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  1. Book ; Online ; E-Book: Comprehensive overview of modern surgical approaches to intrinsic brain tumors

    Chaichana, Kaisorn / Quiñones-Hinojosa, Alfredo

    2019  

    Author's details edited by Kaisorn Chaichana, Alfredo Quiñones-Hinojosa
    Keywords Brain/Surgery ; Brain/Tumors
    Subject code 617.481
    Language English
    Size 1 Online-Ressource (506 Seiten)
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Includes index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020041618
    ISBN 978-0-12-811784-2 ; 9780128117835 ; 0-12-811784-2 ; 0128117834
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Brain mapping

    Quinones-Hinojosa, Alfredo / Chaichana, Kaisorn L. / Mahato, Deependra

    indications and techniques

    2020  

    Author's details Alfredo Quinones-Hinojosa, Kaisorn Chaichana, Deependra Mahato
    Keywords 807
    Subject code 610
    Language English
    Size 1 Online-Ressource (xv, 196 Seiten), Illustrationen
    Publisher Thieme
    Publishing place New York
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020380546
    ISBN 978-1-68420-093-1 ; 9781684200924 ; 1-68420-093-8 ; 168420092X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Controversies in neuro-oncology

    Quiñones-Hinojosa, Alfredo / Raza, Shaan M.

    best evidence medicine for brain tumor surgery

    2014  

    Author's details Alfredo Quiñones-Hinojosa ; Shaan M. Raza
    Keywords Brain Neoplasms / surgery ; Brain Neoplasms / radiotherapy ; Evidence-Based Medicine / methods ; Radiosurgery / methods ; Neurosurgical Procedures
    Language English
    Size XXIII, 495 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017812345
    ISBN 978-1-60406-755-2 ; 1-60406-755-1 ; 9781604067569 ; 160406756X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2917 available for loan (reading room) Lesesaal EG

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  4. Book: Neural stem cells

    Quiñones-Hinojosa, Alfredo

    (Neurosurgery clinics of North America ; 18,1)

    2007  

    Author's details guest ed. Alfredo Quiñones-Hinojosa
    Series title Neurosurgery clinics of North America ; 18,1
    Collection
    Language English
    Size XVI, 198 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015014931
    ISBN 1-4160-4339-X ; 978-1-4160-4339-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1200 -18,1- verfügbar in Königswinter Königswinter

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  5. Article: Case Report: "Aggressive" perioperative antiseizure medication prophylaxis in patients with glioma-related epilepsy at high risk of early postoperative seizures following awake craniotomy.

    Freund, Brin E / Jaeckle, Kurt / Quinones-Hinojosa, Alfredo / Feyissa, Anteneh M

    Frontiers in surgery

    2024  Volume 10, Page(s) 1282013

    Abstract: Early postoperative seizures (EPS) are a common complication of brain tumor surgery. EPS can lead to hemorrhage, cerebral hypoxia, increased intracranial pressure, longer hospitalization, reduced quality of life, decreased overall survival, and increased ...

    Abstract Early postoperative seizures (EPS) are a common complication of brain tumor surgery. EPS can lead to hemorrhage, cerebral hypoxia, increased intracranial pressure, longer hospitalization, reduced quality of life, decreased overall survival, and increased morbidity. However, there are no formal guidelines on perioperative antiseizure medication (ASM) management in patients with tumor-related epilepsy who are deemed high risk for EPS. In this study, we describe the case of a 38-year-old man with isocitrate dehydrogenase-mutant mixed glioma and two episodes of EPS manifesting with status epilepticus during prior tumor surgeries and who presented with tumor progression. The Tumor Board recommended awake craniotomy with direct electrical stimulation (DES). The patient was administered aggressive preoperative "prophylactic" ASMs by increasing the maintenance doses of lacosamide and levetiracetam by 25% 48 h before surgery. An intravenous load of fosphenytoin (20 mg/kg) was administered in the operating room before DES, followed by a maintenance dosing of 300 mg/day for 14 days. EPS did not occur, and he was discharged home on postoperative day 4. Our case illustrates that aggressive perioperative prophylactic ASM therapy beyond the maintenance ASM regimen can be considered in patients with tumor-related epilepsy at risk of EPS.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1282013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Altered glutamatergic and inflammatory pathways promote glioblastoma growth, invasion, and seizures: An overview.

