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  1. Article ; Online: Staging non-small cell lung cancer.

    Quint, Leslie Eisenbud

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2007  Volume 7, Page(s) 148–159

    Abstract: Patients with newly diagnosed non-small cell lung cancer (NSCLC) need accurate tumor staging in order to direct appropriate therapy and establish prognosis; the tumor is usually staged using the TNM system. The major imaging modalities currently used for ...

    Abstract Patients with newly diagnosed non-small cell lung cancer (NSCLC) need accurate tumor staging in order to direct appropriate therapy and establish prognosis; the tumor is usually staged using the TNM system. The major imaging modalities currently used for staging this disease are thoracic computed tomography (CT) (including the adrenal glands) and whole body fluorodeoxyglucose (FDG)-positron emission tomography (PET) scanning. CT is generally most useful in evaluating the T stage, i.e. local spread of the neoplasm, whereas PET is most helpful in assessing the N and M stages, i.e. regional and distant tumor spread, respectively. Integrated CT-PET imaging adds information compared to the use of either modality alone. PET findings frequently lead to upstaging the disease and thus prevent unindicated surgeries. Magnetic resonance imaging (MRI) is helpful in evaluating local extent of disease in patients with superior sulcus tumors and possible brachial plexus involvement. Staging accuracy using any of these imaging techniques is imperfect; therefore, pathologic confirmation of positive findings is recommended, whenever possible, before denying a patient potentially curative therapy.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lymphatic Metastasis ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/secondary ; Neoplasm Staging/methods ; Pleural Neoplasms/secondary ; Radiography ; Sensitivity and Specificity ; Thoracic Wall/diagnostic imaging ; Thoracic Wall/pathology
    Language English
    Publishing date 2007-10-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2104862-9
    ISSN 1470-7330 ; 1470-7330
    ISSN (online) 1470-7330
    ISSN 1470-7330
    DOI 10.1102/1470-7330.2007.0026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Staging esophageal cancer.

    Quint, Leslie Eisenbud / Bogot, Naama R

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2008  Volume 8 Spec No A, Page(s) S33–42

    Abstract: Accurate staging of disease is necessary in patients with newly diagnosed esophageal cancer in order to prompt appropriate curative or palliative therapy. Computed tomography (CT) may be used to evaluate for local spread into adjacent structures (T4 ... ...

    Abstract Accurate staging of disease is necessary in patients with newly diagnosed esophageal cancer in order to prompt appropriate curative or palliative therapy. Computed tomography (CT) may be used to evaluate for local spread into adjacent structures (T4 disease) and to diagnose distant metastases (M1). Endoscopic ultrasonography (EUS) is the modality of choice for distinguishing T1 tumors from higher stage lesions and for detecting and sampling regional lymph nodes (N1 disease). Positron emission tomography (PET) scanning is most helpful for detecting previously occult distant metastases. Optimal staging generally requires a multimodality approach.
    MeSH term(s) Endosonography ; Esophageal Neoplasms/pathology ; Humans ; Lymphatic Metastasis ; Magnetic Resonance Imaging ; Neoplasm Staging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2008-10-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1470-7330
    ISSN (online) 1470-7330
    DOI 10.1102/1470-7330.2008.9007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Incidental findings at chest CT: a needs assessment survey of radiologists' knowledge.

    Quint, Leslie Eisenbud / Watcharotone, Kuanwong / Myles, James D / Gruppen, Larry D / Mullan, Patricia B

    Academic radiology

    2011  Volume 18, Issue 12, Page(s) 1500–1506

    Abstract: Rationale and objectives: To assess practice patterns in evaluating incidental findings at chest computed tomography (CT) to determine the need for further education.: Materials and methods: A survey was given to 1600 radiologists, presenting four ... ...

