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  1. Article ; Online: Stroke research in 2021: insights into the reorganisation of stroke care.

    Puy, Laurent / Cordonnier, Charlotte

    The Lancet. Neurology

    2022  Volume 21, Issue 1, Page(s) 2–3

    MeSH term(s) Humans ; Stroke/therapy
    Language English
    Publishing date 2022-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00410-5
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    Zs.A 5955: Show issues Location:
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  2. Article ; Online: Long-term headache after spontaneous intracerebral haemorrhage.

    Gurol, Ugur / Scopelliti, Giuseppe / Cordonnier, Charlotte / Puy, Laurent

    European journal of neurology

    2024  Volume 31, Issue 5, Page(s) e16247

    Abstract: Background: Though headache is commonly observed after stroke and may affect survivors' quality of life, it has rarely been studied after spontaneous intracerebral haemorrhage (ICH). In a cohort of ICH survivors, we assessed the long-term prevalence and ...

    Abstract Background: Though headache is commonly observed after stroke and may affect survivors' quality of life, it has rarely been studied after spontaneous intracerebral haemorrhage (ICH). In a cohort of ICH survivors, we assessed the long-term prevalence and determinants of headache.
    Methods: We screened consecutive ICH survivors enrolled in the prospective, single-centre Prognosis of Intracerebral Haemorrhage study for headache 1, 3, and 6 years after ICH, according to the International Headache Society's criteria. Depressive and anxiety symptoms severity was measured at 1-year follow-up. Variables associated with the presence of headache 1 year after ICH were analyzed using univariate and multivariable models.
    Results: Among the 146 patients included in this study, 31 (21%), 25 (19%), and 14 (20%) patients reported headache at 1-, 3-, and 6-year follow-up, respectively. In an age-adjusted model, patients with headache at ICH onset (adjusted odds ratio [aOR] 2.75; 95% CI 1.02-7.42) and previous history of headache (aOR 4.60; 95% CI 1.74-12.1) were associated with headache at 1-year follow-up. Patients with headache were more likely to report depressive and anxiety symptoms at 1-year follow-up (both p < 0.02).
    Conclusions: One in five ICH survivors suffered from headache and patients who reported headache at ICH onset were especially at risk.
    MeSH term(s) Humans ; Prospective Studies ; Quality of Life ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/epidemiology ; Stroke/complications ; Headache/epidemiology ; Headache/etiology
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16247
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    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  3. Article ; Online: Balancing risks versus benefits of anticoagulants in stroke prevention.

    Cordonnier, Charlotte

    The Lancet. Neurology

    2018  Volume 17, Issue 6, Page(s) 487–488

    Language English
    Publishing date 2018-05-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(18)30164-9
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  4. Article: Cerebral venous thrombosis: Update on clinical manifestations, diagnosis and management.

    Leys, Didier / Cordonnier, Charlotte

    Annals of Indian Academy of Neurology

    2022  Volume 11, Issue Suppl 1, Page(s) S79–S87

    Abstract: Cerebral venous thrombosis (CVT) has a wide spectrum of clinical manifestations that may mimic many other neurological disorders and lead to misdiagnoses. Headache is the most common symptom and may be associated with other symptoms or remain isolated. ... ...

    Abstract Cerebral venous thrombosis (CVT) has a wide spectrum of clinical manifestations that may mimic many other neurological disorders and lead to misdiagnoses. Headache is the most common symptom and may be associated with other symptoms or remain isolated. The other frequent manifestations are focal neurological deficits and diffuse encephalopathies with seizures. The key to the diagnosis is the imaging of the occluded vessel or of the intravascular thrombus, by a combination of magnetic resonance imaging (MRI) and magnetic resonance venography (MRV). Causes and risk factors include medical, surgical and obstetrical causes of deep vein thrombosis, genetic and acquired prothrombotic disorders, cancer and hematological disorders, inflammatory systemic disorders, pregnancy and puerperium, infections and local causes such as tumors, arteriovenous malformations, trauma, central nervous system infections and local infections. The breakdown of causes differs in different parts of the world. A meta-analysis of the most recent prospectively collected series showed an overall 15% case-fatality or dependency rate. Heparin therapy is the standard therapy at the acute stage, followed by 3-6 months of oral anticoagulation. Patients with isolated intracranial hypertension may require a lumbar puncture to remove cerebrospinal fluid before starting heparin when they develop a papilloedema that may threaten the visual acuity or decompressive hemicraniectomy. Patients who develop seizures should receive antiepileptic drugs. Cerebral venous thrombosis - even pregnancy-related - should not contraindicate future pregnancies. The efficacy and safety of local thrombolysis and decompressive hemicraniectomy should be tested.
    Language English
    Publishing date 2022-01-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
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  5. Article ; Online: Age At Menopause: A Female Risk Factor of Stroke?

    Christensen, Hanne / Cordonnier, Charlotte

    Stroke

    2021  Volume 52, Issue 8, Page(s) 2592–2593

    MeSH term(s) Female ; Humans ; Menopause ; Risk Factors ; Stroke/epidemiology
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.034828
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Cerebral venous sinus thrombosis associated with COVID-19 vaccine-induced thrombocytopenia: Improvement in mortality rate over time.

