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  1. Article ; Online: Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients: A literature review and a case series of 17 patients from 3 studies.

    Ruan, Can-Jun / Olmos, Ismael / Ricciardi, Carina / Schoretsanitis, Georgios / Vincent, Philippe D / Anıl Yağcıoğlu, A Elif / Eap, Chin B / Baptista, Trino / Clark, Scott R / Fernandez-Egea, Emilio / Kim, Se Hyun / Lane, Hsien-Yuan / Leung, Jonathan / Maroñas Amigo, Olalla / Motuca, Mariano / Every-Palmer, Susanna / Procyshyn, Ric M / Rohde, Christopher / Suhas, Satish /
    Schulte, Peter F J / Spina, Edoardo / Takeuchi, Hiroyoshi / Verdoux, Hélène / Correll, Christoph U / Molden, Espen / De Las Cuevas, Carlos / de Leon, Jose

    Schizophrenia research

    2023  

    Abstract: ... proposed a: 1) clozapine concentration/dose (C/D) ratio which drops to half or more of what is expected ... Results: The first index of non-adherence is a clozapine C/D ratio which is less than half the ratio ... adherence was modeled in two patients: 1) the clozapine C/D ratio dropped to ≥1/2 of what is expected ...

    Abstract Background: Up to 1/2 of outpatients prescribed clozapine may be partially/fully non-adherent, based on therapeutic drug monitoring (TDM). Three indices for measuring partial/full non-adherence are proposed a: 1) clozapine concentration/dose (C/D) ratio which drops to half or more of what is expected in the patient; 2) clozapine/norclozapine ratio that becomes inverted; and 3) clozapine concentration that becomes non-detectable.
    Methods: These 3 proposed indices are based on a literature review and 17 cases of possible non-adherence from 3 samples: 1) an inpatient study in a Chinese hospital, 2) an inpatient randomized clinical trial in a United States hospital, and 3) and a Uruguayan outpatient study.
    Results: The first index of non-adherence is a clozapine C/D ratio which is less than half the ratio corresponding to the patient's specific ancestry group and sex-smoking subgroup. Knowing the minimum therapeutic dose of the patient based on repeated TDM makes it much easier to establish non-adherence. The second index is inverted clozapine/norclozapine ratios in the absence of alternative explanations. The third index is undetectable concentrations. By using half-lives, the chronology of the 3 indices of non-adherence was modeled in two patients: 1) the clozapine C/D ratio dropped to ≥1/2 of what is expected from the patient (around day 2); 2) the clozapine/norclozapine ratio became inverted (around day 3); and 3) the clozapine concentration became undetectable by the laboratory (around days 9-11).
    Conclusion: Prospective studies should further explore these proposed clozapine indices in average patients, poor metabolizers (3 presented) and ultrarapid metabolizers (2 presented).
    Language English
    Publishing date 2023-07-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2023.07.002
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  2. Article ; Online: Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli.

    Alkim, Ceren / Cam, Yvan / Trichez, Debora / Auriol, Clément / Spina, Lucie / Vax, Amélie / Bartolo, François / Besse, Philippe / François, Jean Marie / Walther, Thomas

    Microbial cell factories

    2015  Volume 14, Page(s) 127

    Abstract: ... in Escherichia coli through the action of (D)-xylose isomerase, (D)-xylulose-1-kinase, (D)-xylulose-1-phosphate ... The production strain was optimized by deleting the genes encoding for (D)-xylulose-5 kinase (xylB) and ... to produce EG from (D)-xylose via a synthetic pathway in E. coli at approximately 90 % of the theoretical ...

