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Article ; Online: Prospective Pathways from Affect to Drug Outcomes: Refusal Self-Efficacy in the Context of Peer Influences.

Cheesman, Abigail / Read, Jennifer P

2023 Volume 58, Issue 12, Page(s) 1587–1597

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Young Adult ; Humans ; Peer Influence ; NAD ; Prospective Studies ; Self Efficacy ; Peer Group
Chemical Substances	NAD (0U46U6E8UK)
Language	English
Publishing date	2023-07-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2023.2236209
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Article ; Online: Ocular accommodation and wavelength: The effect of longitudinal chromatic aberration on the stimulus-response curve.

Fernandez-Alonso, Maydel / Finch, Abigail P / Love, Gordon D / Read, Jenny C A

Journal of vision

2024 Volume 24, Issue 2, Page(s) 11

Abstract: The longitudinal chromatic aberration (LCA) of the eye creates a chromatic blur on the retina that is an important cue for accommodation. Although this mechanism can work optimally in broadband illuminants such as daylight, it is not clear how the system ...

Abstract	The longitudinal chromatic aberration (LCA) of the eye creates a chromatic blur on the retina that is an important cue for accommodation. Although this mechanism can work optimally in broadband illuminants such as daylight, it is not clear how the system responds to the narrowband illuminants used by many modern displays. Here, we measured pupil and accommodative responses as well as visual acuity under narrowband light-emitting diode (LED) illuminants of different peak wavelengths. Observers were able to accommodate under narrowband light and compensate for the LCA of the eye, with no difference in the variability of the steady-state accommodation response between narrowband and broadband illuminants. Intriguingly, our subjects compensated more fully for LCA at nearer distances. That is, the difference in accommodation to different wavelengths became larger when the object was placed nearer the observer, causing the slope of the accommodation response curve to become shallower for shorter wavelengths and steeper for longer ones. Within the accommodative range of observers, accommodative errors were small and visual acuity normal. When comparing between illuminants, when accommodation was accurate, visual acuity was worst for blue narrowband light. This cannot be due to the sparser spacing for S-cones, as our stimuli had equal luminance and thus activated LM-cones roughly equally. It is likely because ocular LCA changes more rapidly at shorter wavelength and so the finite spectral bandwidth of LEDs corresponds to a greater dioptric range at shorter wavelengths. This effect disappears for larger accommodative errors, due to the increased depth of focus of the eye.
MeSH term(s)	Humans ; Accommodation, Ocular ; Face ; Retina ; Blue Light ; Pupil
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106064-2
ISSN	1534-7362 ; 1534-7362
ISSN (online)	1534-7362
ISSN	1534-7362
DOI	10.1167/jov.24.2.11
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Article ; Online: Coping Flexibility and Alcohol-Related Outcomes: Examining Coping Motives as Mediators.

Jenzer, Tiffany / Cheesman, Abigail J / Shaw, Rachael J / Egerton, Gregory A / Read, Jennifer P

Substance use & misuse

2022 Volume 57, Issue 14, Page(s) 2031–2041

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Universities ; Alcohol Drinking/psychology ; Motivation ; Adaptation, Psychological ; Students/psychology
Language	English
Publishing date	2022-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2022.2125274
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Article ; Online: Classifying risky cannabis involvement in young adults using the Marijuana Consequences Questionnaire (MACQ).

Read, Jennifer P / Egerton, Gregory / Cheesman, Abigail / Steers, Mai-Ly N

Addictive behaviors

2022 Volume 129, Page(s) 107236

Abstract: Background: Despite the growing prevalence of cannabis use and associated consequences among U.S. young adults, relatively little is known about precisely what level of marijuana involvement may be problematic.: Method: With this study we sought to ... ...

Abstract	Background: Despite the growing prevalence of cannabis use and associated consequences among U.S. young adults, relatively little is known about precisely what level of marijuana involvement may be problematic. Method: With this study we sought to identify empirically-derived cut-scores for the Marijuana Consequences Questionnaire (MACQ) that would distinguish among levels of cannabis risk in a sample of young adult college students (N = 496). We also examined how these levels of cannabis risk corresponded to a variety of indicators of cannabis involvement, including frequency of use, intoxication, other measures of cannabis consequences, and indicators of more severe cannabis involvement (e.g., physiological dependence, loss of control over use, cannabis use disorder). Results: Receiver operating characteristic analyses yielded cutoffs that distinguished among three distinct levels of risk, "Low", "Moderate", and "High". These empirically derived cut scores showed strong overall differentiation among classifications, with good sensitivity and specificity. MACQ-based risk levels were validated across several indices of cannabis involvement. Cutoffs differed across genders. Conclusions: Findings offer a new application for the MACQ, allowing for the identification of those at greatest risk. As such, this measure may be used to facilitate appropriately targeted intervention.
MeSH term(s)	Cannabis ; Female ; Hallucinogens ; Humans ; Male ; Marijuana Abuse ; Sensitivity and Specificity ; Students ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Hallucinogens
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2022.107236
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Article ; Online: Splicing dysregulation as a driver of breast cancer.

