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Book ; Online ; E-Book: Netter's neurology

Netter, Frank H. / Srinivasan, Jayashri / Scott, Brian J. / Chaves, Claudia J. / Small, Juan E.

(Expert consult)

2020

Title variant	Neurology
Author's details	editors: Jayashri Srinivasan, Brian J. Scott, Claudia J. Chaves, Juan E. Small ; illustrations by: Frank H. Netter ; contributing illustrators: Carlos A. G. Machado [und viele weitere]
Series title	Expert consult
Keywords	Nervous System Diseases ; Nervous System / anatomy & histology
Subject code	616.8
Language	English
Size	1 Online-Ressource (xvi, 748 Seiten), Illustrationen
Edition	3rd edition
Publisher	Elsevier
Publishing place	Philadelphia, PA
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020030866
ISBN	978-0-323-55479-4 ; 9780323554763 ; 0-323-55479-2 ; 0323554768
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Cuentas y cuentos... Cuida de las cuentas públicas

Suárez Pineda, Jesús Alberto / Cárdenas Chaves, María Luz / Méndez Parada, Vernon Weis / Rojas Ávila, Luisa Katherine / Castillo Caicedo, Iván Jesús / Wilches Cuervo, Claudia Patricia / Contento Sanz, Laura / Varela Urrego, Jorge de Jesús

custodia de la probidad

2020

Keywords	Public finance accounting
Language	Spanish
Size	1 electronic resource (181 pages)
Publisher	Editorial Fundación Universitaria San Mateo
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030376186
ISBN	9789585263338 ; 9585263335
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Description and Clinical Management of Patients With Glanzmann's Thrombasthenia in a University Hospital, a Referral Center Specialized in Hemostasis, in Bogotá, Colombia.

Solano, Maria H / Chaves, Karen / Casas, Claudia P

Cureus

2022 Volume 14, Issue 6, Page(s) e25657

Abstract: Introduction Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelets caused by a deficiency in the glycoprotein IIb-IIIa. Bleeding from the skin, mucous membranes, and ecchymosis are symptoms manifested starting in early childhood. ...

Abstract	Introduction Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelets caused by a deficiency in the glycoprotein IIb-IIIa. Bleeding from the skin, mucous membranes, and ecchymosis are symptoms manifested starting in early childhood. There may also be major bleeding conditions as a result of surgical procedures or trauma. The treatment is based on platelet transfusions, antifibrinolytic agents, and recombinant activated factor VII (rFVIIa). Objective To describe the demographic and clinical characteristics as well as the main treatment strategies used during bleeding events or procedures for patients diagnosed with GT that required inpatient attention at a university hospital, a referral center specialized in hemostasis, in the city of Bogota. Materials and methods A descriptive retrospective cohort study was done over a period of 10 years that included nine patients over 18 years of age diagnosed with GT. Results A total of 34 admissions were reported, 23 due to bleeding and 11 for scheduled surgery. Some of the admissions for bleeding (38%) (n=13) required surgical procedures. Overall, 23 surgical procedures were done, six of which were classified as major. Seventy-seven percent of the patients were women with a median age of 37. Their most common symptoms were mucosal and genitourinary bleeding. The use of antifibrinolytics was registered in 28 events, followed by the use of platelet transfusion in 19, and the use of rFVIIa in 17. The average hospital stay was eight days. Conclusion The characteristics registered and the treatments established for this cohort of Colombian patients with GT are similar to those reported in other hospitals around the world. GT presents diagnostic and therapeutic challenges and, therefore, acquiring more knowledge about this pathology is needed within this context.
Language	English
Publishing date	2022-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25657
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Article ; Online: MRI pattern in acute optic neuritis: Comparing multiple sclerosis, NMO and MOGAD.

Darakdjian, Maximiliano / Chaves, Hernan / Hernandez, Jairo / Cejas, Claudia

The neuroradiology journal

2022 Volume 36, Issue 3, Page(s) 267–272

Abstract: Background: Several MRI findings of optic neuritis (ON) have been described and correlated with specific underlying etiologies. Specifically, optic nerve enhancement is considered an accurate biomarker of acute ON.: Objective: To identify differences ...

Abstract	Background: Several MRI findings of optic neuritis (ON) have been described and correlated with specific underlying etiologies. Specifically, optic nerve enhancement is considered an accurate biomarker of acute ON. Objective: To identify differences in MRI patterns of optic nerve enhancement in certain demyelinating etiologies presenting with acute ON. Methods: Retrospective analysis of enhancement patterns on fat-suppressed T1-weighted images from patients presenting clinical and radiological acute ON, treated at our institution between January 2014 and June 2022. Location and extension of enhancing optic nerve segments, as well as presence of perineural enhancement were evaluated in three predetermined demyelinating conditions. Fisher's exact test and chi Results: Fifty-six subjects met eligibility criteria. Mean age was 31 years (range 6-79) and 70% were females. Thirty-four (61%) patients were diagnosed with multiple sclerosis (MS), 8 (14%) with neuromyelitis optica (NMO), and 14 (25%) with anti-myelin oligodendrocyte glycoprotein disease (MOGAD). Bilateral involvement was more frequent in MOGAD, compared to MS and NMO (43 vs 3% and 12.5% respectively, Conclusion: In the setting of acute ON, patients presenting MOGAD were more likely to show bilateral, longitudinally extended and anterior (intraorbital and canalicular) optic nerve involvement compared to patients with MS or NMO.
MeSH term(s)	Female ; Male ; Humans ; Neuromyelitis Optica/diagnostic imaging ; Multiple Sclerosis/diagnostic imaging ; Myelin-Oligodendrocyte Glycoprotein ; Retrospective Studies ; Optic Neuritis/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Autoantibodies
Chemical Substances	Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
Language	English
Publishing date	2022-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009221124308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2823: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Strategies for drug production and procurement in a context of technological dependency.

Chaves, Gabriela Costa / Moraes, Elaine Lazzaroni / Osorio-de-Castro, Claudia Garcia Serpa

Cadernos de saude publica

2021 Volume 37, Issue 3, Page(s) e00036821

Title translation	Estratégias de produção e aquisição de produtos farmacêuticos em contexto de dependência.
MeSH term(s)	Brazil ; Humans ; Pharmaceutical Preparations ; Technology
Chemical Substances	Pharmaceutical Preparations
Language	Spanish
Publishing date	2021-03-12
Publishing country	Brazil
Document type	Editorial
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00036821
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4981: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer.

Richau, Caroline Stahnke / Scherer, Nicole de Miranda / Matta, Bruna Palma / de Armas, Elvismary Molina / de Barros Moreira, Fábio Carvalho / Bergmann, Anke / Pereira Chaves, Claudia Bessa / Boroni, Mariana / Dos Santos, Anna Claudia Evangelista / Moreira, Miguel Angelo Martins

Cancer medicine

2024 Volume 13, Issue 3, Page(s) e6729

Abstract: Background: Approximately 3/4 of ovarian cancers are diagnosed in advanced stages, with the high-grade epithelial ovarian carcinoma (EOC) accounting for 90% of the cases. EOC present high genomic instability and somatic loss-of-function variants in ... ...

