LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 93

Search options

  1. Article: Starvation ketosis in a pregnant woman with COVID-19: a case report.

    Nana, Melanie / Nelson-Piercy, Catherine

    Endocrinology, diabetes & metabolism case reports

    2022  Volume 2022

    Abstract: Summary: COVID-19 is associated with severe disease in pregnancy. Complications of the disease, or simultaneous diagnoses, may be missed if clinicians do not retain a large differential diagnosis when assessing such women. Starvation ketoacidosis is one ...

    Abstract Summary: COVID-19 is associated with severe disease in pregnancy. Complications of the disease, or simultaneous diagnoses, may be missed if clinicians do not retain a large differential diagnosis when assessing such women. Starvation ketoacidosis is one such diagnosis which may complicate the disease and should not be missed. A 37-year-old woman, 33 weeks' gestation presented with breathlessness. Clinical history, examination and investigations supported a diagnosis of starvation ketosis of pregnancy complicating COVID-19 pneumonitis. Prompt correction of the metabolic disturbance resulted in resolution, and preterm delivery was avoided at this time. Early recognition and prompt management of starvation ketosis of pregnancy in women with COVID-19 are important in reducing maternal and neonatal morbidity and mortality. Preterm delivery may be avoided with prompt resolution of the metabolic disturbance. Clinicians should keep a wide differential diagnosis when assessing women with breathlessness. A multidisciplinary team (MDT) approach is required to facilitate optimal care.
    Learning points: Clinicians should maintain a wide differential when assessing women who are unwell with COVID-19 in pregnancy. Complications such as starvation ketoacidosis are rare but life-threatening. An awareness of such complications facilitates early identification of the condition, and involvement of appropriate specialists who can initiate optimal and timely management. In the context of pregnancy, where ketoacidosis poses a threat to the mother or baby, prompt management and resolution may avoid preterm delivery. Conditions that may increase the risk of developing starvation ketoacidosis include pregnancy, medication use such as corticosteroids or tocolytic therapies, previous gastric surgery, intercurrent illness and pregnancy-related conditions that might contribute towards a degree of chronic starvation. Multidisciplinary input supports the delivery of best practice and care for the patients.
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-22-0222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Comparing pre-pregnancy counselling, diabetes knowledge and risk factors for adverse outcomes in women with type 1 or type 2 diabetes mellitus in Wales: A prospective multi-centre observational study.

    Williams, David M / Moore, Sacha / Coventry, Jennifer / Nana, Melanie

    Diabetic medicine : a journal of the British Diabetic Association

    2023  Volume 40, Issue 10, Page(s) e15161

    MeSH term(s) Pregnancy ; Female ; Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Prospective Studies ; Wales/epidemiology ; Risk Factors ; Pregnancy Outcome ; Counseling
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Observational Study ; Letter
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.15161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: COVID-19 in pregnancy.

    Nana, Melanie / Nelson-Piercy, Catherine

    Clinical medicine (London, England)

    2021  Volume 21, Issue 5, Page(s) e446–e450

    Abstract: Pregnant women with COVID-19 are less likely to be symptomatic than non-pregnant counterparts. Risk factors for severe disease include being overweight or obese, greater than 35 years old, and having pre-existing comorbidities. Those who develop severe ... ...

    Abstract Pregnant women with COVID-19 are less likely to be symptomatic than non-pregnant counterparts. Risk factors for severe disease include being overweight or obese, greater than 35 years old, and having pre-existing comorbidities. Those who develop severe disease have increased rates of admission to an intensive care unit, requiring invasive ventilation and pre-term birth.Pregnant and breastfeeding women with COVID-19 should be investigated as of outside pregnancy and should receive proven therapies (such as corticosteroids and tocilizumab) on a risk/benefit basis. Admitted women should receive multidisciplinary care with input from senior decision makers and early escalation where required. There are no safety concerns -surrounding the COVID-19 vaccination and fertility or pregnancy, and so it should be offered to women based on their age and clinical risk group, in line with non-pregnant women.
    MeSH term(s) Adult ; COVID-19 ; COVID-19 Vaccines ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; Risk Factors ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0503
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Managing COVID-19 in pregnant women.

