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  1. Article ; Online: Stability of SARS-CoV-2 in different environmental conditions - Authors' reply.

    Chin, Alex W H / Poon, Leo L M

    The Lancet. Microbe

    2020  Volume 1, Issue 4, Page(s) e146

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Letter ; Comment
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30095-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stability of SARS-CoV-2 in different environmental conditions – Authors' reply

    Alex W H Chin / Leo L M Poon

    The Lancet Microbe, Vol 1, Iss 4, Pp e146- (2020)

    2020  

    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity.

    Hosseini, Mohsen / Poon, Leo L M / Chin, Alex W H / Ducker, William A

    ACS omega

    2022  Volume 7, Issue 22, Page(s) 18238–18246

    Abstract: Previous reports indicated the low stability of severe actute respiratory syndrome coronovirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonporous solids of ... ...

    Abstract Previous reports indicated the low stability of severe actute respiratory syndrome coronovirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonporous solids of the same chemistry. Through comparing pairs of solids with very similar chemistry, we find that porosity is important: porous glass has a much lower infectivity than nonporous glass. However, porosity is not sufficient to lower infectivity; permeability, which is the ability of a liquid to move through a material, is the important parameter. We show this by comparing a pair of porous CuO coatings where the pores are accessible in one case and inaccessible in the other case. When the pores are inaccessible, the infectivity remains similar to that for nonporous solids. Thus, for both glass and CuO, it is the access to porosity that decreases the infectivity of extracted liquid droplets. Having established the importance of permeability, there is the open question of the mechanism of changing the infectivity of SARS-CoV-2. Several hypotheses are possible, such as increasing the difficulty of extracting the virus from the solid, changing the drying time, increasing the surface area of active ingredient, etc. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) measurements show that less viral DNA is extracted from a permeable surface, suggesting that the virus becomes trapped in the pores. Finally, we consider the effect of drying. We show that permeability and the water contact angle on the solid have effects on the drying time of a contaminated droplet, which may in turn affect infectivity.
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c06880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stability of SARS-CoV-2 in different environmental conditions – Authors' reply

    Chin, Alex W H / Poon, Leo L M

    The Lancet Microbe

    2020  Volume 1, Issue 4, Page(s) e146

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2666-5247
    DOI 10.1016/s2666-5247(20)30095-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Reduction of Infectivity of SARS-CoV-2 by Zinc Oxide Coatings.

    Hosseini, Mohsen / Behzadinasab, Saeed / Chin, Alex W H / Poon, Leo L M / Ducker, William A

    ACS biomaterials science & engineering

    2021  Volume 7, Issue 11, Page(s) 5022–5027

    Abstract: ... suspensions by >99.9% in 1 h. The advantage of a coating is that it can be applied to a variety of objects, e ...

    Abstract We developed antimicrobial coatings from ZnO particles that reduce the infectivity of SARS-CoV-2 suspensions by >99.9% in 1 h. The advantage of a coating is that it can be applied to a variety of objects, e.g., hand rails and door knobs, to hinder the spread of disease. Two porous coatings were prepared: one from submicrometer zinc oxide particles bound with silica menisci and the other from zinc oxide tetrapods bound with polyurethane. Experiments on glass coatings show that infectivity depends on porosity for hydrophilic materials, wherein aqueous droplets are imbibed into the pores.
    MeSH term(s) Anti-Bacterial Agents ; COVID-19 ; Humans ; SARS-CoV-2 ; Suspensions ; Zinc Oxide/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Suspensions ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.1c01076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stability of SARS-CoV-2 on Commercial Aircraft Interior Surfaces with Implications for Effective Control Measures.

    Hui, Kenrie P Y / Chin, Alex W H / Ehret, John / Ng, Ka-Chun / Peiris, Malik / Poon, Leo L M / Wong, Karen H M / Chan, Michael C W / Hosegood, Ian / Nicholls, John M

    International journal of environmental research and public health

    2023  Volume 20, Issue 16

    Abstract: ... 2 was naturally less stable on common contact points in the aircraft interior, and, over a 4 h time ...

    Abstract Background: The COVID-19 pandemic from 2019 to 2022 devastated many aspects of life and the economy, with the commercial aviation industry being no exception. One of the major concerns during the pandemic was the degree to which the internal aircraft environment contributed to virus transmission between humans and, in particular, the stability of SARS-CoV-2 on contact surfaces in the aircraft cabin interior.
    Method: In this study, the stability of various major strains of SARS-CoV-2 on interior aircraft surfaces was evaluated using the TCID
    Results: In contrast to terrestrial materials, SARS-CoV-2 was naturally less stable on common contact points in the aircraft interior, and, over a 4 h time period, there was a 90% reduction in culturable virus. Antiviral and surface coatings were extremely effective at mitigating the persistence of the virus on surfaces; however, their benefit was diminished by regular cleaning and were ineffective after 56 days of regular use and cleaning. Finally, successive strains of SARS-CoV-2 have not evolved to be more resilient to survival on aircraft surfaces.
    Conclusions: We conclude that the mitigation strategies for SARS-CoV-2 on interior aircraft surfaces are more than sufficient, and epidemiological evidence over the past three years has not found that surface spread is a major route of transmission.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics ; Aircraft ; Aviation
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20166598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids.

