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Article: Novel Approaches for the Treatment of Post-Traumatic Stress Disorder: A Systematic Review of Non-Invasive Brain Stimulation Interventions and Insights from Clinical Trials.

Saccenti, Daniele / Lodi, Leandro / Moro, Andrea Stefano / Scaini, Simona / Forresi, Barbara / Lamanna, Jacopo / Ferro, Mattia

Brain sciences

2024 Volume 14, Issue 3

Abstract: First-line treatments for post-traumatic stress disorder (PTSD) encompass a wide range of pharmacotherapies and psychotherapies. However, many patients fail to respond to such interventions, highlighting the need for novel approaches. Due to its ability ... ...

Abstract	First-line treatments for post-traumatic stress disorder (PTSD) encompass a wide range of pharmacotherapies and psychotherapies. However, many patients fail to respond to such interventions, highlighting the need for novel approaches. Due to its ability to modulate cortical activity, non-invasive brain stimulation (NIBS) could represent a valuable therapeutic tool. Therefore, the aim of this systematic review is to summarize and discuss the existing evidence on the ameliorative effects of NIBS on PTSD and comorbid anxiety and depressive symptoms. Our goal is also to debate the effectiveness of an integrated approach characterized by the combination of NIBS and psychotherapy. This search was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines in the PubMed, PsycINFO, PsycARTICLES, PSYINDEX, MEDLINE, and ERIC databases. Overall, 31 studies met the eligibility criteria, yielding a total of 26 clinical trials employing transcranial magnetic stimulation (TMS) and 5 making use of transcranial direct-current stimulation (tDCS). From these studies, it emerged that NIBS consistently reduced overall PTSD symptoms' severity as well as comorbid anxiety and depressive symptoms. Moreover, we speculate that combining NIBS with prolonged exposure or cognitive processing therapy might represent a promising therapeutic approach for consistently ameliorating subjects' clinical conditions.
Language	English
Publishing date	2024-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14030210
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Book ; Online: Guidelines for the Computational Testing of Machine Learning approaches to Vehicle Routing Problems

Accorsi, Luca / Lodi, Andrea / Vigo, Daniele

2021

Abstract: Despite the extensive research efforts and the remarkable results obtained on Vehicle Routing Problems (VRP) by using algorithms proposed by the Machine Learning community that are partially or entirely based on data-driven analysis, most of these ... ...

Abstract	Despite the extensive research efforts and the remarkable results obtained on Vehicle Routing Problems (VRP) by using algorithms proposed by the Machine Learning community that are partially or entirely based on data-driven analysis, most of these approaches are still seldom employed by the Operations Research (OR) community. Among the possible causes, we believe, the different approach to the computational evaluation of the proposed methods may play a major role. With the current work, we want to highlight a number of challenges (and possible ways to handle them) arising during the computational studies of heuristic approaches to VRPs that, if appropriately addressed, may produce a computational study having the characteristics of those presented in OR papers, thus hopefully promoting the collaboration between the two communities.
Keywords	Computer Science - Machine Learning
Publishing date	2021-09-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An upgraded CFA - FLC - MS/MS system for the semi-continuous detection of levoglucosan in ice cores.

Spagnesi, Azzurra / Barbaro, Elena / Feltracco, Matteo / De Blasi, Fabrizio / Zannoni, Daniele / Dreossi, Giuliano / Petteni, Agnese / Notø, Hanne / Lodi, Rachele / Gabrieli, Jacopo / Holzinger, Rupert / Gambaro, Andrea / Barbante, Carlo

Talanta

2023 Volume 265, Page(s) 124799

Abstract: A new Continuous Flow Analysis (CFA) system coupled with Fast Liquid Chromatography - tandem Mass Spectrometry (FLC-MS/MS) has been recently developed for determining organic markers in ice cores. In this work we present an upgrade of this innovative ... ...

