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  1. Article ; Online: Blood pressure augmentation after cardiac arrest: Time to move beyond manipulating vital signs.

    Thiara, Sharanjit / Sekhon, Mypinder S

    Resuscitation

    2023  Volume 190, Page(s) 109913

    MeSH term(s) Humans ; Blood Pressure ; Heart Arrest ; Vital Signs/physiology
    Language English
    Publishing date 2023-07-27
    Publishing country Ireland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Low field magnetic resonance imaging: A "beds-eye-d" view into hypoxic ischemic brain injury after cardiac arrest.

    Sekhon, Mypinder S / Griesdale, Donald E

    Resuscitation

    2022  Volume 176, Page(s) 55–57

    MeSH term(s) Brain/pathology ; Brain Injuries ; Heart Arrest/etiology ; Heart Arrest/therapy ; Humans ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/etiology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2022-05-20
    Publishing country Ireland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2022.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Wolf Creek XVII Part 8: Neuroprotection.

    Hirsch, Karen G / Tamura, Tomoyoshi / Ristagno, Giuseppe / Sekhon, Mypinder S

    Resuscitation plus

    2024  Volume 17, Page(s) 100556

    Abstract: Introduction: Post-cardiac arrest brain injury (PCABI) is the primary determinant of clinical outcomes for patients who achieve return of spontaneous circulation after cardiac arrest (CA). There are limited neuroprotective therapies available to ... ...

    Abstract Introduction: Post-cardiac arrest brain injury (PCABI) is the primary determinant of clinical outcomes for patients who achieve return of spontaneous circulation after cardiac arrest (CA). There are limited neuroprotective therapies available to mitigate the acute pathophysiology of PCABI.
    Methods: Neuroprotection was one of six focus topics for the Wolf Creek XVII Conference held on June 14-17, 2023 in Ann Arbor, Michigan, USA. Conference invitees included international thought leaders and scientists in the field of CA resuscitation from academia and industry. Participants submitted via online survey knowledge gaps, barriers to translation, and research priorities for each focus topic. Expert panels used the survey results and their own perspectives and insights to create and present a preliminary unranked list for each category that was debated, revised and ranked by all attendees to identify the top 5 for each category.
    Results: Top 5 knowledge gaps included developing therapies for neuroprotection; improving understanding of the pathophysiology, mechanisms, and natural history of PCABI; deploying precision medicine approaches; optimizing resuscitation and CPR quality; and determining optimal timing for and duration of interventions. Top 5 barriers to translation included patient heterogeneity; nihilism & lack of knowledge about cardiac arrest; challenges with the translational pipeline; absence of mechanistic biomarkers; and inaccurate neuro-triage and neuroprognostication. Top 5 research priorities focused on translational research and trial optimization; addressing patient heterogeneity and individualized interventions; improving understanding of pathophysiology and mechanisms; developing mechanistic and outcome biomarkers across post-CA time course; and improving implementation of science and technology.
    Conclusion: This overview can serve as a guide to transform the care and outcome of patients with PCABI. Addressing these topics has the potential to improve both research and clinical care in the field of neuroprotection for PCABI.
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2024.100556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correspondence to: Elevated jugular venous oxygen saturation after cardiac arrest.

    Griesdale, Donald E G / Sekhon, Mypinder S

    Resuscitation

    2022  Volume 170, Page(s) 367–368

    MeSH term(s) Heart Arrest/therapy ; Humans ; Oximetry ; Oxygen Saturation
    Language English
    Publishing date 2022-02-02
    Publishing country Ireland
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.11.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Impact of Skin Pigmentation on Cerebral Regional Saturation of Oxygen Using Near-Infrared Spectroscopy: A Systematic Review.

    Patel, Nikunj A / Bhattal, Harvir S / Griesdale, Donald E / Hoiland, Ryan L / Sekhon, Mypinder S

    Critical care explorations

    2024  Volume 6, Issue 2, Page(s) e1049

    Abstract: Objectives: Near-infrared spectroscopy (NIRS) is used in critical care settings to measure regional cerebral tissue oxygenation (rSo: Data sources: We systematically searched MEDLINE, Cochrane Database of Systematic Reviews, Embase, and Google ... ...

    Abstract Objectives: Near-infrared spectroscopy (NIRS) is used in critical care settings to measure regional cerebral tissue oxygenation (rSo
    Data sources: We systematically searched MEDLINE, Cochrane Database of Systematic Reviews, Embase, and Google Scholar from inception to July 1, 2023.
    Study selection: In compliance with our PROSPERO registration (CRD42022347548), we selected articles comparing rSo
    Data extraction: We extracted data on self-reported race or level of skin pigmentation and mean rSo
    Data synthesis: Of the 11,495 unique records screened, two studies (
    Conclusions: Skin pigmentation likely results in attenuated rSo
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000001049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Shining a light on cerebral autoregulation: Are we anywhere near the truth?

