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Article: Infrared spectroscopy reveals metal-independent carbonic anhydrase activity in crotonyl-CoA carboxylase/reductase.

Gomez, Aharon / Tinzl, Matthias / Stoffel, Gabriele / Westedt, Hendrik / Grubmüller, Helmut / Erb, Tobias J / Vöhringer-Martinez, Esteban / Stripp, Sven T

Chemical science

2024 Volume 15, Issue 13, Page(s) 4960–4968

Abstract: The conversion of ... ...

Abstract	The conversion of CO
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc04208a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fate After the Mustard Procedure for d-Transposition of the Great Arteries: Impact of Age, Complexity, and Atrial Tachyarrhythmias: A Single Center Experience.

Krause, Ulrich / Teubener, Sophie Theres / Müller, Matthias J / Schneider, Heike E / Paul, Thomas

Pediatric cardiology

2023 Volume 44, Issue 8, Page(s) 1746–1753

Abstract: Patients with dextro transposition of the great arteries (d-TGA) after atrial switch procedure are at risk to develop heart failure and arrhythmias during long-term follow-up. The present study aims to add knowledge on the fate of subjects after Mustard ... ...

Abstract	Patients with dextro transposition of the great arteries (d-TGA) after atrial switch procedure are at risk to develop heart failure and arrhythmias during long-term follow-up. The present study aims to add knowledge on the fate of subjects after Mustard procedure during long-term follow-up into adulthood. A single center, retrospective chart review analysis was conducted. All subjects who had Mustard-type atrial switch procedure between 1969 and 1994 at our institution were included. A total of 92 subjects were included. Early postoperative death was reported in 2 subjects. Long-term follow-up was available in 49 survivors. Of those, 6 individuals died during further follow-up. Sudden cardiac death was the most prevalent cause for fatal outcome. Mortality during long-term follow-up was associated with the presence of additional cardiovascular malformations (complex d-TGA). Sinus node dysfunction was observed in 65% of the patients and atrial tachyarrhythmias were common in adult survivors (63%). Implantation of a pacemaker or a cardioverter defibrillator was required in 31% and 45% of those surviving into adulthood. Complications were frequently observed during follow-up after either pacemaker or cardioverter defibrillator implantation (43%) with lead failure being the most frequent complication. The aging population of patients after Mustard procedure is facing challenging problems mainly resulting from a failing systemic right ventricle, presence of associated cardiac malformations and the presence of atrial baffles associated with relevant atrial scars. Age, associated cardiac malformations, and atrial tachyarrhythmias seem to play a major role in determining the fate of patients with d-TGA after atrial switch procedures.
MeSH term(s)	Adult ; Humans ; Aged ; Arterial Switch Operation/adverse effects ; Transposition of Great Vessels/surgery ; Retrospective Studies ; Atrial Fibrillation/complications ; Tachycardia/complications ; Arteries ; Follow-Up Studies
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-023-03241-7
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Book: Nutztierhaltung und -hygiene

Hoy, Steffen / Gauly, Matthias / Krieter, Joachim

114 Tabellen

(UTB ; 2801)

2006

Author's details	Steffen Hoy ; Matthias Gauly ; Joachim Krieter
Series title	UTB ; 2801
Collection
Keywords	Nutztierhaltung ; Tierhygiene
Subject	Veterinärhygiene ; Haltungshygiene ; Nutztiere
Language	German
Size	301 S., Ill., graph. Darst.
Publisher	Ulmer
Publishing place	Stuttgart
Publishing country	Germany
Document type	Book
Note	Literaturverz. S. 287 - 293
HBZ-ID	HT014847178
ISBN	978-3-8252-2801-9 ; 3-8252-2801-0 ; 3-8001-2822-5 ; 9783800128225 ; 978-3-8001-2822-8
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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068/1761	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Robotic arm training in neurorehabilitation enhanced by augmented reality - a usability and feasibility study.

de Crignis, Alexandra Charlotte / Ruhnau, Salome-Thamar / Hösl, Matthias / Lefint, Jérémy / Amberger, Tamara / Dressnandt, Jürgen / Brunner, Hans / Müller, Friedemann

Journal of neuroengineering and rehabilitation

2023 Volume 20, Issue 1, Page(s) 105

Abstract: Background: Robotic therapy and serious gaming support motor learning in neurorehabilitation. Traditional monitor-based gaming outputs cannot adequately represent the third dimension, whereas virtual reality headsets lack the connection to the real ... ...

