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Article ; Online: Contralateral knee pain exacerbation after total knee arthroplasty and its impact on functional activity.

Kamitani, Tsukasa / Wada, Osamu / Mizuno, Kiyonori / Kurita, Noriaki

Archives of orthopaedic and trauma surgery

2023 Volume 144, Issue 4, Page(s) 1713–1720

Abstract: Introduction: The purposes of the present study were to (1) describe the prevalence of contralateral knee pain exacerbation after total knee arthroplasty (TKA), (2) explore the risk factors for pain exacerbation, and (3) verify the association of ... ...

Abstract	Introduction: The purposes of the present study were to (1) describe the prevalence of contralateral knee pain exacerbation after total knee arthroplasty (TKA), (2) explore the risk factors for pain exacerbation, and (3) verify the association of contralateral knee pain with future functional activity. Materials and method: We consecutively recruited outpatients with osteoarthritis of both knees who had primary TKA planned. The contralateral knee pain using a Numerical Rating Scale (NRS) and the functional activities subdomain of the new Knee Society Knee Scoring System (KSS) were assessed preoperatively and at 1, 3, and 6 months postoperatively. Among patients with < 5 NRS points preoperatively, we described the frequency of the contralateral knee pain exacerbation, defined as a ≥ 2-point increase from preoperative pain at each postoperative visit. An exploratory analysis was performed to identify preoperative risk factors for contralateral knee pain exacerbation. A linear mixed model was fit to examine the association of the contralateral knee pain with KSS functional activities at subsequent visits. Results: Among 315 patients, 14.6%, 24.1%, and 27.6% of patients experienced contralateral knee pain exacerbation at 1, 3, and 6 months postoperatively, respectively. The identified preoperative risk factors were low quadriceps strength and higher Kellgren-Lawrence grade on the non-operative knee, along with severe pain on the operative knee. The magnitude of the association between contralateral knee pain and worsening KSS functional activities increased with subsequent visits (p for interaction < 0.001). Conclusion: The frequency and impact of pain exacerbation on the contralateral knee increase after TKA and should be carefully evaluated for a prolonged period of time.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Treatment Outcome ; Knee Joint/surgery ; Osteoarthritis/surgery ; Pain/etiology ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology
Language	English
Publishing date	2023-12-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-05163-8
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Article ; Online: Floral pigments and their perception by avian pollinators in three Chilean Puya species.

Mizuno, Takayuki / Mori, Shinnosuke / Sugahara, Kohtaro / Yukawa, Tomohisa / Koi, Satoshi / Iwashina, Tsukasa

Journal of plant research

2024

Abstract: The Chilean Puya species, Puya coerulea var. violacea and P. chilensis bear blue and pale-yellow flowers, respectively, while P. alpestris considered to be their hybrid-derived species has unique turquoise flowers. In this study, the chemical basis ... ...

Abstract	The Chilean Puya species, Puya coerulea var. violacea and P. chilensis bear blue and pale-yellow flowers, respectively, while P. alpestris considered to be their hybrid-derived species has unique turquoise flowers. In this study, the chemical basis underlying the different coloration of the three Puya species was explored. We first isolated and identified three anthocyanins: delphinidin 3,3',5'-tri-O-glucoside, delphinidin 3,3'-di-O-glucoside and delphinidin 3-O-glucoside; seven flavonols: quercetin 3-O-rutinoside-3'-O-glucoside, quercetin 3,3'-di-O-glucoside, quercetin 3-O-rutinoside, isorhamnetin 3-O-rutinoside, myricetin 3,3',5'-tri-O-glucoside, myricetin 3,3'-di-O-glucoside and laricitrin 3,5'-di-O-glucoside; and six flavones: luteolin 4'-O-glucoside, apigenin 4'-O-glucoside, tricetin 4'-O-glucoside, tricetin 3',5'-di-O-glucoside, tricetin 3'-O-glucoside and selagin 5'-O-glucoside, which is a previously undescribed flavone, from their petals. We also compared compositions of floral flavonoid and their aglycone among these species, which suggested that the turquoise species P. alpestris has an essentially intermediate composition between the blue and pale-yellow species. The vacuolar pH was relatively higher in the turquoise (pH 6.2) and pale-yellow (pH 6.2) flower species, while that of blue flower species was usual (pH 5.2). The flower color was reconstructed in vitro using isolated anthocyanin, flavonol and flavone at neutral and acidic pH, and its color was analyzed by reflectance spectra and the visual modeling of their avian pollinators. The modeling demonstrated that the higher pH of the turquoise and pale-yellow species enhances the chromatic contrast and spectral purity. The precise regulation of flower color by flavonoid composition and vacuolar pH may be adapted to the visual perception of their avian pollinator vision.
Language	English
Publishing date	2024-03-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2077362-6
ISSN	1618-0860 ; 0918-9440
ISSN (online)	1618-0860
ISSN	0918-9440
DOI	10.1007/s10265-024-01531-6
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Article: Clinical utility of endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling of patients with biliary tract cancer, especially with intrahepatic cholangiocarcinoma.

