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Article ; Online: Prevalence and correlates of DSM-5 opioid withdrawal syndrome in U.S. adults with non-medical use of prescription opioids: results from a national sample.

Mannes, Zachary L / Livne, Ofir / Knox, Justin / Hasin, Deborah S / Kranzler, Henry R

The American journal of drug and alcohol abuse

2023 Volume 49, Issue 6, Page(s) 799–808

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Humans ; Male ; Analgesics, Opioid/adverse effects ; Prevalence ; Quality of Life ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/psychology ; Substance Withdrawal Syndrome/epidemiology ; Substance Withdrawal Syndrome/psychology ; Prescriptions
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	193086-2
ISSN	1097-9891 ; 0095-2990
ISSN (online)	1097-9891
ISSN	0095-2990
DOI	10.1080/00952990.2023.2248646
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Article ; Online: Alcohol withdrawal in past-year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey.

Livne, Ofir / Feinn, Richard / Knox, Justin / Hartwell, Emily E / Gelernter, Joel / Hasin, Deborah S / Kranzler, Henry R

Alcoholism, clinical and experimental research

2022 Volume 46, Issue 3, Page(s) 422–433

Abstract: Background: Despite its potential to produce serious adverse outcomes, DSM-5 alcohol withdrawal syndrome (AWS) has not been widely studied in the general population.: Methods: We used cross-sectional data from 36,309 U.S. adults from the 2012-2013 ... ...

Abstract	Background: Despite its potential to produce serious adverse outcomes, DSM-5 alcohol withdrawal syndrome (AWS) has not been widely studied in the general population. Methods: We used cross-sectional data from 36,309 U.S. adults from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III to examine the past-year prevalence of AWS and its correlates. We focused on an important clinical population-past-year drinkers with unhealthy alcohol use-i.e., those with a positive score on the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire. We also examined the association of AWS with sociodemographic measures, psychiatric disorders, alcohol-related measures, and healthcare utilization. Results: Approximately one-third (n = 12,634) of respondents reported unhealthy alcohol use (AUDIT-C+). Of these, 14.3% met criteria for a DSM-5 AWS diagnosis. The mean (SE) number of withdrawal symptoms among individuals with AWS was 2.83 (1.88), with the most common being nausea/vomiting and insomnia (19.8% and 11.6%, respectively). Among AUDIT-C+ respondents, the odds of AWS were significantly higher among males (adjusted odds ratio [aOR] = 1.17 [95% CI, 1.02-1.33]), unmarried participants (aOR = 1.55 [95% CI, 1.25-1.92]), and those at the lowest (vs. highest) income levels (aOR = 1.62 [95% CI, 1.37-1.92]). Among AUDIT-C+ respondents, AWS was also associated with psychiatric disorders (with aORs that ranged from 2.08 [95% CI, 1.79-2.41]) for major depressive disorder to 3.14 (95% CI, 1.79-2.41) for borderline personality disorder. AUDIT-C+ respondents with AWS also had higher odds of past-year alcohol use disorder (aOR = 11.2 [95% CI, 9.66-13.07]), other alcohol-related features (e.g., binge drinking), and healthcare utilization. Conclusions: Among individuals with unhealthy alcohol use, AWS is prevalent, highly comorbid, and disabling. Given the risk of AWS among unhealthy drinkers, a comparatively large segment of the general population, clinicians should seek to identify individuals with AWS and intervene with them to prevent serious adverse outcomes.
MeSH term(s)	Adult ; Alcohol Drinking/epidemiology ; Alcoholism/diagnosis ; Alcoholism/epidemiology ; Cross-Sectional Studies ; Depressive Disorder, Major/epidemiology ; Ethanol ; Female ; Humans ; Male ; Prevalence ; Substance Withdrawal Syndrome/diagnosis ; Substance Withdrawal Syndrome/epidemiology
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	428999-7
ISSN	1530-0277 ; 0145-6008
ISSN (online)	1530-0277
ISSN	0145-6008
DOI	10.1111/acer.14781
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Article ; Online: Prevention, screening, and treatment for heavy drinking and alcohol use disorder.

