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  1. AU=Mezzabotta Federica
  2. AU="Jalas, Sören"
  3. AU="Suma, Rache"
  4. AU="Calderón, Alejandro"
  5. AU="Demertzi, Vasiliki"
  6. AU="Leonidov, A"
  7. AU="Luo, Suxin"
  8. AU="Thompson, Charlotte A S"
  9. AU="Dubbel, Polly"
  10. AU="Ten Bosch, Nora"
  11. AU="Giménez-Arnau, Ana Maria"
  12. AU=Maul Robert W.
  13. AU="Ivn Prez-MaldonadoauthorLaboratorio de Toxicologa Molecular, Centro de Investigacin Aplicada en Ambiente y Salud (CIAAS), Coordinacin para la Innovacin y Aplicacin de la Ciencia y la Tecnologa (CIACYT), Universidad Autnoma de San Luis Potos, MexicoFacultad de Medicina, Universidad Autnoma de San Luis Potos, San Luis Potos, MexicoFacultad de Enfermera, Universidad Autnoma de Zacatecas, Mexico"
  14. AU="Hansen, Kristian Schultz"
  15. AU="Davenport, Bennett"

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  1. Artikel ; Online: Cell death in ectopic calcification of the kidney.

    Priante, Giovanna / Mezzabotta, Federica / Cristofaro, Rosalba / Quaggio, Federica / Ceol, Monica / Gianesello, Lisa / Del Prete, Dorella / Anglani, Franca

    Cell death & disease

    2019  Band 10, Heft 6, Seite(n) 466

    Mesh-Begriff(e) Calcinosis ; Cell Death ; Humans ; Kidney
    Sprache Englisch
    Erscheinungsdatum 2019-06-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-019-1697-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The regenerative potential of the kidney: what can we learn from developmental biology?

    Anglani, Franca / Mezzabotta, Federica / Ceol, Monica / Cristofaro, Rosalba / Del Prete, Dorella / D'Angelo, Angela

    Stem cell reviews and reports

    2010  Band 6, Heft 4, Seite(n) 650–657

    Abstract: Cell turnover in the healthy adult kidney is very slow but the kidney has a strong capacity for regeneration after acute injury. Although many molecular aspects of this process have been clarified, the source of the newly-formed renal epithelial cells is ...

    Abstract Cell turnover in the healthy adult kidney is very slow but the kidney has a strong capacity for regeneration after acute injury. Although many molecular aspects of this process have been clarified, the source of the newly-formed renal epithelial cells is still being debated. Several studies have shown, moreover, that the repair of injured renal epithelium starts from mature tubular cells, which enter into an activated proliferative state characterized by the reappearance of mesenchymal markers detectable during nephrogenesis, thus pointing to a marked plasticity of renal epithelial cells. The regenerative potential of mature epithelial cells might stem from their almost unique morphogenetic process. Unlike other tubular organs, all epithelial and mesenchymal cells in the kidney derive from the same germ layer, the mesoderm. In a fascinating view of vertebrate embryogenesis, the mesoderm might be seen as a cell layer capable of oscillating between epithelial and mesenchymal states, thus acquiring a remarkable plasticity that lends it an extended potential for innovation and a better control of three-dimensional body organization. The renal papilla contains a population of cells with the characteristic of adult stem cells. Mesenchymal stromal stem cells (MSC) have been found to reside in the connective tissue of most organs, including the kidney. Recent studies indicate that the MSC compartment extends throughout the body postnatally as a result of its perivascular location. Developmental biology suggests that this might be particularly true of the kidney and that the papilla might represent the perivascular renal stem cell niche. The perivascular niche hypothesis fits well with the evolving concept of the stem cell niche as an entity of action. It is its dynamic capability that makes the niche concept so important and essential to the feasibility of regenerative medicine.
    Mesh-Begriff(e) Animals ; Developmental Biology ; Humans ; Kidney/cytology ; Kidney/growth & development ; Models, Biological ; Pericytes/cytology ; Regeneration/physiology ; Stem Cells/cytology
    Sprache Englisch
    Erscheinungsdatum 2010-08-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-010-9186-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation.

    Mezzabotta, Federica / Cristofaro, Rosalba / Ceol, Monica / Del Prete, Dorella / Priante, Giovanna / Familiari, Alessandra / Fabris, Antonia / D'Angelo, Angela / Gambaro, Giovanni / Anglani, Franca

    Journal of cellular and molecular medicine

    2015  Band 19, Heft 4, Seite(n) 889–902

    Abstract: Medullary nephrocalcinosis is a hallmark of medullary sponge kidney (MSK). We had the opportunity to study a spontaneous calcification process in vitro by utilizing the renal cells of a patient with MSK who was heterozygous for the c.-27 + 18G>A variant ... ...