Abstract	Background: Robotic therapy and serious gaming support motor learning in neurorehabilitation. Traditional monitor-based gaming outputs cannot adequately represent the third dimension, whereas virtual reality headsets lack the connection to the real world. The use of Augmented Reality (AR) techniques could potentially overcome these issues. The objective of this study was thus to evaluate the usability, feasibility and functionality of a novel arm rehabilitation device for neurorehabilitation (RobExReha system) based on a robotic arm (LBR iiwa, KUKA AG) and serious gaming using the AR headset HoloLens (Microsoft Inc.). Methods: The RobExReha system was tested with eleven adult inpatients (mean age: 64.4 ± 11.2 years; diagnoses: 8 stroke, 2 spinal cord injury, 1 Guillain-Barré-Syndrome) who had paretic impairments in their upper limb. Five therapists administered and evaluated the system. Data was compared with a Reference Group (eleven inpatients; mean age: 64.3 ± 9.1 years; diagnoses: 10 stroke, 1 spinal cord injury) who trained with commercially available robotic therapy devices (ArmeoPower or ArmeoSpring, Hocoma AG). Patients used standardized questionnaires for evaluating usability and comfort (Quebec User Evaluation of Satisfaction with assistive technology [QUEST]), workload (Raw Task Load Index [RTLX]) and a questionnaire for rating visual perception of the gaming scenario. Therapists used the QUEST, the System Usability Scale and the short version of the User Experience Questionnaire. Results: Therapy with the RobExReha system was safe and feasible for patients and therapists, with no serious adverse events being reported. Patients and therapists were generally satisfied with usability. The patients' usability ratings were significantly higher in the Reference Group for two items of the QUEST: reliability and ease of use. Workload (RTLX) ratings did not differ significantly between the groups. Nearly all patients using the RobExReha system perceived the gaming scenario in AR as functioning adequately despite eight patients having impairments in stereoscopic vision. The therapists valued the system's approach as interesting and inventive. Conclusions: We demonstrated the clinical feasibility of combining a novel robotic upper limb robot with an AR-serious game in a neurorehabilitation setting. To ensure high usability in future applications, a reliable and easy-to-use system that can be used for task-oriented training should be implemented. Trial registration: Ethical approval was obtained and the trial was registered at the German Clinical Trials Register (DRKS00022136).
MeSH term(s)	Aged ; Humans ; Middle Aged ; Augmented Reality ; Feasibility Studies ; Neurological Rehabilitation ; Reproducibility of Results ; Robotic Surgical Procedures ; Spinal Cord Injuries ; Stroke ; Stroke Rehabilitation/methods
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-023-01225-5
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Article ; Online: Perfusion Air Culture of Precision-Cut Tumor Slices: An Ex Vivo System to Evaluate Individual Drug Response under Controlled Culture Conditions.

Dong, Meng / Böpple, Kathrin / Thiel, Julia / Winkler, Bernd / Liang, Chunguang / Schueler, Julia / Davies, Emma J / Barry, Simon T / Metsalu, Tauno / Mürdter, Thomas E / Sauer, Georg / Ott, German / Schwab, Matthias / Aulitzky, Walter E

Cells

2023 Volume 12, Issue 5

Abstract: Precision-cut tumor slices (PCTS) maintain tissue heterogeneity concerning different cell types and preserve the tumor microenvironment (TME). Typically, PCTS are cultured statically on a filter support at an air-liquid interface, which gives rise to ... ...

