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Book: Sample size calculations for clustered and longitudinal outcomes in clinical research

Ahn, Chul / Heo, Moonseong / Zhang, Song

(Chapman & Hall CRC biostatistics series ; A Chapman & Hall Book)

2015

Author's details	Chul Ahn ; Moonseong Heo ; Song Zhang
Series title	Chapman & Hall CRC biostatistics series A Chapman & Hall Book
Language	English
Size	XV, 244 S. : Ill., graph. Darst.
Publisher	CRC Press
Publishing place	Boca Raton u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT018412962
ISBN	978-1-4665-5626-3 ; 1-4665-5626-9
Database	Catalogue ZB MED Medicine, Health

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2015 A 607	available for loan (reading room)	Lesesaal EG

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Article: Exploratory Assessment of Galectin-1, -3, and -9 in Non-Small Cell Lung Cancer.

Shuster, Hayden / Funkhouser, Avery / Allen, Lorie / Heo, Moonseong / Martin, Julie C / Edenfield, W Jeffery / Blenda, Anna V

Cancers

2024 Volume 16, Issue 6

Abstract: Galectins play a pivotal role in lung cancer oncogenic pathways, influencing apoptosis, angiogenesis, and tumor metastasis. Biomarkers that diagnose, prognose, and guide cancer treatment are crucial, with galectins having the biomarker potential for non- ... ...

Abstract	Galectins play a pivotal role in lung cancer oncogenic pathways, influencing apoptosis, angiogenesis, and tumor metastasis. Biomarkers that diagnose, prognose, and guide cancer treatment are crucial, with galectins having the biomarker potential for non-small cell lung cancer (NSCLC). Using enzyme-linked immunosorbent assay (ELISA), we assessed serum galectin-1, -3, and -9 levels in NSCLC patients. A retrospective chart review was performed to examine patient demographics, cancer stage, tumor biology, cancer treatment, and patient outcomes. Galectin levels were then compared across these factors. In this exploratory analysis, galectin-3 levels were significantly lower in patients with squamous cell lung cancer (
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061165
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Being obese versus trying to lose weight: Relationship with physical inactivity and soda drinking among high school students.

Heo, Moonseong / Wylie-Rosett, Judith

The Journal of school health

2020 Volume 90, Issue 4, Page(s) 301–305

Abstract: Background: Among adolescents, physical inactivity and unhealthy dietary habits are associated with being obese. We know little about how those are associated with trying to lose weight.: Methods: We analyzed the 2013 Centers for Disease Control and ... ...

Abstract	Background: Among adolescents, physical inactivity and unhealthy dietary habits are associated with being obese. We know little about how those are associated with trying to lose weight. Methods: We analyzed the 2013 Centers for Disease Control and Prevention (CDC) Youth Risk Behavior Surveillance data (N = 13,583) to examine how obesity and trying to lose weight are associated with: (1) <5 physically active days per week with ≥60 minutes physical activity; (2) playing with video computer games ≥3 hours per day on average; (3) no participation in any sports team in the past year; and (4) drinking soda ≥2 times per day. We applied survey logistic regression adjusting for age and Hispanic ethnicity, stratified by sex. Results: Both being obese (13.7%) and trying to lose weight (47.7%) are significantly associated with physical inactivity. Soda drinking was associated with being obese (odds ratio [OR] = 1.34, p = .003 for boys and OR = 1.36, p = .014 for girls); it was inversely associated trying to lose weight among girls (OR = 0.72, p < .001) but not among boys (OR = 1.13, p = .174). Conclusion: Obesity was associated with physical inactivity and drinking soda in both sexes. Only girls appeared to avoid drinking soda as a strategy for losing weight. Trying to lose weight was associated with a higher likelihood of physically inactive behaviors both sexes. High schools need to develop collaborative strategies for reducing adolescent obesity and supporting students who are trying to lose weight that address physical inactivity and soda intake.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Behavioral Risk Factor Surveillance System ; Carbonated Beverages/statistics & numerical data ; Female ; Health Behavior ; Humans ; Male ; Pediatric Obesity/psychology ; Sedentary Behavior ; Sex Distribution ; Students ; United States ; Weight Loss
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	952835-0
ISSN	1746-1561 ; 0022-4391
ISSN (online)	1746-1561
ISSN	0022-4391
DOI	10.1111/josh.12879
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Digital quantification of the MMSE interlocking pentagon areas: a three-stage algorithm.

