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Book: Laryngeal cancer

Dedivitis, Rogério A. / Peretti, Giorgio / Hanna, Ehab / Cernea, Claudio R.

clinical case-based approaches

2019

Author's details	Rogério A. Dedivitis, Giorgio Peretti, Ehab Hanna, Claudio R. Cernea
Keywords	Laryngeal Neoplasms / surgery ; Laryngectomy / methods ; Salvage Therapy / methods
Language	English
Size	xxiii, 183 Seiten, Illustrationen
Publisher	Thieme
Publishing place	New York
Publishing country	United States
Document type	Book
Note	Zugang zu e-book über Code
HBZ-ID	HT020082534
ISBN	978-1-68420-001-6 ; 9781684200023 ; 1-68420-001-6 ; 1684200024
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Risk Factors for Malignancy in Patients with Multinodular Goiter

Guilherme Arruda Fernandes / Leandro Luongo de Matos / Rogério Aparecido Dedivitis

International Archives of Otorhinolaryngology (2022)

2022

Abstract: Introduction The identification of thyroid cancer may be conducted through clinical detection, imaging method, and histopathological examination. Both solitary nodules and multinodular goiter are associated with malignancy. Objective To assess the risk ... ...

Abstract	Introduction The identification of thyroid cancer may be conducted through clinical detection, imaging method, and histopathological examination. Both solitary nodules and multinodular goiter are associated with malignancy. Objective To assess the risk factors for malignancy among patients with multinodular goiter submitted to total thyroidectomy. Methods A series of 712 consecutive patients, submitted to total thyroidectomy between 2005 and 2016 with multinodular goiter regarding clinical, ultrasound, and pathological variables, was retrospectively evaluated. Results There were 408 cases of papillary carcinoma (57.3%), with the remaining being benign. Gender had no statistical significance (p = 0.169) for malignancy, unlike the Bethesda index, higher age group (p = 0.005), shorter clinical history time (p = 0.036), smaller number of nodules (p < 0.0001), and smaller nodule size (p < 0.0001), which were related to malignancy. Conclusion The Bethesda index, older age group, shorter clinical history, smaller number of nodules, and smaller size of nodule were related to the diagnosis of papillary carcinoma.
Keywords	thyroid cancer ; thyroidectomy ; carcinoma ; papillary ; Medicine ; R ; Otorhinolaryngology ; RF1-547
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Thieme Revinter Publicações Ltda.
Document type	Article ; Online
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Article ; Online: Hypoparathyroidism after thyroidectomy: prevention, assessment and management.

Dedivitis, Rogerio A / Aires, Felipe T / Cernea, Claudio R

Current opinion in otolaryngology & head and neck surgery

2017 Volume 25, Issue 2, Page(s) 142–146

Abstract: Purpose of review: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy and it can cause significant morbidity and increased costs. Its incidence varies from 30% to 60%.: Recent findings: The surgical ... ...

Abstract	Purpose of review: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy and it can cause significant morbidity and increased costs. Its incidence varies from 30% to 60%. Recent findings: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism. The glands should be identified in situ, carefully manipulated and preserved, as well as their vascularization. In case of incidental removal, routine autotransplantation is advocated. Low calcium levels, identification of fewer than two parathyroid glands at surgery, reoperation for bleeding, Graves disease and heavier thyroid specimens were considered independent predictors of permanent hypocalcemia. Intraoperative parathyroid hormone (PTH) measurements allows the early detection of hypocalcemia. Treatment is recommended for patients with symptoms of hypocalcemia or corrected serum calcium < 7.5 mg/dL. Acute hypocalcemia is treated with either oral calcium or an intravenous infusion. The goal is to preserve serum calcium in the low normal or mildly subnormal levels. Hypocalcemia symptoms should be considered a medical emergency. Treatment with PTH has been recently performed for the management of cases not adequately controlled with conventional therapy. Summary: Hypoparathyroidism is the most common long-term complication after total thyroidectomy. Adequate recognition and management decrease its morbidity and costs.
Language	English
Publishing date	2017-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000346
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Article ; Online: Neutrophil-to-lymphocyte ratio as a prognostic factor for pharyngocutaneous fistula after total laryngectomy.

Aires, F T / Dedivitis, R A / Kulcsar, M A V / Ramos, D M / Cernea, C R

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2018 Volume 38, Issue 1, Page(s) 31–37

Abstract: Summary: The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the ... ...

Abstract	Summary: The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the incidence of pharyngocutaneous fistula (PCF) in patients who underwent total laryngectomy. We conducted a retrospective cohort analysis of 141 patients with squamous cell carcinoma of larynx who underwent total laryngectomy from 2009 to 2015. The incidence of PCF was 49.6%. A higher risk of 23% was observed among patients with NLR > 2.5 for the occurrence of PCF (p = 0.007). Patients with laryngeal squamous cell carcinoma who present elevated values in the ration > LR> (> 2.5) presented a higher risk of developing pharyngocutaneous fistula in the postoperative setting of total laryngectomy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/surgery ; Cohort Studies ; Cutaneous Fistula/blood ; Cutaneous Fistula/epidemiology ; Female ; Fistula/blood ; Fistula/epidemiology ; Humans ; Incidence ; Laryngeal Neoplasms/surgery ; Laryngectomy ; Leukocyte Count ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Pharyngeal Diseases/blood ; Pharyngeal Diseases/epidemiology ; Postoperative Complications/blood ; Predictive Value of Tests ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2018-05-12
Publishing country	Italy
Document type	Journal Article ; Observational Study
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-1572
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Article ; Online: Evaluation of lung function in patients submitted to total laryngectomy.

