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  1. Book ; Online ; E-Book: Febrile seizures

    Baram, Tallie Z. / Shinnar, S. / Stafstrom, Carl E.

    new concepts and consequences

    2022  

    Author's details Tallie Z. Baram, Shlomo Shinnar, and Carl E. Stafstrom
    Keywords Fever/Treatment ; Fever/Immunological aspects
    Subject code 616.047
    Language English
    Size 1 online resource (370 pages)
    Edition 2nd ed.
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-98418-5 ; 9780323899321 ; 978-0-323-98418-8 ; 0323899323
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Infantile spasms: a U.S. consensus report.

    Pellock, John M / Hrachovy, Richard / Shinnar, Shlomo / Baram, Tallie Z / Bettis, David / Dlugos, Dennis J / Gaillard, William D / Gibson, Patricia A / Holmes, Gregory L / Nordl, Douglas R / O'Dell, Christine / Shields, W Donald / Trevathan, Edwin / Wheless, James W

    Epilepsia

    2010  Volume 51, Issue 10, Page(s) 2175–2189

    Abstract: ... occurred in areas where data were lacking; however, this article represents a consensus of the U.S ...

    Abstract The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families—the Infantile Spasms Working Group (ISWG)—was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adrenocorticotropic Hormone/therapeutic use ; Anticonvulsants/therapeutic use ; Consensus ; Consensus Development Conferences as Topic ; Diet, Ketogenic ; Disease-Free Survival ; Electroencephalography/methods ; Female ; Humans ; Infant ; Longitudinal Studies ; Male ; Outcome Assessment (Health Care) ; Pediatrics/standards ; Practice Guidelines as Topic ; Prednisolone/therapeutic use ; Spasms, Infantile/diagnosis ; Spasms, Infantile/drug therapy ; Spasms, Infantile/therapy ; United States ; Vigabatrin/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Anticonvulsants ; Adrenocorticotropic Hormone (9002-60-2) ; Prednisolone (9PHQ9Y1OLM) ; Vigabatrin (GR120KRT6K)
    Language English
    Publishing date 2010-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2010.02657.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Energy. A road map to U.S. decarbonization.

    Shinnar, Reuel / Citro, Francesco

    Science (New York, N.Y.)

    2006  Volume 313, Issue 5791, Page(s) 1243–1244

    Language English
    Publishing date 2006-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1130338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Childhood Seizures

    Shinnar, S.

    (Pediatric and Adolescent Medicine ; Vol.6)

    1995  

    Series title Pediatric and Adolescent Medicine ; Vol.6
    Keywords Neurology ; Pediatrics ; Electroencephalogram ; General Medicine ; Neurosurgery ; Nursing ; Pharmacology ; Psychology ; Social Medicine
    Language English
    Size 1 Online-Ressource (VII + 200 S.)
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    HBZ-ID HT019542137
    ISBN 978-3-318-04059-3 ; 3-318-04059-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Childhood seizures

    Shinnar, Shlomo

    13 tables

    (Pediatric and adolescent medicine ; 6)

    1995  

    Author's details vol. ed. S. Shinnar
    Series title Pediatric and adolescent medicine ; 6
    Collection
    Keywords Seizures / in infancy & childhood ; Seizures / diagnosis ; Seizures / therapy ; Epilepsy / in infancy & childhood ; Epilepsy / in adolescence ; Kind ; Anfallsleiden
    Subject Anfallskrankheit ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size VIII, 200 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT006549392
    ISBN 3-8055-6009-5 ; 978-3-8055-6009-2
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Whatever happened to the primary generalized epilepsies of childhood and adolescence?

    Shinnar, Shlomo

    Annals of neurology

    2014  Volume 76, Issue 5, Page(s) 658–659

    MeSH term(s) Female ; Humans ; Male ; Myoclonic Epilepsy, Juvenile/pathology ; Myoclonic Epilepsy, Juvenile/psychology
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.24277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy.