    Feyissa, Anteneh M / Rosenfeld, Steven S / Quiñones-Hinojosa, Alfredo

    Journal of the neurological sciences

    2022  Volume 443, Page(s) 120488

    Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain cancer. Drug-resistant seizures and cognitive impairments often accompany the invasion of the neocortex by the GBM cells. Recent studies suggest that seizures and ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain cancer. Drug-resistant seizures and cognitive impairments often accompany the invasion of the neocortex by the GBM cells. Recent studies suggest that seizures and glioma share common pathogenic mechanisms and may influence each other. One explanation for the close link between the two conditions is elevated glutamate in the tumor microenvironment (TME) due to an increased expression of the cystine-glutamate transporter with ensuing overactivity of glutamatergic signaling. Excess glutamate in the TME also encourages the polarization of pro-inflammatory tumor-associated macrophages to an anti-inflammatory state causing TME immunosuppression and facilitating tumor invasion. Besides, the recently discovered glutamatergic neurogliomal synapses, partially via their influence on calcium communication in microtube-connected tumor cell networks, drive the progression of GBM by stimulating glioma invasion and growth. Moreover, neuroinflammatory pathways have been shown to have several points of intersection with glutamatergic signaling in the TME, further promoting both epileptogenesis and oncogenesis. Future studies identifying pharmacotherapeutics targeting these elements is an extremely attractive therapeutic strategy for GBM, for which very little therapeutic progress has been made in the past two decades.
    MeSH term(s) Humans ; Brain Neoplasms/pathology ; Glioblastoma/pathology ; Glioma/metabolism ; Glutamic Acid/metabolism ; Seizures ; Tumor Microenvironment
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2022-11-05
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2022.120488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Current State of Functional MRI in the Presurgical Planning of Brain Tumors.

    Lakhani, Dhairya A / Sabsevitz, David S / Chaichana, Kaisorn L / Quiñones-Hinojosa, Alfredo / Middlebrooks, Erik H

    Radiology. Imaging cancer

    2023  Volume 5, Issue 6, Page(s) e230078

    Abstract: Surgical resection of brain tumors is challenging because of the delicate balance between maximizing tumor removal and preserving vital brain functions. Functional MRI (fMRI) offers noninvasive preoperative mapping of widely distributed brain areas and ... ...

    Abstract Surgical resection of brain tumors is challenging because of the delicate balance between maximizing tumor removal and preserving vital brain functions. Functional MRI (fMRI) offers noninvasive preoperative mapping of widely distributed brain areas and is increasingly used in presurgical functional mapping. However, its impact on survival and functional outcomes is still not well-supported by evidence. Task-based fMRI (tb-fMRI) maps blood oxygen level-dependent (BOLD) signal changes during specific tasks, while resting-state fMRI (rs-fMRI) examines spontaneous brain activity. rs-fMRI may be useful for patients who cannot perform tasks, but its reliability is affected by tumor-induced changes, challenges in data processing, and noise. Validation studies comparing fMRI with direct cortical stimulation (DCS) show variable concordance, particularly for cognitive functions such as language; however, concordance for tb-fMRI is generally greater than that for rs-fMRI. Preoperative fMRI, in combination with MRI tractography and intraoperative DCS, may result in improved survival and extent of resection and reduced functional deficits. fMRI has the potential to guide surgical planning and help identify targets for intraoperative mapping, but there is currently limited prospective evidence of its impact on patient outcomes. This review describes the current state of fMRI for preoperative assessment in patients undergoing brain tumor resection.
    MeSH term(s) Humans ; Brain Mapping/methods ; Prospective Studies ; Reproducibility of Results ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2638-616X
    ISSN (online) 2638-616X
    DOI 10.1148/rycan.230078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Epigenetic modifiers either individually or in specific combinations impair viability of patient-derived glioblastoma cell line while exhibit moderate effect on normal stem cells growth.

