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Article ; Online: To J.R.C. with L.O.V.E.

Rubenfeld, Gordon D / Halpern, Scott D

2022 Volume 63, Issue 6, Page(s) e577–e578

Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Editorial
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2022.04.165
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Article ; Online: Capacity Strengthening Undertaking-Farm Organized Response of Workers against Risk for Diabetes: (C.S.U.-F.O.R.W.A.R.D. with Cal Poly)-A Concept Approach to Tackling Diabetes in Vulnerable and Underserved Farmworkers in California.

Sikalidis, Angelos K / Kristo, Aleksandra S / Reaves, Scott K / Kurfess, Franz J / DeLay, Ann M / Vasilaky, Kathryn / Donegan, Lorraine

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 21

Abstract: In our project herein, we use the case of farmworkers, an underserved and understudied population at high risk for Type-2 Diabetes Mellitus (T2DM), as a paradigm of an integrated action-oriented research, education and extension approach involving the ... ...

Abstract	In our project herein, we use the case of farmworkers, an underserved and understudied population at high risk for Type-2 Diabetes Mellitus (T2DM), as a paradigm of an integrated action-oriented research, education and extension approach involving the development of long-term equitable strategies providing empowerment and tailored-made solutions that support practical decision-making aiming to reduce risk of T2DM and ensuing cardiovascular disease (CVD). A Technology-based Empowerment Didactic module (TEDm) and an Informed Decision-Making enhancer (IDMe) coupled in a smart application (app) for farmworkers aiming to teach, set goals, monitor, and support in terms of nutrition, hydration, physical activity, sleep, and circadian rhythm towards lowering T2DM risk, is to be developed and implemented considering the particular characteristics of the population and setting. In parallel, anthropometric, biochemical, and clinical assessments will be utilized to monitor risk parameters for T2DM and compliance to dietary and wellness plans. The app incorporating anthropometric/clinical/biochemical parameters, dietary/lifestyle behavior, and extent of goal achievement can be continuously refined and improved through machine learning and re-programming. The app can function as a programmable tool constantly learning, adapting, and tailoring its services to user needs helping optimization of practical informed decision-making towards mitigating disease symptoms and associated risk factors. This work can benefit apart from the direct beneficiaries being farmworkers, the stakeholders who will be gaining a healthier, more vibrant workforce, and in turn the local communities.
MeSH term(s)	Humans ; Farmers ; Farms ; Poly A ; Diabetes Mellitus, Type 2/prevention & control ; California
Chemical Substances	Poly A (24937-83-5)
Language	English
Publishing date	2022-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22218299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reply to 'Comments on papers relating to soil phosphorus testing in 'Making better fertiliser decisions for cropping systems in Australia" by I.C.R. Holford

Moody, P. W. / Dyson, C. B. / Speirs, S. D. / Scott, B. J. / Bell, R.

Crop & pasture science

2015 Volume 66, Issue 1, Page(s) 110

Language	English
Document type	Article
ZDB-ID	2472536-5
ISSN	1836-0947
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations

Heliyon, Vol 4, Iss 6, Pp e00643- (2018)

2018

Abstract: ... The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R (S ... typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-resistant GIST ... S. typhimurium A1-R group (intravenous [i.v.] injection, weekly, for 3 weeks). All mice ...

Abstract	Gastrointestinal stromal tumor (GIST) is a refractory disease in need of novel efficacious therapy. The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-resistant GIST. The GIST was obtained from a patient with regional recurrence, and implanted in the anterior gastric wall of nude mice. The GIST PDOX mice were randomized into 3 groups of 6 mice each when the tumor volume reached 60 mm3: G1, control group; G2, imatinib group (oral administration [p.o.], daily, for 3 weeks); G3, S. typhimurium A1-R group (intravenous [i.v.] injection, weekly, for 3 weeks). All mice from each group were sacrificed on day 22. Relative tumor volume was estimated by laparotomy on day 0 and day 22. Body weight of the mouse was evaluated 2 times per week. We found that S. typhimurium A1-R significantly reduced tumor growth in contrast to the untreated group (P = 0.001). In addition, we found that S. typhimurium A1-R was more effective compared to imatinib (P = 0.013). Furthermore, Imatinib was not significantly effective compared to the control group (P = 0.462). These results indicate that S. typhimurium A1-R may be new effective therapy for imatinib-resistant GIST and therefore a good candidate for clinical development of this disease.
Keywords	Biochemistry ; Cancer research ; Genetics ; Microbiology ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations

Heliyon. 2018 June, v. 4, no. 6

2018

Abstract	Gastrointestinal stromal tumor (GIST) is a refractory disease in need of novel efficacious therapy. The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-resistant GIST. The GIST was obtained from a patient with regional recurrence, and implanted in the anterior gastric wall of nude mice. The GIST PDOX mice were randomized into 3 groups of 6 mice each when the tumor volume reached 60 mm³: G1, control group; G2, imatinib group (oral administration [p.o.], daily, for 3 weeks); G3, S. typhimurium A1-R group (intravenous [i.v.] injection, weekly, for 3 weeks). All mice from each group were sacrificed on day 22. Relative tumor volume was estimated by laparotomy on day 0 and day 22. Body weight of the mouse was evaluated 2 times per week. We found that S. typhimurium A1-R significantly reduced tumor growth in contrast to the untreated group (P = 0.001). In addition, we found that S. typhimurium A1-R was more effective compared to imatinib (P = 0.013). Furthermore, Imatinib was not significantly effective compared to the control group (P = 0.462). These results indicate that S. typhimurium A1-R may be new effective therapy for imatinib-resistant GIST and therefore a good candidate for clinical development of this disease.
Keywords	Salmonella Typhimurium ; body weight ; exons ; gastrointestinal neoplasms ; intravenous injection ; laparotomy ; mice ; models ; oral administration ; patients ; xenotransplantation
Language	English
Dates of publication	2018-06
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2018.e00643
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

Journal of medicinal chemistry

2016 Volume 59, Issue 18, Page(s) 8535–8548

Abstract: The synthesis and SAR of a series of 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridine P2X7 antagonists are ... afforded methyl substituted 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridines ultimately leading ...

Abstract	The synthesis and SAR of a series of 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridine P2X7 antagonists are described. Addressing P2X7 affinity and liver microsomal stability issues encountered with this template afforded methyl substituted 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridines ultimately leading to the identification of 1 (JNJ 54166060). 1 is a potent P2X7 antagonist with an ED50 = 2.3 mg/kg in rats, high oral bioavailability and low-moderate clearance in preclinical species, acceptable safety margins in rats, and a predicted human dose of 120 mg of QD. Additionally, 1 possesses a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism.
MeSH term(s)	Administration, Oral ; Animals ; Dogs ; Halogenation ; Haplorhini ; Humans ; Imidazoles/administration & dosage ; Imidazoles/chemistry ; Imidazoles/pharmacokinetics ; Imidazoles/pharmacology ; Mice ; Models, Molecular ; Purinergic P2X Receptor Antagonists/administration & dosage ; Purinergic P2X Receptor Antagonists/chemistry ; Purinergic P2X Receptor Antagonists/pharmacokinetics ; Purinergic P2X Receptor Antagonists/pharmacology ; Pyridines/administration & dosage ; Pyridines/chemistry ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Rats ; Receptors, Purinergic P2X7/metabolism
Chemical Substances	Imidazoles ; Purinergic P2X Receptor Antagonists ; Pyridines ; Receptors, Purinergic P2X7
Language	English
Publishing date	2016--22
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.6b00989
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Zs.MB 1: Show issues

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Article: The life and trials of T.R. Allinson ex-L.R.C.P.ED. 1858-1918.

Scott, C J

Proceedings of the Royal College of Physicians of Edinburgh

2001 Volume 29, Issue 3, Page(s) 258–261

MeSH term(s)	Bread/history ; Complementary Therapies/history ; Diet Fads/history ; History, 19th Century ; History, 20th Century ; Licensure, Medical/history ; Scotland ; United Kingdom
Language	English
Publishing date	2001-09-26
Publishing country	Scotland
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
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Zs.A 3088 -Suppl.-: Show issues

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Article: Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.

Rowbottom, Martin W / Tucci, Fabio C / Connors, Patrick J / Gross, Timothy D / Zhu, Yun-Fei / Guo, Zhiqiang / Moorjani, Manisha / Acevedo, Oscar / Carter, Lee / Sullivan, Susan K / Xie, Qiu / Fisher, Andrew / Struthers, R Scott / Saunders, John / Chen, Chen

Bioorganic & medicinal chemistry letters

2004 Volume 14, Issue 19, Page(s) 4967–4973

Abstract: The synthesis of a series of (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils ... containing a substituted thiophene or thiazole at C-5 is described. SAR around C-5 of the uracil led ...

Abstract	The synthesis of a series of (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5 is described. SAR around C-5 of the uracil led to the discovery that a 2-thienyl or (2-phenyl)thiazol-4-yl group is required for optimal receptor binding. The best compound from the series had a binding affinity of 2 nM (K(i)) for the human GnRH receptor. A novel and convenient preparation of N-1-(2,6-difluorobenzyl)-6-methyluracil is also described.
MeSH term(s)	Humans ; Receptors, LHRH/antagonists & inhibitors ; Structure-Activity Relationship ; Thiazoles ; Thiophenes ; Uracil/analogs & derivatives
Chemical Substances	Receptors, LHRH ; Thiazoles ; Thiophenes ; Uracil (56HH86ZVCT)
Language	English
Publishing date	2004-10-04
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2004.07.022
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Book: C.L.R. James and revolutionary Marxism

James, Cyril L / Le Blanc, Paul / McLemee, Scott

selected writings of C.L.R. James 1939-1949

(Revolutionary studies)

1994

Author's details	edited by Scott McLemee and Paul Le Blanc
Series title	Revolutionary studies
Keywords	African Americans/History ; Communism ; Political science ; Revolutions and socialism
Language	English
Size	viii, 252 p, 24 cm
Publisher	Humanities Press
Publishing place	Atlantic Highlands, N.J
Document type	Book
Note	Includes bibliographical references and index
ISBN	0391037862 ; 0391038249 ; 9780391037861 ; 9780391038240
Database	Former special subject collection: coastal and deep sea fishing

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Article: The stereoselectivity and catalytic properties of Xanthobacter autotrophicus 2-[(R)-2-Hydroxypropylthio]ethanesulfonate dehydrogenase are controlled by interactions between C-terminal arginine residues and the sulfonate of coenzyme M.