Yanaidani, Takafumi / Hara, Kazuo / Okuno, Nozomi / Haba, Shin / Kuwahara, Takamichi / Kuraishi, Yasuhiro / Mizuno, Nobumasa / Ishikawa, Sho / Yamada, Masanori / Yasuda, Tsukasa

Clinical endoscopy

2024

Abstract: Background/aims: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is a standard diagnostic method for biliary tract cancer (BTC), and samples obtained in this manner may be used for comprehensive genomic profiling (CGP). This study evaluated the ...

Abstract	Background/aims: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is a standard diagnostic method for biliary tract cancer (BTC), and samples obtained in this manner may be used for comprehensive genomic profiling (CGP). This study evaluated the utility of EUS-TA for CGP in a clinical setting and determined the factors associated with the adequacy of CGP in patients with BTC. Methods: CGP was attempted for 105 samples from 94 patients with BTC at the Aichi Cancer Center, Japan, from October 2019 to April 2022. Results: Overall, 77.1% (81/105) of the samples were adequate for CGP. For 22-G or 19-G fine-needle biopsy (FNB), the sample adequacy was 85.7% (36/42), which was similar to that of surgical specimens (94%, p=0.45). Univariate analysis revealed that 22-G or larger FNB needle usage (86%, p=0.003), the target primary lesions (88%, p=0.015), a target size ≥30 mm (100%, p=0.0013), and number of punctures (90%, p=0.016) were significantly positively associated with CGP sample adequacy. Conclusions: EUS-TA is useful for CGP tissue sampling in patients with BTC. In particular, the use of 22-G or larger FNB needles may allow for specimen adequacy comparable to that of surgical specimens.
Language	English
Publishing date	2024-02-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2023.139
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Article: Flavonoid glycosides from Hylotelephium sieboldii var. sieboldii and var. ettyuense endemic to Japan

Iwashina, Tsukasa / Nakata, Masashi / Nakane, Takahisa / Mizuno, Takayuki

Biochemical systematics and ecology. 2022 Dec., v. 105

2022

Abstract: Twenty-one flavonoids were isolated from the leaves and stems of Hylotelephium sieboldii var. sieboldii and var. ettyuense (Crassulaceae) endemic to Japan. They were characterized as kaempferol and quercetin glycosides such as 3-O-sophorosides, 3-O- ... ...

Abstract	Twenty-one flavonoids were isolated from the leaves and stems of Hylotelephium sieboldii var. sieboldii and var. ettyuense (Crassulaceae) endemic to Japan. They were characterized as kaempferol and quercetin glycosides such as 3-O-sophorosides, 3-O-neohesperidosides, 3,7-di-O-rhamnosides, 3-O-neohesperidoside-7-O-rhamnosides, 3-O-glucoside-7-O-rhamnosides, 3-O-sophoroside-7-O-rhamnosides, 3-O-glucosides and 3-O-rhamnosides by UV, LC-MS, acid hydrolysis, and NMR and/or HPLC comparisons with authentic samples. Flavonoids of H. sieboldii var. sieboldii are 3,7-O-glycosides of kaempferol and quercetin. On the other hand, those of H. sieboldii var. ettyuense were flavonol 3-O-diglycosides, together with a few 3,7-O-glyosides. Flavonol 3-O-monoglycosides were found in both varieties. Flavonoids were reported from Hylotelephium sieboldii in this survey for the first time.
Keywords	Hylotelephium ; Japan ; acid hydrolysis ; chemotaxonomy ; ecology ; glycosides ; kaempferol ; quercetin ; surveys
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0305-1978
DOI	10.1016/j.bse.2022.104505
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Article: Hypercalcemia following discontinuation of denosumab therapy: A systematic review.

