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  1. Article ; Online: TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease.

    Gibbings, Sophie L / Haist, Kelsey C / Redente, Elizabeth F / Henson, Peter M / Bratton, Donna L

    Frontiers in immunology

    2024  Volume 15, Page(s) 1354836

    Abstract: Introduction: Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91: Methods: We ... ...

    Abstract Introduction: Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91
    Methods: We sought to identify key constituents using
    Results: More extensive phenotyping defined normal MoMac maturation and demonstrated failure of maturation of CGD MoMacs both
    Discussion: These data lend mechanistic insights into the utility of TNFα blockade in CGD and to other diseases where such therapy has been shown to be beneficial.
    MeSH term(s) Animals ; Mice ; Culture Media, Conditioned/metabolism ; Cytokines/metabolism ; Granulomatous Disease, Chronic/therapy ; Macrophages/metabolism ; NADPH Oxidases/metabolism ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Culture Media, Conditioned ; Cytokines ; NADPH Oxidases (EC 1.6.3.-) ; Receptors, Tumor Necrosis Factor, Type I ; Tumor Necrosis Factor-alpha ; Tnfrsf1a protein, mouse
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1354836
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  2. Article ; Online: Cell Removal: Efferocytosis.

    Henson, Peter M

    Annual review of cell and developmental biology

    2017  Volume 33, Page(s) 127–144

    Abstract: In metazoans, removal of cells in situ is involved in larval maturation, metamorphosis, and embryonic development. In adults, such cell removal plays a role in the homeostatic maintenance of cell numbers and tissue integrity as well as in the response to ...

    Abstract In metazoans, removal of cells in situ is involved in larval maturation, metamorphosis, and embryonic development. In adults, such cell removal plays a role in the homeostatic maintenance of cell numbers and tissue integrity as well as in the response to cell injury and damage. This removal involves uptake of the whole or fragmented target cells into phagocytes. Depending on the organism, these latter may be near-neighbor tissue cells and/or professional phagocytes such as, in vertebrates, members of the myeloid family of cells, especially macrophages. The uptake processes appear to involve specialized and highly conserved recognition ligands and receptors, intracellular signaling in the phagocytes, and mechanisms for ingestion. The recognition of cells destined for this form of removal is critical and, significantly, is distinguished for the most part from the recognition of foreign materials and organisms by the innate and adaptive immune systems. In keeping with the key role of cell removal in maintaining tissue homeostasis, constant cell removal is normally silent, i.e., does not initiate a local tissue reaction. This article discusses these complex and wide-ranging processes in general terms as well as the implications when these processes are disrupted in inflammation, immunity, and disease.
    Language English
    Publishing date 2017-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1293750-2
    ISSN 1530-8995 ; 1081-0706
    ISSN (online) 1530-8995
    ISSN 1081-0706
    DOI 10.1146/annurev-cellbio-111315-125315
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  3. Article ; Online: A LTB

    Haist, Kelsey C / Gibbings, Sophie L / Jacobelli, Jordan / Mould, Kara J / Henson, Peter M / Bratton, Donna L

    iScience

    2024  Volume 27, Issue 4, Page(s) 109589

    Abstract: Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD ( ... ...

    Abstract Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD (gp91
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109589
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  4. Book: Mediators of the inflammatory process

    Henson, Peter M.

    (Handbook of inflammation ; 6)

    1989  

    Author's details ed.: Peter M. Henson
    Series title Handbook of inflammation ; 6
    Collection
    Keywords Inflammation / immunology ; Entzündung
    Subject Inflammatio ; Entzündungsreaktion
    Size XXII, 404 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT003473980
    ISBN 0-444-81175-3 ; 978-0-444-81175-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1980 A 1630 -6- order for loan Magazin

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  5. Article ; Online: Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation.