    Abstract Background: Ethylene glycol (EG) is a bulk chemical that is mainly used as an anti-freezing agent and a raw material in the synthesis of plastics. Production of commercial EG currently exclusively relies on chemical synthesis using fossil resources. Biochemical production of ethylene glycol from renewable resources may be more sustainable.
    Results: Herein, a synthetic pathway is described that produces EG in Escherichia coli through the action of (D)-xylose isomerase, (D)-xylulose-1-kinase, (D)-xylulose-1-phosphate aldolase, and glycolaldehyde reductase. These reactions were successively catalyzed by the endogenous xylose isomerase (XylA), the heterologously expressed human hexokinase (Khk-C) and aldolase (Aldo-B), and an endogenous glycolaldehyde reductase activity, respectively, which we showed to be encoded by yqhD. The production strain was optimized by deleting the genes encoding for (D)-xylulose-5 kinase (xylB) and glycolaldehyde dehydrogenase (aldA), and by overexpressing the candidate glycolaldehyde reductases YqhD, GldA, and FucO. The strain overproducing FucO was the best EG producer reaching a molar yield of 0.94 in shake flasks, and accumulating 20 g/L EG with a molar yield and productivity of 0.91 and 0.37 g/(L.h), respectively, in a controlled bioreactor under aerobic conditions.
    Conclusions: We have demonstrated the feasibility to produce EG from (D)-xylose via a synthetic pathway in E. coli at approximately 90 % of the theoretical yield.
    MeSH term(s) Bioreactors ; Escherichia coli/metabolism ; Ethylene Glycol/metabolism ; Metabolic Engineering/methods ; Metabolic Networks and Pathways ; Xylose/metabolism
    Chemical Substances Xylose (A1TA934AKO) ; Ethylene Glycol (FC72KVT52F)
    Language English
    Publishing date 2015-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1475-2859
    ISSN (online) 1475-2859
    DOI 10.1186/s12934-015-0312-7
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  3. Article: Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.

    Giretti, Maria Silvia / Montt Guevara, Maria Magdalena / Cecchi, Elena / Mannella, Paolo / Palla, Giulia / Spina, Stefania / Bernacchi, Guja / Di Bello, Silvia / Genazzani, Andrea Riccardo / Genazzani, Alessandro D / Simoncini, Tommaso

    Frontiers in endocrinology

    2014  Volume 5, Page(s) 80

    Abstract: ... We tested the effects of E4 on its own or in the presence of 17β-estradiol (E2) on T47-D ER+ breast ... cancer cell migration and invasion of three-dimensional matrices. E4 administration to T47-D cells weakly ...

    Abstract Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or the central nervous system, while antagonizing the actions of estradiol in the breast. We tested the effects of E4 on its own or in the presence of 17β-estradiol (E2) on T47-D ER+ breast cancer cell migration and invasion of three-dimensional matrices. E4 administration to T47-D cells weakly stimulated migration and invasion. However, E4 decreased the extent of movement and invasion induced by E2. Breast cancer cell movement requires a remodeling of the actin cytoskeleton. During exposure to E4, a weak, concentration-dependent, re-distribution of actin fibers toward the cell membrane was observed. However, when E4 was added to E2, an inhibition of actin remodeling induced by E2 was seen. Estrogens stimulate ER+ breast cancer cell movement through the ezrin-radixin-moesin family of actin regulatory proteins, inducing actin and cell membrane remodeling. E4 was a weak inducer of moesin phosphorylation on Thr(558), which accounts for its functional activation. In co-treatment with E2, E4 blocked the activation of this actin controller in a concentration-related fashion. These effects were obtained through recruitment of estrogen receptor-α. In conclusion, E4 acted as a weak estrogen on breast cancer cell cytoskeleton remodeling and movement. However, when E2 was present, E4 counteracted the stimulatory actions of E2. This contributes to the emerging hypothesis that E4 may be a naturally occurring ER modulator in the breast.
    Language English
    Publishing date 2014-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2014.00080
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  4. Article: Vitamin D and cancer.

    Spina, C S / Tangpricha, V / Uskokovic, M / Adorinic, L / Maehr, H / Holick, M F

    Anticancer research

    2006  Volume 26, Issue 4A, Page(s) 2515–2524

    Abstract: ... known. The many biological functions of vitamin D that contribute to cancer prevention have only ... recently begun to be appreciated. Once activated 1,25-dihydroxyvitamin D [1,25(OH)2D3] functions ... as a potent inhibitor of normal and cancer cellular proliferation. Vitamin D deficiency in mice led to a 60 ...

