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  1. Article ; Online: Treg Therapy for the Induction of Immune Tolerance in Transplantation—Not Lost in Translation?

    Nina Pilat / Romy Steiner / Jonathan Sprent

    International Journal of Molecular Sciences, Vol 24, Iss 1752, p

    2023  Volume 1752

    Abstract: The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment ... ...

    Abstract The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.
    Keywords transplantation ; regulatory T cells ; tolerance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Article: Statistics in medical research.

    Sprent, P

    Swiss medical weekly

    2003  Volume 133, Issue 39-40, Page(s) 522–529

    Abstract: ... quantities such as P-values, confidence intervals, standard deviations, standard errors or application ...

    Abstract The role of statistics in medical research starts at the planning stage of a clinical trial or laboratory experiment to establish the design and size of an experiment that will ensure a good prospect of detecting effects of clinical or scientific interest. Statistics is again used during the analysis of data (sample data) to make inferences valid in a wider population. In simple situations computation of simple quantities such as P-values, confidence intervals, standard deviations, standard errors or application of some standard parametric or nonparametric tests may suffice. Despite their wide use even these simple notions are sometimes misunderstood or misinterpreted by research workers in other disciplines who have only a limited knowledge of statistics. More sophisticated research projects often need advanced statistical methods including the formulation and testing of mathematical models to make relevant inferences from observed data. Such advanced methods should only be applied with a clear understanding both of their purposes and the implication of any conclusions based upon their use. Close collaboration between statisticians, whether professionals in that field or medical research workers with a sound statistical background, and other members of a research team is needed to ensure a seamless integration of the statistical elements into the reporting and discussion of research outcomes. Some suggestions are made as to how that collaboration is best achieved.
    MeSH term(s) Biomedical Research/statistics & numerical data ; Clinical Trials as Topic/statistics & numerical data ; Cooperative Behavior ; Data Interpretation, Statistical ; Humans ; Reproducibility of Results ; Research Design/statistics & numerical data ; Statistics as Topic/education ; Workforce
    Language English
    Publishing date 2003-10-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2003.10470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.152: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Functional Synthetic Biology.

    Aldulijan, Ibrahim / Beal, Jacob / Billerbeck, Sonja / Bouffard, Jeff / Chambonnier, Gaël / Ntelkis, Nikolaos / Guerreiro, Isaac / Holub, Martin / Ross, Paul / Selvarajah, Vinoo / Sprent, Noah / Vidal, Gonzalo / Vignoni, Alejandro

    Synthetic biology (Oxford, England)

    2023  Volume 8, Issue 1, Page(s) ysad006

    Abstract: Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current ... ...

    Abstract Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.
    Language English
    Publishing date 2023-04-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-7000
    ISSN (online) 2397-7000
    DOI 10.1093/synbio/ysad006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Statistics in medical research

    Sprent, P.

    Swiss medical weekly

    2003  Volume 133, Issue 39/40, Page(s) 522

    Language German
    Document type Article
    ZDB-ID 2036179-8
    ISSN 1424-7860
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online: Getting into Print

    Sprent, Prof P / Sprent, P

    A guide for scientists and technologists

    2002  

    Abstract: This is a practical and comprehensive guide to all aspects of writing about science and technology, including both `how to write' and the practical and commercial aspects of publishing as they affect an author. Special features of technical writing are ... ...

    Abstract This is a practical and comprehensive guide to all aspects of writing about science and technology, including both `how to write' and the practical and commercial aspects of publishing as they affect an author. Special features of technical writing are discussed in detail. It also gives special attention to problems facing writers of instruction manuals in catering for users with a wide range of technical backgrounds
    Language English
    Size Online-Ressource (225 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780419192206 ; 0419192204
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Online: Functional Synthetic Biology

    Aldulijan, Ibrahim / Beal, Jacob / Billerbeck, Sonja / Bouffard, Jeff / Chambonnier, Gael / Delkis, Nikolaos / Guerreiro, Isaac / Holub, Martin / Ross, Paul / Selvarajah, Vinoo / Sprent, Noah / Vidal, Gonzalo / Vignoni, Alejandro

    2022  

    Abstract: Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current ... ...

