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Article ; Online: Development of chitosan biopolymer by chemically modified orange peel for safranin O dye removal: A sustainable adsorbent and adsorption modeling using RSM-BBD.

Khan, Mohammad K A / Abdulhameed, Ahmed Saud / Alshahrani, Hassan / Algburi, Sameer

International journal of biological macromolecules

2024 Volume 261, Issue Pt 2, Page(s) 129964

Abstract: This study aimed to develop a biocomposite (hereinafter, CHI/OP- ... ...

Abstract	This study aimed to develop a biocomposite (hereinafter, CHI/OP-H
MeSH term(s)	Coloring Agents ; Chitosan ; Adsorption ; Citrus sinensis ; Hydrogen-Ion Concentration ; Kinetics ; Water Pollutants, Chemical ; Phenazines
Chemical Substances	Coloring Agents ; Chitosan (9012-76-4) ; safranine T (XTX0YXU2HV) ; Water Pollutants, Chemical ; Phenazines
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129964
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Article ; Online: Chitosan/functionalized fruit stones as a highly efficient adsorbent biomaterial for adsorption of brilliant green dye: Comprehensive characterization and statistical optimization.

Khan, Mohammad K A / Abdulhameed, Ahmed Saud / Alshahrani, Hassan / Algburi, Sameer

International journal of biological macromolecules

2024 Volume 263, Issue Pt 2, Page(s) 130465

Abstract: In this research, a highly efficient adsorbent biomaterial (hereinafter, CTS/PPS-HS) of chitosan/functionalized fruit stones (peach and plum) with ... ...

Abstract	In this research, a highly efficient adsorbent biomaterial (hereinafter, CTS/PPS-HS) of chitosan/functionalized fruit stones (peach and plum) with H
MeSH term(s)	Coloring Agents/chemistry ; Adsorption ; Chitosan/chemistry ; Biocompatible Materials ; Fruit ; Water Pollutants, Chemical/chemistry ; Kinetics ; Hydrogen-Ion Concentration ; Quaternary Ammonium Compounds
Chemical Substances	Coloring Agents ; Chitosan (9012-76-4) ; Biocompatible Materials ; brilliant green (G0L543D370) ; Water Pollutants, Chemical ; Quaternary Ammonium Compounds
Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130465
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Article ; Online: Development of Clindamycin Loaded Oral Microsponges (Clindasponges) for Antimicrobial Enhancement: In Vitro Characterization and Simulated in Vivo Studies.

Sammour, Rana M F / Khan, Gazala / Sameer, Sandy / Khan, Shoomela / Zohair, Tuqa / Saraya, Sara / Abdul Rasool, Bazigha K

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 8, Page(s) 1088–1097

Abstract: Clindamycin phosphate (CLP) is a broad-spectrum antibiotic that is used widely for different types of infections. It has a short half-life and hence it should be taken every six hours to ensure adequate antibiotic blood concentration. On the other hand, ... ...

Abstract	Clindamycin phosphate (CLP) is a broad-spectrum antibiotic that is used widely for different types of infections. It has a short half-life and hence it should be taken every six hours to ensure adequate antibiotic blood concentration. On the other hand, microsponges are extremely porous polymeric microspheres, offering the prolonged controlled release of the drug. The present study aims to develop and evaluate innovative CLP-loaded microsponges (named Clindasponges) to prolong and control the drug release and enhance its antimicrobial activity, consequently improving patient compliance. The clindasponges were fabricated successfully by quasi-emulsion solvent diffusion technique using Eudragit S100 (ES100) and ethyl cellulose (EC) as carriers at various drug-polymer ratios. Several variables were optimized for the preparation technique including the type of solvent, stirring time, and stirring speed. The clindasponges were then characterized in terms of particle size, production yield, encapsulation efficiency, scanning electron microscopy, Fourier Transform Infrared Spectroscopy analysis, in vitro drug release with kinetic modeling, and antimicrobial activity study. Moreover, in vivo, pharmacokinetics parameters of CLP from the candidate formula were simulated based on the convolution method and in vitro-in vivo correlation (IVIVC-Level A) was built up successfully. Uniform spherical microsponges with 82.3 µm mean particle size with a porous spongy structure were evident. ES2 batch exhibited the highest production yield and encapsulation efficiency (53.75 and 74.57%, respectively) and it was able to exhaust 94% of the drug at the end of 8 h of the dissolution test. The release profile data of ES2 was best fitted to Hopfenberg kinetic model. ES2 was significantly (p < 0.05) effective against Staphylococcus aureus and Escherichia coli compared to the control. Also, ES2 displayed a twofold increase in the simulated area under the curve (AUC) compared to the reference marketed product.
MeSH term(s)	Humans ; Drug Delivery Systems/methods ; Clindamycin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Polymers ; Solvents ; Particle Size ; Microspheres
Chemical Substances	Clindamycin (3U02EL437C) ; Anti-Bacterial Agents ; Polymers ; Solvents
Language	English
Publishing date	2023-05-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b23-00099
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Article ; Online: Outcomes in elderly patients undergoing hepatic resection compared to liver transplant for hepatocellular carcinoma.