    Moore, Peter K / Anderson, Kelsey C / McManus, Shannon A / Tu, Ting-Hui / King, Emily M / Mould, Kara J / Redente, Elizabeth F / Henson, Peter M / Janssen, William J / McCubbrey, Alexandra L

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 324, Issue 4, Page(s) L536–L549

    Abstract: Interstitial macrophages (IMs) reside in the lung tissue surrounding key structures including airways, vessels, and alveoli. Recent work has described IM heterogeneity during homeostasis, however, there are limited data on IMs during inflammation. We ... ...

    Abstract Interstitial macrophages (IMs) reside in the lung tissue surrounding key structures including airways, vessels, and alveoli. Recent work has described IM heterogeneity during homeostasis, however, there are limited data on IMs during inflammation. We sought to characterize IM origin, subsets, and transcriptomic profiles during homeostasis and lipopolysaccharide (LPS) induced acute lung inflammation. During homeostasis, we used three complementary methods, spectral flow cytometry, single-cell RNA-sequencing, and gene regulatory network enrichment, to demonstrate that IMs can be divided into two core subsets distinguished by surface and transcriptional expression of folate receptor β (
    MeSH term(s) Humans ; Monocytes/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Macrophages/metabolism ; Pneumonia/chemically induced ; Pneumonia/genetics ; Pneumonia/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Sequence Analysis, RNA/methods ; Folate Receptor 2/metabolism
    Chemical Substances Lipopolysaccharides ; FOLR2 protein, human ; Folate Receptor 2
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00223.2022
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  6. Article ; Online: Comparison of tibial alignment parameters based on clinically relevant anatomical landmarks : a deep learning radiological analysis.

    Jang, Seong J / Kunze, Kyle N / Brilliant, Zachary R / Henson, Melissa / Mayman, David J / Jerabek, Seth A / Vigdorchik, Jonathan M / Sculco, Peter K

    Bone & joint open

    2022  Volume 3, Issue 10, Page(s) 767–776

    Abstract: Aims: Accurate identification of the ankle joint centre is critical for estimating tibial coronal alignment in total knee arthroplasty (TKA). The purpose of the current study was to leverage artificial intelligence (AI) to determine the accuracy and ... ...

    Abstract Aims: Accurate identification of the ankle joint centre is critical for estimating tibial coronal alignment in total knee arthroplasty (TKA). The purpose of the current study was to leverage artificial intelligence (AI) to determine the accuracy and effect of using different radiological anatomical landmarks to quantify mechanical alignment in relation to a traditionally defined radiological ankle centre.
    Methods: Patients with full-limb radiographs from the Osteoarthritis Initiative were included. A sub-cohort of 250 radiographs were annotated for landmarks relevant to knee alignment and used to train a deep learning (U-Net) workflow for angle calculation on the entire database. The radiological ankle centre was defined as the midpoint of the superior talus edge/tibial plafond. Knee alignment (hip-knee-ankle angle) was compared against 1) midpoint of the most prominent malleoli points, 2) midpoint of the soft-tissue overlying malleoli, and 3) midpoint of the soft-tissue sulcus above the malleoli.
    Results: A total of 932 bilateral full-limb radiographs (1,864 knees) were measured at a rate of 20.63 seconds/image. The knee alignment using the radiological ankle centre was accurate against ground truth radiologist measurements (inter-class correlation coefficient (ICC) = 0.99 (0.98 to 0.99)). Compared to the radiological ankle centre, the mean midpoint of the malleoli was 2.3 mm (SD 1.3) lateral and 5.2 mm (SD 2.4) distal, shifting alignment by 0.34
    Conclusion: The current study leveraged AI to create a consistent and objective model that can estimate patient-specific adjustments necessary for optimal landmark usage in extramedullary and computer-guided navigation for tibial coronal alignment to match radiological planning.Cite this article:
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article
    ISSN 2633-1462
    ISSN (online) 2633-1462
    DOI 10.1302/2633-1462.310.BJO-2022-0082.R1
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  7. Article ; Online: Phagocytosis: invitation to a feast.