    Abstract Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility, and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability, and reductions in technical risk and cost.

    Comment: 8 pages, 4 figures; submitted to OUP Synthetic Biology
    Keywords Quantitative Biology - Quantitative Methods
    Subject code 501
    Publishing date 2022-07-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Book: Applied nonparametric statistical methods

    Sprent, Peter / Smeeton, Nigel C

    (Texts in statistical science series)

    2007  

    Author's details Peter Sprent and Nigel C. Smeeton
    Series title Texts in statistical science series
    Keywords Nonparametric statistics
    Language English
    Size X, 530 S., graph. Darst., 25 cm
    Edition 4. ed.
    Publisher Chapman & Hall/CRC
    Publishing place Boca Raton, Fla. u.a.
    Document type Book
    Note Literaturverz. S. 511 - 525
    ISBN 158488701X ; 9781584887010
    Database Leibniz Institute of Plant Genetics and Crop Plant Research

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  8. Book: Applied nonparametric statistical methods

    Sprent, Peter / Smeeton, Nigel C

    (Texts in statistical science series)

    2007  

    Author's details Peter Sprent and Nigel C. Smeeton
    Series title Texts in statistical science series
    Keywords Nonparametric statistics
    Language English
    Size X, 530 S., graph. Darst., 25 cm
    Edition 4. ed.
    Publisher Chapman & Hall/CRC
    Publishing place Boca Raton, Fla. u.a.
    Document type Book
    Note Literaturverz. S. 511 - 525
    ISBN 158488701X ; 9781584887010
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: Applied Nonparametric Statistical Methods, Fourth Edition

    Sprent, Peter / Smeeton, Nigel C

    (Chapman & Hall / CRC Texts in Statistical Science)

    2007  

    Abstract: While preserving the clear, accessible style of previous editions, Applied Nonparametric Statistical Methods, Fourth Edition reflects the latest developments in computer-intensive methods that deal with intractable analytical problems and unwieldy data ... ...

    Series title Chapman & Hall / CRC Texts in Statistical Science
    Abstract While preserving the clear, accessible style of previous editions, Applied Nonparametric Statistical Methods, Fourth Edition reflects the latest developments in computer-intensive methods that deal with intractable analytical problems and unwieldy data sets. Reorganized and with additional material, this edition begins with a brief summary of some relevant general statistical concepts and an introduction to basic ideas of nonparametric or distribution-free methods. Designed experiments, including those with factorial treatment structures, are now the focus of an entire chapter. The text also e
    Language English
    Size Online-Ressource (536 p)
    Edition 4th ed
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781584887010 ; 158488701X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: The innovation of the symbiosome has enhanced the evolutionary stability of nitrogen fixation in legumes.

    de Faria, Sergio M / Ringelberg, Jens J / Gross, Eduardo / Koenen, Erik J M / Cardoso, Domingos / Ametsitsi, George K D / Akomatey, John / Maluk, Marta / Tak, Nisha / Gehlot, Hukam S / Wright, Kathryn M / Teaumroong, Neung / Songwattana, Pongpan / de Lima, Haroldo C / Prin, Yves / Zartman, Charles E / Sprent, Janet I / Ardley, Julie / Hughes, Colin E /
    James, Euan K

    The New phytologist

    2022  Volume 235, Issue 6, Page(s) 2365–2377

    Abstract: Nitrogen-fixing symbiosis is globally important in ecosystem functioning and agriculture, yet the evolutionary history of nodulation remains the focus of considerable debate. Recent evidence suggesting a single origin of nodulation followed by massive ... ...

    Abstract Nitrogen-fixing symbiosis is globally important in ecosystem functioning and agriculture, yet the evolutionary history of nodulation remains the focus of considerable debate. Recent evidence suggesting a single origin of nodulation followed by massive parallel evolutionary losses raises questions about why a few lineages in the N
    MeSH term(s) Ecosystem ; Fabaceae/genetics ; Nitrogen ; Nitrogen Fixation ; Plant Root Nodulation/genetics ; Rhizobium ; Root Nodules, Plant ; Symbiosis
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.18321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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