Khan, Sameer A / Ahmed, Fasih A / Hafeez, Muhammad S / Feng, Lawrence R / Seth, Abhinav / Kwon, Yong K / Aziz, Hassan

Journal of surgical oncology

2023 Volume 128, Issue 8, Page(s) 1320–1328

Abstract: Background: Hepatic resection (HR) is an excellent option for patients with hepatocellular carcinoma (HCC). For patients meeting the Milan criteria, a liver transplant (LT) is also a viable option for patients with HCC, especially those with end-stage ... ...

Abstract	Background: Hepatic resection (HR) is an excellent option for patients with hepatocellular carcinoma (HCC). For patients meeting the Milan criteria, a liver transplant (LT) is also a viable option for patients with HCC, especially those with end-stage liver disease. With increasing rates of LTs amongst the elderly, we sought to determine long-term outcomes in patients who underwent HR compared to LTs in this patient population. Methods: We queried the national cancer database for elderly patients (≥70 years) diagnosed with HCC between 2004 and 2020. The primary outcome was overall survival (OS) computed using the Kaplan-Meier method and Cox proportional hazard regression. One-to-one propensity score matching was conducted on the basis of clinicodemographic features to account for baseline differences between patients undergoing each procedure. Results: Of the 5090 patients included, 4674 (91.8%) and 416 (8.2%) patients underwent HR and LT, respectively. Compared with HR patients, patients receiving LT had better OS (p < 0.001) and greater median survival time (65.6 months HR vs. 97.9 months LT, p < 0.001). On multivariable analysis, a LT was independently associated with improved survival (adjusted hazard ratio: 0.61, 95% confidence interval: 0.50-0.76, p < 0.001). Conclusions: LT is associated with improved survival for well-selected elderly patients with HCC. Age alone should not be used as the sole parameter for the candidacy of LT in elderly patients.
MeSH term(s)	Humans ; Aged ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Liver Transplantation ; Retrospective Studies ; Proportional Hazards Models ; Hepatectomy ; Treatment Outcome
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27430
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Article ; Online: Investigating the characteristics of biomass wastes via particle feeder in downdraft gasifier.

Khan, Sameer / Adeyemi, Idowu / Moustakas, Konstantinos / Janajreh, Isam

Environmental research

2024 Volume 252, Issue Pt 2, Page(s) 118597

Abstract: Particle feeding plays a crucial role in the gasifier due to its effects on the efficiency and performance metrics of the thermochemical process. Investigating particle size distribution's impact on downdraft gasification reactor performance, this study ... ...