Clark, Daniel D / Boyd, Jeffrey M / Ensign, Scott A

Biochemistry

2004 Volume 43, Issue 21, Page(s) 6763–6771

Abstract: ... sufficiently poor substrates for R-HPCDH that kinetic parameters could not be determined. Mutagenesis of C ... 2-[(R)-2-Hydroxypropylthio]ethanesulfonate (R-HPC) dehydrogenase (DH) catalyzes the reversible ... oxidation of R-HPC to 2-(2-ketopropylthio)ethanesulfonate (2-KPC) in a key reaction in the bacterial ...

Abstract	2-[(R)-2-Hydroxypropylthio]ethanesulfonate (R-HPC) dehydrogenase (DH) catalyzes the reversible oxidation of R-HPC to 2-(2-ketopropylthio)ethanesulfonate (2-KPC) in a key reaction in the bacterial conversion of chiral epoxides to beta-keto acids. R-HPCDH is highly specific for the R-enantiomer of HPC, while a separate enzyme, S-HPCDH, catalyzes the oxidation of the corresponding S-enantiomer. In the present study, the features of substrate and enzyme imparting stereospecificity have been investigated for R-HPCDH. S-HPC was a substrate for R-HPCDH with a K(m) identical to that for R-HPC but with a k(cat) 600 times lower. Achiral 2-propanol and short-chain (R)- and (S)-2-alkanols were substrates for R-HPCDH. For (R)-alkanols, as the carbon chain length increased, K(m) decreased, with the K(m) for (R)-2-octanol being 1700 times lower than for 2-propanol. At the same time, k(cat) changed very little and was at least 90% lower than k(cat) for R-HPC and at least 22 times higher than k(cat) for S-HPC. (S)-2-Butanol and (S)-2-pentanol were substrates for R-HPCDH. The K(m) for (S)-2-butanol was identical to that for (R)-2-butanol, while the K(m) for (S)-2-pentanol was 7.5 times higher than for (R)-2-pentanol. Longer chain (S)-2-alkanols were sufficiently poor substrates for R-HPCDH that kinetic parameters could not be determined. Mutagenesis of C-terminal arginine residues of R-HPCDH revealed that R152 and R196 are essential for effective catalysis with the natural substrates R-HPC and 2-KPC but not for catalysis with 2-alkanols or ketones as substrates. Short-chain alkylsulfonates and coenzyme M (2-mercaptoethanesulfonate) were found to modify the kinetic parameters for 2-butanone reduction by R-HPCDH in a saturable fashion, with the general effect of increasing k(cat), decreasing K(m), and increasing the enantioselectivity of 2-butanone reduction to a theoretical value of 100% (S)-2-butanol. The modulating effects of ethanesulfonate and propanesulfonate provided thermodynamic binding constants close to K(m) for the natural substrates R-HPC and 2-KPC. The effects of alkylsulfonates on modulating the enantioselectivity and kinetic properties of R-HPCDH were abolished in R152A and R196A mutants but not in mutants of other C-terminal arginine residues. Collectively, the results suggest that interactions between the sulfonate of CoM and specific arginine residues are key to the enantioselectivity and catalytic efficiency of R-HPCDH. A model is proposed wherein sulfonate-arginine interactions within an alkylsulfonate binding pocket control the catalytic properties of R-HPCDH.
MeSH term(s)	Alcohol Oxidoreductases/chemistry ; Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Alcohols/chemistry ; Alcohols/metabolism ; Alkanesulfonates/chemistry ; Alkanesulfonates/metabolism ; Arginine/metabolism ; Binding Sites ; Butanones/metabolism ; Catalysis ; Catalytic Domain ; Kinetics ; Mesna/chemistry ; Mesna/metabolism ; Mutagenesis, Site-Directed ; Oxidation-Reduction ; Stereoisomerism ; Substrate Specificity ; Xanthobacter/enzymology
Chemical Substances	Alcohols ; Alkanesulfonates ; Butanones ; ethane sulfonate (599310E3U2) ; methylethyl ketone (6PT9KLV9IO) ; Arginine (94ZLA3W45F) ; Alcohol Oxidoreductases (EC 1.1.-) ; 2-hydroxypropylthioethanesulfonate dehydrogenase, Xanthobacter (EC 1.1.1.-) ; Mesna (NR7O1405Q9)
Language	English
Publishing date	2004-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi049783h
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