    Abstract Rationale and objectives: To assess practice patterns in evaluating incidental findings at chest computed tomography (CT) to determine the need for further education.
    Materials and methods: A survey was given to 1600 radiologists, presenting four clinical case questions regarding the evaluation/significance of the following incidental findings at chest CT: thyroid lesion; enlarged mediastinal lymph nodes; asymptomatic, small pulmonary embolus; and small lung nodule. The respondents' answers were compared with "truth," as defined by the best evidence available in the medical literature. Additional questions elicited the respondents' demographics and comfort levels in addressing the findings. Analysis of variance models with a Tukey correction for post hoc comparisons and chi-square tests were used to determine if any demographic factors or comfort levels were predictive of higher correct response rates.
    Results: The overall survey response rate was 28% (445/1600). Correct case response rates ranged from 26% (115/442) to 79% (343/445). Only 6% (28/438) of respondents chose the correct answers for all cases. Up to 80% (353/440) of respondents felt comfortable in addressing findings, and only 57% (252/443) of respondents felt that they needed more training in this area. Fellowship training in cardiothoracic radiology, working in a teaching practice, and subspecialization in abdominal or cardiothoracic radiology were predictive of higher correct response rates. Except for one case question, the comfort level was not predictive of correct response rate.
    Conclusions: There was considerable variability among radiologists and substantial deviation from best medical practice with regard to the interpretation/evaluation of incidental findings at chest CT, signifying a significant need for further education.
    MeSH term(s) Data Collection ; Education, Medical, Continuing ; Humans ; Incidental Findings ; Needs Assessment ; Practice Patterns, Physicians' ; Radiography, Thoracic ; Radiology/education ; Tomography, X-Ray Computed ; United States
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2011.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4594: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: CT appearance of thoracic aortic graft complications.

    Sundaram, Baskaran / Quint, Leslie Eisenbud / Patel, Smita / Patel, Himanshu J / Deeb, G Michael

    AJR. American journal of roentgenology

    2007  Volume 188, Issue 5, Page(s) 1273–1277

    Abstract: Objective: The purpose of this study was to document the spectrum of CT findings and the clinical outcome of thoracic aortic graft complications.: Conclusion: Aortic graft complications detected with CT may or may not be clinically apparent and/or ... ...

    Abstract Objective: The purpose of this study was to document the spectrum of CT findings and the clinical outcome of thoracic aortic graft complications.
    Conclusion: Aortic graft complications detected with CT may or may not be clinically apparent and/or relevant. CT characterization in combination with clinical findings helps to determine patient treatment.
    MeSH term(s) Aged ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.05.1654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.57: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Lung lesion doubling times: values and variability based on method of volume determination.

    Quint, Leslie Eisenbud / Cheng, Joan / Schipper, Matthew / Chang, Andrew C / Kalemkerian, Gregory

    Clinical radiology

    2008  Volume 63, Issue 1, Page(s) 41–48

    Abstract: Purpose: To determine doubling times (DTs) of lung lesions based on volumetric measurements from thin-section CT imaging.: Methods: Previously untreated patients with > or = two thin-section CT scans showing a focal lung lesion were identified. ... ...

    Abstract Purpose: To determine doubling times (DTs) of lung lesions based on volumetric measurements from thin-section CT imaging.
    Methods: Previously untreated patients with > or = two thin-section CT scans showing a focal lung lesion were identified. Lesion volumes were derived using direct volume measurements and volume calculations based on lesion area and diameter. Growth rates (GRs) were compared by tissue diagnosis and measurement technique.
    Results: 54 lesions were evaluated including 8 benign lesions, 10 metastases, 3 lymphomas, 15 adenocarcinomas, 11 squamous carcinomas, and 7 miscellaneous lung cancers. Using direct volume measurements, median DTs were 453, 111, 15, 181, 139 and 137 days, respectively. Lung cancer DTs ranged from 23-2239 days. There were no significant differences in GRs among the different lesion types. There was considerable variability among GRs using different volume determination methods.
    Conclusions: Lung cancer doubling times showed a substantial range, and different volume determination methods gave considerably different DTs.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Bronchogenic/diagnostic imaging ; Carcinoma, Bronchogenic/pathology ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Disease Progression ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Lymphoma/diagnostic imaging ; Lymphoma/pathology ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2008-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2007.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.201: Show issues Location:
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