Abstract	Precision-cut tumor slices (PCTS) maintain tissue heterogeneity concerning different cell types and preserve the tumor microenvironment (TME). Typically, PCTS are cultured statically on a filter support at an air-liquid interface, which gives rise to intra-slice gradients during culture. To overcome this problem, we developed a perfusion air culture (PAC) system that can provide a continuous and controlled oxygen medium, and drug supply. This makes it an adaptable ex vivo system for evaluating drug responses in a tissue-specific microenvironment. PCTS from mouse xenografts (MCF-7, H1437) and primary human ovarian tumors (primary OV) cultured in the PAC system maintained the morphology, proliferation, and TME for more than 7 days, and no intra-slice gradients were observed. Cultured PCTS were analyzed for DNA damage, apoptosis, and transcriptional biomarkers for the cellular stress response. For the primary OV slices, cisplatin treatment induced a diverse increase in the cleavage of caspase-3 and PD-L1 expression, indicating a heterogeneous response to drug treatment between patients. Immune cells were preserved throughout the culturing period, indicating that immune therapy can be analyzed. The novel PAC system is suitable for assessing individual drug responses and can thus be used as a preclinical model to predict in vivo therapy responses.
MeSH term(s)	Female ; Humans ; Mice ; Animals ; Ovarian Neoplasms ; Biological Phenomena ; Perfusion ; Tumor Microenvironment
Language	English
Publishing date	2023-03-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12050807
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Article: Risk of PTSD Due to the COVID-19 Pandemic Among Patients in Opioid Substitution Treatment.

Fuchs-Leitner, Isabella / Yazdi, Kurosch / Gerstgrasser, Nikolas W / Tholen, Matthias G / Graffius, Sophie-Therés / Schorb, Alexander / Rosenleitner, Jan

Frontiers in psychiatry

2021 Volume 12, Page(s) 729460

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.729460
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Article ; Online: Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells.

Meedt, Elisabeth / Weber, Daniela / Bonifacius, Agnes / Eiz-Vesper, Britta / Maecker-Kolhoff, Britta / Delecluse, Susanne / Delecluse, Henri-Jacques / Lorenz, Myriam / Schwarz, Klaus / Meedt, Stefan T / Braess, Jan / Herr, Wolfgang / Holler, Ernst / Edinger, Matthias / Wolff, Daniel

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 76, Issue 12, Page(s) 2200–2202

Abstract: We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared ... ...

Abstract	We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.
MeSH term(s)	Female ; Humans ; Adult ; Epstein-Barr Virus Infections/therapy ; Herpesvirus 4, Human ; Transplantation, Homologous/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; T-Lymphocytes ; Graft vs Host Disease
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad131
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Book ; Online: Electrically induced angular momentum flow between separated ferromagnets

Schlitz, Richard / Grammer, Matthias / Wimmer, Tobias / Gückelhorn, Janine / Flacke, Luis / Goennenwein, Sebastian T. B. / Gross, Rudolf / Huebl, Hans / Kamra, Akashdeep / Althammer, Matthias

2023

Abstract: Converting angular momentum between different degrees of freedom within a magnetic material results from a dynamic interplay between electrons, magnons and phonons. This interplay is pivotal to implementing spintronic device concepts that rely on spin ... ...