    Abstract The correlation between decreased morbidity and mortality of cancer and exposure to sunlight is known. The many biological functions of vitamin D that contribute to cancer prevention have only recently begun to be appreciated. Once activated 1,25-dihydroxyvitamin D [1,25(OH)2D3] functions as a potent inhibitor of normal and cancer cellular proliferation. Vitamin D deficiency in mice led to a 60% increase in colon tumor growth, compared to vitamin D-sufficient mice. The ligand binding domain of the Vitamin D receptor was shown to accommodate a class of 1,25(OH)2D3-analogs that possess an additional side-arm. These novel Gemini analogs were evaluated in vitro and in vivo. Select Gemini analogs were 100 times or more effective in inhibiting colon tumor growth in mice, compared to their parent compound. Correcting vitamin D deficiency may decrease the risk of developing colon cancer, while the novel Gemini 1,25(OH)2D3-analogs have the potential for therapeutic application in human colon cancer.
    MeSH term(s) Animals ; Calcitriol/analogs & derivatives ; Calcitriol/chemistry ; Calcitriol/metabolism ; Calcitriol/pharmacology ; Humans ; Models, Molecular ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Receptors, Calcitriol/metabolism ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/metabolism
    Chemical Substances Receptors, Calcitriol ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2006-07
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
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  5. Article: Selective vitamin D receptor modulators and their effects on colorectal tumor growth.

    Spina, C S / Ton, L / Yao, M / Maehr, H / Wolfe, M M / Uskokovic, M / Adorini, L / Holick, M F

    The Journal of steroid biochemistry and molecular biology

    2007  Volume 103, Issue 3-5, Page(s) 757–762

    Abstract: The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an endocrine hormone ... whose classic role is the maintenance of calcium homeostasis. It is well documented that 1,25(OH)(2)D(3) also ... of 1,25(OH)(2)D(3) are its ability to cause antiproliferation, prodifferentation and decrease ...

    Abstract The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an endocrine hormone whose classic role is the maintenance of calcium homeostasis. It is well documented that 1,25(OH)(2)D(3) also has anti-tumor effects on a number of cancers and cancer cell lines including breast, colorectal, gastric, liver, ovarian, prostate, and non-melanoma skin cancers. Included in the anti-tumor activities of 1,25(OH)(2)D(3) are its ability to cause antiproliferation, prodifferentation and decrease angiogenesis. Furthermore, through regulation of the plaminogen activator (PA) system and a class of proteolytic enzymes called matrix metalloproteinases (MMPs), 1,25(OH)(2)D(3) reduces the invasive spread of tumor cells. Because of the calcemic limitations of using 1,25(OH)(2)D(3) as a therapy, we have tested the effects of a novel Gemini vitamin D analogue, Deuterated Gemini (DG), on mouse colorectal cancer. We demonstrated that DG is more potent in reducing tumor volume and mass, compared to control and 1,25(OH)(2)D(3). DG significantly prevented (100% reduction, p<0.05) the invasive spread of colorectal tumor cells into the surrounding muscle, and had no effect on serum calcium levels. Thus, DG acts as a selective vitamin D receptor modulator (SVDRM) by enhancing select anti-tumor characteristic 1,25(OH)(2)D(3) activities, without inducing hypercalcemia. Thus, DG shows promise in the development of colorectal cancer therapies.
    MeSH term(s) Animals ; Calcitriol/therapeutic use ; Calcium/blood ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Disease Progression ; Male ; Mice ; Mice, Inbred BALB C ; Muscle Neoplasms/pathology ; Muscle Neoplasms/secretion ; Neoplasm Invasiveness ; Receptors, Calcitriol/metabolism
    Chemical Substances Receptors, Calcitriol ; Calcitriol (FXC9231JVH) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2007-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2006.12.040
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  6. Article: Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density.

    Tangpricha, Vin / Turner, Adrian / Spina, Catherine / Decastro, Sheila / Chen, Tai C / Holick, Michael F

    The American journal of clinical nutrition

    2004  Volume 80, Issue 6, Page(s) 1645–1649

    Abstract: Background: Vitamin D is made in the skin on exposure to solar radiation, and it is necessary ... are likely to have higher 25-hydroxyvitamin D [25(OH)D] concentrations than do subjects who do not ... whether subjects who regularly use a tanning bed have higher 25(OH)D concentrations than do subjects who do not use ...