Horiuchi, Keisuke / Kobayashi, Eisuke / Mizuno, Tsukasa / Susa, Michiro / Chiba, Kazuhiro

Bone reports

2021 Volume 15, Page(s) 101148

Abstract: Denosumab is a monoclonal antibody that has been approved to treat osteoporosis, skeletal metastasis, and giant cell tumor of bone in skeletally mature patients. Due to its potential adverse effects on normal bone growth, its use has not yet been ... ...

Abstract	Denosumab is a monoclonal antibody that has been approved to treat osteoporosis, skeletal metastasis, and giant cell tumor of bone in skeletally mature patients. Due to its potential adverse effects on normal bone growth, its use has not yet been approved in skeletally immature patients; however, the use of this agent in such patients with overt or dysregulated bone resorptive conditions has been explored in recent years. While most studies have proven the effectiveness of denosumab in controlling the progression of various disorders in skeletally immature patients, they have also revealed that refractory hypercalcemia often follows the discontinuation of denosumab treatment, raising a concern over the use of this agent in these patients. Thus, this study was designed to better understand the pathology of this condition through a systematic review of the published literature. Our analysis suggests that this condition has a potential male predisposition, that there is a correlation between the duration of denosumab treatment and patient age, and that this condition often occurs within 3 months after the last administration of denosumab in skeletally immature patients but is significantly less likely in adults. These results may further underscore that high bone formation and bone turnover rates are critically associated with hypercalcemia after the discontinuation of denosumab. In contrast, given that not all skeletally immature patients develop hypercalcemia, it is probable that other unidentified factors are involved in the pathology of this condition.
Language	English
Publishing date	2021-11-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2021.101148
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Article ; Online: U-TEST, a simple decision support tool for the diagnosis of sarcopenia in orthopaedic patients: the Screening for People Suffering Sarcopenia in Orthopedic cohort of Kobe study (SPSS-OK).

Kamitani, Tsukasa / Wakita, Takafumi / Wada, Osamu / Mizuno, Kiyonori / Kurita, Noriaki

The British journal of nutrition

2021 Volume 126, Issue 9, Page(s) 1323–1330

Abstract: We aimed to develop and validate a new simple decision support tool (U-TEST) for diagnosis of sarcopenia in orthopaedic patients. We created seventeen candidate original questions to detect sarcopenia in orthopaedic patients with sarcopenia through ... ...

Abstract	We aimed to develop and validate a new simple decision support tool (U-TEST) for diagnosis of sarcopenia in orthopaedic patients. We created seventeen candidate original questions to detect sarcopenia in orthopaedic patients with sarcopenia through expert opinions and a semi-structured interview. To derive a decision support tool, a logistic regression model with backward elimination was applied to select variables from the seventeen questions, age and underweight (BMI < 18·5 kg/m2). Sarcopenia was defined by Asian Working Group for Sarcopenia 2019 criteria. After assigning a score to each selected variable, the sum of scores was calculated. We evaluated the diagnostic performance of the new tool using a logistic regression model. A bootstrap technique was used for internal validation. Among a total of 1334 orthopaedic patients, sixty-five (4·9 %) patients were diagnosed with sarcopenia. We succeeded in developing a 'U-TEST' with scores ranging from 0 to 11 consisting of values for BMI (Underweight), age (Elderly) and two original questions ('I can't stand up from a chair without supporting myself with my arms' (Strength) and 'I feel that my arms and legs are thinner than they were in the past' (Thin)). The AUC was 0·77 (95 % CI 0·71, 0·83). With the optimal cut-off set at 3 or greater based on Youden's index, the sensitivity and the specificity were 76·1 and 63·6 %, respectively. In orthopaedic patients, our U-TEST scoring with two questions and two simple clinical variables can help to screen for sarcopenia.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Humans ; Mass Screening ; Muscle Strength ; Orthopedics ; Sarcopenia/diagnosis ; Thinness
Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114521000106
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Article ; Online: Association between phase angle and functional disability among patients with lumbar spinal stenosis: The SPSS-OK study.