Kim, Namhee / Truty, Timothy / Duke Han, S / Heo, Moonseong / Buchman, Aron S / Bennett, David A / Tasaki, Shinya

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9038

Abstract: The Mini-Mental State Examination (MMSE) is a widely employed screening tool for the severity of cognitive impairment. Among the MMSE items, the pentagon copying test (PCT) requires participants to accurately replicate a sample of two interlocking ... ...

Abstract	The Mini-Mental State Examination (MMSE) is a widely employed screening tool for the severity of cognitive impairment. Among the MMSE items, the pentagon copying test (PCT) requires participants to accurately replicate a sample of two interlocking pentagons. While the PCT is traditionally scored on a binary scale, there have been limited developments of granular scoring scale to assess task performance. In this paper, we present a novel three-stage algorithm, called Quantification of Interlocking Pentagons (QIP) which quantifies PCT performance by computing the areas of individual pentagons and their intersection areas, and a balance ratio between the areas of the two individual pentagons. The three stages of the QIP algorithm include: (1) detection of line segments, (2) unraveling of the interlocking pentagons, and (3) quantification of areas. A set of 497 PCTs from 84 participants including their baseline and follow-up PCTs from the Rush Memory and Aging Project was selected blinded about their cognitive and clinical status. Analysis of the quantified data revealed a significant inverse relationship between age and balance ratio (beta = - 0.49, p = 0.0033), indicating that older age was associated with a smaller balance ratio. In addition, balance ratio was associated with perceptual speed (r = 0.71, p = 0.0135), vascular risk factors (beta = - 3.96, p = 0.0269), and medical conditions (beta = - 2.78, p = 0.0389). The QIP algorithm can serve as a useful tool for enhancing the scoring of performance in the PCT.
MeSH term(s)	Humans ; Neuropsychological Tests ; Mental Status and Dementia Tests ; Cognitive Dysfunction/diagnosis
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59194-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comment on Marsigliante et al. Effects on Children's Physical and Mental Well-Being of a Physical-Activity-Based School Intervention Program: A Randomized Study.

Murden, Raphiel / Agley, Jon / Golzarri-Arroyo, Lilian / Peña, Armando / Valdez, Danny / Siddique, Abu Bakkar / Heo, Moonseong / Allison, David B

International journal of environmental research and public health

2023 Volume 20, Issue 23

Abstract: We conducted a critical review of the article "Effects on Children's Physical and Mental Well-Being of a Physical-Activity-Based School Intervention Program: A Randomized Study", published in ... ...

Abstract	We conducted a critical review of the article "Effects on Children's Physical and Mental Well-Being of a Physical-Activity-Based School Intervention Program: A Randomized Study", published in the
MeSH term(s)	Child ; Humans ; Public Health ; Exercise ; Body Mass Index ; Schools
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20237131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of subject attrition on sample size determinations for longitudinal cluster randomized clinical trials.

Heo, Moonseong

Journal of biopharmaceutical statistics

2014 Volume 24, Issue 3, Page(s) 507–522

Abstract: Subject attrition is a ubiquitous problem in any type of clinical trial and, thus, needs to be taken into consideration at the design stage particularly to secure adequate statistical power. Here, we focus on longitudinal cluster randomized clinical ... ...