Castro, Mario A / Dedivitis, Rogério A / Salge, João M / Matos, Leandro L / Cernea, Claudio R

Brazilian journal of otorhinolaryngology

2018 Volume 85, Issue 5, Page(s) 623–627

Abstract: Introduction: The post-laryngectomy state is characterized by several alterations in lung function. A reliable estimation of lung function can be very useful in laryngectomees to prevent postoperative complications and to evaluate the results of the ... ...

Abstract	Introduction: The post-laryngectomy state is characterized by several alterations in lung function. A reliable estimation of lung function can be very useful in laryngectomees to prevent postoperative complications and to evaluate the results of the treatment. Objective: Characterize the presence of respiratory functional disorders and the functional pattern of laryngectomees through the use of an extratracheal device. Methods: This transversal study included 50 patients submitted to total laryngectomy at least 6 months prior to this investigation, as the treatment of choice for laryngeal cancer. Results: 56% percent of the participants had altered breathing pattern, distributed as follows: 14 with obstructive pattern with no air trapping, 11 with obstructive pattern with air trapping and only 3 with restrictive pattern. On average, the diffusion decreased (74.3%) and airway resistance increased (121.7%) when compared to the expected average values for the Brazilian individuals. Conclusion: Most patients submitted to total laryngectomy present altered lung function, usually the obstructive type, frequently associated to a history of smoking.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy ; Lung/physiopathology ; Male ; Middle Aged ; Respiratory Physiological Phenomena ; Spirometry
Language	English
Publishing date	2018-06-29
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2018.05.008
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Article ; Online: Mammary analogue secretory carcinoma in minor salivary gland

Lucas Moreno Ponso / Victor Pereira Zerbinatti / Sílvia Miguéis Picado Petrarolha / Vania Loureiro / Rogério Aparecido Dedivitis

Einstein (São Paulo), Vol

2022 Volume 20

Abstract: ABSTRACT Mammary analogue secretory carcinoma is a rare neoplasm usually confused with other neoplasms in the salivary glands region. It has great similarity with the breast carcinoma. We report a case of a patient who presented with gingival submucosal ... ...

Abstract	ABSTRACT Mammary analogue secretory carcinoma is a rare neoplasm usually confused with other neoplasms in the salivary glands region. It has great similarity with the breast carcinoma. We report a case of a patient who presented with gingival submucosal bleeding and lesion, with the initial histopathological examination revealing salivary gland neoplasm of low crane. Computed tomography revealed the lesion near the tooth 27, with extension to the floor of the left maxillary sinus and to the palate mucosa. Resection of the infra-structure was performed, with a diagnosis of breast cancer secretory carcinoma in the minor salivary gland.
Keywords	Carcinoma ; Salivary gland neoplasms ; Salivary glands ; minor ; Mammary analogue secretory carcinoma ; Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
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Article: Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel's Thyroiditis?

Simões, C A / Tavares, M R / Andrade, N M M / Uehara, T M / Dedivitis, R A / Cernea, C R

Case reports in endocrinology

2018 Volume 2018, Page(s) 4101323

Abstract: Riedel's thyroiditis (RT) represents one type of IgG4-related thyroid disease (IgG4RTD) and the diagnosis involves quantitative immunohistochemistry showing dense lymphoplasmacellular inflammatory infiltrate consisting of IgG4-positive plasma cells with ... ...

Abstract	Riedel's thyroiditis (RT) represents one type of IgG4-related thyroid disease (IgG4RTD) and the diagnosis involves quantitative immunohistochemistry showing dense lymphoplasmacellular inflammatory infiltrate consisting of IgG4-positive plasma cells with storiform fibrosis and obliterative phlebitis. We report a case of RT with progressive enlargement of the anterior neck, severe dysphagia, odynophagia, and dyspnea. The patient underwent surgical decompression of the airway, protection tracheotomy, and gastrostomy for nutritional intake 6 months after first symptoms. Complete resolution occurred after surgical treatment combined with prednisolone. Immunostaining revealed IgG4-positive plasma cells 12/HPF (high-power field) and the IgG4/IgG ratio 25%, values that were disproportionate to the intensity of the patient's symptoms. As to this case and the few cases described and analyzed in the literature, our impression is that there is no relation between the intensity of symptoms in RT with the total number of IgG4-positive plasma cells and the IgG4/IgG ratio, but more studies are needed.
Language	English
Publishing date	2018-04-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627633-1
ISSN	2090-651X ; 2090-6501
ISSN (online)	2090-651X
ISSN	2090-6501
DOI	10.1155/2018/4101323
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Article ; Online: Evaluation of a method for assessing pulmonary function in laryngectomees.