    Wilkinson, Carol L / Yankowitz, Lisa / Chao, Jerry Y / Gutiérrez, Rodrigo / Rhoades, Jeff L / Shinnar, Shlomo / Purdon, Patrick L / Nelson, Charles A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs ... ...

    Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Consistent with the transient developmental progression of thalamocortical circuitry, we observe the presence and then absence of periodic alpha and high beta peaks across the three-year period, as well as the emergence of a low beta peak (12-20Hz) after six months of age. We present preliminary evidence that the emergence of the low beta peak is associated with higher thalamocortical-dependent, anesthesia-induced alpha coherence. Together, these findings suggest that early age-dependent changes in alpha and beta periodic peaks may reflect the state of thalamocortical network development.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.21.550114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study.

    Lewis, Darrell V / Voyvodic, James / Shinnar, Shlomo / Chan, Stephen / Bello, Jacqueline A / Moshé, Solomon L / Nordli, Douglas R / Frank, L Matthew / Pellock, John M / Hesdorffer, Dale C / Xu, Yuan / Shinnar, Ruth C / Seinfeld, Syndi / Epstein, Leon G / Masur, David / Gallentine, William / Weiss, Erica / Deng, Xiaoyan / Sun, Shumei

    Epilepsia

    2024  

    Abstract: Objective: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.: Methods: Acute magnetic resonance ... ...

    Abstract Objective: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.
    Methods: Acute magnetic resonance imaging (MRI) was obtained within a mean of 4.4 (SD = 5.5, median = 2.0) days after febrile status on >200 infants with follow-up MRI at approximately 1, 5, and 10 years. Hippocampal size, morphology, and T2 signal intensity were scored visually by neuroradiologists blinded to clinical details. Hippocampal volumetry provided quantitative measurement. Upon the occurrence of two or more unprovoked seizures, subjects were reassessed for epilepsy. Hippocampal volumes were normalized using total brain volumes.
    Results: Fourteen of 22 subjects with acute hippocampal T2 hyperintensity returned for follow-up MRI, and 10 developed definite hippocampal sclerosis, which persisted through the 10-year follow-up. Hippocampi appearing normal initially remained normal on visual inspection. However, in subjects with normal-appearing hippocampi, volumetrics indicated that male, but not female, hippocampi were smaller than controls, but increasing hippocampal asymmetry was not seen following febrile status. Forty-four subjects developed epilepsy; six developed mesial temporal lobe epilepsy and, of the six, two had definite, two had equivocal, and two had no hippocampal sclerosis. Only one subject developed mesial temporal epilepsy without initial hyperintensity, and that subject had hippocampal malrotation. Ten-year cumulative incidence of all types of epilepsy, including mesial temporal epilepsy, was highest in subjects with initial T2 hyperintensity and lowest in those with normal signal and no other brain abnormalities.
    Significance: Hippocampal T2 hyperintensity following febrile status epilepticus predicted hippocampal sclerosis and significant likelihood of mesial temporal lobe epilepsy. Normal hippocampal appearance in the acute postictal MRI was followed by maintained normal appearance, symmetric growth, and lower risk of epilepsy. Volumetric measurement detected mildly decreased hippocampal volume in males with febrile status.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cognition in childhood-onset epilepsy.

    Shinnar, Shlomo

    Jornal de pediatria

    2010  Volume 86, Issue 5, Page(s) 349–350

    MeSH term(s) Cognition/physiology ; Epilepsy/psychology ; Humans
    Language Portuguese
    Publishing date 2010-09-23
    Publishing country Brazil
    Document type Comment ; Editorial
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.2223/JPED.2038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The new ILAE classification.

    Shinnar, Shlomo

    Epilepsia

    2010  Volume 51, Issue 4, Page(s) 715–717

    MeSH term(s) Diagnosis, Differential ; Electroencephalography/classification ; Epilepsy/classification ; Epilepsy/diagnosis ; Epilepsy/etiology ; Humans ; Seizures/classification ; Seizures/diagnosis ; Seizures/etiology ; Syndrome ; Terminology as Topic
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2010.02542.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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