Abstract	Converting angular momentum between different degrees of freedom within a magnetic material results from a dynamic interplay between electrons, magnons and phonons. This interplay is pivotal to implementing spintronic device concepts that rely on spin angular momentum transport. We establish a new concept for long-range angular momentum transport that further allows to address and isolate the magnonic contribution to angular momentum transport in a nanostructured metallic ferromagnet. To this end, we electrically excite and detect spin transport between two parallel and electrically insulated ferromagnetic metal strips on top of a diamagnetic substrate. Charge-to-spin current conversion within the ferromagnetic strip generates electronic spin angular momentum that is transferred to magnons via electron-magnon coupling. We observe a finite angular momentum flow to the second ferromagnetic strip across a diamagnetic substrate over micron distances, which is electrically detected in the second strip by the inverse charge-to-spin current conversion process. We discuss phononic and dipolar interactions as the likely cause to transfer angular momentum between the two strips. Moreover, our work provides the experimental basis to separate the electronic and magnonic spin transport and thereby paves the way towards magnonic device concepts that do not rely on magnetic insulators. Comment: 6 pages, 4 figures, see ancillary filles for supplemental material
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
Subject code	539 ; 530
Publishing date	2023-11-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy.

Yam, Andrew O / Bailey, Jacqueline / Lin, Francis / Jakovija, Arnolda / Youlten, Scott E / Counoupas, Claudio / Gunzer, Matthias / Bald, Tobias / Woodruff, Trent M / Triccas, James A / Goldstein, Leonard D / Gallego-Ortega, David / Grey, Shane T / Chtanova, Tatyana

Cancer research

2023 Volume 83, Issue 8, Page(s) 1315–1328

Abstract: The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically ...

Abstract	The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically inflamed state to one of acute microbial inflammation by injecting microbial bioparticles directly into tumors. Intratumoral microbial bioparticle injection led to rapid and dramatic changes in the tumor immune composition, the most striking of which was a substantial increase in the presence of activated neutrophils. In situ photoconversion and intravital microscopy indicated that tumor neutrophils transiently switched from sessile producers of VEGF to highly motile neutrophils that clustered to make neutrophil-rich domains in the tumor. The neutrophil clusters remodeled tumor tissue and repressed tumor growth. Single-cell transcriptional analysis of microbe-stimulated neutrophils showed a profound shift in gene expression towards heightened activation and antimicrobial effector function. Microbe-activated neutrophils also upregulated chemokines known to regulate neutrophil and CD8+ T-cell recruitment. Microbial therapy also boosted CD8+ T-cell function and enhanced the therapeutic benefit of checkpoint inhibitor therapy in tumor-bearing mice and provided protection in a model of tumor recurrence. These data indicate that one of the major effector mechanisms of microbial therapy is the conversion of tumor neutrophils from a wound healing to an acutely activated cytotoxic phenotype, highlighting a rationale for broader deployment of microbial therapy in the treatment of solid cancers. Significance: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, suggesting pathways for optimizing efficacy of microbial therapies and paving the way for their broader utilization in the clinic.
MeSH term(s)	Mice ; Animals ; Neutrophils/metabolism ; Neoplasms/genetics ; Neoplasms/therapy ; Neoplasms/metabolism ; CD8-Positive T-Lymphocytes ; Inflammation/pathology ; Phenotype ; Neutrophil Infiltration ; Tumor Microenvironment
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-21-4025
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Article ; Online: Concordance of regional hypoperfusion by pCASL MRI and

Ssali, Tracy / Narciso, Lucas / Hicks, Justin / Liu, Linshan / Jesso, Sarah / Richardson, Lauryn / Günther, Matthias / Konstandin, Simon / Eickel, Klaus / Prato, Frank / Anazodo, Udunna C / Finger, Elizabeth / St Lawrence, Keith

NeuroImage. Clinical

2022 Volume 33, Page(s) 102950

Abstract: Background: Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive ... ...

Abstract	Background: Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities. Purpose: This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water ( Methods and materials: Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and Results: Region of interest (ROI) based perfusion measured by Conclusions: This study demonstrates the potential of pCASL for assessing regional hypoperfusion related to FTD and supports its use as a cost-effective alternative to PET.
MeSH term(s)	Cerebrovascular Circulation/physiology ; Frontotemporal Dementia/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Spin Labels ; Tomography, X-Ray Computed ; Water
Chemical Substances	Spin Labels ; Water (059QF0KO0R)
Language	English
Publishing date	2022-01-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2022.102950
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