Read, Abigail / Natrajan, Rachael

Endocrine-related cancer

2018 Volume 25, Issue 9, Page(s) R467–R478

Abstract: Breast cancer is known to be a heterogeneous disease driven by a large repertoire of molecular abnormalities, which contribute to its diverse clinical behaviour. Despite the success of targeted therapy approaches for breast cancer patient management, ... ...

Abstract	Breast cancer is known to be a heterogeneous disease driven by a large repertoire of molecular abnormalities, which contribute to its diverse clinical behaviour. Despite the success of targeted therapy approaches for breast cancer patient management, there is still a lack of the molecular understanding of aggressive forms of the disease and clinical management of these patients remains difficult. The advent of high-throughput sequencing technologies has paved the way for a more complete understanding of the molecular make-up of the breast cancer genome. As such, it is becoming apparent that disruption of canonical splicing within breast cancer governs its clinical progression. In this review, we discuss the role of dysregulation of spliceosomal component genes and associated factors in the progression of breast cancer, their role in therapy resistance and the use of quantitative isoform expression as potential prognostic and predictive biomarkers with a particular focus on oestrogen receptor-positive breast cancer.
MeSH term(s)	Alternative Splicing ; Biomarkers ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Drug Resistance, Neoplasm ; Female ; Humans ; Prognosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1218450-0
ISSN	1479-6821 ; 1351-0088
ISSN (online)	1479-6821
ISSN	1351-0088
DOI	10.1530/ERC-18-0068
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Article ; Online: Curcumin: an inflammasome silencer.

Hasanzadeh, Shima / Read, Morgayn I / Bland, Abigail R / Majeed, Muhammed / Jamialahmadi, Tannaz / Sahebkar, Amirhossein

Pharmacological research

2020 Volume 159, Page(s) 104921

Abstract: Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence indicates that the health benefits of curcumin are mediated through its anti-inflammatory and antioxidant effects. Inflammasomes are essential components of ... ...

Abstract	Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence indicates that the health benefits of curcumin are mediated through its anti-inflammatory and antioxidant effects. Inflammasomes are essential components of inflammatory pathways that activate caspase-1 leading to pyroptosis and stimulate maturation and secretion of the proinflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) through nuclear factor kappa-B (NF-κB) signaling. The current review outlines the mechanisms of curcumin as an inflammasome modulator in inflammatory-related diseases. Regulation of NF-κB signaling and interleukins secretion is the most prominent functional mechanism of curcumin in modulating inflammasomes. More importantly, curcumin can exert its anti-inflammatory role mainly through the down-regulation of NLRP3 inflammasomes. Given the fundamental role of inflammation in diseases, such as arthritis, cancer and cardiorenal disease, curcumin may have a pivotal therapeutic role through its ability to produce beneficial anti-inflammatory effects.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/therapeutic use ; Curcumin/pharmacokinetics ; Curcumin/therapeutic use ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Humans ; Inflammasomes/antagonists & inhibitors ; Inflammasomes/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Signal Transduction
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Inflammasomes ; Inflammation Mediators ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2020-05-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2020.104921
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Article ; Online: Flexible CRISPR library construction using parallel oligonucleotide retrieval.

Read, Abigail / Gao, Shaojian / Batchelor, Eric / Luo, Ji

Nucleic acids research

2017 Volume 45, Issue 11, Page(s) e101

Abstract: CRISPR/Cas9-based gene knockout libraries have emerged as a powerful tool for functional screens. We present here a set of pre-designed human and mouse sgRNA sequences that are optimized for both high on-target potency and low off-target effect. To ... ...