    Alexanian, Arshak R / Stoellinger, Heidi Marie / de Araujo Farias, Virginea / Quiñones-Hinojosa, Alfredo

    Investigational new drugs

    2023  Volume 41, Issue 3, Page(s) 371–375

    Abstract: Glioblastomas (GBM), also known as glioblastoma multiforme, are the most aggressive type of brain cancer. Currently, there is no effective treatment for GBM, highlighting the pressing need for new therapeutic strategies. In a recent study, we ... ...

    Abstract Glioblastomas (GBM), also known as glioblastoma multiforme, are the most aggressive type of brain cancer. Currently, there is no effective treatment for GBM, highlighting the pressing need for new therapeutic strategies. In a recent study, we demonstrated that specific combinations of epigenetic modifiers significantly affect the metabolism and proliferation rate of the two most aggressive GBM cell lines, D54 and U-87. Importantly, these combinations exhibited minimal effects on the growth of normal stem cells. In this study, we extended our investigation to include a patient-derived GBM stem cell line. Our results showed that the combinations of modulators of histone and DNA covalent modifying enzymes that synergistically suppress D54 and U87 cell line growth also impair the viability of the patient-derived GBM stem cell line. These findings suggest that epigenetic modifiers alone or in specific combinations exhibit a cytotoxic effect on established and low-passage patient-derived GBM cell lines, and thus could be a promising therapeutic approach for this type of brain cancer.
    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Cell Proliferation ; Cell Line ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Epigenesis, Genetic ; Stem Cells/metabolism ; Cell Line, Tumor
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604895-x
    ISSN 1573-0646 ; 0167-6997
    ISSN (online) 1573-0646
    ISSN 0167-6997
    DOI 10.1007/s10637-023-01370-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1823: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Preoperative Risk Assessment Before Elective Craniotomy: Are Aspirin, Arrhythmias, Deep Venous Thromboses, and Hyperglycemia Contraindications to Surgery?

    Kulikov, Alexander / Gruenbaum, Shaun E / Quinones-Hinojosa, Alfredo / Pugnaloni, Pier Paolo / Lubnin, Andrey / Bilotta, Federico

    World neurosurgery

    2024  Volume 186, Page(s) 68–77

    Abstract: Objective: Perioperative risk assessment and stratification before craniotomy is necessary to identify and optimize modifiable risk factors. Due to the high costs of diagnostic testing and concerns for delaying surgery, some have questioned whether and ... ...

    Abstract Objective: Perioperative risk assessment and stratification before craniotomy is necessary to identify and optimize modifiable risk factors. Due to the high costs of diagnostic testing and concerns for delaying surgery, some have questioned whether and when surgery delays are warranted and supported by the current body of literature. The objective of this scoping review was to evaluate the available evidence on the prognostic value of preoperative risk assessment before anesthesia for elective craniotomy.
    Methods: In this scoping review, we reviewed 156 papers that assess preoperative risk assessment before elective craniotomy, of which 27 papers were included in the final analysis.
    Results: There is little high-quality evidence to suggest significant risk reduction when 4 common preexisting abnormalities are present: preoperative chronic aspirin therapy, cardiac arrhythmias, deep vein thrombosis, or hyperglycemia.
    Conclusions: The risk of delaying craniotomy should ultimately be weighed against the perceived risks associated the patient's comorbid conditions and should be considered on an individualized basis.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Introduction. Immunology of neurosurgical diseases.

    Quiñones-Hinojosa, Alfredo / Rahman, Maryam / Lim, Michael / Suarez-Meade, Paola / Marenco-Hillembrand, Lina

    Neurosurgical focus

    2022  Volume 52, Issue 2, Page(s) E1

    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2021.12.FOCUS21730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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