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Article ; Online: Diagnoselabyrinth: Morbus Cushing.

Manstein, Moritz C / Piel, Esther / Stumvoll, Michael / Kische, Stephan

Innere Medizin (Heidelberg, Germany)

2024

Abstract: The case of a 78-year-old female presenting to the authors' department with heart failure with dyspnea at minimal exertion (NYHA III) as well as hypertensive blood pressure and hypokalaemia is reported. Laboratory workup showed hypercortisolism. Further ... ...

Title translation	A diagnostic maze: Cushing's disease.
Abstract	The case of a 78-year-old female presenting to the authors' department with heart failure with dyspnea at minimal exertion (NYHA III) as well as hypertensive blood pressure and hypokalaemia is reported. Laboratory workup showed hypercortisolism. Further workup, including imaging studies and selective catheterisation of the inferior petrosal sinus, resulted in the diagnosis of Cushing's disease caused by a pituitary microadenoma.
Language	German
Publishing date	2024-01-04
Publishing country	Germany
Document type	English Abstract ; Journal Article
ISSN	2731-7099
ISSN (online)	2731-7099
DOI	10.1007/s00108-023-01653-4
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Article ; Online: Percutaneous treatment of adult aortic coarctation with multiple intrathoracic aneurysms.

Kische, Stephan / D'Ancona, Giuseppe / Ince, Hüseyin

Journal of vascular surgery

2017 Volume 66, Issue 1, Page(s) 265

Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2016.03.448
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Zs.A 1933: Show issues

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Article ; Online: Sex-related differences in outcome after left atrial appendage occlusion: Insights from Europe and the EWOLUTION registry.

Paitazoglou, Christina / Eitel, Ingo / Stiermaier, Thomas / Ince, Hueseyin / Kische, Stephan / Pokushalov, Evgeny / Schmitz, Thomas / Schmidt, Boris / Gori, Tommaso / Meincke, Felix / Vireca, Elisa / Wohlmuth, Peter / Lucas, Boersma / Bergmann, Martin W

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 2, Page(s) 283–292

Abstract: Background: Women with atrial fibrillation (AF) generally experience worse symptoms, poorer quality of life, and have a higher risk of stroke and death. There is limited availability of sex-related differences regarding left atrial appendage occlusion ( ... ...

Abstract	Background: Women with atrial fibrillation (AF) generally experience worse symptoms, poorer quality of life, and have a higher risk of stroke and death. There is limited availability of sex-related differences regarding left atrial appendage occlusion (LAAO). Aims: The aim of this study was to evaluate the sex-related differences in patients undergoing LAAO in EWOLUTION. Methods: A total of 1025 patients scheduled for elective LAAO therapy employing the WATCHMAN Gen 2.5 prospectively consented for participation; 1005 patients received a successful implant and were followed for 2 years. As we detected sex-related differences in baseline data we performed a propensity score matching. The primary endpoint is a combined endpoint of survival free from mortality, major bleeding, ischemic stroke, transitory ischemic attack (TIA) and systemic embolization (SE) up to 2-year clinical follow-up. Secondary Endpoints were periprocedural data and overall 2-year survival. Results: Women were older but had less often vascular disease and hemorrhagic stroke. There was no sex-related significant difference after LAAO at 2 years in the combined endpoint of survival free from mortality, major bleeding, ischemic stroke, TIA, and SE (female vs. male: 79% vs.76%, p = 0.24) or in overall survival (female vs. male: 85% vs. 82%, p = 0.16). Procedural data showed a higher sealing rate after the implantation in women (complete sealing female 94% vs. male 90%, p = 0.033), significantly more pericardial effusions (female 1.2% vs. male 0.2%, p = 0.031) and a similar periprocedural risk profile. Conclusions: Females undergoing LAAO differ in various baseline variables, but after adjustment, we observed similar safety and efficacy of LAAO with no significant difference in long-term outcomes between women and men.
MeSH term(s)	Humans ; Male ; Female ; Treatment Outcome ; Atrial Appendage/diagnostic imaging ; Ischemic Attack, Transient/etiology ; Quality of Life ; Stroke/etiology ; Stroke/prevention & control ; Europe ; Hemorrhage ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Atrial Fibrillation/complications ; Ischemic Stroke ; Registries
Language	English
Publishing date	2023-07-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30759
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Article ; Online: Off-pump versus on-pump coronary artery bypass grafting in patients with depressed left ventricular ejection fraction percentage: "If this is the best of all possible worlds, what then are the others?".

D'Ancona, Giuseppe / Kische, Stephan / Ince, Hüseyin

The Journal of thoracic and cardiovascular surgery

2016 Volume 151, Issue 4, Page(s) 1099–1100

MeSH term(s)	Cardiopulmonary Bypass ; Coronary Artery Bypass ; Coronary Artery Bypass, Off-Pump ; Coronary Artery Disease/surgery ; Female ; Humans ; Male ; Stroke Volume ; Ventricular Dysfunction, Left/complications ; Ventricular Function, Left
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2015.11.065
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Article ; Online: Perioperative endothelin-1 levels: Searching for the hidden fingerprint of nonocclusive mesenteric ischemia.

