LIVIVO - Search results -

Search results

Result 1 - 10 of total 33

Search options

Article ; Online: Spotlight on COVID-19 rapid guidance: NICE's experience of producing rapid guidelines during the pandemic.

Southall, Sara / Taske, Nichole / Power, Eric / Desai, Monica / Baillie, Nick

Journal of public health (Oxford, England)

2020 Volume 43, Issue 1, Page(s) e103–e106

Abstract: This article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It provides an overview of the COVID-19 rapid guidance produced since March 2020, along with an account of how the organization adapted during the ... ...

Abstract	This article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It provides an overview of the COVID-19 rapid guidance produced since March 2020, along with an account of how the organization adapted during the pandemic, developing resources to guide practice with the limited time and evidence available. The growing COVID-19 evidence base is also considered, with reference to international initiatives supporting production of the best possible information to guide the global pandemic response. What’s new?: Since March 2020, the NICE has developed 21 rapid guidelines with NHS England and NHS Improvement (NHSE&I) and a cross-speciality clinical group, supported by specialist societies and royal colleges. The 21 guidelines can be summarized into three groups-managing symptoms and complications, managing conditions that increase risk, and providing services during the pandemic. The rapid guidelines are part of a suite of rapid resources, including innovative technology briefings, shared learning examples and rapid evidence summaries, such as that for Vitamin D in COVID-19 (ES28).
MeSH term(s)	COVID-19 ; Humans ; Practice Guidelines as Topic ; State Medicine ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdaa184
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2186: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants.

Thompson, Robin N / Southall, Emma / Daon, Yair / Lovell-Read, Francesca A / Iwami, Shingo / Thompson, Craig P / Obolski, Uri

Frontiers in immunology

2023 Volume 13, Page(s) 1049458

Abstract: Introduction: A key feature of the COVID-19 pandemic has been the emergence of SARS-CoV-2 variants ... of immunity in the population. Immunity against novel SARS-CoV-2 variants may be influenced by prior exposures ... to related viruses, such as other SARS-CoV-2 variants and seasonal coronaviruses, and the level ...

Abstract	Introduction: A key feature of the COVID-19 pandemic has been the emergence of SARS-CoV-2 variants with different transmission characteristics. However, when a novel variant arrives in a host population, it will not necessarily lead to many cases. Instead, it may fade out, due to stochastic effects and the level of immunity in the population. Immunity against novel SARS-CoV-2 variants may be influenced by prior exposures to related viruses, such as other SARS-CoV-2 variants and seasonal coronaviruses, and the level of cross-reactive immunity conferred by those exposures. Methods: Here, we investigate the impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants in a simplified scenario in which a novel SARS-CoV-2 variant is introduced after an antigenically related virus has spread in the population. We use mathematical modelling to explore the risk that the novel variant invades the population and causes a large number of cases, as opposed to fading out with few cases. Results: We find that, if cross-reactive immunity is complete (i.e. someone infected by the previously circulating virus is not susceptible to the novel variant), the novel variant must be more transmissible than the previous virus to invade the population. However, in a more realistic scenario in which cross-reactive immunity is partial, we show that it is possible for novel variants to invade, even if they are less transmissible than previously circulating viruses. This is because partial cross-reactive immunity effectively increases the pool of susceptible hosts that are available to the novel variant compared to complete cross-reactive immunity. Furthermore, if previous infection with the antigenically related virus assists the establishment of infection with the novel variant, as has been proposed following some experimental studies, then even variants with very limited transmissibility are able to invade the host population. Discussion: Our results highlight that fast assessment of the level of cross-reactive immunity conferred by related viruses against novel SARS-CoV-2 variants is an essential component of novel variant risk assessments.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19 ; Pandemics ; Cross Reactions
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1049458
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Spotlight on COVID-19 rapid guidance: NICE's experience of producing rapid guidelines during the pandemic

Southall, Sara / Taske, Nichole / Power, Eric / Desai, Monica / Baillie, Nick

J. public health (Oxf)

Abstract	: This article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It provides an overview of the COVID-19 rapid guidance produced since March 2020, along with an account of how the organization adapted during the pandemic, developing resources to guide practice with the limited time and evidence available. The growing COVID-19 evidence base is also considered, with reference to international initiatives supporting production of the best possible information to guide the global pandemic response. WHAT'S NEW?: Since March 2020, the NICE has developed 21 rapid guidelines with NHS England and NHS Improvement (NHSE&I) and a cross-speciality clinical group, supported by specialist societies and royal colleges. The 21 guidelines can be summarized into three groups-managing symptoms and complications, managing conditions that increase risk, and providing services during the pandemic. The rapid guidelines are part of a suite of rapid resources, including innovative technology briefings, shared learning examples and rapid evidence summaries, such as that for Vitamin D in COVID-19 (ES28).
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #930056
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Spotlight on COVID-19 rapid guidance

Southall, Sara / Taske, Nichole / Power, Eric / Desai, Monica / Baillie, Nick

Journal of Public Health ; ISSN 1741-3842 1741-3850

NICE’s experience of producing rapid guidelines during the pandemic

2020

Abstract: Abstract This article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It provides an overview of the COVID-19 rapid guidance produced since March 2020, along with an account of how the organization adapted ... ...