Abstract	Subject attrition is a ubiquitous problem in any type of clinical trial and, thus, needs to be taken into consideration at the design stage particularly to secure adequate statistical power. Here, we focus on longitudinal cluster randomized clinical trials (cluster-RCT) that aim to test the hypothesis that an intervention has an effect on the rate of change in the outcome over time. In this setting, the cluster-RCT assumes a three-level hierarchical data structure in which subjects are nested within a higher level unit such as clinics and are evaluated for outcome repeatedly over the study period. Furthermore, the subject-specific slopes can be modeled in terms of fixed or random coefficients in a mixed-effects linear model. Closed-form sample size formulas for testing the preceding hypothesis have been developed under an assumption of no attrition. In this article, we propose closed-form approximate samples size determinations with anticipated attrition rates by modifying those existing sample size formulas. With extensive simulations, we examine performances of the modified formulas under three attrition mechanisms: attrition completely at random, attrition at random, and attrition not at random. In conclusion, the proposed modification is very effective under fixed-slope models but yields biased, perhaps substantially so, statistical power under random slope models.
MeSH term(s)	Cluster Analysis ; Computer Simulation ; Humans ; Longitudinal Studies ; Models, Statistical ; Patient Dropouts/statistics & numerical data ; Randomized Controlled Trials as Topic/statistics & numerical data ; Sample Size ; Time Factors
Language	English
Publishing date	2014-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1131763-2
ISSN	1520-5711 ; 1054-3406
ISSN (online)	1520-5711
ISSN	1054-3406
DOI	10.1080/10543406.2014.888442
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Accounting for Confounding by Time, Early Intervention Adoption, and Time-Varying Effect Modification in the Design and Analysis of Stepped-Wedge Designs: Application to a Proposed Study Design to Reduce Opioid-Related Mortality.

Rennert, Lior / Heo, Moonseong / Litwin, Alain H / De Gruttola, Victor

Research square

2020

Abstract: Background: ...

Abstract	Background:
Keywords	covid19
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-103992/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of Transitional Care Program among High-Risk Discharged Patients: A Quasi-Experimental Study on Saving Costs, Post-Discharge Readmissions and Emergency Department Visits.

Heo, Moonseong / Taaffe, Kevin / Ghadshi, Ankita / Teague, Leigh D / Watts, Jeffrey / Lopes, Snehal S / Tilkemeier, Peter / Litwin, Alain H

International journal of environmental research and public health

2023 Volume 20, Issue 23

Abstract: Transitional care programs (TCPs), where hospital care team members repeatedly follow up with discharged patients, aim to reduce post-discharge hospital or emergency department (ED) utilization and healthcare costs. We examined the effectiveness of TCPs ... ...

Abstract	Transitional care programs (TCPs), where hospital care team members repeatedly follow up with discharged patients, aim to reduce post-discharge hospital or emergency department (ED) utilization and healthcare costs. We examined the effectiveness of TCPs at reducing healthcare costs, hospital readmissions, and ED visits. Centers for Medicare and Medicaid Services Bundled Payments for Care Improvement (BPCI) program adjudicated claims files and electronic health records from Greenville Memorial Hospital, Greenville, SC, were accessed. Data on post-discharge 30- and 90-day ED visits and readmissions, total costs, and episodes with costs over BPCI target prices were extracted from November 2017 to July 2020 and compared between the "TCP-Graduates" (N = 85) and "Did Not Graduate" (DNG) (N = 1310) groups. As compared to the DNG group, the TCP-Graduates group had significantly fewer 30-day (7.1% vs. 14.9%,
MeSH term(s)	Humans ; Aged ; United States ; Patient Readmission ; Transitional Care ; Aftercare ; Medicare ; Patient Discharge ; Emergency Service, Hospital
Language	English
Publishing date	2023-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20237136
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Longitudinal Interleaved Residency Training: A Consensus Definition.

Zeller, T Aaron / Beben, Katherine / Kong, Marianna / Martonffy, Ildi / Patterson, Seth / Deas, Weldon / Heo, Moonseong / Keister, Drew M

Family medicine

2023 Volume 55, Issue 5, Page(s) 311–316

Abstract: Background and objectives: Cognitive benefits of longitudinal curricula and interleaving have been demonstrated in several disciplines. However, most residency curricula are structured in a block format. There is no consensus definition as to what ... ...