Abstract	Particle feeding plays a crucial role in the gasifier due to its effects on the efficiency and performance metrics of the thermochemical process. Investigating particle size distribution's impact on downdraft gasification reactor performance, this study delves into the significance of feedstock characteristics (moisture, volatile matter, fixed carbon, and ash contents) during the particle feeding stage. Various biomass wastes (date palm waste, olive pomace and sewage sludge) at diverse compositions and sizes are subjected to empirical determination of mass flow rates (MFR), power ratings, and storage times for each feedstock. The preheating process in the gasifier is considered, employing both an approximation and analytical solution. In addition, the influence of the equivalence ratio (ER) on the syngas yield is analyzed. The collected data reveals that for average particle size of 200 μm, the highest MFR (in g/min) are 0.518 ± 0.033, 7.691 ± 0.415, and 16.111 ± 1.050, for palm wood biomass, olive pomace and sewage sludge, respectively. Smaller particles (80 μm) led to extended storage times. Moreover, the lumped capacitance approximation method consistently underestimates preheating time, with a percentage error of 6.26%-17.08%. Response surface methodology (RSM) optimization analysis provides optimal gasification conditions for palm wood biomass, olive pomace, and sewage sludge with maximum cold gas efficiencies (CGEs) of 58.01%, 63.29%, and 52.27%. The peak conversion was attained at gasification temperatures of 1089.83 °C, 1151.93 °C, and 1102.91 °C for palm wood biomass, olive pomace, and sewage sludge, respectively. In addition, gasification equilibrium model determined optimal gasification temperatures as 1150 °C for palm biomass, 1200 °C for olive pomace, and 1150 °C for sewage sludge with respective syngas efficiencies of 59.62%, 64.13%, and 53.66%. Consequently, the examination of the dosing procedure, preheating dynamics, particle dimensions, ER, storage time, and their combined impacts offer practical insights to effectively control downdraft gasifiers in handling a variety of feedstocks.
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118597
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Article ; Online: Regeneration status and soil site characteristics of Spruce (Picea smithiana Wall. Boiss) dominated forest along altitudinal gradient in North Indian Himalaya

Wani, Sameer A. / Mugloo, J.A. / Pala, Nazir A. / Malik, Zubair A. / Khan, P.A. / Masoodi, T.H. / Qaisar, K.N. / Khan, Imran / Malik, A.R.

Ecological Society of China Acta Ecologica Sinica. 2023 June, v. 43, no. 3 p.487-497

2023

Abstract: ... was a decrease in availability of OC, N, P, K, Fe and Zn with increase in soil depth at all the three ... altitudes. However, soil pH showed the reverse trend. There was an increase in availability of OC, N, P, K ...

Abstract	The present study carried out at three altitudes in Daksum range of Anantnag Forest division aimed to study the variation in floristic composition, community structure, regeneration status, soil characteristics and soil seed bank of Spruce dominated forests. A total of 47 plant species belonging to 41 genera and 29 families were reported. The number of species decreased with increasing altitude. Abies pindrow, Acer caesium and Pinus wallichiana were main tree associates of Picea smithiana. The regeneration of Spruce at all the sites was low and did not show any definite trend along the altitudinal gradient. There was a decrease in availability of OC, N, P, K, Fe and Zn with increase in soil depth at all the three altitudes. However, soil pH showed the reverse trend. There was an increase in availability of OC, N, P, K and Zn while decrease in pH and available Fe in soil with the increase in altitude. The viability of soil seed bank of spruce was found to be very low (15.36 to 18.18%). The study is a pioneer in this region in many aspects and hence shall be a benchmark for further management and conservation of this important species.
Keywords	Abies pindrow ; Acer caesium ; Picea smithiana ; Pinus wallichiana ; altitude ; botanical composition ; buried seeds ; community structure ; forests ; soil depth ; soil pH ; trees ; viability ; Himalayan region ; Himalaya ; Regeneration ; Spruce ; Soil seed bank
Language	English
Dates of publication	2023-06
Size	p. 487-497.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2233694-1
ISSN	1872-2032 ; 1000-0933
ISSN (online)	1872-2032
ISSN	1000-0933
DOI	10.1016/j.chnaes.2022.03.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunophenotypic characterization of leukemic stem cells in acute myeloid leukemia using single tube 10-colour panel by multiparametric flow cytometry: Deciphering the spectrum, complexity and immunophenotypic heterogeneity.

Das, Nupur / Panda, Devasis / Gajendra, Smeeta / Gupta, Ritu / Thakral, Deepshi / Kaur, Gurvinder / Khan, Aafreen / Singh, Vivek Kumar / Vemprala, Arushi / Bakhshi, Sameer / Seth, Rachna / Sahoo, Ranjit Kumar / Sharma, Atul / Rai, Sandeep / Prajapati, Vijay K / Singh, Saroj

International journal of laboratory hematology

2024

Abstract: Introduction: Despite extensive research, comprehensive characterization of leukaemic stem cells (LSC) and information on their immunophenotypic differences from normal haematopoietic stem cells (HSC) is lacking. Herein, we attempted to unravel the ... ...

