report the case of a male infant with DBA who presented with anemic crisis (hemoglobin [Hb] concentration 1.5 g/dL) at 58 days after birth. On admission, the infant was pale and had tachypnea, but recovered with intensive care, including red blood cell transfusions, and prednisolone. Based on the clinical diagnosis of DBA, the father of the infant had cyclosporine-A-dependent anemia. On analysis of RP genes when the infant was 6 months old, both the infant and the father, but not the mother, were found to harbor a mutation of RPS19 (c.167G > C, p. R56P). Therefore, genetic background search and early neonatal health check-ups are recommended for families with a history of inherited bone marrow failure syndromes.
MeSH term(s)	Anemia, Diamond-Blackfan/blood ; Anemia, Diamond-Blackfan/diagnosis ; Anemia, Diamond-Blackfan/genetics ; DNA Mutational Analysis ; DNA, Neoplasm/genetics ; Humans ; Infant ; Male ; Mutation, Missense ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism
Chemical Substances	DNA, Neoplasm ; Ribosomal Proteins ; ribosomal protein S19
Language	English
Publishing date	2016-09
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.13018
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Article ; Online: Stroke Risk Stratification With the CHADS<sub>2</sub> Score in Patients Without Atrial Fibrillation Who Underwent Percutaneous Coronary Intervention.

Obayashi, Yuki / Shiomi, Hiroki / Morimoto, Takeshi / Tamaki, Yodo / Inoko, Moriaki / Nishikawa, Ryusuke / Kaneda, Kazuhisa / Yamamoto, Ko / Takeji, Yasuaki / Komasa, Akihiro / Yamaji, Kyohei / Shizuta, Satoshi / Tada, Tomohisa / Nagao, Kazuya / Suwa, Satoru / Tamura, Toshihiro / Sakamoto, Hiroki / Inada, Tsukasa / Matsuda, Mitsuo /

Sato, Yukihito / Furukawa, Yutaka / Ando, Kenji / Kadota, Kazushige / Nakagawa, Yoshihisa / Kimura, Takeshi

The American journal of cardiology

2022 Volume 181, Page(s) 9–17

Abstract: The clinical significance of the CHADS ... 2 ... score remains unclear in patients with coronary artery disease (CAD) without atrial fibrillation (AF). Therefore, the purpose of this study was to evaluate the association between the CHADS ... 2 ... ... ...

Abstract	The clinical significance of the CHADS<sub>2</sub> score remains unclear in patients with coronary artery disease (CAD) without atrial fibrillation (AF). Therefore, the purpose of this study was to evaluate the association between the CHADS<sub>2</sub> score and the long-term risk of ischemic stroke and its severity in patients with CAD with and without AF. Using the CREDO (Coronary Revascularization Demonstrating Outcome study)-Kyoto Registry Cohort-3, the present study population consisted of 11,516 patients with CAD who underwent percutaneous coronary intervention without oral anticoagulants at discharge. We divided the patients into 2 groups according to the presence (n = 721) or absence (n = 10,795) of AF. As the CHADS<sub>2</sub> score increased from 0 or 1 to 6, the cumulative 5-year incidence of ischemic stroke incrementally increased from 2.1% to 17.1% in patients without AF and from 4.2% to 40.7% in patients with AF. The cumulative 5-year incidence of ischemic stroke in patients without AF and a CHADS<sub>2</sub> score of 2 were numerically comparable to that in patients with AF and a CHADS<sub>2</sub> score of 1 (3.4% and 3.7%). In the 423 patients who developed ischemic stroke, the modified Rankin Scale score was not significantly different between patients with and without AF (p for trend = 0.12). In patients with and without AF, the increase in the CHADS<sub>2</sub> score was significantly associated with the greater prevalence of higher modified Rankin Scale scores (p for trend = 0.03 and <0.001, respectively). An increasing CHADS<sub>2</sub> score was associated with an incrementally increased risk for ischemic stroke and greater severity of ischemic stroke in patients with and without AF.
MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/surgery ; Coronary Artery Disease/complications ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/surgery ; Humans ; Ischemic Stroke ; Percutaneous Coronary Intervention/adverse effects ; Risk Assessment ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology
Language	English
Publishing date	2022-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.06.057
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In stock of ZB MED Cologne/Königswinter

Order via subito