Abstract	A new Continuous Flow Analysis (CFA) system coupled with Fast Liquid Chromatography - tandem Mass Spectrometry (FLC-MS/MS) has been recently developed for determining organic markers in ice cores. In this work we present an upgrade of this innovative technique, optimized for the detection of levoglucosan in ice cores, a crucial tracer for reconstructing past fires. The upgrade involved a specific optimization of the chromatographic and mass spectrometric parameters, allowing for a higher sampling resolution (down to 1 cm) and the simultaneous collection of discrete samples, for off-line analysis of water stable isotopes and additional chemical markers. The robustness and repeatability of the method has been tested by the analysis of multiple sticks of ice cut from the same shallow alpine ice core, and running the system for several hours on different days. The results show similar and comparable trends between the ice sticks. With this upgraded system, a higher sensitivity and a lower limit of detection (LOD) was achieved compared to discrete analysis of alpine samples for levoglucosan measurements. The new LOD was as low as 66 ng L
Language	English
Publishing date	2023-06-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.124799
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Article: Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets.

Maggio, Ilaria / Franceschi, Enrico / Di Nunno, Vincenzo / Gatto, Lidia / Tosoni, Alicia / Angelini, Daniele / Bartolini, Stefania / Lodi, Raffaele / Brandes, Alba Ariela

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 10

Abstract: Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. ...

Abstract	Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other genetic alterations, particularly affecting SMO, TRAF7, KLF4 AKT1 and PI3KCA. In higher grade meningiomas, mutations of TERT promoter and deletion of CDKN2A/B seem to have a prognostic value. Furthermore, other genetic alterations have been identified, such as BAP1, DMD and PBRM1. Different subgroups of DNA methylation appear to be correlated with prognosis. In this review, we explored the genetic landscape of meningiomas and the possible therapeutic implications.
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11101852
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Article ; Online: Clinical and Molecular Features of Patients with Gliomas Harboring IDH1 Non-canonical Mutations: A Systematic Review and Meta-Analysis.

Di Nunno, Vincenzo / Franceschi, Enrico / Tosoni, Alicia / Gatto, Lidia / Maggio, Ilaria / Lodi, Raffaele / Angelini, Daniele / Bartolini, Stefania / Brandes, Alba Ariela

Advances in therapy

2021 Volume 39, Issue 1, Page(s) 165–177

Abstract: Introduction: The canonical isocitrate dehydrogenase 1 R132 mutation (IDH1 R132) is the most frequent mutation among IDH-mutated gliomas. Non-canonical IDH1 mutations or IDH2 mutations are unusual and their clinical and biological role is still unclear.! ...

Abstract	Introduction: The canonical isocitrate dehydrogenase 1 R132 mutation (IDH1 R132) is the most frequent mutation among IDH-mutated gliomas. Non-canonical IDH1 mutations or IDH2 mutations are unusual and their clinical and biological role is still unclear. Methods: We performed a systematic review and meta-analysis to assess the clinical role of IDH non-canonical mutations. Results: Overall, we selected 13 of 3513 studies reporting data of 4007 patients with a diagnosis of grade 2 and grade 3 glioma including 3091 patients with a molecularly proven IDH1 or IDH2 mutation. Patients with non-canonical IDH1 mutations were younger and presented a higher DNA methylation level as compared to those with canonical IDH1 R132H alteration. The overall incidence of non-canonical IDH1 mutations was 7.9% (95% CI 5.4-10.7%) in patients with IDH-mutated gliomas. There was no statistical difference in terms of incidence between patients with grade 2 or grade 3 glioma. Patients with non-canonical IDH mutations had a lower rate of 1p19q codeletion (risk difference 31%, 95% CI 23-38%) and presented a significantly prolonged survival (pooled HR 0.47, 95% CI 0.28-0.81) as compared to those with IDH1 R132H mutation. Conclusion: Non-canonical IDH1 mutations occur in 7.9% of IDH-mutated gliomas and identify a specific subgroup of patients with an improved survival despite a lower rate of 1p19q codeletion. Data about the type of IDH mutation should be collected in clinical practice and within interventional trials as this could be a critical variable for improved stratification and selection of patients.
MeSH term(s)	Brain Neoplasms/genetics ; Glioma/diagnosis ; Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Mutation
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-021-01977-3
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Zs.A 2101: Show issues

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Article ; Online: Report on an Italian survey of 72 stuck hemodialysis catheters.

Forneris, Giacomo / Savio, Daniele / Quaretti, Pietro / Lodi, Massimo / Comelli, Simone / Morale, Walter / Spina, Monica / Di Maggio, Luca / Cornacchiari, Marina / Punzi, Massimo / Gatta, Giuseppe / Cecere, Pasqualina / Pozzato, Marco / Marciello, Antonio / Roccatello, Dario

Journal of nephrology

2022 Volume 36, Issue 2, Page(s) 359–365

Abstract: Background: Reports of stuck hemodialysis catheters have been on the rise in recent years. Aim of this work is to report how this complication has been managed and the relative outcomes in a multicente Italian survey.: Methods: Since 2012, the ... ...