    Bird, Jordan D / MacLeod, David B / Griesdale, Donald E / Sekhon, Mypinder S / Hoiland, Ryan L

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2024  , Page(s) 271678X241245488

    Abstract: The near-infrared spectroscopy (NIRS)-derived cerebral oximetry index (COx) has become popularized for non-invasive neuromonitoring of cerebrovascular function in post-cardiac arrest patients with hypoxic-ischemic brain injury (HIBI). We provide ... ...

    Abstract The near-infrared spectroscopy (NIRS)-derived cerebral oximetry index (COx) has become popularized for non-invasive neuromonitoring of cerebrovascular function in post-cardiac arrest patients with hypoxic-ischemic brain injury (HIBI). We provide commentary on the physiologic underpinnings and assumptions of NIRS and the COx, potential confounds in the context of HIBI, and the implications for the assessment of cerebral autoregulation.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X241245488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1663: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The importance of the oxygen cascade after cardiac arrest.

    Sekhon, Mypinder S / Hoiland, Ryan L / Griesdale, Donald E

    Resuscitation

    2021  Volume 168, Page(s) 231–233

    MeSH term(s) Cardiopulmonary Resuscitation ; Heart Arrest/therapy ; Humans ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-09-27
    Publishing country Ireland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Cerebral hemodynamics after cardiac arrest: implications for clinical management.

    Schoenthal, Tison / Hoiland, Ryan / Griesdale, Donald E / Sekhon, Mypinder S

    Minerva anestesiologica

    2023  Volume 89, Issue 9, Page(s) 824–833

    Abstract: Following resuscitation from cardiac arrest, hypoxic ischemic brain injury (HIBI) ensues, which is the primary determinant of adverse outcome. The pathophysiology of HIBI can be compartmentalized into primary and secondary injury, resulting from cerebral ...

    Abstract Following resuscitation from cardiac arrest, hypoxic ischemic brain injury (HIBI) ensues, which is the primary determinant of adverse outcome. The pathophysiology of HIBI can be compartmentalized into primary and secondary injury, resulting from cerebral ischemia during cardiac arrest and reperfusion following successful resuscitation, respectively. During the secondary injury phase, increased attention has been directed towards the optimization of cerebral oxygen delivery to prevent additive injury to the brain. During this phase, cerebral hemodynamics are characterized by early hyperemia following resuscitation and then a protracted phase of cerebral hypoperfusion termed "no-reflow" during which additional hypoxic-ischemic injury can occur. As such, identification of therapeutic strategies to optimize cerebral delivery of oxygen is at the forefront of HIBI research. Unfortunately, randomized control trials investigating the manipulation of arterial carbon dioxide tension and mean arterial pressure augmentation as methods to potentially improve cerebral oxygen delivery have shown no impact on clinical outcomes. Emerging literature suggests differential patient-specific phenotypes may exist in patients with HIBI. The potential to personalize therapeutic strategies in the critical care setting based upon patient-specific pathophysiology presents an attractive strategy to improve HIBI outcomes. Herein, we review the cerebral hemodynamic pathophysiology of HIBI, discuss patient phenotypes as it pertains to personalizing care, as well as suggest future directions.
    MeSH term(s) Humans ; Heart Arrest/therapy ; Brain ; Critical Care ; Hemodynamics ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-05-04
    Publishing country Italy
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.23.17268-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 516: Show issues Location:
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    Zs.MO 192: Show issues

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  9. Article ; Online: Invasive neuromonitoring post-cardiac arrest: Key considerations.

    Hoiland, Ryan L / Griesdale, Donald E / Sekhon, Mypinder S

    Resuscitation

    2021  Volume 164, Page(s) 144–146

    MeSH term(s) Brain Injuries ; Heart Arrest/therapy ; Humans ; Hypoxia-Ischemia, Brain ; Intracranial Pressure
    Language English
    Publishing date 2021-05-14
    Publishing country Ireland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
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  10. Article ; Online: Assessing autoregulation using near infrared spectroscopy: more questions than answers.

    Hoiland, Ryan L / Griesdale, Donald E / Sekhon, Mypinder S

    Resuscitation

    2020  Volume 156, Page(s) 280–281

    MeSH term(s) Blood Pressure ; Cerebrovascular Circulation ; Homeostasis ; Humans ; Spectroscopy, Near-Infrared
    Language English
    Publishing date 2020-08-25
    Publishing country Ireland
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2020.07.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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