Wada, Osamu / Yamada, Minoru / Kamitani, Tsukasa / Mizuno, Kiyonori / Tadokoro, Kou / Kurita, Noriaki

Journal of back and musculoskeletal rehabilitation

2022 Volume 36, Issue 2, Page(s) 399–405

Abstract: Background: Whether the lower phase angle associated with worse physical function is a result of pain and muscle weakness in patients with lumbar spinal stenosis (LSS) is unclear.: Objective: To evaluate the association between phase angle and back ... ...

Abstract	Background: Whether the lower phase angle associated with worse physical function is a result of pain and muscle weakness in patients with lumbar spinal stenosis (LSS) is unclear. Objective: To evaluate the association between phase angle and back pain-specific disabilities in patients with LSS. Methods: In this single-center, cross-sectional study, 491 participants with LSS were enrolled. The phase angle and back pain-specific disability were measured using bioelectrical impedance analysis and the Oswestry Disability Index, respectively. General linear models were used to examine associations between phase angle and the Oswestry Disability Index with or without adjustment for age, sex, low back and lower limb pain, numbness in the lower extremities, total fat mass, and lower limb muscle mass. Results: The mean (SD) phase angle was 4.4∘ (1.0∘), and the mean Oswestry Disability Index was 36.1 (14.1) points. Greater phase angles were associated with less Oswestry Disability Index points (p= 0.037) independent of fat mass, low back pain, and hip or lower limb pain. Conclusions: A lower phase angle was associated with worse functional disability. Low phase angle may be an indicator of functional impairment due to low back pain associated with LSS.
MeSH term(s)	Humans ; Spinal Stenosis/complications ; Low Back Pain ; Cross-Sectional Studies ; Lumbar Vertebrae ; Back Pain
Language	English
Publishing date	2022-09-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1184721-9
ISSN	1878-6324 ; 1053-8127
ISSN (online)	1878-6324
ISSN	1053-8127
DOI	10.3233/BMR-220038
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Article ; Online: New insights into the role of microheterogeneity of ZP3 during structural maturation of the avian equivalent of mammalian zona pellucida.

Okumura, Hiroki / Mizuno, Ayaka / Iwamoto, Eri / Sakuma, Rio / Nishio, Shunsuke / Nishijima, Ken-Ichi / Matsuda, Tsukasa / Ujita, Minoru

PloS one

2023 Volume 18, Issue 3, Page(s) e0283087

Abstract: The egg coat including mammalian zona pellucida (ZP) and the avian equivalent, i.e., inner-perivitelline layer (IPVL), is a specialized extracellular matrix being composed of the ZP glycoproteins and surrounds both pre-ovulatory oocytes and ovulated egg ... ...

Abstract	The egg coat including mammalian zona pellucida (ZP) and the avian equivalent, i.e., inner-perivitelline layer (IPVL), is a specialized extracellular matrix being composed of the ZP glycoproteins and surrounds both pre-ovulatory oocytes and ovulated egg cells in vertebrates. The egg coat is well known for its potential importance in both the reproduction and early development, although the underlying molecular mechanisms remain to be fully elucidated. Interestingly, ZP3, one of the ZP-glycoprotein family members forming scaffolds of the egg-coat matrices with other ZP glycoproteins, exhibits extreme but distinctive microheterogeneity to form a large number of isoelectric-point isoforms at least in the chicken IPVL. In the present study, we performed three-dimensional confocal imaging and two-dimensional polyacrylamide-gel electrophoresis (2D-PAGE) of chicken IPVLs that were isolated from the ovarian follicles at different growth stages before ovulation. The results suggest that the relative proportions of the ZP3 isoforms are differentially altered during the structural maturation of the egg-coat matrices. Furthermore, tandem mass spectrometry (MS/MS) analyses and ZP1 binding assays against separated ZP3 isoforms demonstrated that each ZP3 isoform contains characteristic modifications, and there are large differences among ZP3 isoforms in the ZP1 binding affinities. These results suggest that the microheterogeneity of chicken ZP3 might be regulated to be associated with the formation of egg-coat matrices during the structural maturation of chicken IPVL. Our findings may provide new insights into molecular mechanisms of egg-coat assembly processes.
MeSH term(s)	Animals ; Female ; Zona Pellucida/metabolism ; Tandem Mass Spectrometry ; Egg Proteins/metabolism ; Zona Pellucida Glycoproteins/metabolism ; Chickens/metabolism ; Protein Isoforms/metabolism ; Extracellular Matrix Proteins/metabolism ; Mammals/metabolism
Chemical Substances	Egg Proteins ; Zona Pellucida Glycoproteins ; Protein Isoforms ; Extracellular Matrix Proteins
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283087
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Safety and feasibility of opening window fistulotomy as a new precutting technique for primary biliary access in endoscopic retrograde cholangiopancreatography.

