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  1. Book ; Online: Muscle Homeostasis and Regeneration : From Molecular Mechanisms to Therapeutic Opportunities

    Musarò, Antonio / Musarò, Antonio

    2020  

    Keywords Research & information: general ; Biology, life sciences ; lysine ; mTORC1 ; satellite cells ; proliferation ; skeletal muscle growth ; muscle satellite cell ; transthyretin ; thyroid hormone ; myogenesis ; exosomes ; skeletal muscle ; genotype ; genetic variation ; muscle phenotypes ; sarcopenia ; aging ; calcium homeostasis ; hibernation ; mitochondria ; sarcoplasmic reticulum ; Acvr1b ; Tgfbr1 ; myostatin ; Col1a1 ; fibrosis ; atrophy ; IGF2R ; muscle homeostasis ; inflammation ; muscular dystrophy ; pericytes ; macrophages ; Nfix ; phagocytosis ; RhoA-ROCK1 ; splicing isoforms ; CRISPR-Cas9 ; exon deletion ; NF-Y ; muscle differentiation ; C2C12 cells ; denervation ; neuromuscular junction ; heavy resistance exercise ; acetylcholine receptor ; cell culture ; neonatal myosin ; neural cell adhesion molecule ; biomarkers ; mitophagy ; mitochondrial dynamics ; mitochondrial quality control ; mitochondrial-derived vesicles (MDVs) ; mitochondrial-lysosomal axis ; Hibernation ; electron microscopy ; immunocytochemistry ; α-smooth muscle actin ; confocal microscopy ; connexin 43 ; connexin 26 ; gap junctions ; myofibroblasts ; Platelet-Rich Plasma ; transforming growth factor (TGF)-β1 ; muscle regeneration ; inflammatory response ; cell precursors ; experimental methods ; stem cell markers ; muscles ; heterotopic ossification ; skeletal muscle stem and progenitor cells ; HO precursors ; muscle atrophy ; septicemia ; mitochondrial fusion ; mitochondrial fission ; iPSC ; extracellular vesicles ; Drosophila ; muscle ; genetic control ; muscle diversification ; fascicle ; myofiber ; myofibril ; sarcomere ; hypertrophy ; hyperplasia ; splitting ; radial growth ; longitudinal growth ; exercise ; muscle stem cells ; stem cells niche ; neuromuscular disorders ; Duchenne muscular dystrophy ; pharmacological approach ; single-cell ; mass cytometry ; skeletal muscle regeneration ; skeletal muscle homeostasis ; fibro/adipogenic progenitors ; myogenic progenitors ; muscle populations ; evolution ; metazoans ; differentiation ; transdifferentiation ; muscle precursors ; regenerative medicine ; stem cells ; FAPs ; tissue niche ; growth factors ; muscle pathology
    Size 1 electronic resource (500 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046951
    ISBN 9783039434374 ; 3039434373
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities.

    Musarò, Antonio

    Cells

    2020  Volume 9, Issue 9

    Abstract: The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the ... ...

    Abstract The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit the damaged tissues from efficiently activating a regenerative program. It is, therefore, plausible that the loss of control over these cells' fate might lead to pathological cell differentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. This Special Issue aims to bring together a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration and to suggest potential therapeutic approaches for degenerating muscle disease.
    MeSH term(s) Cell Differentiation ; Homeostasis ; Humans ; Muscle, Skeletal/physiology ; Regeneration/physiology
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9092033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rejuvenating muscle stem cells with the glutathione system.

    Forcina, Laura / Musarò, Antonio

    Cell metabolism

    2023  Volume 35, Issue 3, Page(s) 379–381

    Abstract: Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell ( ... ...

    Abstract Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle.
    MeSH term(s) Muscle, Skeletal/metabolism ; Stem Cells/metabolism ; Glutathione/metabolism
    Chemical Substances Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Muscle Homeostasis and Regeneration

    Antonio Musarò

    Cells, Vol 9, Iss 2033, p

    From Molecular Mechanisms to Therapeutic Opportunities

    2020  Volume 2033

    Abstract: The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the ... ...

    Abstract The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit the damaged tissues from efficiently activating a regenerative program. It is, therefore, plausible that the loss of control over these cells’ fate might lead to pathological cell differentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. This Special Issue aims to bring together a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration and to suggest potential therapeutic approaches for degenerating muscle disease.
    Keywords muscle homeostasis ; muscle regeneration ; satellite cells ; stem cells ; FAPs ; tissue niche ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The hormetic and hermetic role of IL-6.

    Forcina, Laura / Franceschi, Claudio / Musarò, Antonio

    Ageing research reviews

    2022  Volume 80, Page(s) 101697

    Abstract: Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been highlighted in several contexts and can be explained by the concept of ...

    Abstract Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been highlighted in several contexts and can be explained by the concept of hormesis, in which beneficial or toxic effects can be induced by the same molecule depending on the intensity, persistence, and nature of the stimulation. According with hormesis, a low and/or controlled IL-6 release is associated with anti-inflammatory, antioxidant, and pro-myogenic actions, whereas increased systemic levels of IL-6 can induce pro-inflammatory, pro-oxidant and pro-fibrotic responses. However, many aspects regarding the multifaceted action of IL-6 and the complex nature of its signal transduction remains to be fully elucidated. In this review we collect mechanistic insight into the molecular networks contributing to normal or pathologic changes during advancing age and in chronic diseases. We point out the involvement of IL-6 deregulation in aging-related diseases, dissecting the hormetic action of this key mediator in different tissues, with a special focus on skeletal muscle. Since IL-6 can act as an enhancer of detrimental factor associated with both aging and pathologic conditions, such as chronic inflammation and oxidative stress, this cytokine could represent a "Gerokine", a determinant of the switch from physiologic aging to age-related diseases.
    MeSH term(s) Aging/physiology ; Dose-Response Relationship, Immunologic ; Gene Expression Regulation ; Humans ; Inflammation/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Oxidative Stress ; Signal Transduction
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2022.101697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
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  6. Article: 16th Meeting of the Interuniversity Institute of Myology (IIM) - Assisi (Italy), October 17-20, 2019: Foreword, Program and Abstracts.