Knox, Justin / Hasin, Deborah S / Larson, Farren R R / Kranzler, Henry R

The lancet. Psychiatry

2019 Volume 6, Issue 12, Page(s) 1054–1067

Abstract: Heavy drinking and alcohol use disorder are major public health problems. Practitioners not specialising in alcohol treatment are often unaware of the guidelines for preventing, identifying, and treating heavy drinking and alcohol use disorder. However, ... ...

Abstract	Heavy drinking and alcohol use disorder are major public health problems. Practitioners not specialising in alcohol treatment are often unaware of the guidelines for preventing, identifying, and treating heavy drinking and alcohol use disorder. However, a consensus exists that clinically useful and valuable tools are available to address these issues. Here, we review existing information and developments from the past 5 years in these areas. We also include information on heavy drinking and alcohol use disorder among individuals with co-occurring psychiatric disorders, including drug use disorders. Areas covered include prevention; screening, brief intervention, and referral for treatment; evidence-based behavioural interventions; medication-assisted treatment; technology-based interventions (eHealth and mHealth); and population-level interventions. We also discuss the key topics for future research.
MeSH term(s)	Alcohol-Related Disorders/diagnosis ; Alcohol-Related Disorders/therapy ; Comorbidity ; Global Health ; Humans ; Mass Screening ; Public Health ; Referral and Consultation ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/therapy ; Surveys and Questionnaires
Language	English
Publishing date	2019-10-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(19)30213-5
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Article ; Online: Demographic differences in the cascade of care for unhealthy alcohol use: A cross-sectional analysis of data from the 2015-2019 National Survey on Drug Use and Health.

Mintz, Carrie M / Knox, Justin / Hartz, Sarah M / Hasin, Deborah S / Martins, Silvia S / Kranzler, Henry R / Greene, Emily / Geng, Elvin H / Grucza, Richard A / Bierut, Laura J

Alcohol, clinical & experimental research

2023 Volume 47, Issue 10, Page(s) 1890–1903

Abstract: Background: The screening, brief intervention, and referral to treatment (SBIRT) model is recommended by the U.S. Preventive Services Task Force to improve recognition of and intervention for unhealthy alcohol use. How SBIRT implementation differs by ... ...

Abstract	Background: The screening, brief intervention, and referral to treatment (SBIRT) model is recommended by the U.S. Preventive Services Task Force to improve recognition of and intervention for unhealthy alcohol use. How SBIRT implementation differs by demographic characteristics is poorly understood. Methods: We analyzed data from the 2015-2019 National Survey on Drug Use and Health from respondents ≥18 years old who used an outpatient clinic and had at least one alcoholic drink within the past year. Respondents were grouped into one of three mutually exclusive groups: "no binge drinking or alcohol use disorder (AUD)," "binge drinking without AUD," or "AUD." Outcome variables were likelihood of screening, brief intervention (BI), referral to treatment (RT), and AUD treatment. The demographic predictors on which outcomes were regressed included gender, age, race and ethnicity, sexual orientation, insurance status, and history of military involvement. Consistent with SBIRT guidelines, the entire sample was included in the screening model; screened persons with either binge drinking without AUD or with AUD were included in the BI model; screened persons with AUD were included in the RT model, and persons referred to treatment with AUD were included in the AUD treatment model. Results: Analyses included 120,804 respondents. Women were more likely than men to be screened, but less likely to receive BI or RT. When referred to treatment, women were more likely than men to receive it. Persons aged ≥50 were least likely to be screened about alcohol, but most likely to receive BI, while persons aged 18-25 were least likely to receive BI or AUD treatment. Racial and ethnic minorities were less likely than White persons to be screened; Asians were less likely to receive RT, and Black persons were less likely to receive treatment than White persons. Persons identifying as gay, lesbian, or bisexual were equally as likely or more likely to receive SBIRT or AUD treatment as those identifying as heterosexual. Persons without insurance were less likely to be screened than those with insurance. Persons with a history of military involvement were more likely to be screened and receive BI and RT than persons who had not served in the military. Conclusions: Demographic disparities in SBIRT implementation exist. Addressing the sources of these disparities and minimizing attrition from care could improve outcomes for persons with unhealthy alcohol use.
Language	English
Publishing date	2023-09-10
Publishing country	United States
Document type	Journal Article
ISSN	2993-7175
ISSN (online)	2993-7175
DOI	10.1111/acer.15176
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Article ; Online: Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.