    Casolla, Barbara / Cordonnier, Charlotte

    European journal of neurology

    2021  Volume 29, Issue 1, Page(s) 1–2

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/etiology ; Thrombocytopenia
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15151
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    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  7. Article ; Online: Low-Density Lipoprotein Cholesterol Level After a Stroke-Reducing It by Any Means.

    Leys, Didier / Casolla, Barbara / Cordonnier, Charlotte

    JAMA neurology

    2022  Volume 79, Issue 4, Page(s) 329–330

    MeSH term(s) Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Risk Factors ; Stroke
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2021.5586
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    Ui II Zs.191: Show issues Location:
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  8. Article ; Online: Impact of prodromal symptoms on the prognosis of patients with basilar artery occlusion treated with mechanical thrombectomy.

    Accettone, Thomas / Personnic, Thomas / Bretzner, Martin / Behal, Helene / Cordonnier, Charlotte / Henon, Hilde / Puy, Laurent

    European stroke journal

    2024  , Page(s) 23969873241234844

    Abstract: Introduction: Even with reperfusion therapies, the prognosis of patients with basilar artery occlusion (BAO) related stroke remains poor. We aimed to test the hypothesis that the presence of prodromal symptoms, an easily available anamnestic data, is a ... ...

    Abstract Introduction: Even with reperfusion therapies, the prognosis of patients with basilar artery occlusion (BAO) related stroke remains poor. We aimed to test the hypothesis that the presence of prodromal symptoms, an easily available anamnestic data, is a key determinant of poor functional outcome.
    Patients and methods: Data from patients with BAO treated in Lille, France, with mechanical thrombectomy (MT) between 2015 and 2021 were prospectively collected. The presence of prodromal symptoms was defined by previous transient neurological deficit or gradual progressive clinical worsening preceding a secondary sudden clinical worsening. We compared the characteristics of patients with and without prodromal symptoms. We built multivariate logistic regression models to study the association between the presence of prodromal symptoms and functional (mRS 0-3 and mortality), and procedural (successful recanalization and early reocclusion) outcomes.
    Results: Among the 180 patients, 63 (35%) had prodromal symptoms, most frequently a vertigo. Large artery atherosclerosis was the predominant cause of stroke (41.3%). The presence of prodromal symptoms was an independent predictor of worse 90-day functional outcome (mRS 0-3: 25.4% vs 47.0%, odds ratio (OR) 0.39; 95% confidence interval (CI) 0.16-0.86) and 90-day mortality (OR 2.17; 95% CI 1.02-4.65). Despite similar successful recanalization rate, the proportion of early basilar artery reocclusion was higher in patients with prodromal symptoms (23.8% vs 5.6%,
    Discussion and conclusion: More than one third of BAO patients treated with MT had prodromal symptoms, especially patients with large-artery atherosclerosis. Clinicians should systematically screen for prodromal symptoms given the poor related functional outcome and increased risk of early basilar artery reocclusion.
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2851287-X
    ISSN 2396-9881 ; 2396-9873
    ISSN (online) 2396-9881
    ISSN 2396-9873
    DOI 10.1177/23969873241234844
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  9. Article ; Online: Intracerebral haemorrhage.

    Puy, Laurent / Parry-Jones, Adrian R / Sandset, Else Charlotte / Dowlatshahi, Dar / Ziai, Wendy / Cordonnier, Charlotte

    Nature reviews. Disease primers

    2023  Volume 9, Issue 1, Page(s) 14

    Abstract: Intracerebral haemorrhage (ICH) is a dramatic condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. ICH is a major contributor to stroke-related mortality and dependency: only half of patients survive for ... ...

    Abstract Intracerebral haemorrhage (ICH) is a dramatic condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. ICH is a major contributor to stroke-related mortality and dependency: only half of patients survive for 1 year after ICH, and patients who survive have sequelae that affect their quality of life. The incidence of ICH has increased in the past few decades with shifts in the underlying vessel disease over time as vascular prevention has improved and use of antithrombotic agents has increased. The pathophysiology of ICH is complex and encompasses mechanical mass effect, haematoma expansion and secondary injury. Identifying the causes of ICH and predicting the vital and functional outcome of patients and their long-term vascular risk have improved in the past decade; however, no specific treatment is available for ICH. ICH remains a medical emergency, with prevention of haematoma expansion as the key therapeutic target. After discharge, secondary prevention and management of vascular risk factors in patients remains challenging and is based on an individual benefit-risk balance evaluation.
    MeSH term(s) Humans ; Quality of Life ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/epidemiology ; Stroke/complications ; Stroke/epidemiology ; Brain ; Hematoma/complications ; Hematoma/epidemiology
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2056-676X
    ISSN (online) 2056-676X
    DOI 10.1038/s41572-023-00424-7
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  10. Article ; Online: Cerebral Microbleeds and Antithrombotic Treatments-Stop Worrying About Bleeding.

    Puy, Laurent / Cordonnier, Charlotte

    JAMA neurology

    2020  Volume 78, Issue 1, Page(s) 9–10

    MeSH term(s) Anticoagulants ; Brain Ischemia ; Cerebral Hemorrhage/chemically induced ; Cerebral Hemorrhage/diagnostic imaging ; Embolic Stroke ; Fibrinolytic Agents/adverse effects ; Humans
    Chemical Substances Anticoagulants ; Fibrinolytic Agents
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2020.3847
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    Ui II Zs.191: Show issues Location:
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