LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 67

Search options

  1. Article ; Online: COVID-19 infection outcomes in patients receiving CD20 targeting T-cell engaging bispecific antibodies for B-cell non-Hodgkin lymphoma.

    Nachar, Victoria R / Perissinotti, Anthony J / Marini, Bernard L / Karimi, Yasmin H / Phillips, Tycel J

    Annals of hematology

    2023  Volume 102, Issue 9, Page(s) 2635–2637

    MeSH term(s) Humans ; Antibodies, Bispecific/therapeutic use ; Antigens, CD20 ; COVID-19/therapy ; Lymphoma, B-Cell/therapy ; T-Lymphocytes
    Chemical Substances Antibodies, Bispecific ; Antigens, CD20
    Language English
    Publishing date 2023-06-09
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05315-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: MUS81 cleaves TOP1-derived lesions and other DNA-protein cross-links.

    Marini, Victoria / Nikulenkov, Fedor / Samadder, Pounami / Juul, Sissel / Knudsen, Birgitta R / Krejci, Lumir

    BMC biology

    2023  Volume 21, Issue 1, Page(s) 110

    Abstract: Background: DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA metabolic processes such as ... ...

    Abstract Background: DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA metabolic processes such as replication and transcription, can be trapped and remain covalently bound to DNA in the presence of poisons or nearby DNA damage. Given the complexity of individual DPCs, numerous repair pathways have been described. The protein tyrosyl-DNA phosphodiesterase 1 (Tdp1) has been demonstrated to be responsible for removing topoisomerase 1 (Top1). Nevertheless, studies in budding yeast have indicated that alternative pathways involving Mus81, a structure-specific DNA endonuclease, could also remove Top1 and other DPCs.
    Results: This study shows that MUS81 can efficiently cleave various DNA substrates modified by fluorescein, streptavidin or proteolytically processed topoisomerase. Furthermore, the inability of MUS81 to cleave substrates bearing native TOP1 suggests that TOP1 must be either dislodged or partially degraded prior to MUS81 cleavage. We demonstrated that MUS81 could cleave a model DPC in nuclear extracts and that depletion of TDP1 in MUS81-KO cells induces sensitivity to the TOP1 poison camptothecin (CPT) and affects cell proliferation. This sensitivity is only partially suppressed by TOP1 depletion, indicating that other DPCs might require the MUS81 activity for cell proliferation.
    Conclusions: Our data indicate that MUS81 and TDP1 play independent roles in the repair of CPT-induced lesions, thus representing new therapeutic targets for cancer cell sensitisation in combination with TOP1 inhibitors.
    MeSH term(s) DNA Damage ; DNA Repair ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; DNA Topoisomerases, Type I/genetics ; DNA Topoisomerases, Type I/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endonucleases/genetics ; Endonucleases/metabolism
    Chemical Substances Phosphoric Diester Hydrolases (EC 3.1.4.-) ; MUS81 protein, S cerevisiae (EC 3.1.-) ; TOP1 protein, S cerevisiae (EC 5.99.1.1) ; Saccharomyces cerevisiae Proteins ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; Tdp1 protein, S cerevisiae (EC 3.1.4.-) ; DNA-Binding Proteins ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-023-01614-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Place attachment and perceptions of land-use change

    Theresa Selfa / Victoria Marini / Jesse B. Abrams

    Ecology and Society, Vol 26, Iss 4, p

    cultural ecosystem services impacts of eucalyptus plantation expansion in Ubajay, Entre Ríos, Argentina

    2021  Volume 44

    Abstract: In recent decades, the landscape in northeastern Entre Ríos Province, Argentina has undergone significant changes because of the expansion of eucalyptus plantations. These plantations have generated perceived socioeconomic and environmental impacts and ... ...