Abstract	Background: Reports of stuck hemodialysis catheters have been on the rise in recent years. Aim of this work is to report how this complication has been managed and the relative outcomes in a multicente Italian survey. Methods: Since 2012, the Italian Society of Nephrology (SIN) Project Group of Vascular Access has collected data among nephrologists on this complication. Data regarding 72 cases of stuck tunnelled central venous catheter (tCVC) in 72 patients were retrieved thanks to this survey. Results: In 11 patients (15%) the stuck catheter was directly buried or left in place. Sixty-one cases were managed through advanced removal techniques. Among these, 47 (77%) stuck tunnelled central venous catheters were successfully removed, while 14 (23%) failed to be withdrawn. Considering removed tCVCs, the use of endoluminal balloon dilatation alone or in combination with other tools showed a percentage of success of 88%. The removal procedure involved numerous specialists. Some complications occurred, such as breakage of the line or bleeding, and two cases of haemopericardium during an advanced procedure. Conclusion: The survey shows how the stuck catheter complication was managed in different ways, with conflicting results. When utilized, endoluminal balloon dilatation proved to be the most effective and most often utilized technique, while some cases had suboptimal management or failure. This underlines how delicate the procedure is, and the need for both precise knowledge of this complication and timely organization of removal attempts.
MeSH term(s)	Humans ; Catheterization, Central Venous/adverse effects ; Catheters, Indwelling/adverse effects ; Treatment Outcome ; Device Removal/methods ; Central Venous Catheters/adverse effects ; Renal Dialysis/adverse effects ; Italy
Language	English
Publishing date	2022-10-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-022-01474-y
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Zs.A 3369: Show issues

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Article ; Online: Discovering the Molecular Landscape of Meningioma

Ilaria Maggio / Enrico Franceschi / Vincenzo Di Nunno / Lidia Gatto / Alicia Tosoni / Daniele Angelini / Stefania Bartolini / Raffaele Lodi / Alba Ariela Brandes

Diagnostics, Vol 11, Iss 1852, p

The Struggle to Find New Therapeutic Targets

2021 Volume 1852

Abstract	Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other genetic alterations, particularly affecting SMO, TRAF7, KLF4 AKT1 and PI3KCA. In higher grade meningiomas, mutations of TERT promoter and deletion of CDKN2A/B seem to have a prognostic value. Furthermore, other genetic alterations have been identified, such as BAP1, DMD and PBRM1. Different subgroups of DNA methylation appear to be correlated with prognosis. In this review, we explored the genetic landscape of meningiomas and the possible therapeutic implications.
Keywords	meningioma ; NF2 ; SMO ; DNA methylation ; molecular alterations ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Immunological Evaluation of Patients Affected with Jacobsen Syndrome Reveals Profound Not Age-Related Lymphocyte Alterations.

Baronio, Manuela / Saettini, Francesco / Gazzurelli, Luisa / Rossi, Stefano / Marzollo, Antonio / Ricci, Silvia / Zama, Daniele / Palterer, Boaz / Clementina, Canessa / Lorenzo, Lodi / Chiarini, Marco / Sottini, Alessandra / Imberti, Luisa / Gorio, Chiara / Rossini, Linda / Badolato, Raffaele / Plebani, Alessandro / Moratto, Daniele / Lougaris, Vassilios

Journal of clinical immunology

2021 Volume 42, Issue 2, Page(s) 365–374

Abstract: Purpose: Jacobsen syndrome (JS) is a rare form of genetic disorder that was recently classified as a syndromic immunodeficiency. Available detailed immunological data from JS patients are limited.: Methods: Clinical and immunological presentation of ... ...

