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Article: Asociación de células NKT con la expresión del gen CTSL en población pediátrica mexicana con diabetes tipo 1 de reciente diagnóstico.

Gómez-Díaz, Rita Angélica / Medina-Santillán, Roberto / Castro-Magdonel, Blanca Elena / Bekker-Méndez, Carolina / Gómez-Zamudio, Jaime / Nishimura-Meguro, Elisa / Garrido-Magaña, Eulalia / Lizárraga-Paulin, Lorena / Aguilar-Herrera, Blanca E / Valladares-Salgado, Adán / Cruz, Miguel / Mondragón-González, Rafael / Ortiz-Navarrete, Vianney / Wacher, Niels H

Gaceta medica de Mexico

2016 Volume 152, Issue Suppl 2, Page(s) 14–21

Abstract: ... Percentages and absolute numbers of NKT cells were measured with expression of the CTSL gene.: Results: 124 ... higher in siblings (0.246 ± 0.188; p = 0.002). Lower level of expression of the CTSL gene associated ...

Title translation	Level of expression of gene CTSL and its correlation with natural killer T-Cells in mexican pediatric patients with recent-onset type 1 diabetes.
Abstract	Objective: To compare the level of expression of the gene CTSL and its correlation with NKT cells in patients with recent-onset type 1 diabetes (T1D), their siblings, and healthy controls. Methods: Analytical cross-sectional design. Patients with T1D < 3 months evolution, their siblings, and healthy controls were included. Percentages and absolute numbers of NKT cells were measured with expression of the CTSL gene. Results: 124 subjects: with T1D (n = 48), siblings (n = 44) and controls (n = 32) were included. HbA1c was greater and C-peptide lower in T1D than the other groups and sibling age was higher (p < 0.001). There were no differences in NKT cells between T1D (0.176 ± 0.202) and controls (0.118 ± 0.133), but the percentage was higher in siblings (0.246 ± 0.188; p = 0.002). Lower level of expression of the CTSL gene associated with both absolute number (r: 0.4607; 95% CI: -0.08425 to -0.7935; p = 0.043) and percentage of NKT cells (r: 0.4540; 95% CI: -0.0927 to -0.7903; p = 0.045) in the T1D group. Conclusions: Patients with T1D have lower percentage and absolute number of NKT cells compared to their siblings. NKT cells absolute numbers are correlated with the expression of CTSL in T1D patients.
MeSH term(s)	Adolescent ; Case-Control Studies ; Cathepsin L/genetics ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Lymphocyte Count ; Male ; Natural Killer T-Cells/cytology ; Siblings
Chemical Substances	Glycated Hemoglobin A ; hemoglobin A1c protein, human ; CTSL protein, human (EC 3.4.22.15) ; Cathepsin L (EC 3.4.22.15)
Language	Spanish
Publishing date	2016-10-27
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
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Article: Roseibacterium elongatum gen. nov., sp. nov., an aerobic, bacteriochlorophyll-containing bacterium isolated from the west coast of Australia.

Suzuki, Tomonori / Mori, Youichirou / Nishimura, Yukimasa

International journal of systematic and evolutionary microbiology

2006 Volume 56, Issue Pt 2, Page(s) 417–421

Abstract: ... 107377T) should be placed in a novel genus, Roseibacterium gen. nov., as the type strain of a novel ...

Abstract	A novel aerobic, chemoheterotrophic, bacteriochlorophyll-containing bacterium, strain OCh 323T, was isolated from sand at Monkey Mia, Shark Bay, located on the west coast of Australia. The cells were Gram-negative, non-motile rods of variable length; one or both cell poles was narrower. Bacteriochlorophyll a was synthesized under aerobic conditions. Catalase, oxidase and urease were produced. The ONPG reaction was positive. The major component of the cellular fatty acid was octadecenoic acid (18:1). The DNA G+C content was 68.1 mol%. The results of 16S rRNA gene sequence comparisons revealed that strain OCh 323T formed a novel, separate line of descent within the alpha-3 group of the Alphaproteobacteria. The similarity value for the 16S rRNA gene sequence of strain OCh 323T and that of the most closely related species, Rhodovulum sulfidophilum, was 91.4%. It is concluded that strain OCh 323T (=JCM 11220T=CIP 107377T) should be placed in a novel genus, Roseibacterium gen. nov., as the type strain of a novel species Roseibacterium elongatum sp. nov.
MeSH term(s)	Aerobiosis ; Bacteriochlorophyll A/biosynthesis ; Base Composition ; DNA, Bacterial/analysis ; DNA, Ribosomal/analysis ; Fatty Acids/analysis ; Genes, rRNA ; Geologic Sediments/microbiology ; Molecular Sequence Data ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Rhodobacteraceae/chemistry ; Rhodobacteraceae/classification ; Rhodobacteraceae/genetics ; Rhodobacteraceae/isolation & purification ; Sequence Analysis, DNA ; Western Australia
Chemical Substances	Bacteriochlorophyll A ; DNA, Bacterial ; DNA, Ribosomal ; Fatty Acids ; RNA, Ribosomal, 16S
Language	English
Publishing date	2006-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijs.0.02094-0
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Article: Proposal of Craurococcus roseus gen. nov., sp. nov. and Paracraurococcus ruber gen. nov., sp. nov., novel aerobic bacteriochlorophyll a-containing bacteria from soil.