    Hosseini, Mohsen / Chin, Alex W H / Behzadinasab, Saeed / Poon, Leo L M / Ducker, William A

    ACS applied materials & interfaces

    2021  Volume 13, Issue 5, Page(s) 5919–5928

    Abstract: ... then thermally treated at 700 °C for 2 h to produce a CuO coating that is ≈30 μm thick. The heat treatment oxidized ... from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating ...

    Abstract The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission and fear of touching objects. Herein, we describe the design, fabrication, and testing of a cupric oxide anti-SARS-CoV-2 coating. Rapid loss of infectivity is an important design criterion, so a porous hydrophilic coating was created to allow rapid infiltration of aqueous solutions into the coating where diffusion distances to the cupric oxide surface are short and the surface area is large. The coating was deposited onto glass from a dispersion of cuprous oxide in ethanol and then thermally treated at 700 °C for 2 h to produce a CuO coating that is ≈30 μm thick. The heat treatment oxidized the cuprous oxide to cupric oxide and sintered the particles into a robust film. The SARS-CoV-2 infectivity from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating remained hydrophilic for at least 5 months, and there was no significant change in the cross-hatch test of robustness after exposure to 70% ethanol or 3 wt % bleach.
    MeSH term(s) Animals ; COVID-19/prevention & control ; COVID-19/virology ; Chlorocebus aethiops ; Copper/pharmacology ; Humans ; Photoelectron Spectroscopy ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Surface Properties ; Vero Cells ; Virus Inactivation/drug effects ; X-Ray Diffraction
    Chemical Substances Copper (789U1901C5) ; cupric oxide (V1XJQ704R4)
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c19465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 virus transfers to skin through contact with contaminated solids.

    Behzadinasab, Saeed / Chin, Alex W H / Hosseini, Mohsen / Poon, Leo L M / Ducker, William A

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 22868

    Abstract: Transfer of SARS-CoV-2 from solids to fingers is one step in infection via contaminated solids, and the possibility of infection from this route has driven calls for increased frequency of handwashing during the COVID-19 pandemic. To analyze this route ... ...

    Abstract Transfer of SARS-CoV-2 from solids to fingers is one step in infection via contaminated solids, and the possibility of infection from this route has driven calls for increased frequency of handwashing during the COVID-19 pandemic. To analyze this route of infection, we measured the percentage of SARS-CoV-2 that was transferred from a solid to an artificial finger. A droplet of SARS-CoV-2 suspension (1 µL) was placed on a solid, and then artificial skin was briefly pressed against the solid with a light force (3 N). Transfer from a variety of solids was detected, and transfer from the non-porous solids, glass, stainless steel, and Teflon, was substantial when the droplet was still wet. The viral titer for the finger was 13-16% or 0.8-0.9 log less than for the input droplet. Transfer still occurred after the droplet evaporated, but was smaller, 3-9%. We found a lower level of transfer from porous solids but did not find a significant effect of solid wettability for non-porous solids.
    MeSH term(s) COVID-19/metabolism ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Equipment Contamination/prevention & control ; Equipment Contamination/statistics & numerical data ; Humans ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Skin/virology ; Viral Load
    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-00843-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transparent Anti-SARS-CoV-2 and Antibacterial Silver Oxide Coatings.

    Hosseini, Mohsen / Chin, Alex W H / Williams, Myra D / Behzadinasab, Saeed / Falkinham, Joseph O / Poon, Leo L M / Ducker, William A

    ACS applied materials & interfaces

    2022  Volume 14, Issue 7, Page(s) 8718–8727

    Abstract: Transparent antimicrobial coatings can maintain the aesthetic appeal of surfaces and the functionality of a touch-screen while adding the benefit of reducing disease transmission. We fabricated an antimicrobial coating of silver oxide particles in a ... ...

    Abstract Transparent antimicrobial coatings can maintain the aesthetic appeal of surfaces and the functionality of a touch-screen while adding the benefit of reducing disease transmission. We fabricated an antimicrobial coating of silver oxide particles in a silicate matrix on glass. The matrix was grown by a modified Stöber sol-gel process with vapor-phase water and ammonia. A coating on glass with 2.4 mg of Ag
    MeSH term(s) Ammonia/chemistry ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; COVID-19/prevention & control ; COVID-19/virology ; Glass/chemistry ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Oxides/chemistry ; Oxides/pharmacology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Silicates/chemistry ; Silver Compounds/chemistry ; Silver Compounds/pharmacology ; Water/chemistry
    Chemical Substances Anti-Infective Agents ; Oxides ; Silicates ; Silver Compounds ; Water (059QF0KO0R) ; Ammonia (7664-41-7) ; disilver oxide (897WUN6G6T)
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c20872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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