    Abstract In recent decades, the landscape in northeastern Entre Ríos Province, Argentina has undergone significant changes because of the expansion of eucalyptus plantations. These plantations have generated perceived socioeconomic and environmental impacts and changes in ecosystem services in this traditionally agricultural region of the Argentine pampas. This study draws on the concept of sense of place as a cultural ecosystem service to explore residents' perceptions of impacts from eucalyptus plantation expansion and to explain how place meanings can change in response to physical landscape change. Although scholars have posited an important link between sense of place and perceptions of land-use change impacts, there has been relatively little empirical work exploring these cultural, emotional, economic, and generational attachments to diverse landscapes, especially to working landscapes that are representative of broad land-use change occurring in many regions in the Global South. In-depth interviews and participatory mapping are used to document the range of place meanings and attachments for residents of the rural municipality of Ubajay, Entre Ríos, and to explore how residents have responded to land-use change. This research shows that sense of place may support community resilience, and thus, that place attachment may enhance adaptation to social-ecological change.
    Keywords argentina ; cultural ecosystem services ; eucalyptus plantations ; global south ; monoculture plantations ; participatory mapping ; sense of place ; Biology (General) ; QH301-705.5 ; Ecology ; QH540-549.5
    Subject code 710
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Resilience Alliance
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: PET-guided, BEACOPP

    Reid, Justin H / Marini, Bernard L / Nachar, Victoria R / Devata, Sumana / Perissinotti, Anthony J

    The Lancet. Oncology

    2019  Volume 20, Issue 4, Page(s) e188

    MeSH term(s) Cyclophosphamide ; Hodgkin Disease ; Humans ; Positron-Emission Tomography ; Procarbazine ; Vincristine
    Chemical Substances Procarbazine (35S93Y190K) ; Vincristine (5J49Q6B70F) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2019-04-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30081-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Late-onset complications with bendamustine versus CHOP or CVP based chemoimmunotherapy in indolent Non-Hodgkin's lymphoma.

    Baek, Grace T / Mathis, Noah J / Perissinotti, Anthony J / Marini, Bernard L / Brown, Anna / Phillips, Tycel J / Wilcox, Ryan A / Nachar, Victoria R

    Leukemia & lymphoma

    2021  Volume 62, Issue 13, Page(s) 3138–3146

    Abstract: Bendamustine is a preferred first-line chemoimmunotherapy regimen for indolent non-Hodgkin's lymphoma (iNHL). Emerging evidence suggests an increased incidence of late-onset complications with bendamustine-based regimens compared with CHOP/CVP; however, ... ...

    Abstract Bendamustine is a preferred first-line chemoimmunotherapy regimen for indolent non-Hodgkin's lymphoma (iNHL). Emerging evidence suggests an increased incidence of late-onset complications with bendamustine-based regimens compared with CHOP/CVP; however, this evidence is limited. We retrospectively compared late-onset complications from January 2005 to May 2020 in adults with previously untreated iNHL who received rituximab or obinutuzumab with CHOP, CVP, or bendamustine. Forty-six patients received CHOP/CVP; 119 received bendamustine. No difference in incidence of late-onset infections was observed. Bendamustine led to a higher rate of prolonged and unresolved lymphocytopenia and a greater incidence of late-onset neutropenia. Many patients receiving bendamustine did not have lymphocyte recovery even three years following administration. Ongoing infection prophylaxis with bendamustine-based regimens may offset translation of these laboratory findings to late-onset infectious risk.
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bendamustine Hydrochloride/adverse effects ; Cyclophosphamide/adverse effects ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Retrospective Studies ; Rituximab/adverse effects
    Chemical Substances Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Bendamustine Hydrochloride (981Y8SX18M)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1953014
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: The glass door remains closed

    Marini Davis, Laura / Geyfman, Victoria

    Journal of education for business Vol. 90, No. 2 , p. 81-88

    another look at gender inequality in undergraduate business schools

    2015  Volume 90, Issue 2, Page(s) 81–88

    Author's details Laura Marini Davis and Victoria Geyfman
    Keywords female enrollment ; gender gap in business programs ; women in business
    Language English
    Publisher Heldref
    Publishing place Washington,DC
    Document type Article
    ZDB-ID 633641-3 ; 2068714-X
    ISSN 1940-3356 ; 0883-2323
    ISSN (online) 1940-3356
    ISSN 0883-2323
    Database ECONomics Information System

    More links

    Kategorien

  7. Article ; Online: Dosing Vincristine in Dose-Adjusted EPOCH-R: To Cap or Not to Cap?

    Weis, Taylor M / Perissinotti, Anthony J / Nachar, Victoria R / Brown, Anna M / Phillips, Tycel J / Marini, Bernard L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 31, Page(s) 2952

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide ; Doxorubicin ; Etoposide ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Prednisone ; Vincristine
    Chemical Substances Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-09-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.01259
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Evaluating the Role of Novel Oncology Agents: Oncology Stewardship in Relapsed/Refractory Diffuse Large B-Cell Lymphoma.

    Bazzell, Brian G / Benitez, Lydia L / Marini, Bernard L / Perissinotti, Anthony J / Phillips, Tycel J / Nachar, Victoria R

    Clinical lymphoma, myeloma & leukemia

    2020  Volume 21, Issue 5, Page(s) 295–308

    Abstract: Novel treatment strategies have shifted the treatment landscape for patients with diffuse large B-cell lymphoma, particularly for those with relapsed/refractory disease. However, uncertainty remains regarding the therapeutic value of these novel agents ... ...

    Abstract Novel treatment strategies have shifted the treatment landscape for patients with diffuse large B-cell lymphoma, particularly for those with relapsed/refractory disease. However, uncertainty remains regarding the therapeutic value of these novel agents compared to existing salvage chemotherapy regimens. In addition, the high cost associated with these agents puts both patients and health systems at risk of financial toxicity, further complicating their use. The development of clinical pathways incorporating oncology stewardship principles are necessary in order to maximize value-based care. This comprehensive review assesses the efficacy and safety data available for novel treatment options in relapsed/refractory diffuse large B-cell lymphoma and applies stewardship principles to evaluate their optimal place in therapy, with the aim of optimizing safe, effective, and financially responsible patient care.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Middle Aged ; Young Adult
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2020.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Contemporary treatment options for a classical disease: Advanced Hodgkin lymphoma.

    Reid, Justin H / Marini, Bernard L / Nachar, Victoria R / Brown, Anna M / Devata, Sumana / Perissinotti, Anthony J

    Critical reviews in oncology/hematology

    2020  Volume 148, Page(s) 102897

    Abstract: Advanced classical Hodgkin lymphoma (cHL) is a rare lymphoid disease characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells. Each year, cHL accounts for 0.5% of all new cancer diagnoses and about 80% are diagnosed with advanced stage ... ...

    Abstract Advanced classical Hodgkin lymphoma (cHL) is a rare lymphoid disease characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells. Each year, cHL accounts for 0.5% of all new cancer diagnoses and about 80% are diagnosed with advanced stage disease. Given the significant improvement in cure rates, the focus of treatment has shifted towards minimization of acute and long-term toxicities. PET-adapted strategies have largely been adopted as standard of care in the United States in an attempt to balance toxicities with adequate lymphoma control. However, the appropriate upfront chemotherapy regimen (ABVD versus eBEACOPP) remains controversial.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Bleomycin/administration & dosage ; Cyclophosphamide/administration & dosage ; Dacarbazine/administration & dosage ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Humans ; Neoplasm Staging ; Positron-Emission Tomography ; Predictive Value of Tests ; Prednisone/administration & dosage ; Procarbazine/administration & dosage ; Treatment Outcome ; Vinblastine/administration & dosage ; Vincristine/administration & dosage
    Chemical Substances Bleomycin (11056-06-7) ; Procarbazine (35S93Y190K) ; Vincristine (5J49Q6B70F) ; Vinblastine (5V9KLZ54CY) ; Etoposide (6PLQ3CP4P3) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2020-02-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2020.102897
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Alterations of bone material properties in growing Ifitm5/BRIL p.S42 knock-in mice, a new model for atypical type VI osteogenesis imperfecta.

    Hedjazi, Ghazal / Guterman-Ram, Gali / Blouin, Stéphane / Schemenz, Victoria / Wagermaier, Wolfgang / Fratzl, Peter / Hartmann, Markus A / Zwerina, Jochen / Fratzl-Zelman, Nadja / Marini, Joan C

    Bone

    2022  Volume 162, Page(s) 116451

    Abstract: Introduction: Osteogenesis imperfecta (OI) is a heterogenous group of heritable connective tissue disorders characterized by high bone fragility due to low bone mass and impaired bone material properties. Atypical type VI OI is an extremely rare and ... ...

    Abstract Introduction: Osteogenesis imperfecta (OI) is a heterogenous group of heritable connective tissue disorders characterized by high bone fragility due to low bone mass and impaired bone material properties. Atypical type VI OI is an extremely rare and severe form of bone dysplasia resulting from a loss-of-function mutation (p.S40L) in IFITM5/BRIL,the causative gene of OI type V and decreased osteoblast secretion of pigment epithelium-derived factor (PEDF), as in OI type VI. It is not yet known which alterations at the material level might lead to such a severe phenotype. We therefore characterized bone tissue at the micrometer level in a novel heterozygous Ifitm5/BRIL p.S42L knock-in murine model at 4 and 8 weeks of age.
    Methods: We evaluated in female mice, total body size, femoral and lumbar bone mineral density (BMD) by dual-energy X-ray absorptiometry. In the femoral bone we examined osteoid deposition by light microscopy, assessed bone histomorphometry and mineralization density distribution by quantitative backscattered electron imaging (qBEI). Osteocyte lacunae were examined by qBEI and the osteocyte lacuno-canalicular network by confocal laser scanning microscopy. Vasculature was examined indirectly by qBEI as 2D porosity in cortex, and as 3D porosity by micro-CT in third trochanter. Collagen orientation was examined by second harmonic generation microscopy. Two-way ANOVA was used to discriminate the effect of age and genotype.
    Results: Ifitm5/BRIL p.S42L female mice are viable, do not differ in body size, fat and lean mass from wild type (WT) littermates but have lower whole-body, lumbar and femoral BMD and multiple fractures. The average and most frequent calcium concentration, CaMean and CaPeak, increased with age in metaphyseal and cortical bone in both genotypes and were always higher in Ifitm5/BRIL p.S42L than in WT, except CaMean in metaphysis at 4 weeks of age. The fraction of highly mineralized bone area, CaHigh, was also increased in Ifitm5/BRIL p.S42L metaphyseal bone at 8 weeks of age and at both ages in cortical bone. The fraction of lowly mineralized bone area, CaLow, decreased with age and was not higher in Ifitm5/BRIL p.S42L, consistent with lack of hyperosteoidosis on histological sections by visual exam. Osteocyte lacunae density was higher in Ifitm5/BRIL p.S42L than WT, whereas canalicular density was decreased. Indirect measurements of vascularity revealed a higher pore density at 4 weeks in cortical bone of Ifitm5/BRIL p.S42L than in WT and at both ages in the third trochanter. Importantly, the proportion of bone area with disordered collagen fibrils was highly increased in Ifitm5/BRIL p.S42L at both ages.
    Conclusions: Despite normal skeletal growth and the lack of a collagen gene mutation, the Ifitm5/BRIL p.S42L mouse shows major OI-related bone tissue alterations such as hypermineralization of the matrix and elevated osteocyte porosity. Together with the disordered lacuno-canalicular network and the disordered collagen fibril orientation, these abnormalities likely contribute to overall bone fragility.
    MeSH term(s) Animals ; Bone Density/genetics ; Bone and Bones/pathology ; Collagen ; Disease Models, Animal ; Female ; Gene Knock-In Techniques ; Membrane Proteins/genetics ; Mice ; Osteogenesis Imperfecta/diagnostic imaging ; Osteogenesis Imperfecta/genetics ; Osteogenesis Imperfecta/pathology
    Chemical Substances IFITM5 protein, mouse ; Membrane Proteins ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2022.116451
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top