Saitoh, S / Suzuki, T / Nishimura, Y

International journal of systematic bacteriology

1998 Volume 48 Pt 3, Page(s) 1043–1047

Abstract: ... Craurococcus gen. nov. and Paracraurococcus gen. nov. The type species are Craurococus roseus sp. nov. and ... Sequences of the 16S rRNA gene were determined for three strains of aerobic bacteriochlorophyll ...

Abstract	Sequences of the 16S rRNA gene were determined for three strains of aerobic bacteriochlorophyll a-containing bacteria isolated from soil. The sequence of two strains (NS89(T) and NS102) were identical for approximately 1500 nucleotides. Phylogenetic analysis revealed that the three strains belonged to the alpha-1 subclass of the Proteobacteria, constituting one line of descent. The three strains are comparatively related to Roseoccus thiosulfatophilus, which is an aerobic bacteriochlorophyll a-containing bacterium. The 16S rRNA gene sequence similarity and the DNA-DNA relatedness allow the proposal of two new genera, Craurococcus gen. nov. and Paracraurococcus gen. nov. The type species are Craurococus roseus sp. nov. and Paracraurococcus ruber sp. nov., and their type strains are NS130(T) (=JCM 9933(T)) and NS89(T) (=JCM 9931(T)), respectively.
MeSH term(s)	Bacteriochlorophylls/analysis ; Base Sequence ; Gram-Negative Aerobic Bacteria/classification ; Molecular Sequence Data ; Soil Microbiology
Chemical Substances	Bacteriochlorophylls
Language	English
Publishing date	1998-07
Publishing country	England
Document type	Journal Article
ZDB-ID	215062-1
ISSN	1465-2102 ; 0020-7713
ISSN (online)	1465-2102
ISSN	0020-7713
DOI	10.1099/00207713-48-3-1043
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Article: A new peronosporomycete, Halioticida noduliformans gen. et sp. nov., isolated from white nodules in the abalone Haliotis spp. from Japan

Muraosa, Yasunori / Morimoto, Kyoko / Sano, Ayako / Nishimura, Kazuko / Hatai, Kishio

Mycoscience. 2009 Mar., v. 50, no. 2

2009

Abstract: ... genus and species, Halioticida noduliformans gen. et sp. nov. Phylogenetic analysis of the D1/D2 region ... of the large subunit ribosomal RNA gene (LSU rDNA) was performed, and the four isolates showed 100%-99.8 ...

Abstract	Four strains belonging to the Peronosporomycetes (formerly Oomycetes) were isolated from white nodules found on the mantle of three species of abalone. In artificial seawater, the four isolates formed fragments such as in the genus Haliphthoros, but the protoplasm constriction was weaker, and fragments were longer, with smaller spaces between them, than those of Haliphthoros. The four strains form one or more discharge tubes from each zoosporangium. The four strains were similar, but not identical, to the genus Haliphthoros based on morphological characteristics. As a result, the four isolates were classified in a new genus and species, Halioticida noduliformans gen. et sp. nov. Phylogenetic analysis of the D1/D2 region of the large subunit ribosomal RNA gene (LSU rDNA) was performed, and the four isolates showed 100%-99.8% concordance. In the phylogenetic tree, the four isolates were not classified in the subclass Peronosporomycetidae, Saprolegniomycetidae, or Rhipidiomycetidae. However, the four isolates formed a new clade with genera Haliphthoros and Halocrusticida in Peronosporomycetes. Within this new clade, the four isolates, Haliphthoros spp. and Halocrusticida spp., were grouped in their respective independent subclades. These results showed that these were the new genus and species from the morphological characteristics.
Keywords	abalone
Language	English
Dates of publication	2009-03
Size	p. 106-115.
Publisher	Springer Japan
Publishing place	Japan
Document type	Article
ZDB-ID	1285813-4
ISSN	1618-2545 ; 1340-3540
ISSN (online)	1618-2545
ISSN	1340-3540
DOI	10.1007/s10267-008-0462-0
Database	NAL-Catalogue (AGRICOLA)