    Teelucksingh, Siara / Nana, Melanie / Nelson-Piercy, Catherine

    Breathe (Sheffield, England)

    2022  Volume 18, Issue 2, Page(s) 220019

    Abstract: Principles of management of COVID-19 in the general population apply in pregnancy with few exceptions. Clinical inertia can lead to preventable morbidity and mortality. COVID-19 vaccines are safe and should be recommended at any stage of pregnancy. ...

    Abstract Principles of management of COVID-19 in the general population apply in pregnancy with few exceptions. Clinical inertia can lead to preventable morbidity and mortality. COVID-19 vaccines are safe and should be recommended at any stage of pregnancy.
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0019-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: 'The Core' - the ultimate online resource for core medical trainees (CMTs).

    Nana, Melanie / Morgan, Holly

    Future healthcare journal

    2019  Volume 4, Issue Suppl 2, Page(s) s26

    Language English
    Publishing date 2019-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/futurehosp.4-2s-s26
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Hyperemesis gravidarum in the primary care setting: cross-sectional study of GPs.

    Nana, Melanie / Morgan, Holly / Ahmed, Haroon / Williamson, Catherine

    BJGP open

    2022  Volume 6, Issue 1

    Abstract: Background: Hyperemesis gravidarum (HG), if untreated, can lead to malnutrition, dehydration, and Wernicke's encephalopathy. Foetal complications include low birth weight and neurodevelopmental delay. Recent evidence supports increased rates of ... ...

    Abstract Background: Hyperemesis gravidarum (HG), if untreated, can lead to malnutrition, dehydration, and Wernicke's encephalopathy. Foetal complications include low birth weight and neurodevelopmental delay. Recent evidence supports increased rates of termination of pregnancy and suicidal ideation. Drivers included difficulty in accessing medications, which thus contributed to poor perception of care.
    Aim: To identify factors that may influence prescribers' confidence and knowledge regarding pharmacological therapy for HG.
    Design & setting: Cross-sectional study of qualified GPs and GP trainees in Wales.
    Method: Distribution of a 22-item online survey. Statistical analysis was carried out using SPSS.
    Results: In total, 241 responses were received, with 216 included in the analysis (59% qualified GPs, 41% GP trainees). In total, 93% of responders correctly identified cyclizine as being safe in pregnancy, but no other drug recommended in the Royal College of Obstetrics and Gynaecology guidance was considered safe by more than 58%. Those reporting higher confidence levels in managing HG were more likely to correctly report guideline-recommended drugs as safe in pregnancy (
    Conclusion: This study demonstrates a demand for improved dissemination of evidence-based education on HG to support those working in primary care. The extent to which HG is covered in pre-existing educational programmes should also be revisited.
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2021.0119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Improving 'The Core' aspects of medical training: a trainee-led innovation.

    Nana, Melanie / Morgan, Holly

    Future healthcare journal

    2020  Volume 7, Issue 1, Page(s) 90–93

    Abstract: Introduction: The successful achievement of training requirements at core medical training level is central to gaining the competence and confidence to progress to higher specialty training. Achieving such requirements is, however, challenging in the ... ...

    Abstract Introduction: The successful achievement of training requirements at core medical training level is central to gaining the competence and confidence to progress to higher specialty training. Achieving such requirements is, however, challenging in the context of busy medical rotas and numerous rota gaps.
    Solution/methodology: To develop an online resource for core medical trainees which would facilitate the completion of such training requirements and provide information and support for those progressing to higher specialty training.
    Outcome: The online resource has been well received in Wales with 478 users and regular use of the site being reported using Google Analytics. Qualitative feedback has also been favourable.
    Conclusion: The use of digital resources, flexible training and focus on trainee-led innovation can positively affect the training of medical trainees. In the advent of internal medicine training, the support of the Royal College of Physicians is greatly appreciated in expanding this trainee-led innovation across the UK such that it can support a larger number of trainees.
    Language English
    Publishing date 2020-02-25
    Publishing country England
    Document type Case Reports
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.2019-0035
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: The Wrong Side of the Bed.