Castro, M A / Dedivitis, R A / Macedo, A G

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2011 Volume 31, Issue 4, Page(s) 243–247

Abstract: In total laryngectomies the impairment of pulmonary function reflects the sum of pre- and post-operative ventilatory changes. Objective information on the respiratory condition in laryngectomees, as assessed in the pulmonary function laboratory is ... ...

Abstract	In total laryngectomies the impairment of pulmonary function reflects the sum of pre- and post-operative ventilatory changes. Objective information on the respiratory condition in laryngectomees, as assessed in the pulmonary function laboratory is somewhat limited, perhaps because of difficulties related to methodology. The aim of our study was to evaluate the reproducibility of a method employed to assess the pulmonary function in laryngectomized patients. The experimental extra-tracheal device was set up with a silicone adapter through a cardboard tube to the skin around the tracheostoma. Pulmonary function tests included measurements of forced vital capacity, force expiratory volume at 1 second and Tiffeneau index in 3 consecutive evaluations, in 11 patients who underwent total laryngectomy. The control group comprised 11 patients, not laryngectomized, evaluated by conventional spirometry. Those responsible for evaluating were asked to report possible technical failures and to demonstrate the reproducibility of the curves resulting from the tests. The use of the silicone adapter and skin adhesive provided a complete, airtight seal of the system, in all cases. The presence of the tracheo-oesophageal prosthesis did not negatively affect the test results. All patients attributed a maximum value, both for comfort and acceptance, of the device. The values are comparable in both groups, thus indicating the accuracy of the proposed methodology. All examinations were reproducible. After total laryngectomy, pulmonary function testing, with an extra-tracheal device, is not only reliable but also easy to perform in a routine out-patient setting. The methodology did not present air leaks and was, therefore, well accepted by all patients tested.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Laryngectomy ; Male ; Middle Aged ; Reproducibility of Results ; Respiratory Function Tests/methods
Language	English
Publishing date	2011-09-14
Publishing country	Italy
Document type	Clinical Trial ; Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
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Article: The surgical management of parotid gland tumours.

Castro, M A F / Dedivitis, R A / Guimarães, A V / Cernea, R C / Brandão, L G

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

2015 Volume 53, Issue 3 and 4, Page(s) 45–47

Abstract: Background: The parotid tissue can give rise to a large variety of benign and malignant neoplasms. The objective of this study was to describe the management and outcome of parotid gland tumours over a 15-year period.: Method: The records of ... ...

Abstract	Background: The parotid tissue can give rise to a large variety of benign and malignant neoplasms. The objective of this study was to describe the management and outcome of parotid gland tumours over a 15-year period. Method: The records of consecutive patients treated by parotid gland excision from January 1995 to December 2008 were reviewed retrospectively. Data recorded were age, gender, history, physical findings, surgical procedure, fine-needle aspiration biopsy (FNAB), final pathological diagnosis and complications. Results: The vast majority of patients (306) had benign neoplasms, and 14 patients had malignant neoplasms. Overall, pleomorphic adenoma contributed to 76% of the lesions, and Warthin's tumour to 17%. The sensitivity and specificity of FNAB was 79% and 100%, respectively. There were 15 cases of marginal mandibular transitory paresis and 12 cases of seroma. Marginal mandibular definitive paralysis was observed in three cases with malignant tumour. Conclusion: Standardised parotidectomy is a safe operation, with a low complication rate.
Language	English
Publishing date	2015-12
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	416504-4
ISSN	0038-2361
ISSN	0038-2361
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Article: A Case of "Late" Postsurgical Hypoparathyroidism.

Simões, Cesar Augusto / Costa, M K / Comerlato, L B / Ogusco, A A / Araújo Filho, V / Dedivitis, R A / Cernea, C R

Case reports in endocrinology

2017 Volume 2017, Page(s) 3962951

Abstract: Introduction: Postsurgical hypoparathyroidism normally occurs a short time after thyroid surgery in form of two clinical syndromes of different etiology and prognosis. The first is transitory and might spontaneously recover within a few weeks or months. ...

Abstract	Introduction: Postsurgical hypoparathyroidism normally occurs a short time after thyroid surgery in form of two clinical syndromes of different etiology and prognosis. The first is transitory and might spontaneously recover within a few weeks or months. The second is permanent and needs a definitive treatment. Only few cases of hypoparathyroidism clinically evident after many years from surgery have been reported. Case report: A case of hypoparathyroidism clinically evident only three and a half years after surgery is reported. Our findings and review of a few cases reported by medical literature suggest the existence of a third form of postsurgical hypoparathyroidism, characterized by a late beginning.
Language	English
Publishing date	2017-05-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627633-1
ISSN	2090-651X ; 2090-6501
ISSN (online)	2090-651X
ISSN	2090-6501
DOI	10.1155/2017/3962951
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