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Article: A new peronosporomycete, Halioticida noduliformans gen. et sp. nov., isolated from white nodules in the abalone Haliotis spp. from Japan

Muraosa, Y.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan)) / Morimoto, K. / Sano, A. / Nishimura, K. / Hatai, K.

Mycoscience (Japan)

Mar 2009 Volume v. 50, Issue (2), Page(s) p. 106–115

Abstract	Four strains belonging to the Peronosporomycetes (formerly Oomycetes) were isolated from white nodules found on the mantle of three species of abalone. In artificial seawater, the four isolates formed fragments such as in the genus Haliphthoros, but the protoplasm constriction was weaker, and fragments were longer, with smaller spaces between them, than those of Haliphthoros. The four strains form one or more discharge tubes from each zoosporangium. The four strains were similar, but not identical, to the genus Haliphthoros based on morphological characteristics. As a result, the four isolates were classified in a new genus and species, Halioticida noduliformans gen. et sp. nov. Phylogenetic analysis of the D1/D2 region of the large subunit ribosomal RNA gene (LSU rDNA) was performed, and the four isolates showed 100%-99.8% concordance. In the phylogenetic tree, the four isolates were not classified in the subclass Peronosporomycetidae, Saprolegniomycetidae, or Rhipidiomycetidae. However, the four isolates formed a new clade with genera Haliphthoros and Halocrusticida in Peronosporomycetes. Within this new clade, the four isolates, Haliphthoros spp. and Halocrusticida spp., were grouped in their respective independent subclades. These results showed that these were the new genus and species from the morphological characteristics.
Keywords	TAXONOMY ; MASTIGOMYCOTINA ; ABALONES ; GENERA ; NEW SPECIES ; FUNGAL MORPHOLOGY ; MOLECULAR GENETICS ; JAPAN ; TAXONOMIE ; MASTIGOMYCOTINA ; ORMEAU ; GENRE ; ESPECE NOUVELLE ; MORPHOLOGIE DU CHAMPIGNON ; GENETIQUE MOLECULAIRE ; JAPON ; TAXONOMIA ; MASTIGOMYCOTINA ; OREJA DE MAR ; GENERA ; ESPECIES NUEVAS ; MORFOLOGIA FUNGICA ; GENETICA MOLECULAR ; JAPON
Language	English
Document type	Article
ISSN	1340-3540
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Skeletal Dysplasia Families: A Stepwise Approach to Diagnosis.

Handa, Atsuhiko / Grigelioniene, Giedre / Nishimura, Gen

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 43, Issue 5, Page(s) e220067

Abstract: Skeletal dysplasias are a heterogeneous collection of genetic disorders characterized by bone and cartilage abnormalities, and they encompass over 400 disorders. These disorders are rare individually, but collectively they are common (approximate ... ...

Abstract	Skeletal dysplasias are a heterogeneous collection of genetic disorders characterized by bone and cartilage abnormalities, and they encompass over 400 disorders. These disorders are rare individually, but collectively they are common (approximate incidence of one in 5000 births). Radiologists occasionally encounter skeletal dysplasias in daily practice. In the 1980s, Professor Juergen Spranger proposed a concept suitable for the diagnosis of skeletal dysplasias termed
MeSH term(s)	Male ; Humans ; Osteochondrodysplasias/diagnostic imaging ; Osteochondrodysplasias/genetics ; Bone Diseases, Developmental/diagnostic imaging ; Bone Diseases, Developmental/genetics ; Radiography ; Hand Deformities, Congenital
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220067
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Article: A novel mutation in the ACAN gene in a family with autosomal dominant short stature and intervertebral disc disease.