Abstract	Introduction: Despite extensive research, comprehensive characterization of leukaemic stem cells (LSC) and information on their immunophenotypic differences from normal haematopoietic stem cells (HSC) is lacking. Herein, we attempted to unravel the immunophenotypic (IPT) characteristics and heterogeneity of LSC using multiparametric flow cytometry (MFC) and single-cell sequencing. Materials and methods: Bone marrow aspirate samples from patients with acute myeloid leukaemia (AML) were evaluated using MFC at diagnostic and post induction time points using a single tube-10-colour-panel containing LSC-associated antibodies CD123, CD45RA, CD44, CD33 and COMPOSITE (CLL-1, TIM-3, CD25, CD11b, CD22, CD7, CD56) with backbone markers that is, CD45, CD34, CD38, CD117, sCD3. Single-cell sequencing of the whole transcriptome was also done in a bone marrow sample. Results: LSCs and HSCs were identified in 225/255 (88.2%) and 183/255 (71.6%) samples, respectively. Significantly higher expression was noted for COMPOSITE, CD45RA, CD123, CD33, and CD44 in LSCs than HSCs (p < 0.0001). On comparing the LSC specific antigen expressions between CD34+ (n = 184) and CD34- LSCs (n = 41), no difference was observed between the groups. More than one sub-population of LSC was demonstrated in 4.4% of cases, which further revealed high concordance between MFC and single cell transcriptomic analysis in one of the cases displaying three LSC subpopulations by both methods. Conclusion: A single tube-10-colour MFC panel is proposed as an easy and reproducible tool to identify and discriminate LSCs from HSCs. LSCs display both inter- and intra-sample heterogeneity in terms of antigen expressions, which opens the facets for single cell molecular analysis to elucidate the role of subpopulations of LSCs in AML progression.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14250
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Article ; Online: VE1 immunohistochemistry is an adjunct tool for detection of BRAF

Rashid, Faiza A / Tabassum, Sobia / Khan, Mosin S / Ansari, Hifzur R / Asif, Muhammad / Sheikh, Ahmareen K / Sameer Aga, Syed

Journal of clinical laboratory analysis

2020 Volume 35, Issue 2, Page(s) e23628

Abstract: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy among other endocrine tumors, and ... ...

Abstract	Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy among other endocrine tumors, and BRAF
MeSH term(s)	Adult ; Antibodies ; DNA Mutational Analysis/methods ; Female ; Humans ; Immunohistochemistry/methods ; Male ; Middle Aged ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/immunology ; Retrospective Studies ; Thyroid Cancer, Papillary/genetics ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology
Chemical Substances	Antibodies ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2020-12-10
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.23628
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Article: Proteo-Molecular Investigation of Cultivated Rice, Wild Rice, and Barley Provides Clues of Defense Responses against

Shamim, Md / Sharma, Divakar / Bisht, Deepa / Maurya, Rashmi / Kaashyap, Mayank / Srivastava, Deepti / Mishra, Anurag / Kumar, Deepak / Kumar, Mahesh / Juturu, Vijaya Naresh / Khan, N A / Chaudhary, Sameer / Hussain, Raja / Singh, K N

Bioengineering (Basel, Switzerland)

2022 Volume 9, Issue 10

Abstract: Rhizoctonia ... ...

Abstract	Rhizoctonia solani
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering9100589
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Article ; Online: Unveiling the mechanisms and challenges of cancer drug resistance.

Khan, Sameer Ullah / Fatima, Kaneez / Aisha, Shariqa / Malik, Fayaz

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 109

Abstract: Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ... ...

Abstract	Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells to survive and progress under unfavorable conditions. Although the mechanism of drug resistance is being widely studied to generate new target-based drugs with better potency than existing ones. However, due to the broader flexibility in acquired drug resistance, advanced therapeutic options with better efficacy need to be explored. Combination therapy is an alternative with a better success rate though the risk of amplified side effects is commonplace. Moreover, recent groundbreaking precision immune therapy is one of the ways to overcome drug resistance and has revolutionized anticancer therapy to a greater extent with the only limitation of being individual-specific and needs further attention. This review will focus on the challenges and strategies opted by cancer cells to withstand the current therapies at the molecular level and also highlights the emerging therapeutic options -like immunological, and stem cell-based options that may prove to have better potential to challenge the existing problem of therapy resistance. Video Abstract.
MeSH term(s)	Humans ; Proteomics ; Drug Resistance, Neoplasm/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Review
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01302-1
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