    Abstract Medullary nephrocalcinosis is a hallmark of medullary sponge kidney (MSK). We had the opportunity to study a spontaneous calcification process in vitro by utilizing the renal cells of a patient with MSK who was heterozygous for the c.-27 + 18G>A variant in the GDNF gene encoding glial cell-derived neurotrophic factor. The cells were obtained by collagenase digestion of papillary tissues from the MSK patient and from two patients who had no MSK or nephrocalcinosis. These cells were typed by immunocytochemistry, and the presence of mineral deposits was studied using von Kossa staining, scanning electron microscopy analysis and an ALP assay. Osteoblastic lineage markers were studied using immunocytochemistry and RT-PCR. Staminality markers were also analysed using flow cytometry, magnetic cell separation technology, immunocytochemistry and RT-PCR. Starting from p2, MSK and control cells formed nodules with a behaviour similar to that of calcifying pericytes; however, Ca₂PO₄ was only found in the MSK cultures. The MSK cells had morphologies and immunophenotypes resembling those of pericytes or stromal stem cells and were positive for vimentin, ZO1, αSMA and CD146. In addition, the MSK cells expressed osteocalcin and osteonectin, indicating an osteoblast-like phenotype. In contrast to the control cells, GDNF was down-regulated in the MSK cells. Stable GDNF knockdown was established in the HK2 cell line and was found to promote Ca₂PO₄ deposition when the cells were incubated with calcifying medium by regulating the osteonectin/osteopontin ratio in favour of osteonectin. Our data indicate that the human papilla may be a perivascular niche in which pericyte/stromal-like cells can undergo osteogenic differentiation under particular conditions and suggest that GDNF down-regulation may have influenced the observed phenomenon.
    Mesh-Begriff(e) Actins/metabolism ; Aged ; CD146 Antigen/metabolism ; Calcification, Physiologic ; Calcinosis ; Cell Line ; Cells, Cultured ; Female ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Humans ; Immunohistochemistry ; Kidney/metabolism ; Kidney/pathology ; Kidney/ultrastructure ; Medullary Sponge Kidney/genetics ; Medullary Sponge Kidney/metabolism ; Medullary Sponge Kidney/pathology ; Microscopy, Electron, Scanning ; Middle Aged ; Muscle, Smooth/chemistry ; Mutation ; Osteonectin/genetics ; Osteonectin/metabolism ; Osteopontin/genetics ; Osteopontin/metabolism ; Primary Cell Culture ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Vimentin/metabolism ; Zonula Occludens-1 Protein
    Chemische Substanzen Actins ; CD146 Antigen ; Glial Cell Line-Derived Neurotrophic Factor ; Osteonectin ; TJP1 protein, human ; Vimentin ; Zonula Occludens-1 Protein ; Osteopontin (106441-73-0)
    Sprache Englisch
    Erscheinungsdatum 2015-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.12514
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology.

    Gambaro, Giovanni / Fabris, Antonia / Abaterusso, Cataldo / Cosaro, Alex / Ceol, Monica / Mezzabotta, Federica / Torregrossa, Rossella / Tiralongo, Emilia / Del Prete, Dorella / D'Angelo, Angela / Anglani, Franca

    Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

    2012  Band 5, Heft 2, Seite(n) 107–109

    Abstract: Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we ... ...

    Abstract Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.
    Sprache Englisch
    Erscheinungsdatum 2012-03-19
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2660444-9
    ISSN 1971-3266 ; 1724-8914
    ISSN (online) 1971-3266
    ISSN 1724-8914
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: The renal stem cell system in kidney repair and regeneration.

    Anglani, Franca / Ceol, Monica / Mezzabotta, Federica / Torregrossa, Rossella / Tiralongo, Emilia / Tosetto, Enrica / Del Prete, Dorella / D'Angelo, Angela

    Frontiers in bioscience : a journal and virtual library

    2008  Band 13, Seite(n) 6395–6405

    Abstract: The adult mammalian renal tubular epithelium exists in a relatively quiescent to slowly replicating state, but has great potential for regenerative morphogenesis following severe ischemic or toxic injury. Kidney regeneration and repair occur through ... ...

    Abstract The adult mammalian renal tubular epithelium exists in a relatively quiescent to slowly replicating state, but has great potential for regenerative morphogenesis following severe ischemic or toxic injury. Kidney regeneration and repair occur through three cellular and molecular mechanisms: differentiation of the somatic stem cells, recruitment of circulating stem cells and, more importantly, proliferation/dedifferentiation of mature cells. Dedifferentiation seems to represent a critical step for the recovery of tubular integrity. Dedifferentiation of tubular cells after injury is characterized by the reactivation of a mesenchymal program that is active during nephrogenesis. Epithelial-to-mesenchymal transition (EMT) of renal tubular cells is an extreme manifestation of epithelial cell plasticity. It is now widely recognized as a fundamental process that marks some physiological, such as morphogenesis, as well as pathological events, such as oncogenesis and fibrogenesis. It might be also considered as a key event in the regenerative process of the kidney. Understanding the molecular mechanisms involved in EMT might be useful for designing therapeutic strategies in order to potentiate the innate capacity of the kidney to regenerate.
    Mesh-Begriff(e) Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/physiology ; Cell Differentiation ; Epithelial Cells/cytology ; Epithelial Cells/physiology ; Humans ; Ischemia/physiopathology ; Kidney/cytology ; Kidney/injuries ; Kidney/physiology ; Kidney/physiopathology ; Kidney Tubules/cytology ; Kidney Tubules/physiology ; Mammals ; Reference Values ; Regeneration/physiology ; Renal Circulation/physiology ; Stem Cells/cytology ; Stem Cells/physiology
    Sprache Englisch
    Erscheinungsdatum 2008-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2141320-4
    ISSN 1093-9946
    ISSN 1093-9946
    DOI 10.2741/3161
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Encrusted cystitis by Corynebacterium urealyticum: a case report with novel insights into bladder lesions.