Kuraishi, Yasuhiro / Hara, Kazuo / Haba, Shin / Kuwahara, Takamichi / Okuno, Nozomi / Yanaidani, Takafumi / Ishikawa, Sho / Yasuda, Tsukasa / Yamada, Masanori / Mizuno, Nobumasa

Clinical endoscopy

2023 Volume 56, Issue 4, Page(s) 490–498

Abstract: Background/aims: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common and serious complication of endoscopic retrograde cholangiopancreatography. To prevent this event, a unique precutting method, termed opening ... ...

Abstract	Background/aims: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common and serious complication of endoscopic retrograde cholangiopancreatography. To prevent this event, a unique precutting method, termed opening window fistulotomy, was performed in patients with a large infundibulum as the primary procedure for biliary cannulation, whereby a suprapapillary laid-down H-shaped incision was made without touching the orifice. This study aimed to assess the safety and feasibility of this novel technique. Methods: One hundred and ten patients were prospectively enrolled in this study. Patients with a papillary roof size ≥10 mm underwent opening window fistulotomy for primary biliary access. In addition, the incidence of complications and success rate of biliary cannulation were evaluated. Results: The median size of the papillary roof was 6 mm (range, 3-20 mm). Opening window fistulotomy was performed in 30 patients (27.3%), none of whom displayed PEP. Duodenal perforation was recorded in one patient (3.3%), which was resolved by conservative treatment. The cannulation rate was high (96.7%, 29/30 patients). The median duration of biliary access was 8 minutes (range, 3-15 minutes). Conclusion: Opening window fistulotomy demonstrated its feasibility for primary biliary access by achieving great safety with no PEP complications and a high success rate for biliary cannulation.
Language	English
Publishing date	2023-04-27
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2022.130
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Article: Safety and efficacy of novel oblique-viewing scope for B2-endoscopic ultrasound-guided hepaticogastrostomy.

Ishikawa, Sho / Hara, Kazuo / Okuno, Nozomi / Mizuno, Nobumasa / Haba, Shin / Kuwahara, Takamichi / Kuraishi, Yasuhiro / Yanaidani, Takafumi / Yamada, Masanori / Yasuda, Tsukasa / Fukui, Toshitaka / Kumagi, Teru / Hiasa, Yoichi

Clinical endoscopy

2024

Abstract: Background/aims: Endoscopic ultrasound (EUS)-guided hepaticogastrostomy (EUS-HGS) performed at the intrahepatic bile duct segment 3 (B3) is widely used for biliary drainage. Although performing post-puncture procedures is easier in the intrahepatic bile ...

Abstract	Background/aims: Endoscopic ultrasound (EUS)-guided hepaticogastrostomy (EUS-HGS) performed at the intrahepatic bile duct segment 3 (B3) is widely used for biliary drainage. Although performing post-puncture procedures is easier in the intrahepatic bile duct segment 2 (B2) when using a conventional oblique-viewing (OV) EUS scope, this method may cause transesophageal puncture and severe adverse events. We evaluated the safety and efficacy of B2 puncture using a novel OV-EUS scope. Methods: In this single-center retrospective study, we prospectively enrolled and collected data from 45 patients who consecutively underwent EUS-HGS procedures with a novel OV-EUS scope between September 2021 and December 2022 at our cancer center. Results: The technical success rates of B2-EUS-HGS and EUS-HGS were 93.3% (42/45) and 97.8% (44/45), respectively. The early adverse event rate was 8.9% (4/45) with no cases of scope changes or transesophageal punctures. The median procedure time was 13 minutes (range, 5-30). Conclusions: B2-EUS-HGS can be performed safely with the novel EG-740UT (Fujifilm) OV-scope without transesophageal puncture and with a high success rate. B2-EUS-HGS using this novel OV scope may be the preferred strategy for EUS-HGS.
Language	English
Publishing date	2024-03-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2023.129
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