    Henson, Peter M

    Current biology : CB

    2009  Volume 19, Issue 21, Page(s) R989–91

    MeSH term(s) Adenosine Triphosphate/physiology ; Apoptosis ; Chemotactic Factors/physiology ; Chemotaxis/physiology ; Macrophages/physiology ; Models, Biological ; Phagocytosis/physiology ; Uridine Triphosphate/physiology
    Chemical Substances Chemotactic Factors ; Adenosine Triphosphate (8L70Q75FXE) ; Uridine Triphosphate (UT0S826Z60)
    Language English
    Publishing date 2009-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2009.09.031
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  8. Article ; Online: Monocyte differentiation and antigen-presenting functions.

    Jakubzick, Claudia V / Randolph, Gwendalyn J / Henson, Peter M

    Nature reviews. Immunology

    2017  Volume 17, Issue 6, Page(s) 349–362

    Abstract: Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the ... ...

    Abstract Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes of tissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues. In addition, we consider the emerging roles for monocytes in adaptive immunity as antigen-presenting cells.
    MeSH term(s) Adaptive Immunity ; Animals ; Antigen Presentation ; Cell Differentiation ; Dendritic Cells/immunology ; Humans ; Immunity, Innate ; Macrophages/cytology ; Macrophages/immunology ; Monocytes/cytology
    Language English
    Publishing date 2017-04-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.28
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  9. Article ; Online: Conceptual approaches to lung injury and repair.

    Zemans, Rachel L / Henson, Peter M / Henson, Jan E / Janssen, William J

    Annals of the American Thoracic Society

    2015  Volume 12 Suppl 1, Page(s) S9–15

    Abstract: Lung injury and repair is a broad topic that includes many cell types and is relevant to the pathogenesis of most lung diseases. Here, we focus on injury and repair of the alveolus, the principal function of which is to achieve gas exchange. The many ... ...

    Abstract Lung injury and repair is a broad topic that includes many cell types and is relevant to the pathogenesis of most lung diseases. Here, we focus on injury and repair of the alveolus, the principal function of which is to achieve gas exchange. The many cell types and structures present in the alveolus are discussed, with emphasis on their interactions in both health and disease. We define injury as damage resulting in impaired gas exchange; physiologic repair, then, requires restoration of normal alveolar architecture and function. The role of inflammation in both injury and repair of structural alveolar cells, particularly epithelial cells, as well as mechanisms of resolution of inflammation will be addressed. Finally, emphasis is placed on the importance of addressing quantitatively the dynamic and complex multidirectional interactions between the many alveolar cell types and structures in three dimensions over time and in relating such mechanistic studies to physiologic outcomes and human disease.
    MeSH term(s) Epithelial Cells/cytology ; Humans ; Lung Injury/therapy ; Pulmonary Alveoli/physiopathology ; Pulmonary Fibrosis/physiopathology
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201408-402MG
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  10. Article ; Online: Antiinflammatory effects of apoptotic cells.

    Henson, Peter M / Bratton, Donna L

    The Journal of clinical investigation

    2013  Volume 123, Issue 7, Page(s) 2773–2774

    Abstract: ... in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna ...

    Abstract Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.
    MeSH term(s) Animals ; Apoptosis ; Cell Membrane/immunology ; Cell Membrane/metabolism ; Dinoprostone/metabolism ; Humans ; Inflammation Mediators/metabolism ; Macrophages/physiology ; Phagocytosis ; Phosphatidylserines/immunology ; Phosphatidylserines/metabolism ; Receptors, Cell Surface/physiology ; Transforming Growth Factor beta/metabolism
    Chemical Substances Inflammation Mediators ; Phosphatidylserines ; Receptors, Cell Surface ; Transforming Growth Factor beta ; phosphatidylserine receptor ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2013-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI69344
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