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Article ; Online: Stellate ganglion block reduces symptoms of Long COVID: A case series.

Liu, Luke D / Duricka, Deborah L

2021 Volume 362, Page(s) 577784

Abstract: After recovering from COVID-19, a significant proportion of symptomatic and asymptomatic individuals develop Long COVID. Fatigue, orthostatic intolerance, brain fog, anosmia, and ageusia/dysgeusia in Long COVID resemble "sickness behavior," the autonomic ...

Abstract	After recovering from COVID-19, a significant proportion of symptomatic and asymptomatic individuals develop Long COVID. Fatigue, orthostatic intolerance, brain fog, anosmia, and ageusia/dysgeusia in Long COVID resemble "sickness behavior," the autonomic nervous system response to pro-inflammatory cytokines (Dantzer et al., 2008). Aberrant network adaptation to sympathetic/parasympathetic imbalance is expected to produce long-standing dysautonomia. Cervical sympathetic chain activity can be blocked with local anesthetic, allowing the regional autonomic nervous system to "reboot." In this case series, we successfully treated two Long COVID patients using stellate ganglion block, implicating dysautonomia in the pathophysiology of Long COVID and suggesting a novel treatment.
MeSH term(s)	Adult ; Autonomic Nerve Block/methods ; COVID-19/complications ; COVID-19/surgery ; Female ; Humans ; SARS-CoV-2 ; Stellate Ganglion/surgery ; Post-Acute COVID-19 Syndrome
Language	English
Publishing date	2021-12-08
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2021.577784
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Article ; Online: Addressing Biases in Ambient PM

Katoch, Varun / Kumar, Alok / Imam, Fahad / Sarkar, Debajit / Knibbs, Luke D / Liu, Yang / Ganguly, Dilip / Dey, Sagnik

Environmental science & technology

2023 Volume 57, Issue 48, Page(s) 19190–19201

Abstract: ... Ambient ... ...

Abstract	Ambient PM
MeSH term(s)	Particulate Matter/analysis ; Air Pollution/analysis ; Environmental Monitoring/methods ; Aerosols/analysis ; Bias ; India ; Air Pollutants/analysis
Chemical Substances	Particulate Matter ; Aerosols ; Air Pollutants
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c03355
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Article ; Online: Correction: Maternal Embryonic Leucine Zipper Kinase Is Associated with Metastasis in Triple-negative Breast Cancer.

Xie, Xuemei / Chauhan, Gaurav B / Edupuganti, Ramakrishna / Kogawa, Takahiro / Park, Jihyun / Tacam, Moises / Tan, Alex W / Mughees, Mohd / Vidhu, Fnu / Liu, Diane D / Taliaferro, Juliana M / Pitner, Mary Kathryn / Browning, Luke S / Lee, Ju-Hyeon / Bertucci, François / Shen, Yu / Wang, Jian / Ueno, Naoto T / Krishnamurthy, Savitri /

Hortobagyi, Gabriel N / Tripathy, Debu / Van Laere, Steven J / Bartholomeusz, Geoffrey / Dalby, Kevin N / Bartholomeusz, Chandra

Cancer research communications

2024 Volume 4, Issue 1, Page(s) 236

Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Published Erratum
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-24-0046
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Article ; Online: Elevated cerebrospinal fluid ubiquitin C-terminal hydrolase-L1 levels correlate with phenotypic severity and therapeutic response in Niemann-Pick disease, type C1.

Cawley, Niamh X / Giddens, Spencer / Farhat, Nicole M / Luke, Rachel A / Scott, Katelin E J / Mohamed, Hibaaq O / Dang Do, An / Berry-Kravis, Elizabeth / Cologna, Stephanie M / Liu, Fang / Porter, Forbes D

Molecular genetics and metabolism

2023 Volume 140, Issue 3, Page(s) 107656

Abstract: Background: Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive disorder due to pathological variants of NPC1. The NPC1 phenotype is characterized by progressive cerebellar ataxia and cognitive impairment. Although classically a childhood/ ... ...

Abstract	Background: Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive disorder due to pathological variants of NPC1. The NPC1 phenotype is characterized by progressive cerebellar ataxia and cognitive impairment. Although classically a childhood/adolescent disease, NPC1 is heterogeneous with respect to the age of onset of neurological signs and symptoms. While miglustat has shown to be clinically effective, there are currently no FDA approved drugs to treat NPC1. Identification and characterization of biomarkers may provide tools to facilitate therapeutic trials. Ubiquitin C-terminal hydrolase-L1 (UCHL1) is a protein which is highly expressed by neurons and is a biomarker of neuronal damage. We thus measured cerebrospinal fluid (CSF) levels of UCHL1 in individuals with NPC1. Methods: CSF levels of UCHL1 were measured using a Quanterix Neuroplex 4 assay in 94 individuals with NPC1 and 35 age-appropriate comparison samples. Cross-sectional and longitudinal CSF UCHL1 levels were then evaluated for correlation with phenotypic measures and treatment status. Results: CSF UCHL1 levels were markedly elevated (3.3-fold) in individuals with NPC1 relative to comparison samples. The CSF UCHL1 levels showed statistically significant (adj p < 0.0001), moderate, positive correlations with both the 17- and 5-domain NPC Neurological Severity Scores and the Annual Severity Increment Scores. Miglustat treatment significantly decreased (adj p < 0.0001) CSF UCHL1 levels by 30% (95% CI 17-40%). Conclusions: CSF UCHL1 levels are elevated in NPC1, increase with increasing clinical severity and decrease in response to therapy with miglustat. Based on these data, UCHL1 may be a useful biomarker to monitor disease progression and therapeutic response in individuals with NPC1.
MeSH term(s)	Adolescent ; Child ; Humans ; Biomarkers/metabolism ; Cross-Sectional Studies ; Niemann-Pick Disease, Type C/drug therapy ; Niemann-Pick Disease, Type C/genetics ; Niemann-Pick Disease, Type C/metabolism ; Phenotype ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/therapeutic use
Chemical Substances	Biomarkers ; miglustat (ADN3S497AZ) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; UCHL1 protein, human
Language	English
Publishing date	2023-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1418518-0
ISSN	1096-7206 ; 1096-7192
ISSN (online)	1096-7206
ISSN	1096-7192
DOI	10.1016/j.ymgme.2023.107656
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Article ; Online: Land-use change interacts with island biogeography to alter bird community assembly.

Zhao, Yuhao / Mendenhall, Chase D / Matthews, Thomas J / Wang, Duorun / Li, Wande / Liu, Xiangxu / Tang, Shupei / Han, Peng / Wei, Guangpeng / Kang, Yi / Wu, Chenxiao / Wang, Rui / Zeng, Di / Frishkoff, Luke O / Si, Xingfeng

Proceedings. Biological sciences

2024 Volume 291, Issue 2018, Page(s) 20232245

Abstract: Anthropogenic activities have reshaped biodiversity on islands worldwide. However, it remains unclear how island attributes and land-use change interactively shape multiple facets of island biodiversity through community assembly processes. To answer ... ...

Abstract	Anthropogenic activities have reshaped biodiversity on islands worldwide. However, it remains unclear how island attributes and land-use change interactively shape multiple facets of island biodiversity through community assembly processes. To answer this, we conducted bird surveys in various land-use types (mainly forest and farmland) using transects on 34 oceanic land-bridge islands in the largest archipelago of China. We found that bird species richness increased with island area and decreased with isolation, regardless of the intensity of land-use change. However, forest-dominated habitats exhibited lower richness than farmland-dominated habitats. Island bird assemblages generally comprised species that share more similar traits or evolutionary histories (i.e. functional and/or phylogenetic clustering) than expected if assemblages were randomly assembled. Contrary to our expectations, we observed that bird assemblages in forest-dominated habitats were more clustered on large and close islands, whereas assemblages in farmland-dominated habitats were more clustered on small islands. These contrasting results indicate that land-use change interacts with island biogeography to alter the community assembly of birds on inhabited islands. Our findings emphasize the importance of incorporating human-modified habitats when examining the community assembly of island biota, and further suggest that agricultural landscapes on large islands may play essential roles in protecting countryside island biodiversity.
MeSH term(s)	Animals ; Humans ; Phylogeny ; Islands ; Birds ; Biodiversity ; Ecosystem
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.2245
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Article ; Online: Flow cells and reactor design: general discussion.

Alkayal, Anas / Avanthay, Mickaël / Batanero, Belen / Broersen, Pim / Brown, Richard C D / Chen, Luke / Chuang, Ping-Chang / Fuchigami, Toshio / Inagi, Shinsuke / Kalyani, Dipannita / Lam, Kevin / Landis, Maya / Liu, T Leo / Milner, Matthew J / Price, Robert / Shida, Naoki / Wirth, Thomas

Faraday discussions

2023 Volume 247, Page(s) 333–341

Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Congress
ISSN	1364-5498
ISSN (online)	1364-5498
DOI	10.1039/d3fd90042h
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Article ; Online: Primary somatosensory cortex organization for engineering artificial somatosensation.

Lamorie-Foote, Krista / Kramer, Daniel R / Sundaram, Shivani / Cavaleri, Jonathon / Gilbert, Zachary D / Tang, Austin M / Bashford, Luke / Liu, Charles Y / Kellis, Spencer / Lee, Brian

Neuroscience research

2024

Abstract: Somatosensory deficits from stroke, spinal cord injury, or other neurologic damage can lead to a significant degree of functional impairment. The primary (SI) and secondary (SII) somatosensory cortices encode information in a medial to lateral ... ...

Abstract	Somatosensory deficits from stroke, spinal cord injury, or other neurologic damage can lead to a significant degree of functional impairment. The primary (SI) and secondary (SII) somatosensory cortices encode information in a medial to lateral organization. SI is generally organized topographically, with more discrete cortical representations of specific body regions. SII regions corresponding to anatomical areas are less discrete and may represent a more functional rather than topographic organization. Human somatosensory research continues to map cortical areas of sensory processing with efforts primarily focused on hand and upper extremity information in SI. However, research into SII and other body regions is lacking. In this review, we synthesize the current state of knowledge regarding the cortical organization of human somatosensation and discuss potential applications for brain computer interface. In addition to accurate individualized mapping of cortical somatosensation, further research is required to uncover the neurophysiological mechanisms of how somatosensory information is encoded in the cortex.
Language	English
Publishing date	2024-01-24
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	605842-5
ISSN	1872-8111 ; 0168-0102 ; 0921-8696
ISSN (online)	1872-8111
ISSN	0168-0102 ; 0921-8696
DOI	10.1016/j.neures.2024.01.005
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Article ; Online: Rh(I)-Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity.

Deihl, Eric D / Jesikiewicz, Luke T / Newman, Logan J / Liu, Peng / Brummond, Kay M

Organic letters

2022 Volume 24, Issue 4, Page(s) 995–999

Abstract: Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson-Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the ... ...

Abstract	Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson-Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the 5,7,5-ring system of Tg in good yields and high enantioselectivity. Computational studies of the oxidative cyclization step show that the furan and chloroacetate groups contribute to this high selectivity.
MeSH term(s)	COVID-19/drug therapy ; Catalysis ; Chloroacetates/chemistry ; Cyclization ; Furans/chemistry ; Models, Molecular ; Molecular Structure ; Rhodium/chemistry ; Stereoisomerism ; Thapsia/chemistry ; Thapsigargin/analogs & derivatives ; Thapsigargin/chemistry
Chemical Substances	Chloroacetates ; Furans ; Thapsigargin (67526-95-8) ; Rhodium (DMK383DSAC)
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.1c03951
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Article: Rh(I)-Catalyzed Allenic Pauson–Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity

Deihl, Eric D. / Jesikiewicz, Luke T. / Newman, Logan J. / Liu, Peng / Brummond, Kay M.

Organic letters. 2022 Jan. 26, v. 24, no. 4

2022

Abstract: Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson–Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the ... ...

Abstract	Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson–Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the 5,7,5-ring system of Tg in good yields and high enantioselectivity. Computational studies of the oxidative cyclization step show that the furan and chloroacetate groups contribute to this high selectivity.
Keywords	COVID-19 infection ; Ca2-transporting ATPase ; cyclization reactions ; enantioselectivity ; furans
Language	English
Dates of publication	2022-0126
Size	p. 995-999.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c03951
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Optimized Red-Absorbing Dyes for Imaging and Sensing.

Grimm, Jonathan B / Tkachuk, Ariana N / Patel, Ronak / Hennigan, S Thomas / Gutu, Alina / Dong, Peng / Gandin, Valentina / Osowski, Anastasia M / Holland, Katie L / Liu, Zhe J / Brown, Timothy A / Lavis, Luke D

Journal of the American Chemical Society

2023 Volume 145, Issue 42, Page(s) 23000–23013

Abstract: Rhodamine dyes are excellent scaffolds for developing a broad range of fluorescent probes. A key property of rhodamines is their equilibrium between a colorless lactone and fluorescent zwitterion. Tuning the lactone-zwitterion equilibrium constant ( ...

Abstract	Rhodamine dyes are excellent scaffolds for developing a broad range of fluorescent probes. A key property of rhodamines is their equilibrium between a colorless lactone and fluorescent zwitterion. Tuning the lactone-zwitterion equilibrium constant (
MeSH term(s)	Fluorescent Dyes/chemistry ; Rhodamines/chemistry ; Fluorescence Resonance Energy Transfer ; Microscopy, Fluorescence/methods ; Lactones
Chemical Substances	Fluorescent Dyes ; Rhodamines ; Lactones
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c05273
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