Abstract	Purpose: Jacobsen syndrome (JS) is a rare form of genetic disorder that was recently classified as a syndromic immunodeficiency. Available detailed immunological data from JS patients are limited. Methods: Clinical and immunological presentation of twelve pediatric patients with JS by means of revision of clinical records, flow cytometry, real-time PCR, and lymphocyte functional testing were collected. Results: Recurrent infections were registered in 6/12 patients (50%), while bleeding episodes in 2/12 (16.7%). White blood cell and absolute lymphocyte counts were reduced in 8/12 (66.7%) and 7/12 (58.3%) patients, respectively. Absolute numbers of CD3 Conclusions: Our data suggest that patients affected with JS may display important numeric and maturational alterations in the T-, B-, and NK-cell compartments. These findings suggest that JS patients should be regularly monitored from an immunological point of view.
MeSH term(s)	B-Lymphocytes ; Child ; Flow Cytometry ; Humans ; Jacobsen Distal 11q Deletion Syndrome ; Killer Cells, Natural ; Lymphocyte Count
Language	English
Publishing date	2021-11-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-021-01169-2
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Article: The Role of PEC Progenitors in ADPKD Progression.

Lodi, Daniele / Ligabue, Giulia / Lupo, Valentina / Cavazzini, Fabrizio

International journal of stem cells

2013 Volume 5, Issue 1, Page(s) 65–72

Abstract: Background and objectives: Autosomal dominant polycystic kidney disease is a pathology mainly characterized by the progressive development and enlargement of cysts in each kidneys. Such as many adult epithelial tissue, renal tubule replaces damaged or ... ...

Abstract	Background and objectives: Autosomal dominant polycystic kidney disease is a pathology mainly characterized by the progressive development and enlargement of cysts in each kidneys. Such as many adult epithelial tissue, renal tubule replaces damaged or death cells through the presence of stem/progenitor cells CD133(+)CD24(+) Obviously, in ADPKD the repair of damages is insufficient to block the disease, but renal stem cells could have a role in the pathology. In this study we investigate the localization and the involvement of cells CD133(+)CD24(+) in ADPKD progression. Methods and results: Two normal kidneys and two ADPKD kidneys were examined. CD133 and CD24 expression was investigated by confocal microscopy and immunoblotting. Renal tissue and cells were analyzed. CD133 and CD24 have the same localization in ADPKD tissues and in normal kidneys: a subset of epithelial cells (PEC) of Bowman' s capsule and luminal side of tubules. It is interesting that CD133(+) CD24(+) cells are statistically more represented in ADPKD tubules (p＜ 0.001) and in healthy glomeruli (p= 0.0016). Cysts express CD133 and CD24. Conclusions: Renal epithelial progenitors demonstrate to be involved in ADPKD pathogenesis but their role will have to be clarified and possibly managed to obtain improvement, or at least stabilization, of disease.
Language	English
Publishing date	2013-11-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2914134-5
ISSN	2005-5447 ; 2005-3606
ISSN (online)	2005-5447
ISSN	2005-3606
DOI	10.15283/ijsc.2012.5.1.65
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Article ; Online: [

Zanoni, Lucia / Bianchi, Lorenzo / Nanni, Cristina / Pultrone, Cristian / Giunchi, Francesca / Bossert, Irene / Matti, Antonella / Schiavina, Riccardo / Fiorentino, Michelangelo / Romagnoli, Daniele / Fonti, Cristina / Lodi, Filippo / D'Errico, Antonietta / Brunocilla, Eugenio / Porreca, Angelo / Fanti, Stefano

European journal of nuclear medicine and molecular imaging

2021 Volume 49, Issue 1, Page(s) 390–409

Abstract: Purpose: The conventional imaging flowchart for prostate cancer (PCa) staging may fail in correctly detecting lymph node metastases (LNM). Pelvic lymph node dissection (PLND) represents the only reliable method, although invasive. A new amino acid PET ... ...

Abstract	Purpose: The conventional imaging flowchart for prostate cancer (PCa) staging may fail in correctly detecting lymph node metastases (LNM). Pelvic lymph node dissection (PLND) represents the only reliable method, although invasive. A new amino acid PET compound, [ Methods: Consecutive patients (pts) with biopsy-proven PCa, standard staging (including [ Results: Overall, 94 pts underwent [ Conclusion: In high-risk primary PCa, [ Trial registration: EudraCT number: 2014-003,165-15.
MeSH term(s)	Choline ; Humans ; Lymphatic Metastasis ; Male ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
Chemical Substances	Choline (N91BDP6H0X)
Language	English
Publishing date	2021-07-02
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-021-05429-6
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