Abstract	Abstract This article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It provides an overview of the COVID-19 rapid guidance produced since March 2020, along with an account of how the organization adapted during the pandemic, developing resources to guide practice with the limited time and evidence available. The growing COVID-19 evidence base is also considered, with reference to international initiatives supporting production of the best possible information to guide the global pandemic response. What’s new? Since March 2020, the NICE has developed 21 rapid guidelines with NHS England and NHS Improvement (NHSE&I) and a cross-speciality clinical group, supported by specialist societies and royal colleges. The 21 guidelines can be summarized into three groups—managing symptoms and complications, managing conditions that increase risk, and providing services during the pandemic. The rapid guidelines are part of a suite of rapid resources, including innovative technology briefings, shared learning examples and rapid evidence summaries, such as that for Vitamin D in COVID-19 (ES28).
Keywords	Public Health, Environmental and Occupational Health ; General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/pubmed/fdaa184
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Does informal online media provide supportive or unreliable information about pregnancy and birth during the COVID-19 pandemic?

Pinto, Alexandra Cardoso / Southall, Emily / Gromala, Justyna / Graf, Vivian

Clinical medicine (London, England)

2021 Volume 21, Issue Suppl 2, Page(s) 32–33

MeSH term(s)	COVID-19 ; Female ; Humans ; Pandemics/prevention & control ; Pregnancy ; SARS-CoV-2 ; Social Media
Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.21-2-s32
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5439: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Quantifying pupil-to-pupil SARS-CoV-2 transmission and the impact of lateral flow testing in English secondary schools.

Leng, Trystan / Hill, Edward M / Holmes, Alex / Southall, Emma / Thompson, Robin N / Tildesley, Michael J / Keeling, Matt J / Dyson, Louise

Nature communications

2022 Volume 13, Issue 1, Page(s) 1106

Abstract: A range of measures have been implemented to control within-school SARS-CoV-2 transmission ... can lead to high levels of absences, negatively impacting pupils. To quantify pupil-to-pupil SARS-CoV-2 ...

Abstract	A range of measures have been implemented to control within-school SARS-CoV-2 transmission in England, including the self-isolation of close contacts and twice weekly mass testing of secondary school pupils using lateral flow device tests (LFTs). Despite reducing transmission, isolating close contacts can lead to high levels of absences, negatively impacting pupils. To quantify pupil-to-pupil SARS-CoV-2 transmission and the impact of implemented control measures, we fit a stochastic individual-based model of secondary school infection to both swab testing data and secondary school absences data from England, and then simulate outbreaks from 31st August 2020 until 23rd May 2021. We find that the pupil-to-pupil reproduction number, R
MeSH term(s)	Adolescent ; COVID-19/transmission ; COVID-19 Testing ; Child ; Contact Tracing ; Disease Outbreaks ; England ; Epidemiological Models ; Humans ; SARS-CoV-2 ; Schools
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28731-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The crystal structure of mycobacterial epoxide hydrolase A.

Schulz, Eike C / Henderson, Sara R / Illarionov, Boris / Crosskey, Thomas / Southall, Stacey M / Krichel, Boris / Uetrecht, Charlotte / Fischer, Markus / Wilmanns, Matthias

Scientific reports

2020 Volume 10, Issue 1, Page(s) 16539

Abstract: The human pathogen Mycobacterium tuberculosis is the causative agent of tuberculosis resulting in over 1 million fatalities every year, despite decades of research into the development of new anti-TB compounds. Unlike most other organisms M. tuberculosis ...

Abstract	The human pathogen Mycobacterium tuberculosis is the causative agent of tuberculosis resulting in over 1 million fatalities every year, despite decades of research into the development of new anti-TB compounds. Unlike most other organisms M. tuberculosis has six putative genes for epoxide hydrolases (EH) of the α/β-hydrolase family with little known about their individual substrates, suggesting functional significance for these genes to the organism. Due to their role in detoxification, M. tuberculosis EH's have been identified as potential drug targets. Here, we demonstrate epoxide hydrolase activity of M. thermoresistibile epoxide hydrolase A (Mth-EphA) and report its crystal structure in complex with the inhibitor 1,3-diphenylurea at 2.0 Å resolution. Mth-EphA displays high sequence similarity to its orthologue from M. tuberculosis and generally high structural similarity to α/β-hydrolase EHs. The structure of the inhibitor bound complex reveals the geometry of the catalytic residues and the conformation of the inhibitor. Comparison to other EHs from mycobacteria allows insight into the active site plasticity with respect to substrate specificity. We speculate that mycobacterial EHs may have a narrow substrate specificity providing a potential explanation for the genetic repertoire of epoxide hydrolase genes in M. tuberculosis.
MeSH term(s)	Carbanilides ; Crystallization ; Epoxide Hydrolases/chemistry ; Epoxide Hydrolases/genetics ; Epoxide Hydrolases/physiology ; Genes, Bacterial/genetics ; Inactivation, Metabolic/genetics ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/genetics ; Substrate Specificity
Chemical Substances	Carbanilides ; Epoxide Hydrolases (EC 3.3.2.-)
Language	English
Publishing date	2020-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-73452-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Response to chicco et al. communication entitled 'Management and outcomes of mammalian bite injuries during COVID-19 and implications for future practice' Published: November 07, 2020DOI:https://doi.org/10.1016/j.bjps.2020.10.090.

