Article ; Online: Single high-energy arc proton therapy with Bragg peak boost (SHARP).
Journal of medical radiation sciences
2024 Volume 71 Suppl 2, Page(s) 27–36
Abstract: Introduction: Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for ...
| Abstract | Introduction: Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for these cases, but in many instances, compromises in target coverage are still required to achieve critical organ at risk (OAR) tolerance doses. A number of techniques have been proposed to further improve the penumbra of PBT. In the current study, we propose a novel, collimator-free treatment planning technique that combines high-energy shoot-through proton beams with conventional Bragg peak spot placement. The small spot size of the high-energy pencil beams provides a sharp penumbra at the target boundary, and the Bragg peak spots provide a higher linear energy transfer (LET) boost to the target centre. Methods: Three base of skull chordoma patients were retrospectively planned with three different PBT treatment planning techniques: (1) conventional intensity-modulated proton therapy (IMPT); (2) high-energy proton arc therapy (HE-PAT); and (3) the novel technique combining HE-PAT and IMPT, referred to as single high-energy arc with Bragg peak boost (SHARP). The Monaco 6 treatment planning system was used. Results: SHARP was found to improve the PBT penumbra in the plane perpendicular to the HE-PAT beams. Minimal penumbra differences were observed in the plane of the HE-PAT beams. SHARP reduced dose-averaged LET to surrounding organs at risk. Conclusion: A novel PBT treatment planning technique was successfully implemented. Initial results indicate the potential for SHARP to improve the penumbra of PBT treatments for base of skull tumours. |
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| MeSH term(s) | Humans ; Proton Therapy ; Protons ; Radiotherapy Dosage ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Neoplasms |
| Chemical Substances | Protons |
| Language | English |
| Publishing date | 2024-02-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2734841-6 |
| ISSN | 2051-3909 ; 2051-3909 |
| ISSN (online) | 2051-3909 |
| ISSN | 2051-3909 |
| DOI | 10.1002/jmrs.769 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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