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  1. Article: Repurposing Approved Drugs for Sarcopenia Based on Transcriptomics Data in Humans.

    Liang, Shuang / Liu, Danyang / Xiao, Zhengwu / Greenbaum, Jonathan / Shen, Hui / Xiao, Hongmei / Deng, Hongwen

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 4

    Abstract: Sarcopenia, characterized by age-related loss of muscle mass, strength, and decreased physical performance, is a growing public health challenge amid the rapidly ageing population. As there are no approved drugs that target sarcopenia, it has become ... ...

    Abstract Sarcopenia, characterized by age-related loss of muscle mass, strength, and decreased physical performance, is a growing public health challenge amid the rapidly ageing population. As there are no approved drugs that target sarcopenia, it has become increasingly urgent to identify promising pharmacological interventions. In this study, we conducted an integrative drug repurposing analysis utilizing three distinct approaches. Firstly, we analyzed skeletal muscle transcriptomic sequencing data in humans and mice using gene differential expression analysis, weighted gene co-expression analysis, and gene set enrichment analysis. Subsequently, we employed gene expression profile similarity assessment, hub gene expression reversal, and disease-related pathway enrichment to identify and repurpose candidate drugs, followed by the integration of findings with rank aggregation algorithms. Vorinostat, the top-ranking drug, was also validated in an in vitro study, which demonstrated its efficacy in promoting muscle fiber formation. Although still requiring further validation in animal models and human clinical trials, these results suggest a promising drug repurposing prospect in the treatment and prevention of sarcopenia.
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16040607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion.

    Jia, Shilin / Mai, Lijia / Yang, Hui / Huang, Fang / He, Hongwen / Fan, Wenguo

    Life sciences

    2023  Volume 332, Page(s) 122130

    Abstract: Purinergic signaling system plays a pivotal role in the trigeminal ganglion (TG) which is a primary sensory tissue in vertebrate nervous systems involving orofacial nociception and peripheral sensitization. Despite previous efforts to reveal the ... ...

    Abstract Purinergic signaling system plays a pivotal role in the trigeminal ganglion (TG) which is a primary sensory tissue in vertebrate nervous systems involving orofacial nociception and peripheral sensitization. Despite previous efforts to reveal the expression patterns of purinergic components in the mouse TG, it is still unknown the interspecies differences between human and mouse. In this study, we provide a comprehensive transcriptome profile of the purinergic signaling system across diverse cell types and neuronal subpopulations within the human TG, systematically comparing it with mouse TG. In addition, the evolutionary conservation and species-specific expression patterns of the purinergic components are also discussed. We propose that the data can improve our understanding of purinergic signaling in the peripheral nervous system and facilitate the identification of novel therapeutic targets.
    Language English
    Publishing date 2023-09-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122130
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  3. Article: Effect and Mechanism of Solidified Microstructure on Deformation Behavior, Mechanical Properties, and Residual Stress of Cu-Ni-Si Alloy.

    Liao, Wanneng / Zhang, Chenxing / Qiang, Hui / Song, Weifei / Ren, Hongwen

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 24

    Abstract: Cu-Ni-Si alloy is the key raw material for the lead frame of large integrated circuits. The disordered grain orientation of alloy billet, high hardening rate, residual stress, and poor surface quality of cold working strips seriously affect its ... ...

    Abstract Cu-Ni-Si alloy is the key raw material for the lead frame of large integrated circuits. The disordered grain orientation of alloy billet, high hardening rate, residual stress, and poor surface quality of cold working strips seriously affect its processability. In order to improve the cold-working properties of Cu-Ni-Si alloy, two kinds of C70250 copper alloy strips were produced through hot mold continuous casting (HMCC) and cold mold continuous casting (CMCC) technology. The effects of solidified microstructure on the cold-working deformation behavior, mechanical properties, and residual stress of the alloy were studied. The results show that C70250 copper alloys with columnar grain and equiaxed grain were prepared through HMCC and CMCC. After a 98% reduction in cold rolling, columnar grain strip surface quality was very good, and the elongation was still as high as 3.2%, which is 2.9 times that of equiaxed grain alloy. The residual stress of equiaxed grain strips reached 363 MPa, which is 2.7 times that of columnar grain strips. During the cold rolling process, equiaxed grain strips are prone to cause intersecting plane dislocations, stacking faults, shear bands, and grain breakage during large deformation cold rolling. The columnar grain strip causes parallel plane dislocations, stacking faults, and shearbands. Furthermore, the deformation structure was found to be uniform, and, ultimately, the alloy formed a fibrous structure. Therefore, the elongation and latter distortion of columnar grain strips improved after being put through large deformation cold rolling, which greatly reduced residual stress.
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15248724
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  4. Article: Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.

    Meng, Qian / Zhu, Hongwen / Li, Yuanyuan / Peng, Xiaotian / Wang, Tianming / Huang, Hui / Zhou, Hu / Liu, Yuejia / Ru, Sujie / Wu, Jiasheng / Ma, Yueming

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1341020

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1341020
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  5. Article ; Online: Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq.

    Li, Hui / Liu, Hongyi / Liu, Yifei / Wang, Xuefei / Yu, Shiya / Huang, Hongwen / Shen, Xiangru / Zhang, Qi / Hong, Ni / Jin, Wenfei

    iScience

    2023  Volume 26, Issue 9, Page(s) 107588

    Abstract: T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the ... ...

    Abstract T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the factors affecting T cell activation. We found a stimulated T subset (HSP
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107588
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  6. Article: Spread mechanism and control strategy of social network rumors under the influence of COVID-19.

