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  1. Article ; Online: So long, and thanks for all the papers about fish (and other organisms too)

    Steven Kelly

    Biology Open, Vol 12, Iss

    2023  Volume 6

    Keywords Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Ten years (and counting) of Biology Open.

    Kelly, Steven

    Biology open

    2022  Volume 11, Issue 5

    MeSH term(s) Biology
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Editorial
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The quest for more food.

    Kelly, Steven

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6604, Page(s) 370–371

    Abstract: Rice yield is increased by boosting nitrogen uptake and photosynthesis. ...

    Abstract Rice yield is increased by boosting nitrogen uptake and photosynthesis.
    MeSH term(s) Crop Production/methods ; Nitrogen/metabolism ; Oryza/growth & development ; Oryza/metabolism ; Photosynthesis
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add3882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  4. Article ; Online: Ten years (and counting) of Biology Open

    Steven Kelly

    Biology Open, Vol 11, Iss

    2022  Volume 5

    Keywords Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Early-career researchers: answering the most important scientific questions of our time.

    Kelly, Steven

    Biology open

    2021  Volume 10, Issue 11

    MeSH term(s) Biological Science Disciplines/trends ; Humans ; Intersectoral Collaboration ; Research Personnel/trends
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early-career researchers

    Steven Kelly

    Biology Open, Vol 10, Iss

    answering the most important scientific questions of our time

    2021  Volume 11

    Keywords Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The economics of organellar gene loss and endosymbiotic gene transfer.

    Kelly, Steven

    Genome biology

    2021  Volume 22, Issue 1, Page(s) 345

    Abstract: Background: The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this ... ...

    Abstract Background: The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this complexity is not reflected in the content of their genomes. Instead, the organellar genomes encode fewer than 5% of the genes found in living relatives of their ancestors. While many of the 95% of missing organellar genes have been discarded, others have been transferred to the host nuclear genome through a process known as endosymbiotic gene transfer.
    Results: Here, we demonstrate that the difference in the per-cell copy number of the organellar and nuclear genomes presents an energetic incentive to the cell to either delete organellar genes or transfer them to the nuclear genome. We show that, for the majority of transferred organellar genes, the energy saved by nuclear transfer exceeds the costs incurred from importing the encoded protein into the organelle where it can provide its function. Finally, we show that the net energy saved by endosymbiotic gene transfer can constitute an appreciable proportion of total cellular energy budgets and is therefore sufficient to impart a selectable advantage to the cell.
    Conclusion: Thus, reduced cellular cost and improved energy efficiency likely played a role in the reductive evolution of mitochondrial and chloroplast genomes and the transfer of organellar genes to the nuclear genome.
    MeSH term(s) Arabidopsis/genetics ; Bacteria/genetics ; Cell Nucleus ; Chloroplasts ; Gene Transfer, Horizontal ; Genome, Chloroplast ; Genome, Mitochondrial ; Genome, Plant ; Host Microbial Interactions/genetics ; Mitochondria/genetics ; Proteomics ; Symbiosis/genetics
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-021-02567-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The economics of organellar gene loss and endosymbiotic gene transfer

    Steven Kelly

    Genome Biology, Vol 22, Iss 1, Pp 1-

    2021  Volume 22

    Abstract: Abstract Background The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this ... ...

    Abstract Abstract Background The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this complexity is not reflected in the content of their genomes. Instead, the organellar genomes encode fewer than 5% of the genes found in living relatives of their ancestors. While many of the 95% of missing organellar genes have been discarded, others have been transferred to the host nuclear genome through a process known as endosymbiotic gene transfer. Results Here, we demonstrate that the difference in the per-cell copy number of the organellar and nuclear genomes presents an energetic incentive to the cell to either delete organellar genes or transfer them to the nuclear genome. We show that, for the majority of transferred organellar genes, the energy saved by nuclear transfer exceeds the costs incurred from importing the encoded protein into the organelle where it can provide its function. Finally, we show that the net energy saved by endosymbiotic gene transfer can constitute an appreciable proportion of total cellular energy budgets and is therefore sufficient to impart a selectable advantage to the cell. Conclusion Thus, reduced cellular cost and improved energy efficiency likely played a role in the reductive evolution of mitochondrial and chloroplast genomes and the transfer of organellar genes to the nuclear genome.
    Keywords Endosymbiosis ; Gene loss endosymbiotic gene transfer ; Mitochondrion ; Chloroplast ; Organellar genome ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Subject code 612
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Tumor Microenvironment and Immune Response in Breast Cancer.

    Monzavi-Karbassi, Behjatolah / Kelly, Thomas / Post, Steven R

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: The complex interactions between cancer cells and their surrounding microenvironment are fundamental in determining tumor progression, response to therapy, and, ultimately, patient prognosis [ ... ]. ...

    Abstract The complex interactions between cancer cells and their surrounding microenvironment are fundamental in determining tumor progression, response to therapy, and, ultimately, patient prognosis [...].
    MeSH term(s) Humans ; Female ; Breast Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020914
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  10. Article ; Online: Response to Tcherkez and Farquhar: Rubisco adaptation is more limited by phylogenetic constraint than by catalytic trade-off.

    Bouvier, Jacques W / Kelly, Steven

    Journal of plant physiology

    2023  Volume 287, Page(s) 154021

    Abstract: Rubisco is the primary entry point for carbon into the biosphere. It has been widely proposed that rubisco is highly constrained by catalytic trade-offs due to correlations between the enzyme's kinetic traits across species. In previous work, we have ... ...

    Abstract Rubisco is the primary entry point for carbon into the biosphere. It has been widely proposed that rubisco is highly constrained by catalytic trade-offs due to correlations between the enzyme's kinetic traits across species. In previous work, we have shown that the strength of these correlations, and thus the strength of catalytic trade-offs, have been overestimated due to the presence of phylogenetic signal in the kinetic trait data (Bouvier et al., 2021). We demonstrated that only the trade-offs between the Michaelis constant for CO
    MeSH term(s) Phylogeny ; Ribulose-Bisphosphate Carboxylase/genetics ; Ribulose-Bisphosphate Carboxylase/metabolism ; Carbon Dioxide ; Acclimatization ; Catalysis ; Kinetics
    Chemical Substances Ribulose-Bisphosphate Carboxylase (EC 4.1.1.39) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-06-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2023.154021
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    In stock of ZB MED Bonn / Germany

    Z 46/302: Show issues

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