Knox, Justin / Scodes, Jennifer / Witkiewitz, Katie / Kranzler, Henry R / Mann, Karl / O'Malley, Stephanie S / Wall, Melanie / Anton, Raymond / Hasin, Deborah S

Alcoholism, clinical and experimental research

2020 Volume 44, Issue 8, Page(s) 1625–1635

Abstract: Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to ... ...

Abstract	Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to cardiovascular disease (CVD), the leading cause of death for men and women in the United States and of global mortality. This study examined associations between reductions in WHO risk drinking levels and subsequent risk for CVD. Methods: In a US national survey, 1,058 very-high-risk and high-risk drinkers participated in Wave 1 interviews (2001 to 2002) and Wave 2 follow-ups (2004 to 2005). Self-reported CVD history that was communicated to the participant by a doctor or other healthcare professionals included arteriosclerosis, hypertension, angina, tachycardia, or myocardial infarction. We used logistic regression to estimate adjusted odds ratios (aOR) evaluating relationships between ≥2-level reductions in WHO risk drinking levels from Wave 1 to Wave 2 and the risk of Wave 2 CVD, controlling for baseline characteristics. Results: Reductions of ≥2 WHO risk drinking levels were associated with significantly lower odds of CVD in individuals who at Wave 1 were very-high-risk (aOR = 0.58 [0.41 to 0.80]) or high-risk drinkers (aOR = 0.81 [0.70 to 0.94]). Interaction terms showed that this relationship varied by age. Among individuals >40 years old at Wave 1, reductions of ≥2 WHO risk drinking levels were associated with significantly lower odds of CVD among very-high-risk drinkers (aOR = 0.42 [0.28 to 0.63]) but not high-risk drinkers (p = 0.50). Among individuals ≤40 years old at Wave 1, reductions of ≥2 WHO risk drinking levels were associated with significantly lower odds of CVD among high-risk drinkers (aOR = 0.50 [0.37 to 0.69]) but not very-high-risk drinkers (p = 0.27). Conclusions: These results show that reductions in WHO risk drinking levels are associated with reduced CVD risk among very-high-risk and high-risk drinkers in the US general population, and provide further evidence that reducing high levels of drinking provides important benefit across multiple clinical domains.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Alcohol Drinking/epidemiology ; Alcoholism/epidemiology ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Risk Reduction Behavior ; World Health Organization ; Young Adult
Language	English
Publishing date	2020-07-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	428999-7
ISSN	1530-0277 ; 0145-6008
ISSN (online)	1530-0277
ISSN	0145-6008
DOI	10.1111/acer.14386
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Article ; Online: Reduction in non-abstinent World Health Organization (WHO) drinking risk levels and drug use disorders: 3-year follow-up results in the US general population.

Knox, Justin / Wall, Melanie / Witkiewitz, Katie / Kranzler, Henry R / Falk, Daniel E / Litten, Raye / Mann, Karl / O'Malley, Stephanie S / Scodes, Jennifer / Anton, Raymond / Hasin, Deborah S

Drug and alcohol dependence

2019 Volume 201, Page(s) 16–22

Abstract: Background: To provide information on the clinical relevance of a reduction in the World Health Organization (WHO) drinking risk categories, we examined their relationship to an important indicator of how individuals feel and function: drug use ... ...

Abstract	Background: To provide information on the clinical relevance of a reduction in the World Health Organization (WHO) drinking risk categories, we examined their relationship to an important indicator of how individuals feel and function: drug use disorders (DUDs), i.e., those involving substances other than alcohol. Method: Current drinkers in a U.S. national survey (n = 22,005) were interviewed in 2001-02 and re-interviewed 3 years later. WHO drinking risk levels and DSM-IV-defined DUD were assessed at both waves. The relationship of changes in WHO drinking risk levels to the presence of DUD were examined using adjusted odds ratios (aOR). Results: At Wave 1, 2.5% of respondents were WHO very-high-risk drinkers, and 2.5%, 4.8%, and 90.2% were high-risk, moderate-risk, and low-risk drinkers, respectively. Among Wave 1 very-high-risk drinkers, significantly lower odds of DUD at Wave 2 were predicted by reductions in WHO risk levels of one, two or three levels (aOR = 0.15, 0.01, 0.24, respectively; all p-values <.0001). Among participants who initially were drinking at lower risk levels, reductions in drinking or abstinence were generally associated with significantly lower odds of DUD, although the results were less consistent. Conclusions: Among very-high-risk drinkers, reduction in the WHO drinking risk categories were associated with lower risk of a DUD. These results add to findings indicating that reductions in WHO drinking risk levels are a meaningful indicator of how individuals feel and function and could therefore serve as informative outcomes in alcohol clinical trials. WHO risk levels can also guide treatment goals and clinical recommendations on drinking reduction.
MeSH term(s)	Adult ; Alcohol Drinking/epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Odds Ratio ; Substance-Related Disorders/epidemiology ; Time Factors ; United States/epidemiology ; World Health Organization
Language	English
Publishing date	2019-05-29
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2019.03.020
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Article ; Online: Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population.

Knox, Justin / Scodes, Jennifer / Wall, Melanie / Witkiewitz, Katie / Kranzler, Henry R / Falk, Daniel / Litten, Raye / Mann, Karl / O'Malley, Stephanie S / Anton, Raymond / Hasin, Deborah S

Drug and alcohol dependence

2019 Volume 197, Page(s) 228–235

Abstract: Background: Non-abstinent drinking reductions that predict improvement in how individuals feel or function, such as the World Health Organization (WHO) drinking risk levels, may be useful outcomes in clinical trials for alcohol use disorders (AUD).: ... ...

Abstract	Background: Non-abstinent drinking reductions that predict improvement in how individuals feel or function, such as the World Health Organization (WHO) drinking risk levels, may be useful outcomes in clinical trials for alcohol use disorders (AUD). Methods: Current drinkers in a U.S. national survey (n = 22,005) were interviewed in 2001-02 (Wave 1) and re-interviewed 3 years later (Wave 2). WHO drinking risk levels, a 4- level categorization system (very-high-risk, high-risk, moderate-risk, and low-risk drinkers) defined using estimated mean ethanol consumption (grams) per day in the prior 12 months, and DSM-IV depressive and anxiety disorders were assessed at both waves. Logistic regression was used to produce adjusted odds ratios (aOR) testing the associations of changes between Wave 1 and Wave 2 WHO risk levels to the presence or persistence of depression and/or anxiety disorder by each initial Wave 1 risk level. Results: Among Wave 1 very-high-risk drinkers, lower odds of depression and/or anxiety disorders at Wave 2 were predicted by reductions in WHO risk levels of one-, two- or three-levels (aOR = 0.42, 0.37, 0.67, p-values 0.04-<.0001), as was the persistence of depression and/or anxiety disorders among those with such disorders at Wave 1 (aOR = 0.37, 0.29, 0.51, p-values .03-<.0001). Results were less consistent for participants initially drinking at lower risk levels. Conclusions: Among very-high-risk drinkers, reductions in the WHO drinking risk categories were associated with lower risk of depression and/or anxiety disorders. These results add to findings indicating reductions in WHO risk levels are a meaningful indicator of how individuals feel and function.
MeSH term(s)	Adolescent ; Adult ; Alcohol Drinking/epidemiology ; Alcohol Drinking/psychology ; Alcoholism/epidemiology ; Alcoholism/psychology ; Anxiety Disorders/epidemiology ; Anxiety Disorders/psychology ; Depressive Disorder/epidemiology ; Depressive Disorder/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Odds Ratio ; Risk Assessment/standards ; United States/epidemiology ; World Health Organization ; Young Adult
Language	English
Publishing date	2019-02-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2019.01.009
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Article ; Online: Reduction in Nonabstinent WHO Drinking Risk Levels and Change in Risk for Liver Disease and Positive AUDIT-C Scores: Prospective 3-Year Follow-Up Results in the U.S. General Population.

Knox, Justin / Wall, Melanie / Witkiewitz, Katie / Kranzler, Henry R / Falk, Daniel / Litten, Raye / Mann, Karl / O'Malley, Stephanie S / Scodes, Jennifer / Anton, Raymond / Hasin, Deborah S

Alcoholism, clinical and experimental research

2018 Volume 42, Issue 11, Page(s) 2256–2265

Abstract: Background: Abstinence is often the treatment aim for alcohol use disorders (AUD), but this may deter individuals who prefer drinking reduction goals from entering treatment, and be an overly restrictive end point in alcohol clinical trials. ... ...

Abstract	Background: Abstinence is often the treatment aim for alcohol use disorders (AUD), but this may deter individuals who prefer drinking reduction goals from entering treatment, and be an overly restrictive end point in alcohol clinical trials. Nonabstinent drinking reductions that predict improvement in how individuals feel or function may be useful clinical trial outcomes, for example, reductions in the 4-category World Health Organization (WHO) drinking risk levels. To investigate the clinical relevance of these reductions, we examined their relationship with 2 outcomes of interest to medical providers: liver disease, and positive scores on an alcohol screening measure. Methods: Current drinkers in a U.S. national survey (n = 21,925) were interviewed in 2001 to 2002 (Wave 1) and re-interviewed 3 years later (Wave 2). WHO drinking risk levels, liver disease, and the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) were assessed at both waves. Adjusted odds ratios (aORs) were used to indicate the association of change in WHO drinking risk levels with Wave 2 liver disease and AUDIT-C scores. Results: Wave 1 very-high-risk drinkers who reduced 1, 2, or 3 WHO drinking risk levels had significantly lower odds of Wave 2 liver disease (aORs = 0.34, 0.23, 0.17) and positive AUDIT-C scores (aORs = 0.27, 0.09, 0.03). Wave 1 high-risk drinkers who reduced 1 or 2 WHO risk levels had significantly lower odds of positive AUDIT-C scores (aORs = 0.61, 0.25). Adjusting for alcohol dependence or AUDIT-C scoring variations did not affect results. Conclusions: In the highest-risk drinkers, reductions in WHO drinking risk levels predicted lower likelihood of liver disease and positive AUDIT-C scores. Results add to findings that reductions in the 4-category WHO drinking risk levels are a meaningful indicator of how individuals feel and function, and could serve as nonabstinent end points in clinical trials. Results also connect the WHO risk drinking levels to commonly used alcohol screening questions, which may be more familiar to healthcare providers.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcoholism/epidemiology ; Endpoint Determination ; Female ; Follow-Up Studies ; Humans ; Liver Diseases, Alcoholic/epidemiology ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Research Design ; Risk Assessment ; Surveys and Questionnaires ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2018-10-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	428999-7
ISSN	1530-0277 ; 0145-6008
ISSN (online)	1530-0277
ISSN	0145-6008
DOI	10.1111/acer.13884
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Article ; Online: Stem cells as delivery vehicles for oncolytic adenoviral virotherapy.

Kranzler, Justin / Tyler, Matthew A / Sonabend, Adam M / Ulasov, Ilya V / Lesniak, Maciej S

Current gene therapy

2009 Volume 9, Issue 5, Page(s) 389–395

Abstract: Glioblastoma multiforme is the most common primary intracranial tumor in humans. Despite continued advances in cancer therapy, the outcome for patients diagnosed with this disease remains bleak. Novel treatments involving the use of conditionally ... ...

Abstract	Glioblastoma multiforme is the most common primary intracranial tumor in humans. Despite continued advances in cancer therapy, the outcome for patients diagnosed with this disease remains bleak. Novel treatments involving the use of conditionally replicating adenoviruses (CRAds) to target malignant brain tumors have undergone extensive research and proven to be a promising mode of glioblastoma therapy. CRAds are genetically manipulated to replicate within tumor cells, exhibiting a high degree of infectivity, cytotoxicity, and transgene expression. While the use of various CRAds has been deemed safe for intracranial injection in preclinical trials, a significant therapeutic effect has yet to be seen in patients. This shortcoming stems from the distribution limitations involved with local delivery of virolytic agents. To enhance this modality of treatment, stem cells have been explored as cellular vehicles in virotherapy applications, given that they possess an intrinsic tropism for malignant brain tumors. Stem cell loaded CRAd delivery offers a more specific and effective method of targeting disseminated tumor cells and forms the basis for this review.
MeSH term(s)	Adenoviridae/genetics ; Brain Neoplasms/therapy ; Genetic Vectors ; Glioblastoma/therapy ; Humans ; Oncolytic Virotherapy ; Stem Cells/metabolism
Language	English
Publishing date	2009-05-16
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2146187-9
ISSN	1875-5631 ; 1566-5232
ISSN (online)	1875-5631
ISSN	1566-5232
DOI	10.2174/156652309789753347
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Article ; Online: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.

Docherty, Anna R / Mullins, Niamh / Ashley-Koch, Allison E / Qin, Xuejun / Coleman, Jonathan R I / Shabalin, Andrey / Kang, JooEun / Murnyak, Balasz / Wendt, Frank / Adams, Mark / Campos, Adrian I / DiBlasi, Emily / Fullerton, Janice M / Kranzler, Henry R / Bakian, Amanda V / Monson, Eric T / Rentería, Miguel E / Walss-Bass, Consuelo / Andreassen, Ole A /

Behera, Chittaranjan / Bulik, Cynthia M / Edenberg, Howard J / Kessler, Ronald C / Mann, J John / Nurnberger, John I / Pistis, Giorgio / Streit, Fabian / Ursano, Robert J / Polimanti, Renato / Dennis, Michelle / Garrett, Melanie / Hair, Lauren / Harvey, Philip / Hauser, Elizabeth R / Hauser, Michael A / Huffman, Jennifer / Jacobson, Daniel / Madduri, Ravi / McMahon, Benjamin / Oslin, David W / Trafton, Jodie / Awasthi, Swapnil / Berrettini, Wade H / Bohus, Martin / Chang, Xiao / Chen, Hsi-Chung / Chen, Wei J / Christensen, Erik D / Crow, Scott / Duriez, Philibert / Edwards, Alexis C / Fernández-Aranda, Fernando / Galfalvy, Hanga / Gandal, Michael / Gorwood, Philip / Guo, Yiran / Hafferty, Jonathan D / Hakonarson, Hakon / Halmi, Katherine A / Hishimoto, Akitoyo / Jain, Sonia / Jamain, Stéphane / Jiménez-Murcia, Susana / Johnson, Craig / Kaplan, Allan S / Kaye, Walter H / Keel, Pamela K / Kennedy, James L / Kim, Minsoo / Klump, Kelly L / Levey, Daniel F / Li, Dong / Liao, Shih-Cheng / Lieb, Klaus / Lilenfeld, Lisa / Marshall, Christian R / Mitchell, James E / Okazaki, Satoshi / Otsuka, Ikuo / Pinto, Dalila / Powers, Abigail / Ramoz, Nicolas / Ripke, Stephan / Roepke, Stefan / Rozanov, Vsevolod / Scherer, Stephen W / Schmahl, Christian / Sokolowski, Marcus / Starnawska, Anna / Strober, Michael / Su, Mei-Hsin / Thornton, Laura M / Treasure, Janet / Ware, Erin B / Watson, Hunna J / Witt, Stephanie H / Woodside, D Blake / Yilmaz, Zeynep / Zillich, Lea / Adolfsson, Rolf / Agartz, Ingrid / Alda, Martin / Alfredsson, Lars / Appadurai, Vivek / Artigas, María Soler / Van der Auwera, Sandra / Azevedo, M Helena / Bass, Nicholas / Bau, Claiton H D / Baune, Bernhard T / Bellivier, Frank / Berger, Klaus / Biernacka, Joanna M / Bigdeli, Tim B / Binder, Elisabeth B / Boehnke, Michael / Boks, Marco P / Braff, David L / Bryant, Richard / Budde, Monika / Byrne, Enda M / Cahn, Wiepke / Castelao, Enrique / Cervilla, Jorge A / Chaumette, Boris / Corvin, Aiden / Craddock, Nicholas / Djurovic, Srdjan / Foo, Jerome C / Forstner, Andreas J / Frye, Mark / Gatt, Justine M / Giegling, Ina / Grabe, Hans J / Green, Melissa J / Grevet, Eugenio H / Grigoroiu-Serbanescu, Maria / Gutierrez, Blanca / Guzman-Parra, Jose / Hamshere, Marian L / Hartmann, Annette M / Hauser, Joanna / Heilmann-Heimbach, Stefanie / Hoffmann, Per / Ising, Marcus / Jones, Ian / Jones, Lisa A / Jonsson, Lina / Kahn, René S / Kelsoe, John R / Kendler, Kenneth S / Kloiber, Stefan / Koenen, Karestan C / Kogevinas, Manolis / Krebs, Marie-Odile / Landén, Mikael / Leboyer, Marion / Lee, Phil H / Levinson, Douglas F / Liao, Calwing / Lissowska, Jolanta / Mayoral, Fermin / McElroy, Susan L / McGrath, Patrick / McGuffin, Peter / McQuillin, Andrew / Mehta, Divya / Melle, Ingrid / Mitchell, Philip B / Molina, Esther / Morken, Gunnar / Nievergelt, Caroline / Nöthen, Markus M / O'Donovan, Michael C / Ophoff, Roel A / Owen, Michael J / Pato, Carlos / Pato, Michele T / Penninx, Brenda W J H / Potash, James B / Power, Robert A / Preisig, Martin / Quested, Digby / Ramos-Quiroga, Josep Antoni / Reif, Andreas / Ribasés, Marta / Richarte, Vanesa / Rietschel, Marcella / Rivera, Margarita / Roberts, Andrea / Roberts, Gloria / Rouleau, Guy A / Rovaris, Diego L / Sanders, Alan R / Schofield, Peter R / Schulze, Thomas G / Scott, Laura J / Serretti, Alessandro / Shi, Jianxin / Sirignano, Lea / Sklar, Pamela / Smeland, Olav B / Smoller, Jordan W / Sonuga-Barke, Edmund J S / Trzaskowski, Maciej / Tsuang, Ming T / Turecki, Gustavo / Vilar-Ribó, Laura / Vincent, John B / Völzke, Henry / Walters, James T R / Weickert, Cynthia Shannon / Weickert, Thomas W / Weissman, Myrna M / Williams, Leanne M / Wray, Naomi R / Zai, Clement C / Agerbo, Esben / Børglum, Anders D / Breen, Gerome / Demontis, Ditte / Erlangsen, Annette / Gelernter, Joel / Glatt, Stephen J / Hougaard, David M / Hwu, Hai-Gwo / Kuo, Po-Hsiu / Lewis, Cathryn M / Li, Qingqin S / Liu, Chih-Min / Martin, Nicholas G / McIntosh, Andrew M / Medland, Sarah E / Mors, Ole / Nordentoft, Merete / Olsen, Catherine M / Porteous, David / Smith, Daniel J / Stahl, Eli A / Stein, Murray B / Wasserman, Danuta / Werge, Thomas / Whiteman, David C / Willour, Virginia / Coon, Hilary / Beckham, Jean C / Kimbrel, Nathan A / Ruderfer, Douglas M

The American journal of psychiatry

2023 Volume 180, Issue 10, Page(s) 723–738

Abstract: Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present ... ...

Abstract	Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. Methods: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. Results: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10 Conclusions: This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Suicide, Attempted ; Depressive Disorder, Major/genetics ; Risk Factors ; Suicidal Ideation ; Polymorphism, Single Nucleotide/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Loci/genetics
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.21121266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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