    Abstract Background: Vitamin D is made in the skin on exposure to solar radiation, and it is necessary to optimal skeletal health. Subjects who use a tanning bed that emits ultraviolet B radiation (290-315 nm) are likely to have higher 25-hydroxyvitamin D [25(OH)D] concentrations than do subjects who do not regularly use a tanning bed.
    Objective: The first objective of this study was to ascertain whether subjects who regularly use a tanning bed have higher 25(OH)D concentrations than do subjects who do not use a tanning bed. The second objective was to ascertain whether higher 25(OH)D concentrations correlated positively with bone mineral density.
    Design: This cross-sectional analysis examined 50 subjects who used a tanning bed at least once a week and 106 control subjects. Each subject gave a blood specimen for measurement of serum 25(OH)D and parathyroid hormone concentrations. Each subject underwent bone mineral density testing of the hip and spine.
    Results: Subjects who used a tanning bed had serum 25(OH)D concentrations 90% higher than those of control subjects (115.5 +/- 8.0 and 60.3 +/- 3.0 nmol/L, respectively; P <0.001). Subjects who used a tanning bed had parathyroid hormone concentrations 18% lower than those of control subjects (21.4 +/- 1.0 and 25.3 +/- 0.8 pg/mL, respectively; P=0.01). Tanners had significantly higher BMD and z scores at the total hip than did nontanners.
    Conclusion: The regular use of a tanning bed that emits vitamin D-producing ultraviolet radiation is associated with higher 25(OH)D concentrations and thus may have a benefit for the skeleton.
    MeSH term(s) Absorptiometry, Photon ; Adult ; Aged ; Bone Density/physiology ; Bone Density/radiation effects ; Bone and Bones/metabolism ; Bone and Bones/radiation effects ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Hip/diagnostic imaging ; Humans ; Male ; Middle Aged ; Nutritional Status ; Parathyroid Hormone/blood ; Seasons ; Spine/diagnostic imaging ; Sunlight ; Ultraviolet Rays ; United States ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/metabolism ; Vitamin D/radiation effects ; Vitamin D Deficiency/epidemiology
    Chemical Substances Parathyroid Hormone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2004-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/80.6.1645
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  7. Article: Linoleic acid, vitamin D and other nutrient intakes in the risk of non-Hodgkin lymphoma: an Italian case-control study.

    Polesel, J / Talamini, R / Montella, M / Parpinel, M / Dal Maso, L / Crispo, A / Crovatto, M / Spina, M / La Vecchia, C / Franceschi, S

    Annals of oncology : official journal of the European Society for Medical Oncology

    2006  Volume 17, Issue 4, Page(s) 713–718

    Abstract: ... for polyunsaturated fatty acids (OR=0.6; 95% CI: 0.4-0.9), linoleic acid (OR=0.6; 95% CI: 0.4-0.9), and vitamin D (OR=0.6; 95% CI ... 0.4-0.9). The protective effect for linoleic acid (OR=0.3; 95% CI: 0.2-0.7) and vitamin D (OR=0.4 ... inversely related to follicular and diffuse large B-cell lymphoma; the protective effect of vitamin D ...

    Abstract Background: Dietary habits have been suggested as a factor related to the increase of non-Hodgkin lymphoma (NHL) incidence in western populations, but the role of individual nutrients is still unclear.
    Patients and methods: A hospital-based case-control study was conducted in Italy, 1999-2002.
    Cases: 190 incident, histologically-confirmed NHL cases aged 18-84 years.
    Controls: 484 subjects admitted to hospital for acute, non-neoplastic diseases unrelated to diet. Dietary habits were assessed by a validated food-frequency questionnaire; nutrient intakes were computed using the Italian food composition database. Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for tertiles of intake of nutrient were computed using the energy-adjusted residual models.
    Results: Inverse association emerged for polyunsaturated fatty acids (OR=0.6; 95% CI: 0.4-0.9), linoleic acid (OR=0.6; 95% CI: 0.4-0.9), and vitamin D (OR=0.6; 95% CI: 0.4-0.9). The protective effect for linoleic acid (OR=0.3; 95% CI: 0.2-0.7) and vitamin D (OR=0.4; 95% CI: 0.2-0.9) was stronger in women; no differences emerged according to age. Linoleic acid was inversely related to follicular and diffuse large B-cell lymphoma; the protective effect of vitamin D emerged most clearly for follicular subtypes.
    Conclusions: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.
    MeSH term(s) Aged ; Case-Control Studies ; Female ; Humans ; Linoleic Acid/administration & dosage ; Lymphoma, Non-Hodgkin/etiology ; Male ; Middle Aged ; Risk Factors ; Vitamin D/administration & dosage
    Chemical Substances Vitamin D (1406-16-2) ; Linoleic Acid (9KJL21T0QJ)
    Language English
    Publishing date 2006-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdl054
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  8. Article ; Online: Wideband parametric baseband macromodeling of linear and passive photonic circuits via complex vector fitting.