Friebel, T R / Gardiner, S / Southall, C / Akhavani, M

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2020 Volume 74, Issue 5, Page(s) 1101–1160

Abstract: The Covid-19 pandemic has forced us to treat mammalian bite injuries more conservatively as resources were redirected to the Covid effort resulting in limited availability of hospital beds and theatre space. When comparing our outcomes before and during ... ...

Abstract	The Covid-19 pandemic has forced us to treat mammalian bite injuries more conservatively as resources were redirected to the Covid effort resulting in limited availability of hospital beds and theatre space. When comparing our outcomes before and during the first Covid-19 lockdown, this more conservative approach, which resulted in 24% less admissions and 19% less washouts in theatre, did not result in an increased infection rate. An increased rate of bite injuries during the national lockdown period was also noted. We support the conclusion by Chicco et al. that the majority of patients with bite injuries can 'safely be managed with washout under local anaesthesia, oral antibiotics and discharge on the same day with safety net advice'. It is interesting that in some aspects of our care we may find Covid-19 has been beneficial in de-medicalising management of certain injuries and conditions.
MeSH term(s)	Animals ; COVID-19 ; Communicable Disease Control ; Communication ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2020-12-30
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2020.12.053
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.157: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Decoding gene regulation in the fly brain.

Janssens, Jasper / Aibar, Sara / Taskiran, Ibrahim Ihsan / Ismail, Joy N / Gomez, Alicia Estacio / Aughey, Gabriel / Spanier, Katina I / De Rop, Florian V / González-Blas, Carmen Bravo / Dionne, Marc / Grimes, Krista / Quan, Xiao Jiang / Papasokrati, Dafni / Hulselmans, Gert / Makhzami, Samira / De Waegeneer, Maxime / Christiaens, Valerie / Southall, Tony / Aerts, Stein

Nature

2022 Volume 601, Issue 7894, Page(s) 630–636

Abstract: The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome ... ...

Abstract	The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome analysis
MeSH term(s)	Animals ; Brain/metabolism ; Drosophila/genetics ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks/genetics ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-04262-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants

Thompson, Robin N / Southall, Emma / Daon, Yair / Lovell-Read, Francesca A / Iwami, Shingo / Thompson, Craig P / Obolski, Uri

medRxiv

Abstract: A key feature of the COVID-19 pandemic has been the emergence of SARS-CoV-2 variants with different ... in the population. Immunity against novel SARS-CoV-2 variants may be influenced by prior exposures to related ... viruses, such as other SARS-CoV-2 variants and seasonal coronaviruses, and the level of cross-reactive ...

Abstract	A key feature of the COVID-19 pandemic has been the emergence of SARS-CoV-2 variants with different transmission characteristics. However, when a novel variant arrives in a host population, it will not necessarily lead to many cases. Instead, it may fade out, due to stochastic effects and the level of immunity in the population. Immunity against novel SARS-CoV-2 variants may be influenced by prior exposures to related viruses, such as other SARS-CoV-2 variants and seasonal coronaviruses, and the level of cross-reactive immunity conferred by those exposures. Here, we investigate the impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants in a simplified scenario in which a novel SARS-CoV-2 variant is introduced after an antigenically related virus has spread in the population. We use mathematical modelling to explore the risk that the novel variant invades the population and causes a large number of cases, as opposed to fading out. If cross-reactive immunity is complete (i.e. someone infected by the previously circulating virus is no longer susceptible to the novel variant), the novel variant must be more transmissible than the previous virus to invade the population. However, in a more realistic scenario in which cross-reactive immunity is partial, we show that it is possible for novel variants to invade, even if they are less transmissible than previously circulating viruses. This is because partial cross-reactive immunity effectively increases the pool of susceptible hosts that are available to the novel variant compared to complete cross-reactive immunity. Furthermore, if previous infection with the antigenically related virus assists the establishment of infection with the novel variant, as has been proposed following some experimental studies, then even variants with very limited transmissibility are able to invade the host population. Our results highlight that fast assessment of the level of cross-reactive immunity conferred by related viruses on novel SARS-CoV-2 variants is an essential component of novel variant risk assessments.
Keywords	covid19
Language	English
Publishing date	2022-09-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.09.20.22280161
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED