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  1. Article ; Online: School-Based Mandatory Masking Policies and Absenteeism in Ottawa, Canada, in 2022.

    Thampi, Nisha / Schwartz, Kevin L / Science, Michelle / Brown, Kevin A

    JAMA network open

    2023  Volume 6, Issue 7, Page(s) e2325799

    MeSH term(s) Humans ; Absenteeism ; Canada ; Students ; Policy ; Schools
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.25799
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  2. Article ; Online: Injuries From Legal Interventions Involving Conducted Energy Devices.

    Achola, Emma M / Griffith, Kevin N / Wrenn, Jesse O / Mitchell, Carmen R / Schwartz, Dawn / Roumie, Christianne L

    JAMA internal medicine

    2024  Volume 184, Issue 4, Page(s) 440–443

    MeSH term(s) Humans ; Law Enforcement ; Emergency Service, Hospital ; Black People
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.8012
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  3. Article ; Online: Case 16-2023: A 13-Year-Old Boy with Depression and Hypotension.

    Schwartz, Kevin R / Donovan, Abigail L / Hayes, Bryan D / Uchida, Mai / Rosen, Joy B

    The New England journal of medicine

    2023  Volume 388, Issue 21, Page(s) 1992–1999

    MeSH term(s) Adolescent ; Humans ; Male ; Depression/etiology ; Hypotension/etiology
    Language English
    Publishing date 2023-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2201237
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  4. Article ; Online: Variability in changes in physician outpatient antibiotic prescribing from 2019 to 2021 during the COVID-19 pandemic in Ontario, Canada.

    Tandon, Pranav / Brown, Kevin A / Daneman, Nick / Langford, Bradley J / Leung, Valerie / Friedman, Lindsay / Schwartz, Kevin L

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e171

    Abstract: Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic.: Methods: We conducted a retrospective cohort analysis of ... ...

    Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic.
    Methods: We conducted a retrospective cohort analysis of physicians in Ontario, Canada prescribing oral antibiotics in the outpatient setting between January 1, 2019 and December 31, 2021 using the IQVIA Xponent data set. The primary outcome was the change in the number of antibiotic prescriptions between the prepandemic and pandemic period. Secondary outcomes were changes in the selection of broad-spectrum agents and long-duration (>7 d) antibiotic use. We used multivariable linear regression models to evaluate predictors of change.
    Results: There were 17,288 physicians included in the study with substantial inter-physician variability in changes in antibiotic prescribing (median change of -43.5 antibiotics per physician, interquartile range -136.5 to -5.0). In the multivariable model, later career stage (adjusted mean difference [aMD] -45.3, 95% confidence interval [CI] -52.9 to -37.8,
    Conclusions: Antibiotic prescribing changed throughout the COVID-19 pandemic with overall decreases in antibiotic initiation, broad-spectrum agents, and prolonged antibiotic courses with inter-physician variability. These findings present opportunities for community antibiotic stewardship interventions.
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.433
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  5. Article ; Online: Author Correction: Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes.

    Grewal, Ramandip / Nguyen, Lena / Buchan, Sarah A / Wilson, Sarah E / Nasreen, Sharifa / Austin, Peter C / Brown, Kevin A / Fell, Deshayne B / Gubbay, Jonathan B / Schwartz, Kevin L / Tadrous, Mina / Wilson, Kumanan / Kwong, Jeffrey C

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2031

    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37906-x
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  6. Article ; Online: Follow-up blood cultures do not reduce mortality in hospitalized patients with Gram-negative bloodstream infection: a retrospective population-wide cohort study.

    Ong, Sean W X / Luo, Jin / Fridman, Daniel J / Lee, Samantha M / Johnstone, Jennie / Schwartz, Kevin L / Diong, Christina / Patel, Samir N / MacFadden, Derek / Langford, Bradley / Tong, Steven Y C / Brown, Kevin A / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Objectives: The utility of follow-up blood cultures (FUBCs) in patients with Gram-negative bloodstream infection (GN-BSI) is controversial. Observational studies have suggested significant mortality benefit but may be limited by single-centre designs, ... ...

    Abstract Objectives: The utility of follow-up blood cultures (FUBCs) in patients with Gram-negative bloodstream infection (GN-BSI) is controversial. Observational studies have suggested significant mortality benefit but may be limited by single-centre designs, immortal time bias, and residual confounding. We examined the impact of FUBCs on mortality in patients with GN-BSI in a retrospective population-wide cohort study in Ontario, Canada.
    Methods: Adult patients with GN-BSI hospitalized between April 2017 and December 2021 were included. Primary outcome was all-cause mortality within 30 days. FUBC was treated as a time-varying exposure. Secondary outcomes were 90-day mortality, length of stay, and number of days alive and out of hospital at 30 and 90 days.
    Results: Thirty-four thousand one hundred patients were included; 8807 (25.8%) patients received FUBC, of which 966 (11.0%) were positive. Median proportion of patients receiving FUBC was 18.8% (interquartile range, 10.0-29.7%; range, 0-66.1%) across 101 hospitals; this correlated with positivity and contamination rate. Eight hundred ninety (10.1%) patients in the FUBC group and 2263 (8.9%) patients in the no FUBC group died within 30 days. In the fully adjusted model, there was no association between FUBC and mortality (hazard ratio, 0.97; 95% CI, 0.90-1.04). Patients with FUBC had significantly longer length of stay (median, 11 vs. 7 days; adjusted risk ratio, 1.18; 95% CI, 1.16-1.21) and fewer number of days alive and out of hospital at 30 and 90 days.
    Discussion: FUBC collection in patients with GN-BSI varies widely across hospitals and may be associated with prolonged hospitalization without clear survival benefit. Residual confounding may be present given the observational design. Clear benefit should be demonstrated in a randomized trial before widespread adoption of routine FUBC.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.03.025
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    Zs.MO 284: Show issues

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  7. Article ; Online: [No title information]

    Schwartz, Kevin L / McGeer, Allison J / Bogoch, Isaac I

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 193, Issue 23, Page(s) E888–E891

    Title translation Le dépistage des personnes asymptomatiques au moyen de tests antigéniques rapides: un outil de santé publique pour lutter contre la COVID-19.
    Language French
    Publishing date 2021-06-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.210100-f
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  8. Article ; Online: Corrigendum to "Highly versus less bioavailable oral antibiotics in the treatment of gram-negative bloodstream infections: a propensity-matched cohort analysis" [Clin Microbiol Infect 29(4) (2023 April) 490-497].

    Mponponsuo, Kwadwo / Brown, Kevin A / Fridman, Daniel J / Johnstone, Jennie / Langford, Bradley J / Lee, Samantha M / MacFadden, Derek R / Patel, Samir N / Schwartz, Kevin L / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 12, Page(s) 1617

    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.011
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  9. Article ; Online: Stability and Viability of SARS-CoV-2.

    Schwartz, Kevin L / Kim, JinHee / Garber, Gary

    The New England journal of medicine

    2020  Volume 382, Issue 20, Page(s) 1963

    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2007942
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  10. Article ; Online: Variability in changes in physician outpatient antibiotic prescribing from 2019 to 2021 during the COVID-19 pandemic in Ontario, Canada

    Pranav Tandon / Kevin A. Brown / Nick Daneman / Bradley J. Langford / Valerie Leung / Lindsay Friedman / Kevin L. Schwartz

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol

    2023  Volume 3

    Abstract: Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic. Methods: We conducted a retrospective cohort analysis ... ...

    Abstract Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic. Methods: We conducted a retrospective cohort analysis of physicians in Ontario, Canada prescribing oral antibiotics in the outpatient setting between January 1, 2019 and December 31, 2021 using the IQVIA Xponent data set. The primary outcome was the change in the number of antibiotic prescriptions between the prepandemic and pandemic period. Secondary outcomes were changes in the selection of broad-spectrum agents and long-duration (>7 d) antibiotic use. We used multivariable linear regression models to evaluate predictors of change. Results: There were 17,288 physicians included in the study with substantial inter-physician variability in changes in antibiotic prescribing (median change of −43.5 antibiotics per physician, interquartile range −136.5 to −5.0). In the multivariable model, later career stage (adjusted mean difference [aMD] −45.3, 95% confidence interval [CI] −52.9 to −37.8, p < .001), family medicine (aMD −46.0, 95% CI −62.5 to −29.4, p < .001), male patient sex (aMD −52.4, 95% CI −71.1 to −33.7, p < .001), low patient comorbidity (aMD −42.5, 95% CI −50.3 to −34.8, p < .001), and high prescribing to new patients (aMD −216.5, 95% CI −223.5 to −209.5, p < .001) were associated with decreases in antibiotic initiation. Family medicine and high prescribing to new patients were associated with a decrease in selection of broad-spectrum agents and prolonged antibiotic use. Conclusions: Antibiotic prescribing changed throughout the COVID-19 pandemic with overall decreases in antibiotic initiation, broad-spectrum agents, and prolonged antibiotic courses with inter-physician variability. These findings present opportunities for community antibiotic stewardship interventions.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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