    Morgan, Holly / Nana, Melanie / Siddiqi, Nishat

    JAMA cardiology

    2020  Volume 5, Issue 12, Page(s) 1325–1326

    MeSH term(s) Communication ; Humans ; Professional-Family Relations ; Truth Disclosure
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.4405
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Hyperemesis gravidarum in the primary care setting

    Melanie Nana / Holly Morgan / Haroon Ahmed / Catherine Williamson

    BJGP Open, Vol 6, Iss

    cross-sectional study of GPs

    2022  Volume 1

    Abstract: Background: Hyperemesis gravidarum (HG), if untreated, can lead to malnutrition, dehydration, and Wernicke’s encephalopathy. Foetal complications include low birth weight and neurodevelopmental delay. Recent evidence supports increased rates of ... ...

    Abstract Background: Hyperemesis gravidarum (HG), if untreated, can lead to malnutrition, dehydration, and Wernicke’s encephalopathy. Foetal complications include low birth weight and neurodevelopmental delay. Recent evidence supports increased rates of termination of pregnancy and suicidal ideation. Drivers included difficulty in accessing medications, which thus contributed to poor perception of care. Aim: To identify factors that may influence prescribers’ confidence and knowledge regarding pharmacological therapy for HG. Design & setting: Cross-sectional study of qualified GPs and GP trainees in Wales. Method: Distribution of a 22-item online survey. Statistical analysis was carried out using SPSS. Results: In total, 241 responses were received, with 216 included in the analysis (59% qualified GPs, 41% GP trainees). In total, 93% of responders correctly identified cyclizine as being safe in pregnancy, but no other drug recommended in the Royal College of Obstetrics and Gynaecology guidance was considered safe by more than 58%. Those reporting higher confidence levels in managing HG were more likely to correctly report guideline-recommended drugs as safe in pregnancy (P = 0.04). Additional qualifications related to obstetrics and gynaecology (O&G) and/or prior clinical experience increased confidence levels (P = 0.0001 and P = 0.0002, respectively). Only 19% of participants routinely screened for signs of mental health complications, and prior experience or education did not increase likelihood of this happening. The majority of participants (87%) would like additional education and/or access to evidence-based resources. Conclusion: This study demonstrates a demand for improved dissemination of evidence-based education on HG to support those working in primary care. The extent to which HG is covered in pre-existing educational programmes should also be revisited.
    Keywords hyperemesis gravidarum ; education ; pregnancy ; antiemetics ; primary health care ; general practice ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Royal College of General Practitioners
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: Endocrine complications of immunotherapies: a review.

    Hattersley, Rosie / Nana, Melanie / Lansdown, Andrew J

    Clinical medicine (London, England)

    2021  Volume 21, Issue 2, Page(s) e212–e222

    Abstract: Use of immune checkpoint inhibitors in cancer treatment has increased vastly over the past decade, as both single and combination agent therapies. While having a positive impact on survival rates, adverse effects have been noted, with endocrine effects ... ...

    Abstract Use of immune checkpoint inhibitors in cancer treatment has increased vastly over the past decade, as both single and combination agent therapies. While having a positive impact on survival rates, adverse effects have been noted, with endocrine effects in around 10% of patients. Thyroid disease and hypophysitis are the most commonly encountered, with diabetes mellitus and primary adrenal insufficiency also reported, as well as more rare endocrinopathies. Patient and clinician education to raise awareness of these effects, as well as regular monitoring to enable early recognition, diagnosis and prompt treatment of the immune side effects, are key. In this review, we discuss the aetiology, presentation and management of the endocrine complications of immunotherapies that are relevant to the general physician, as well as highlighting important areas where further research is still needed.
    MeSH term(s) Addison Disease ; Drug-Related Side Effects and Adverse Reactions ; Endocrine System Diseases ; Humans ; Hypophysitis/chemically induced ; Immunotherapy/adverse effects ; Neoplasms ; Thyroid Diseases
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2020-0827
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top