Abstract	Background and objectives: Cognitive benefits of longitudinal curricula and interleaving have been demonstrated in several disciplines. However, most residency curricula are structured in a block format. There is no consensus definition as to what constitutes a longitudinal program, making comparative research on curricular efficacy a challenge. The objective of our study was to arrive at a consensus definition of Longitudinal Interleaved Residency Training (LIRT) in family medicine. Methods: A national workgroup was convened and utilized a Delphi method between October 2021 and March 2022 to arrive at a consensus definition. Results: Twenty-four invitations were sent, and 18 participants initially accepted. The final workgroup (n=13) was representative of the nationwide diversity of family medicine residency programs in terms of geographic location (P=.977) and population density (P=.123). The following definition was approved: "LIRT is a curricular design and program structure that offers graduated, concurrent clinical experiences in the core competencies of the specialty. LIRT models the comprehensive scope of practice and continuity that defines the specialty; applies training methods that enhance long-term retention of knowledge, skills, and attitudes across all dimensions and locations of care delivery; and accomplishes program objectives through employment of longitudinal curricular scheduling and interleaving with spaced repetition." Additional technical criteria and definitions of terms are elucidated in the body of this article. Conclusions: A representative national workgroup crafted a consensus definition of Longitudinal Interleaved Residency Training (LIRT) in family medicine, a program structure with a basis in emerging evidence-based cognitive science.
MeSH term(s)	Humans ; Internship and Residency ; Curriculum ; Consensus ; Employment ; Family Practice
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639374-3
ISSN	1938-3800 ; 0742-3225
ISSN (online)	1938-3800
ISSN	0742-3225
DOI	10.22454/FamMed.2023.378423
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2327: Show issues

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Article ; Online: A Prospective, Randomized Comparison of Lower Eyelid Retraction Repair With Autologous Auricular Cartilage, Bovine Acellular Dermal Matrix (Surgimend), and Porcine Acellular Dermal Matrix (Enduragen) Spacer Grafts.

Barmettler, Anne / Heo, Moonseong

Ophthalmic plastic and reconstructive surgery

2018 Volume 34, Issue 3, Page(s) 266–273

Abstract: Purpose: To compare outcomes of lower eyelid retraction repair with 3 types of spacer grafts: autologous auricular cartilage, bovine acellular dermal matrix (Surgimend, Integra, Plainsboro, NJ), porcine acellular dermal matrix (Enduragen, Stryker, ... ...

Abstract	Purpose: To compare outcomes of lower eyelid retraction repair with 3 types of spacer grafts: autologous auricular cartilage, bovine acellular dermal matrix (Surgimend, Integra, Plainsboro, NJ), porcine acellular dermal matrix (Enduragen, Stryker, Kalamazoo, MI). Methods: A prospective, randomized clinical trial was conducted in patients undergoing lower eyelid retraction repair with spacer graft. Subjects received autologous auricular cartilage, bovine acellular dermal matrix, or porcine acellular dermal matrix between June 2015 and July 2016. Patient demographics, margin to reflex distance 2, conjunctival injection, eyelid swelling, tearing, discomfort, itching, and complications were recorded preoperatively and at postoperative week 1, month 1, month 3, and month 6. Results: Of the 49 randomized lower eyelids (39 patients), 42 eyelids (32 patients) completed the study. The preoperative margin to reflex distance 2, conjunctival injection, eyelid swelling, tearing, discomfort, and itching showed no statistical difference. Postoperative week 1 swelling was statistically significantly higher in auricular cartilage, followed by bovine acellular dermal matrix, then porcine acellular dermal matrix (p = 0.04). The mean postoperative month 6 margin to reflex distance 2 trended toward a better outcome from auricular cartilage over bovine acellular dermal matrix (p = 0.029), but after p was adjusted for multiple pairwise comparisons, this was no longer statistically significant (p = 0.088). All other postoperative 6-month measurements showed no statistical difference. Conclusions: Among patients randomized to 3 types of spacer grafts for lower eyelid retraction repair, outcomes were not statistically significant different when the 3 groups were compared.
MeSH term(s)	Acellular Dermis ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cattle ; Collagen/therapeutic use ; Ear Cartilage/transplantation ; Eyelid Diseases/surgery ; Eyelids/surgery ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Skin Transplantation/methods ; Swine ; Transplantation, Heterologous ; Young Adult
Chemical Substances	Surgimend ; Collagen (9007-34-5)
Language	English
Publishing date	2018-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000000946
Database	MEDical Literature Analysis and Retrieval System OnLINE

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