Abstract	CRISPR/Cas9-based gene knockout libraries have emerged as a powerful tool for functional screens. We present here a set of pre-designed human and mouse sgRNA sequences that are optimized for both high on-target potency and low off-target effect. To maximize the chance of target gene inactivation, sgRNAs were curated to target both 5΄ constitutive exons and exons that encode conserved protein domains. We describe here a robust and cost-effective method to construct multiple small sized CRISPR library from a single oligo pool generated by array synthesis using parallel oligonucleotide retrieval. Together, these resources provide a convenient means for individual labs to generate customized CRISPR libraries of variable size and coverage depth for functional genomics application.
MeSH term(s)	Animals ; CRISPR-Cas Systems ; Exons ; Gene Knockout Techniques ; Gene Library ; Humans ; Mice ; Oligonucleotides/genetics
Chemical Substances	Oligonucleotides
Language	English
Publishing date	2017-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkx181
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Article ; Online: Yes, we do need to demonstrate the survival advantage of pancreas after kidney transplantation.

Fridell, Jonathan A / Niederhaus, Silke / Urban, Read / Fox, Abigail / Odorico, Jon

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2019 Volume 19, Issue 4, Page(s) 1243–1244

MeSH term(s)	Humans ; Kidney Transplantation ; Living Donors ; Pancreas Transplantation
Language	English
Publishing date	2019-01-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.15221
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Article: Reuse of Molecules for Glioblastoma Therapy.

Koehler, Abigail / Karve, Aniruddha / Desai, Pankaj / Arbiser, Jack / Plas, David R / Qi, Xiaoyang / Read, Renee D / Sasaki, Atsuo T / Gawali, Vaibhavkumar S / Toukam, Donatien K / Bhattacharya, Debanjan / Kallay, Laura / Pomeranz Krummel, Daniel A / Sengupta, Soma

Pharmaceuticals (Basel, Switzerland)

2021 Volume 14, Issue 2

Abstract: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM is the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with the DNA alkylator temozolomide; however, ... ...

Abstract	Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM is the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with the DNA alkylator temozolomide; however, survival under this treatment regimen is an abysmal 12-18 months. New and emerging treatments include the application of a physical device, non-invasive 'tumor treating fields' (TTFs), including its concomitant use with standard of care; and varied vaccines and immunotherapeutics being trialed. Some of these approaches have extended life by a few months over standard of care, but in some cases are only available for a minority of GBM patients. Extensive activity is also underway to repurpose and reposition therapeutics for GBM, either alone or in combination with the standard of care. In this review, we present select molecules that target different pathways and are at various stages of clinical translation as case studies to illustrate the rationale for their repurposing-repositioning and potential clinical use.
Language	English
Publishing date	2021-01-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph14020099
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Article ; Online: The survival advantage of pancreas after kidney transplant.

Fridell, Jonathan A / Niederhaus, Silke / Curry, Michael / Urban, Read / Fox, Abigail / Odorico, Jon

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2018 Volume 19, Issue 3, Page(s) 823–830

Abstract: Patient survival after pancreas after kidney transplant (PAK) has been reported to be inferior to patient survival after simultaneous pancreas-kidney transplant (SPK). The authors examine national data to further explore allograft (kidney and pancreas) ... ...

Abstract	Patient survival after pancreas after kidney transplant (PAK) has been reported to be inferior to patient survival after simultaneous pancreas-kidney transplant (SPK). The authors examine national data to further explore allograft (kidney and pancreas) and patient survival after PAK. Kaplan-Meier and Cox proportional hazard models were used to analyze Organ Procurement and Transplantation Network data from 1995 to 2010. The analysis compared PAK and SPK candidates and recipients. Kaplan-Meier analysis results showed that PAK after either a living or a deceased donor kidney transplant is associated with increased kidney graft survival compared with recipients with type 1 diabetes who received only a kidney. The best kidney allograft survival was for patients who received a living donor kidney followed by PAK. Receiving a living donor kidney was associated with increased pancreas allograft survival compared with receiving a deceased donor kidney. PAK transplant recipients who receive both organs have a survival advantage compared with uremic candidates who receive neither (SPK waitlist). Compared with uremic diabetic waitlist patients, SPK and PAK recipients showed similar overall patient survival. Successful PAK offers a survival advantage compared with receiving neither a kidney nor a pancreas transplant. These data also suggest that receiving a pancreas (after kidney) transplant may have a protective effect on the kidney allograft.
MeSH term(s)	Adult ; Diabetes Mellitus, Type 1/mortality ; Diabetes Mellitus, Type 1/surgery ; Female ; Follow-Up Studies ; Graft Survival ; Humans ; Kidney Transplantation/mortality ; Male ; Pancreas Transplantation/mortality ; Prognosis ; Survival Rate ; Transplantation, Homologous
Language	English
Publishing date	2018-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.15106
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