    Hui, Hongwen / Zhou, Chengcheng / Lü, Xing / Li, Jiarong

    Nonlinear dynamics

    2020  Volume 101, Issue 3, Page(s) 1933–1949

    Abstract: Since the outbreak of coronavirus disease in 2019 (COVID-19), the disease has rapidly spread to the world, and the cumulative number of cases is now more than 2.3 million. We aim to study the spread mechanism of rumors on social network platform during ... ...

    Abstract Since the outbreak of coronavirus disease in 2019 (COVID-19), the disease has rapidly spread to the world, and the cumulative number of cases is now more than 2.3 million. We aim to study the spread mechanism of rumors on social network platform during the spread of COVID-19 and consider education as a control measure of the spread of rumors. Firstly, a novel epidemic-like model is established to characterize the spread of rumor, which depends on the nonautonomous partial differential equation. Furthermore, the registration time of network users is abstracted as 'age,' and the spreading principle of rumors is described from two dimensions of age and time. Specifically, the susceptible users are divided into higher-educators class and lower-educators class, in which the higher-educators class will be immune to rumors with a higher probability and the lower-educators class is more likely to accept and spread the rumors. Secondly, the existence and uniqueness of the solution is discussed and the stability of steady-state solution of the model is obtained. Additionally, an interesting conclusion is that the education level of the crowd is an essential factor affecting the final scale of the spread of rumors. Finally, some control strategies are presented to effectively restrain the rumor propagation, and numerical simulations are carried out to verify the main theoretical results.
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012600-1
    ISSN 1573-269X ; 0924-090X
    ISSN (online) 1573-269X
    ISSN 0924-090X
    DOI 10.1007/s11071-020-05842-w
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  7. Article ; Online: Cu

    Liu, Xianhu / Shen, Hui / Gao, Yang / Deng, Guocheng / Deng, Hongwen / Han, Ying-Zi / Teo, Boon K / Zheng, Nanfeng

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 55, Page(s) 7670–7673

    Abstract: Reported herein is a racemate of a chiral nanocluster [ ... ...

    Abstract Reported herein is a racemate of a chiral nanocluster [Cu
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06415k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq

    Hui Li / Hongyi Liu / Yifei Liu / Xuefei Wang / Shiya Yu / Hongwen Huang / Xiangru Shen / Qi Zhang / Ni Hong / Wenfei Jin

    iScience, Vol 26, Iss 9, Pp 107588- (2023)

    2023  

    Abstract: Summary: T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore ... ...

    Abstract Summary: T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the factors affecting T cell activation. We found a stimulated T subset (HSPhi T) highly expressing heat shock proteins, which was derived from stimulated naive T. We identified and characterized inert T, a stimulated T cell subset in transitional state from resting T to activated T. Interestingly, resting CXCR4low T responded to stimulation more efficiently than resting CXCR4hi T. Furthermore, stimulation of CD4 T in the presence of CD8 T resulted in more effector T and more homogeneous expressions of CD25, supporting that presence of CD8 T reduces the extreme response of T cells, which can be explained by regulation of CD4 T activation through CD8 T-initiated cytokine signaling and FAS/FASLG signaling.
    Keywords Immune response ; Components of the immune system ; Specialized functions of cells ; Transcriptomics ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Spread mechanism and control strategy of social network rumors under the influence of COVID-19

    Hui, Hongwen / Zhou, Chengcheng / Lü, Xing / Li, Jiarong

    Nonlinear Dynamics ; ISSN 0924-090X 1573-269X

    2020  

    Keywords Control and Systems Engineering ; Mechanical Engineering ; Electrical and Electronic Engineering ; Applied Mathematics ; Ocean Engineering ; Aerospace Engineering ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s11071-020-05842-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Five-Year Physical and Psychosocial Outcomes in Obese Adolescents With and Without Metabolic Bariatric Surgery.

    Guan, Wei / Lin, Shibo / Fu, Zhenzhen / Yang, Ningli / Shen, Jiajia / Liu, Ruiping / Li, Cong / Zhou, Hongwen / Liang, Hui

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2023  Volume 73, Issue 4, Page(s) 784–789

    Abstract: Purpose: Metabolic bariatric surgery (MBS) is increasingly accepted as a treatment for severely obese adolescents. However, its long-term efficacy and safety are not well characterized, particularly in the Eastern Asian population. We aimed to explore ... ...

    Abstract Purpose: Metabolic bariatric surgery (MBS) is increasingly accepted as a treatment for severely obese adolescents. However, its long-term efficacy and safety are not well characterized, particularly in the Eastern Asian population. We aimed to explore the long-term effects of MBS on Chinese adolescents with severe obesity.
    Methods: A total of 44 obese adolescents (≤18 years old) underwent MBS at our institution from May 2011 to May 2017. A matched nonsurgical control group, including 43 patients, was recruited from lifestyle modification programs in the same period. All patients completed assessments at presurgery/baseline and five years after surgery. The data were collected and analyzed using the χ2 test and an independent sample t-test.
    Results: Comparing the surgical and control groups revealed that the surgical patients showed significant weight loss and improvement in comorbidities, while the nonsurgical patients showed a trend of weight gain and increased comorbidities (p < .05). Furthermore, the surgical patients had a higher composite physical quality of life (as determined by the Short Form-36 questionnaire). On the other hand, the patients who underwent MBS had a higher risk of malnutrition.
    Discussion: Compared with nonsurgical patients, severely obese adolescents who undergo MBS exhibit more effective long-term weight loss, remission of comorbidities, and improved quality of life. Furthermore, more attention should be paid to helping adolescents avoid malnutrition after they undergo MBS.
    MeSH term(s) Humans ; Adolescent ; Quality of Life/psychology ; Pediatric Obesity/surgery ; Pediatric Obesity/epidemiology ; Bariatric Surgery ; Malnutrition ; Weight Loss
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2023.05.034
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