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  1. Article ; Online: T-cell epitopes of PLA2R1 in membranous nephropathy: another step toward antigen-based immunotherapies.

    Hoxha, Elion

    Kidney international

    2023  Volume 103, Issue 3, Page(s) 466–469

    Abstract: The discovery of phospholipase A2 receptor 1 as the major target antigen in membranous nephropathy (MN) has initiated a decade of major advances in the understanding of MN pathophysiology and improvement of patient care. In this Issue, Zhang et al. ... ...

    Abstract The discovery of phospholipase A2 receptor 1 as the major target antigen in membranous nephropathy (MN) has initiated a decade of major advances in the understanding of MN pathophysiology and improvement of patient care. In this Issue, Zhang et al. identified potential T-cell epitopes of phospholipase A2 receptor 1 in patients with MN. The characterization of the pathogenic T- and B-cell epitopes on phospholipase A2 receptor 1 is an important step moving from the current unspecific immunosuppressive therapies toward antigen-specific MN treatments.
    MeSH term(s) Humans ; Glomerulonephritis, Membranous ; Epitopes, T-Lymphocyte ; Receptors, Phospholipase A2 ; Autoantibodies ; Immunotherapy
    Chemical Substances Epitopes, T-Lymphocyte ; Receptors, Phospholipase A2 ; Autoantibodies ; PLA2R1 protein, human
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.12.018
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  2. Article ; Online: Update nephrotisches Syndrom – neue pathophysiologische Konzepte 2022.

    Hoxha, Elion

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 17, Page(s) 1134–1140

    Abstract: The identification of autoantibodies responsible for the development of membranous nephropathy (MN) in most patients, has led to the development of antigen-specific diagnosis and treatment options for this disease. Pathomechanisms leading to the ... ...

    Title translation Update nephrotic syndrome - new pathophysiologic concepts 2022.
    Abstract The identification of autoantibodies responsible for the development of membranous nephropathy (MN) in most patients, has led to the development of antigen-specific diagnosis and treatment options for this disease. Pathomechanisms leading to the initiation of the immune response against PLA2R1 are not clear, yet. Environmental and genetic factors may play a role in these processes. In THSD7A-induced MN THSD7A-expressing tumors may play an important pathogenic role.An antigen-specific diagnosis of MN is important for the development of individualized disease management strategies in these patients. These strategies include for example tumor screening, the decision to perform a kidney biopsy, adjustment of treatment based on the immunologic disease activity, better estimation of the risk for disease progression as well as the prognosis of disease etc. The clinical role of domain-specific PLA2R1-antibodies needs to be better defined. In the last years, several novel target antigens have been described in patients with MN. The pathogenetic role of these antigens needs to be better defined.In MCD and FSGS a T-cell disruption is assumed to play a central role for disease pathogenesis, which, however, remains not well understood. In the last years, a potential role for B-cells and autoantibodies has been postulated in these patients. For both MCD and FSGS steroids remain the first line treatment strategy. When a steroid treatment needs to be avoided, calcineurin inhibitors are often used as a second line therapy. Other treatment options include cyclophosphamide, MMF and rituximab.
    MeSH term(s) Autoantibodies ; Glomerulonephritis, Membranous ; Glomerulosclerosis, Focal Segmental ; Humans ; Nephrotic Syndrome ; Receptors, Phospholipase A2 ; Thrombospondins
    Chemical Substances Autoantibodies ; PLA2R1 protein, human ; Receptors, Phospholipase A2 ; Thrombospondins
    Language German
    Publishing date 2022-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1585-3260
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  3. Article: Update zu: Erfahrungen aus dem deutschen COVID-19-Register.

    Hoxha, Elion

    Der nephrologe

    2021  Volume 16, Issue 5, Page(s) 311–313

    Title translation Update on: Experiences from the German COVID-19 register.
    Language German
    Publishing date 2021-08-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2274530-0
    ISSN 1862-0418 ; 1862-040X
    ISSN (online) 1862-0418
    ISSN 1862-040X
    DOI 10.1007/s11560-021-00528-9
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  4. Article: Erfahrungen aus dem deutschen COVID-19-Register.

    Hoxha, Elion

    Der nephrologe

    2020  Volume 16, Issue 1, Page(s) 10–13

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections represent a particular risk for several groups of patients with nephrological diseases. Patients on dialysis represent a particularly vulnerable group during the SARS-CoV‑2 pandemic. ...

    Title translation Experiences from the German COVID-19 register.
    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections represent a particular risk for several groups of patients with nephrological diseases. Patients on dialysis represent a particularly vulnerable group during the SARS-CoV‑2 pandemic. Initial data from international registries show a much higher mortality of dialysis patients with SARS-CoV‑2 infections. Because of the substantial differences between the healthcare systems, (state) preventive measures and treatment possibilities etc., in the different countries worldwide, local and national registry data cannot be easily transferred. In order to gain a reliable overview of the prevalence and mortality of dialysis patients with SARS-CoV‑2 infection in Germany, the German Society of Nephrology implemented a national registry for dialysis patients with a SARS-CoV‑2 infection. Within this framework a standardized collection of these data is carried out on a weekly basis, which should enable a real-time overview of the case numbers and perhaps the acquisition of new scientific knowledge. Particularly in the current phase of the pandemic (autumn 2020), which is accompanied by a multiplication of the numbers of daily new-onset cases within only a few weeks, such data are highly relevant for the estimation and adjustment of the personnel, structural and organizational needs as well as the capacities for the treatment of patients.
    Language German
    Publishing date 2020-12-09
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2274530-0
    ISSN 1862-0418 ; 1862-040X
    ISSN (online) 1862-0418
    ISSN 1862-040X
    DOI 10.1007/s11560-020-00468-w
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  5. Book ; Online ; Thesis: Untersuchung der Wirksamkeit einer intravenösen Cyclophosphamid-Therapie verglichen mit der oralen Cyclophosphamid-Therapie bei Patienten mit membranöser Glomerulonephritis

    Gratzfeld, Lydia Verfasser] / [Hoxha, Elion [Akademischer Betreuer]

    2023  

    Author's details Lydia Gratzfeld ; Betreuer: Elion Hoxha
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
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  6. Article ; Online: Membranous nephropathy: new pathogenic mechanisms and their clinical implications.

    Hoxha, Elion / Reinhard, Linda / Stahl, Rolf A K

    Nature reviews. Nephrology

    2022  Volume 18, Issue 7, Page(s) 466–478

    Abstract: Membranous nephropathy (MN) is characterized histomorphologically by the presence of immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical hallmarks are nephrotic range proteinuria with oedema. In patients with ... ...

    Abstract Membranous nephropathy (MN) is characterized histomorphologically by the presence of immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical hallmarks are nephrotic range proteinuria with oedema. In patients with primary MN, autoimmunity is driven by circulating autoantibodies that bind to one or more antigens on the surface of glomerular podocytes. Compared with other autoimmune kidney diseases, the understanding of the pathogenesis of MN has substantially improved in the past decade, thanks to the discovery of pathogenic circulating autoantibodies against phospholipase A
    MeSH term(s) Autoantibodies ; Glomerulonephritis, Membranous ; Humans ; Kidney/metabolism ; Kidney Glomerulus/pathology ; Receptors, Phospholipase A2/metabolism
    Chemical Substances Autoantibodies ; Receptors, Phospholipase A2
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00564-1
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  7. Article ; Online: False positivity for PLA

    Hoxha, Elion / Reinhard, Linda / Castedello, Thomas / Becker, Jan U

    Kidney international

    2022  Volume 103, Issue 2, Page(s) 411–415

    MeSH term(s) Humans ; Antibodies ; Autoantibodies ; Enzyme-Linked Immunosorbent Assay ; Glomerulonephritis, Membranous/diagnosis ; Polyesters ; Receptors, Phospholipase A2
    Chemical Substances Antibodies ; Autoantibodies ; Polyesters ; Receptors, Phospholipase A2
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.09.011
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  8. Article ; Online: Update membranöse Glomerulonephritis.

    Hoxha, Elion / Huber, Tobias B

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 20, Page(s) 1481–1485

    Abstract: Membranous nephropathy is an autoimmune disease caused in most cases by binding of circulating antibodies to antigens on podocytes. ... ...

    Title translation Update membranous nephropathy.
    Abstract Membranous nephropathy is an autoimmune disease caused in most cases by binding of circulating antibodies to antigens on podocytes. PLA
    MeSH term(s) Autoantibodies/blood ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/immunology ; Glomerulonephritis, Membranous/pathology ; Glomerulonephritis, Membranous/therapy ; Humans ; Immunologic Factors/therapeutic use ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Proteinuria ; Receptors, Phospholipase A2/immunology ; Rituximab/therapeutic use ; Thrombospondins/immunology
    Chemical Substances Autoantibodies ; Immunologic Factors ; PLA2R1 protein, human ; Receptors, Phospholipase A2 ; THSD7A protein, human ; Thrombospondins ; Rituximab (4F4X42SYQ6)
    Language German
    Publishing date 2020-10-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-0976-8893
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  9. Book ; Online ; Thesis: Retrospektive Auswertung der Behandlung der Minimal-Change-Glomerulonephritis und der fokalen segmentalen Glomerulosklerose mit niedrig dosiertem Cyclosporin A

    Möllmann, Ann-Kathrin [Verfasser] / Hoxha, Elion [Akademischer Betreuer]

    2022  

    Author's details Ann-Kathrin Möllmann ; Betreuer: Elion Hoxha
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
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  10. Book ; Online ; Thesis: Untersuchung der Wirksamkeit einer intravenösen Cyclophosphamid-Therapie verglichen mit der oralen Cyclophosphamid-Therapie bei Patienten mit membranöser Glomerulonephritis

    Gratzfeld, Lydia Verfasser] / [Hoxha, Elion [Akademischer Betreuer]

    2022  

    Author's details Lydia Gratzfeld ; Betreuer: Elion Hoxha
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
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