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  1. Article ; Online: Beta-blocking patients with cardiac amyloidosis: Adelante cum juicio.

    Emdin, Michele / Aimo, Alberto / Vergaro, Giuseppe / Castiglione, Vincenzo

    International journal of cardiology

    2024  , Page(s) 132039

    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cost-effectiveness of transthyretin cardiac amyloidosis screening and treatment: A Dilemma for the clinician.

    Castiglione, Vincenzo / Aimo, Alberto / Vergaro, Giuseppe

    International journal of cardiology

    2024  Volume 402, Page(s) 131855

    MeSH term(s) Humans ; Prealbumin ; Cost-Benefit Analysis ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/therapy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy
    Chemical Substances Prealbumin
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.131855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cachexia, sarcopenia and heart failure: A last mile to be walked.

    Castiglione, Vincenzo / Gentile, Francesco / Vergaro, Giuseppe

    International journal of cardiology

    2023  Volume 388, Page(s) 131131

    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Cachexia/diagnosis ; Cachexia/epidemiology ; Heart Failure/complications ; Heart Failure/diagnosis ; Muscle, Skeletal ; Walking
    Language English
    Publishing date 2023-06-24
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cardiac Richter's syndrome: a rare case of chronic lymphocytic leukaemia transformation.

    Guarnieri, Eleonora / Castiglione, Vincenzo / De Caterina, Raffaele

    European heart journal

    2023  Volume 44, Issue 20, Page(s) 1842

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Lymphoma, Large B-Cell, Diffuse
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Trattamento della fibrosi cardiaca: dagli antagonisti neuro-ormonali alle cellule CAR-T.

    Morfino, Paolo / Aimo, Alberto / Castiglione, Vincenzo / Emdin, Michele

    Giornale italiano di cardiologia (2006)

    2023  Volume 24, Issue 7, Page(s) 508–520

    Abstract: Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the spaces between cardiomyocytes following both acute and chronic tissue damage events, resulting in the remodeling and stiffening of heart tissue. Fibrosis plays an ...

    Title translation Treatment of cardiac fibrosis: from neurohormonal antagonists to CAR-T cells.
    Abstract Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the spaces between cardiomyocytes following both acute and chronic tissue damage events, resulting in the remodeling and stiffening of heart tissue. Fibrosis plays an important role in the pathogenesis of many cardiovascular disorders, including heart failure and myocardial infarction. Several studies have identified fibroblasts, which are induced to differentiate into myofibroblasts in response to various types of damage, as one of the most important cell types involved in the fibrotic process. There are currently no drugs with primarily antifibrotic action approved for clinical use, as the evidence of a clinical efficacy of these drugs is extremely limited, despite the numerous encouraging results from experimental studies. A new approach is represented by the use of chimeric antigen receptor T cells engineered in vivo using lipid nanoparticles containing mRNA encoding a receptor directed against the fibroblast activation protein, expressed by activated cardiac fibroblasts. This strategy has proved to be safe and effective in reducing myocardial fibrosis and improving cardiac function in mouse models of cardiac fibrosis. Clinical studies are required to test this novel approach in humans.
    MeSH term(s) Humans ; Animals ; Mice ; Heart Failure/therapy ; Myocardial Infarction ; Disease Models, Animal ; Myocytes, Cardiac ; T-Lymphocytes
    Language Italian
    Publishing date 2023-07-03
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/4060.40430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Case Report: Role of numerical simulations in the management of acute aortic syndromes.

    Rizza, Antonio / Castiglione, Vincenzo / Capellini, Katia / Palmieri, Cataldo / Gasparotti, Emanuele / Berti, Sergio / Celi, Simona

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1309840

    Abstract: Penetrating aortic ulcer (PAU) represents a subset of acute aortic syndromes characterized by high rupture risk and management challenges, particularly in elderly patients with significant comorbidities. This case report showcases a 75-year-old patient ... ...

    Abstract Penetrating aortic ulcer (PAU) represents a subset of acute aortic syndromes characterized by high rupture risk and management challenges, particularly in elderly patients with significant comorbidities. This case report showcases a 75-year-old patient with a history of coronary artery bypass graft (CABG) and with multiple PAUs involving the aortic arch, deemed unfit for conventional open surgery. A branched aortic endograft with a pre-cannulated side component for the left subclavian artery (LSA) was employed to preserve the patency of the previous CABG. Two computational fluid dynamics (CFD) simulations and a morphological analysis were performed on the pre- and post-intervention aortic configurations to evaluate changes in flow rate and pressure drop at LSA level and differences in the lumen size. The results revealed a decrease in the flow rate equal to 2.38% after the intervention and an increase in pressure drop of 4.48 mmHg, while the maximum differences in LSA cross-sectional areas and diameters were 1.49 cm
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1309840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Targeting precipitants to prevent heart failure hospitalization. Does season matter?

    Castiglione, Vincenzo / Vergaro, Giuseppe / Emdin, Michele

    International journal of cardiology

    2022  Volume 358, Page(s) 74–75

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/prevention & control ; Hospitalization ; Humans ; Seasons
    Language English
    Publishing date 2022-04-17
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.04.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Do we need to EVALUATE multiple biomarkers and/or the same biomarkers multiple times in patients with heart failure?

    Aimo, Alberto / Castiglione, Vincenzo / Bayes-Genis, Antoni

    European journal of heart failure

    2022  Volume 24, Issue 7, Page(s) 1209–1211

    MeSH term(s) Biomarkers ; Heart Failure/diagnosis ; Humans ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stroke in ATTR cardiac amyloidosis: Does only rhythm matter?

    Vergaro, Giuseppe / Aimo, Alberto / Castiglione, Vincenzo / Emdin, Michele

    International journal of cardiology

    2022  Volume 363, Page(s) 127–128

    MeSH term(s) Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/diagnostic imaging ; Cardiomyopathies/diagnostic imaging ; Humans ; Prealbumin ; Stroke/diagnostic imaging ; Stroke/etiology
    Chemical Substances Prealbumin
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.06.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Is targeting cyclic guanosine monophosphate by vericiguat effective to treat ischaemic heart failure with reduced ejection fraction? Yes, it is.

    Emdin, Michele / Aimo, Alberto / Castiglione, Vincenzo

    European journal of heart failure

    2022  Volume 24, Issue 5, Page(s) 791–793

    MeSH term(s) Cyclic GMP ; Guanosine Monophosphate ; Heart Failure/drug therapy ; Heterocyclic Compounds, 2-Ring ; Humans ; Pyrimidines ; Stroke Volume ; Ventricular Dysfunction, Left
    Chemical Substances Heterocyclic Compounds, 2-Ring ; Pyrimidines ; Guanosine Monophosphate (85-32-5) ; Cyclic GMP (H2D2X058MU) ; vericiguat (LV66ADM269)
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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