Abstract	Background: Approximately 3/4 of ovarian cancers are diagnosed in advanced stages, with the high-grade epithelial ovarian carcinoma (EOC) accounting for 90% of the cases. EOC present high genomic instability and somatic loss-of-function variants in genes associated with homologous recombination mutational repair pathway (HR), such as BRCA1 and BRCA2, and in TP53. The identification of germline variants in HR genes in EOC is relevant for treatment of platinum resistant tumors and relapsed tumors with therapies based in synthetic lethality such as PARP inhibitors. Patients with somatic variants in HR genes may also benefit from these therapies. In this work was analyzed the frequency of somatic variants in BRCA1, BRCA2, and TP53 in an EOC cohort of Brazilian patients, estimating the proportion of variants in tumoral tissue and their association with progression-free survival and overall survival. Methods: The study was conducted with paired blood/tumor samples from 56 patients. Germline and tumoral sequences of BRCA1, BRCA2, and TP53 were obtained by massive parallel sequencing. The HaplotypeCaller method was used for calling germline variants, and somatic variants were called with Mutect2. Results: A total of 26 germline variants were found, and seven patients presented germline pathogenic or likely pathogenic variants in BRCA1 or BRCA2. The analysis of tumoral tissue identified 52 somatic variants in 41 patients, being 43 somatic variants affecting or likely affecting protein functionality. Survival analyses showed that tumor staging was associated with overall survival (OS), while the presence of somatic mutation in TP53 was not associated with OS or progression-free survival. Conclusion: Frequency of pathogenic or likely pathogenic germline variants in BRCA1 and BRCA2 (12.5%) was lower in comparison with other studies. TP53 was the most altered gene in tumors, with 62.5% presenting likely non-functional or non-functional somatic variants, while eight 14.2% presented likely non-functional or non-functional somatic variants in BRCA1 or BRCA2.
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/genetics ; Brazil/epidemiology ; Ovarian Neoplasms/genetics ; DNA Repair ; Germ Cells ; Tumor Suppressor Protein p53/genetics ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53 ; BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6729
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoactive glycoconjugates with a very large Stokes shift: synthesis, photophysics, and copper(II) and BSA sensing.

da Silva, Cláudia Brito / Silva, Luana / Debia, Natalí Pires / Chaves, Otávio Augusto / Lüdtke, Diogo Seibert / Rodembusch, Fabiano Severo

Organic & biomolecular chemistry

2023 Volume 21, Issue 46, Page(s) 9242–9254

Abstract: This study presents the synthesis of novel glycoconjugates by connecting benzazole and carbohydrate units with a 1,2,3-triazole linker. A simple synthetic route employing a copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) was utilized. ... ...

Abstract	This study presents the synthesis of novel glycoconjugates by connecting benzazole and carbohydrate units with a 1,2,3-triazole linker. A simple synthetic route employing a copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) was utilized. The synthesized compounds exhibit excited-state intramolecular proton transfer (ESIPT), resulting in longer wavelength emission with a significantly large Stokes shift (∼10 000 cm
MeSH term(s)	Serum Albumin, Bovine/chemistry ; Copper/chemistry ; Glycoconjugates ; Triazoles
Chemical Substances	Serum Albumin, Bovine (27432CM55Q) ; Copper (789U1901C5) ; Glycoconjugates ; Triazoles
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01388j
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Article ; Online: What contributes to Primary Health Care effectiveness? Integrative literature review, 2010-2020.

Chaves, Ana Cláudia Cardozo / Scherer, Magda Duarte Dos Anjos / Conill, Eleonor Minho

Ciencia & saude coletiva

2023 Volume 28, Issue 9, Page(s) 2537–2551

Abstract: Primary Health Care (PHC) intends to rearrange services to make it more effective. Nevertheless, effectiveness in PHC is quite a challenge. This study reviews several articles regarding the effectiveness improvements in PHC between 2010 and 2020. Ninety ... ...

Title translation	O que contribui para a resolubilidade na Atenção Primária à Saúde? Revisão integrativa da literatura, 2010-2020.
Abstract	Primary Health Care (PHC) intends to rearrange services to make it more effective. Nevertheless, effectiveness in PHC is quite a challenge. This study reviews several articles regarding the effectiveness improvements in PHC between 2010 and 2020. Ninety out of 8,369 articles found in PubMed and the Virtual Health Library databases search were selected for thematic analysis using the Atlas.ti® 9.0 software. There were four categories identified: strategies for monitoring and evaluating health services, organizational arrangements, models and technologies applied to PHC. Studies concerning the sensitive conditions indicators were predominant. Institutional assessment programs, PHC as a structuring policy, appropriate workforce, measures to increase access and digital technologies showed positive effects. However, payment for performance is still controversial. The expressive number of Brazilian publications reveals the broad diffusion of PHC in the country and the concern on its performance. These findings reassure well-known aspects, but it also points to the need for a logical model to better define what is intended as effectiveness within primary health care as well as clarify the polysemy that surrounds the concept. We also suggest substituting the term "resolvability", commonly used in Brazil, for "effectiveness".
MeSH term(s)	Humans ; Brazil ; Databases, Factual ; Health Facilities ; Program Evaluation ; Primary Health Care
Language	English
Publishing date	2023-01-13
Publishing country	Brazil
Document type	Review ; Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232023289.15342022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Translation, Adaptation and Assessment of the Psychometric Properties of the Mental Health Knowledge Questionnaire in a Sample of Higher Education Students in Portugal.