    Del Prete, Dorella / Polverino, Biagio / Ceol, Monica / Vianello, Daniela / Mezzabotta, Federica / Tiralongo, Emilia / Iafrate, Massimo / De Canale, Ettore / Mengoli, Carlo / Valente, Marialuisa / Anglani, Franca / D'Angelo, Angela

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2008  Band 23, Heft 8, Seite(n) 2685–2687

    Mesh-Begriff(e) Aged ; Calcinosis/etiology ; Calcinosis/pathology ; Catheter-Related Infections/etiology ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/pathology ; Corynebacterium Infections/etiology ; Corynebacterium Infections/microbiology ; Corynebacterium Infections/pathology ; Cystitis/etiology ; Cystitis/microbiology ; Cystitis/pathology ; Female ; Humans ; Risk Factors ; Urinary Catheterization/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2008-08
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfn243
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Primary IgA nephropathy is more severe in TGF-beta1 high secretor patients.

    Brezzi, Brigida / Del Prete, Dorella / Lupo, Antonio / Magistroni, Riccardo / Gomez-Lira, Macarena / Bernich, Patrizia / Anglani, Franca / Mezzabotta, Federica / Turco, Alberto / Furci, Luciana / Ceol, Monica / Antonucci, Francesco / Abaterusso, Cataldo / Bonfante, Luciana / D'Angelo, Angela / Albertazzi, Alberto / Gambaro, Giovanni

    Journal of nephrology

    2009  Band 22, Heft 6, Seite(n) 747–759

    Abstract: Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and is characterized by extremely variable clinical and morphological features and outcome. TGF-beta1 has a key role in fibrogenesis and the progression of renal ... ...

    Abstract Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and is characterized by extremely variable clinical and morphological features and outcome. TGF-beta1 has a key role in fibrogenesis and the progression of renal damage. Its production is under genetic control.
    Methods: We recruited 105 Italian biopsy-proven IgAN patients for genotyping for the TGF-beta1 C-509T, T869C (COD 10) and G915C (COD 25) polymorphisms; 200 healthy blood donors were used as normal controls. Glomerular and interstitial mRNA levels of TGF-beta1 were assessed by real-time PCR in 34 patients to seek relationships with clinical, renal histopathological features and outcome.
    Results: The genotype distributions in the IgAN population were not statistically different from the controls. The COD 10 TT genotype was associated with more severe histological damage as assessed by Lee's classification (CC 50%, CT 39.6% and TT 17.2% were graded as mild; CC 35.7%, CT 43.7% and TT 44.8% as moderate, and CC 14.3%, CT 16.7% and TT 37.9% as severe [p=0.0049]) and with severe interstitial infiltrates (CC 10.4%, CT 35.2% and TT 54.2% [p=0.03]). A higher interstitial immunodeposition was observed for TGF-beta1, collagen IV and alpha-SMA in patients with the COD 10 T allele (p=0.045, p=0.049, p=0.032, respectively). The T allele was associated with significantly higher TGF-beta1 mRNA levels in the interstitium (TT+CT vs. CC: 0.52 +/- 0.16 vs. 0.18 +/- 0.10 copies/mL, respectively; p=0.000). The T allele was also associated with higher mRNA levels in glomeruli, though the difference was not statistically significant. Finally, the T allele was significantly associated with a worse prognosis, the end points being reached by 40% of TT+CT and 32% of CC patients (p=0.009).
    Conclusions: In primary IgA nephropathy, the T allele of the TGF-beta1 COD 10 C/T polymorphism seems to be associated with more severe histological lesions, higher renal TGF-beta1 mRNA levels and a worse prognosis. This polymorphism seems to be functionally relevant and to have a prognostic impact.
    Mesh-Begriff(e) Adult ; Biopsy ; Case-Control Studies ; Disease Progression ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Glomerulonephritis, IGA/genetics ; Glomerulonephritis, IGA/metabolism ; Glomerulonephritis, IGA/pathology ; Humans ; Italy ; Kaplan-Meier Estimate ; Kidney/pathology ; Kidney/secretion ; Male ; Middle Aged ; Phenotype ; Polymorphism, Genetic ; Prognosis ; Proportional Hazards Models ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/secretion ; Up-Regulation ; Young Adult
    Chemische Substanzen RNA, Messenger ; Transforming Growth Factor beta1
    Sprache Englisch
    Erscheinungsdatum 2009-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1121-8428 ; 1120-3625
    ISSN (online) 1724-6059
    ISSN 1121-8428 ; 1120-3625
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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