Uchida, Noboru / Shibata, Hironori / Nishimura, Gen / Hasegawa, Tomonobu

Human genome variation

2020 Volume 7, Issue 1, Page(s) 44

Abstract: Heterozygous mutations in the ACAN gene have been reported in individuals with short stature and ... a family with a phenotypic constellation carrying a novel mutation in the ACAN gene. The proband was a 7 ... and intervertebral disc disease. We analyzed the ACAN gene in the family and identified a novel ...

Abstract	Heterozygous mutations in the ACAN gene have been reported in individuals with short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans. We report a family with a phenotypic constellation carrying a novel mutation in the ACAN gene. The proband was a 7-year-old Japanese girl with short stature. Her mother and maternal grandmother also had short stature and intervertebral disc disease. We analyzed the ACAN gene in the family and identified a novel heterozygous mutation: c.4634delT, Leu1545Profs*11.
Language	English
Publishing date	2020-12-03
Publishing country	England
Document type	Journal Article
ISSN	2054-345X
ISSN	2054-345X
DOI	10.1038/s41439-020-00132-8
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Article: Rubrimonas cliftonensis gen. nov., sp. nov., an aerobic bacteriochlorophyll-containing bacterium isolated from a saline lake.

Suzuki, T / Muroga, Y / Takahama, M / Shiba, T / Nishimura, Y

International journal of systematic bacteriology

1999 Volume 49 Pt 1, Page(s) 201–205

Abstract: Phenotypic and phylogenetic studies were performed with two strains (OCh 317T and OCh 318; T = type strain) of aerobic chemoheterotrophic bacteriochlorophyll-containing bacteria isolated from water of a saline lake located on the west coast of Australia. ...

Abstract	Phenotypic and phylogenetic studies were performed with two strains (OCh 317T and OCh 318; T = type strain) of aerobic chemoheterotrophic bacteriochlorophyll-containing bacteria isolated from water of a saline lake located on the west coast of Australia. Both strains were Gram-negative, short rods and were motile by means of polar flagella. Catalase, oxidase, nitrate reductase, phosphatase and urease were produced. The cells utilized D-glucose, citrate, glycolate, pyruvate and ethanol. Acids were produced from L-arabinose, D-fructose, D-galactose, D-glucose, D-ribose and D-xylose. The strains could grow in media containing 0.5-7.5% NaCl. Bacteriochlorophyll a was synthesized under aerobic conditions. The results of 16S rRNA gene sequence comparisons revealed that strain OCh 317T represented a new lineage in the alpha-3 group of the class Proteobacteria. Strains OCh 317T and OCh 318 were identified as strains of the same species because of their very similar phenotypic characteristics and their previously described high DNA-DNA homology. Therefore, it was concluded that the two strains should be assigned to a new genus and species, for which the name Rubrimonas cliftonensis is proposed. The type strain is OCh 317T (= JCM 10189T).
MeSH term(s)	Bacteria, Aerobic/classification ; Bacteria, Aerobic/isolation & purification ; Bacteria, Aerobic/physiology ; Bacteriochlorophylls/analysis ; Base Sequence ; Molecular Sequence Data ; Phylogeny ; Water Microbiology
Chemical Substances	Bacteriochlorophylls
Language	English
Publishing date	1999-01
Publishing country	England
Document type	Journal Article
ZDB-ID	215062-1
ISSN	1465-2102 ; 0020-7713
ISSN (online)	1465-2102
ISSN	0020-7713
DOI	10.1099/00207713-49-1-201
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Article ; Online: Exploring human genetic skeletal disorders provides important insights into skeletogenesis and elucidates basic developmental signaling pathways

Giedre Grigelioniene / Gen Nishimura

EBioMedicine, Vol 62, Iss , Pp 103091- (2020)

2020

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring human genetic skeletal disorders provides important insights into skeletogenesis and elucidates basic developmental signaling pathways.

Grigelioniene, Giedre / Nishimura, Gen

EBioMedicine

2020 Volume 62, Page(s) 103091

MeSH term(s)	Bone Diseases, Developmental/diagnosis ; Bone Diseases, Developmental/genetics ; Bone Diseases, Developmental/metabolism ; Bone Diseases, Developmental/therapy ; Disease Management ; Genetic Association Studies ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/metabolism ; Genetic Diseases, Inborn/therapy ; Genetic Predisposition to Disease ; Humans ; Osteogenesis/genetics ; Phenotype ; Signal Transduction
Language	English
Publishing date	2020-11-26
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2020.103091
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