Chaves, Cláudia / Duarte, João / Sampaio, Francisco / Coelho, Joana / Sequeira, Carlos

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: A significant part of the worldwide population is affected by some mental disorder. Previous research conducted with the general population has revealed poor knowledge when it comes to mental health. Therefore, it is imperative to assess mental health ... ...

Abstract	A significant part of the worldwide population is affected by some mental disorder. Previous research conducted with the general population has revealed poor knowledge when it comes to mental health. Therefore, it is imperative to assess mental health literacy using robust assessment tools. Thus, this study aimed to translate, adapt and assess the psychometric properties of the Mental Health Knowledge Questionnaire in a sample of higher education students in Portugal. This study used a sample consisting of 2887 participants. Internal consistency for the psychometric study was estimated using Cronbach's alpha coefficient. Construct validity was tested using exploratory and confirmatory factor analysis, convergent validity, and discriminant validity. After data analysis, the final Portuguese version of the Mental Health Knowledge Questionnaire was composed of 14 items. The goodness-of-fit indices were adequate, confirming the quality of the model's fit to the empirical data (χ²/df = 2.459, GFI = 0.983, CFI = 0.969, RMSEA = 0.032, RMR = 0.023, SRMR = 0.032). This assessment tool is valid and reliable to assess higher education students' mental health literacy in Portugal. Analyses to confirm the scale's external validity, measurement equivalence and replicability are still required.
MeSH term(s)	Humans ; Portugal ; Mental Health ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires ; Students
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043022
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Article ; Online: Prácticas de salud/salud mental y producción de cuidado durante la pandemia de Covid-19

Claudia Bang / Viviana Lazarte / Federico Agustin Chaves / Mariana Casal

Saúde em Debate, Vol 46, Iss spe1, Pp 194-

2022 Volume 205

Abstract: RESUMEN El presente escrito se vincula a dos proyectos institucionales de investigación científica, en los que se ha propuesto indagar sobre prácticas de cuidado en salud mental durante la pandemia de Covid-19. El objetivo de este trabajo es describir y ... ...

Abstract	RESUMEN El presente escrito se vincula a dos proyectos institucionales de investigación científica, en los que se ha propuesto indagar sobre prácticas de cuidado en salud mental durante la pandemia de Covid-19. El objetivo de este trabajo es describir y analizar prácticas de salud/salud mental centradas en el sostenimiento del vínculo en la atención y el fortalecimiento de redes productoras de cuidados en contexto de pandemia, desarrolladas en el Área Metropolitana de Buenos Aires, Argentina. Se trata de un estudio exploratorio y descriptivo que utiliza técnicas cualitativas para la recolección y análisis de datos. A partir de la reconstrucción de cuatro breves relatos vivenciales de nuestra propia práctica profesional, se abordan diversos núcleos temáticos de caracterización y análisis de la experiencia. Se concluye que estas prácticas recuperan la perspectiva de cuidados en salud/salud mental a través de la humanización del vínculo y la inclusión de la dimensión afectiva en la atención. Se trata de prácticas que, desde territo- rios institucionales muy diversos y por medio de dispositivos flexibles y creativos, han logrado sostener procesos participativos, afianzar abordajes interdisciplinarios y fortalecer las redes comunitarias de cuidados en un contexto de excepcionalidad y alta complejidad.
Keywords	Salud mental ; Pandemia ; Creatividad ; Atención a la salud ; Redes comunitarias ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Centro Brasileiro de Estudos de Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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