    Ullrick, Thijs / Spina, Domenico / Bogaerts, Wim / Dhaene, Tom

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15407

    Abstract: A novel wideband parametric baseband macromodeling technique for passive photonic devices and circuits is presented. It allows to efficiently estimate the baseband scattering representations of a linear, passive photonic system as a function of a set of ... ...

    Abstract A novel wideband parametric baseband macromodeling technique for passive photonic devices and circuits is presented. It allows to efficiently estimate the baseband scattering representations of a linear, passive photonic system as a function of a set of design variables, such as geometrical layout or substrate features. The proposed technique relies on the interpolation of macromodels computed via a complex vector fitting (CVF) algorithm, by adopting a methodology based on amplitude and frequency scaling that preserves, by construction, the physical properties of the system, such as causality, stability and passivity. For a specified combination of the design parameters, a rational CVF model is derived that can be simulated by a wide range of ordinary differential equation (ODE) solvers or circuit simulators. Additionally, time-domain simulations using the computed model can be performed at arbitrary optical carrier frequencies, thus allowing for the simulation of multi-wavelength systems. Two application examples are presented to demonstrate the flexibility and advantages of the proposed method.
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41227-w
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  9. Article ; Online: Prevalence of Workplace Cyberbullying among Dental Hygienists.

    Lee, Caitlin / Boyd, Linda D / LaSpina, Lisa / Vineyard, Jared

    Journal of dental hygiene : JDH

    2023  Volume 97, Issue 2, Page(s) 22–30

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Humans ; Cyberbullying ; Cross-Sectional Studies ; Prevalence ; Dental Hygienists ; Workplace ; Surveys and Questionnaires
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035719-1
    ISSN 1553-0205 ; 1043-254X
    ISSN (online) 1553-0205
    ISSN 1043-254X
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  10. Article: Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice.

    Tangpricha, Vin / Spina, Catherine / Yao, Min / Chen, Tai C / Wolfe, M Michael / Holick, Michael F

    The Journal of nutrition

    2003  Volume 135, Issue 10, Page(s) 2350–2354

    Abstract: Vitamin D deficiency has been associated with increased risk of colon cancer in epidemiologic and ... the effect of vitamin D deficiency on the development and growth of colon cancer. To assess ... the antiproliferative effects of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH)2D3 in vitro, we cultured MC-26 ...

    Abstract Vitamin D deficiency has been associated with increased risk of colon cancer in epidemiologic and prospective clinical studies. In vitro and in vivo studies demonstrated that 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and its analogs inhibit colon cancer cell proliferation. Few studies have evaluated the effect of vitamin D deficiency on the development and growth of colon cancer. To assess the antiproliferative effects of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH)2D3 in vitro, we cultured MC-26 (a colon cancer cell line) in the presence of 25(OH)D3 and 1,25(OH)2D3 and performed [3H]thymidine incorporation. The proliferation of MC-26 was significantly inhibited by both 25(OH)D3 and 1,25(OH)2D3. To determine the effect of vitamin D deficiency on colon cancer proliferation, Balb/c mice were rendered vitamin D deficient by feeding them a vitamin D-deficient diet for 3 mo. A group of vitamin D-sufficient mice was given the same diet with supplemental vitamin D. The mice were injected with MC-26 colon cancer cells and the tumors were measured daily for 20 d. Vitamin D-sufficient mice had 40% smaller tumors than vitamin D-deficient mice. The tumors were evaluated for mRNA expression of the vitamin D receptor (VDR) and 25-hydroxvitamin D-1alpha-hydroxylase (1alpha-OHase) by quantitative RT-PCR. The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice. We conclude that vitamin D deficiency enhances the growth of colon cancer in mice. The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D.
    MeSH term(s) 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Animals ; Calcitriol/blood ; Calcitriol/pharmacology ; Cell Division/drug effects ; Cell Line, Tumor ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/physiopathology ; Gene Expression Regulation, Neoplastic/drug effects ; Mice ; Mice, Inbred BALB C ; Neoplasm Transplantation ; Receptors, Calcitriol/genetics ; Transplantation, Heterologous ; Vitamin D Deficiency/physiopathology ; Vitamins/blood ; Vitamins/pharmacology
    Chemical Substances Receptors, Calcitriol ; Vitamins ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2003-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/135.10.2350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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