    Gabellini, Davide / Musarò, Antonio

    European journal of translational myology

    2020  Volume 30, Issue 3, Page(s) 9345

    Abstract: The 16th Meeting of the Interuniversity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy brought together scientists, pharma and patient organization representatives discussing new results on muscle research. Internationally renowned ... ...

    Abstract The 16th Meeting of the Interuniversity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy brought together scientists, pharma and patient organization representatives discussing new results on muscle research. Internationally renowned Keynote speakers presented advances on muscle development, homeostasis, metabolism, and disease. Speakers selected among submitted abstracts presented their new, unpublished data in seven scientific sessions. The remaining abstracts were showcased in two poster sessions. Young trainees where directly involved in the selection of keynote speakers, the organizing scientific sessions and roundtables discussions tailored to the interests of their peers. A broad Italian, European and North-American audience participated to the different initiatives. The meeting allowed muscle biology researchers to discuss ideas and scientific collaborations aimed at better understanding the mechanisms underlying muscle diseases in order to develop better therapeutic strategies. The active participation of young trainees was facilitated by the friendly and inclusive atmosphere, which fostered lively discussions identifying emerging areas of myology research and stimulated scientific cross-fertilization. The meeting was a success and the IIM community will continue to bring forward significant contributions to the understanding of muscle development and function, the pathogenesis of muscular diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting illustrating novel results of basic, translational, and clinical research, which confirms that the Myology field is strong and healthy.
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2545577-1
    ISSN 2037-7460 ; 2037-7452
    ISSN (online) 2037-7460
    ISSN 2037-7452
    DOI 10.4081/ejtm.2020.9345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Counteracting sarcopenia: the role of IGF-1 isoforms.

    Musarò, Antonio / Scicchitano, Bianca Maria

    Aging

    2019  Volume 11, Issue 11, Page(s) 3410–3411

    MeSH term(s) Aging/metabolism ; Aging/pathology ; Animals ; Humans ; Insulin-Like Growth Factor I/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Protein Isoforms/metabolism ; Sarcopenia/metabolism ; Sarcopenia/pathology
    Chemical Substances Protein Isoforms ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2019-06-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients.

    Musarò, Antonio / Dobrowolny, Gabriella / Cambieri, Chiara / Libonati, Laura / Moret, Federica / Casola, Irene / Laurenzi, Gaia / Garibaldi, Matteo / Inghilleri, Maurizio / Ceccanti, Marco

    Neuromolecular medicine

    2024  Volume 26, Issue 1, Page(s) 5

    Abstract: Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several efforts to develop efficient biomarkers, many concerns about the available ones still need to be addressed. MicroRNA (miR) are non-coding ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several efforts to develop efficient biomarkers, many concerns about the available ones still need to be addressed. MicroRNA (miR) are non-coding RNAs that can modulate molecular circuits and are involved in ALS pathogenic mechanisms. 22 fast and 23 slow-progressing-defined ALS patients were recruited. ALSFRS-R, strength, respiratory function, nerve conduction studies, and creatine kinase were evaluated at the baseline and after 6 months of follow-up. The mean monthly reduction of the previous variables (progression index - PI) was calculated. MiR206, 133a-3p, 151a-5p, 199a-5p, and 423-3p were dosed. The univariate analysis showed an independent reduction of miR206 and an increase of miR423-3p in patients with a slow slope of ALSFRS-R and weakness, respectively. MiR206 and 423-3p are differently modulated in fast and slow-progressing ALS patients, suggesting a role for microRNAs in prognosis and therapeutic target.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/genetics ; Disease Progression ; MicroRNAs/genetics ; Research Design ; Biomarkers
    Chemical Substances MicroRNAs ; Biomarkers ; MIRN206 microRNA, human
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2077809-0
    ISSN 1559-1174 ; 1535-1084
    ISSN (online) 1559-1174
    ISSN 1535-1084
    DOI 10.1007/s12017-024-08773-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5818: Show issues Location:
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  9. Article: Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis.

    Mazzaro, Antonio / Vita, Veronica / Ronfini, Marco / Casola, Irene / Klein, Arianna / Dobrowolny, Gabriella / Sorarù, Gianni / Musarò, Antonio / Mongillo, Marco / Zaglia, Tania

    Frontiers in physiology

    2023  Volume 14, Page(s) 1165811

    Abstract: Rationale: ...

    Abstract Rationale:
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1165811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Understanding ALS: new therapeutic approaches.

    Musarò, Antonio

    The FEBS journal

    2013  Volume 280, Issue 17, Page(s) 4315–4322

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological mechanisms have been elucidated, ALS remains an invariably fatal disease in ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological mechanisms have been elucidated, ALS remains an invariably fatal disease in the absence of any effective therapy. The heterogeneity of the disease and the failure to develop satisfactory therapeutic protocols reinforce the view that ALS is a multi-factorial and multi-systemic disease. Thus, a better understanding of the pathogenic mechanisms and study of the potential pathological relationship between the various cellular processes is required to ensure efficacious therapy. The pathogenic mechanisms associated with ALS are reviewed, and the strengths and limitations of some new therapeutic approaches are discussed.
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/immunology ; Amyotrophic Lateral Sclerosis/therapy ; Animals ; Antibodies, Monoclonal/therapeutic use ; Exercise Therapy ; Genetic Therapy ; Humans
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.12087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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