D'Ancona, Giuseppe / Kische, Stephan / Ince, Hüseyin

The Journal of thoracic and cardiovascular surgery

2015 Volume 149, Issue 5, Page(s) 1443–1444

MeSH term(s)	Cardiac Surgical Procedures/adverse effects ; Endothelin-1/blood ; Female ; Humans ; Male ; Mesenteric Ischemia/etiology
Chemical Substances	Endothelin-1
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2015.02.034
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Article ; Online: True Efficacy of LAA Closure: Patient Outcomes on Long-term Single-Antiplatelet or No Therapy: Insights From the EWOLUTION Registry.

Paitazoglou, Christina / Bergmann, Martin W / Ince, Hüseyin / Kische, Stephan / Romanov, Aleksandr / Schmitz, Thomas / Schmidt, Boris / Gori, Tommaso / Meincke, Felix / Protopopov, Alexey Vladimir / Betts, Timothy / Vireca, Elisa / Wohlmuth, Peter / Boersma, Lucas

The Journal of invasive cardiology

2022 Volume 34, Issue 5, Page(s) E348–E355

Abstract: Background: Left atrial appendage occlusion (LAAO) is recommended for patients with atrial fibrillation at increased stroke risk, where effective long-term oral anticoagulation (OAC) is not feasible. In order to assess long-term safety of LAAO with ... ...

Abstract	Background: Left atrial appendage occlusion (LAAO) is recommended for patients with atrial fibrillation at increased stroke risk, where effective long-term oral anticoagulation (OAC) is not feasible. In order to assess long-term safety of LAAO with aspirin monotherapy or no therapy, we aimed to report on patients with the Watchman LAAO device (Boston Scientific) once postimplantation intensified antiplatelet or anticoagulation therapy is discontinued. Methods: A total of 1025 patients scheduled for elective LAAO therapy prospectively consented for participation in the EWOLUTION registry; 1005 patients received a successful implant and were followed for 2 years. We identified 766 patients in EWOLUTION on single-antiplatelet therapy (SAPT; n = 639) or no therapy (n = 127) for ≥1 year following LAAO. Results: Three to 6 months after LAAO, 766 patients were switched to SAPT or no therapy and were followed for at least 1 year until the study's conclusion or with events while on SAPT/ no therapy; mean time on SAPT/no therapy was 536.56 ± 177.59 days. Patients experienced 1.4 ischemic strokes per 100 patient years (PY) despite a CHA2DS2-VASC score of 4.3 ± 1.6. Major nonprocedural bleeding rates were low, with 1.3 major bleeds per 100 PY with a mean HAS-BLED score of 2.2 ± 1.2. Furthermore, the ischemic stroke rate in the SAPT/no-therapy subgroup was similar to the whole EWOLUTION collective and high-risk subgroups; the bleeding rate was even lower. When analyzed separately, strokes (2.1/100 PY) and bleedings (1.4/100 PY) of the no-therapy subgroup were similar to patients on SAPT (strokes 0.7/100 PY [P=.70]; bleedings 1.4/100 PY [P=.90]). Conclusions: Outcome data of patients on SAPT/no therapy for ≥1 year following Watchman implantation in the EWOLUTION registry suggest the efficacy and safety of LAAO.
MeSH term(s)	Anticoagulants/adverse effects ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Hemorrhage/prevention & control ; Humans ; Registries ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 272: Show issues
Zs.MG 31: Show issues

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Article ; Online: Percutaneous left atrial appendage closure for cerebrovascular accident prevention: rationale, indications, technical aspects, clinical results and future perspective.

D'Ancona, Giuseppe / Ketterer, Ulrike / Kische, Stephan / Murero, Monica / Feickert, Sebastian / Ortak, Jasmin / Öner, Alper / Ince, Hüseyin

Future cardiology

2020 Volume 16, Issue 4, Page(s) 237–250

Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The most feared complication of AF is thromboembolism. Oral anticoagulation (OAC) is the standard treatment to reduce thromboembolism occurrence in patients with AF. The rate of ... ...

Abstract	Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The most feared complication of AF is thromboembolism. Oral anticoagulation (OAC) is the standard treatment to reduce thromboembolism occurrence in patients with AF. The rate of relevant bleeding, medical interactions and incompliance under OAC remains consistent. In this context, patients with AF at high risk for thromboembolism and with a contraindication to OAC may be considered as candidates for percutaneous left atrial appendage closure. In this review, we discuss the rationale, indications, technical aspects and clinical results of left atrial appendage closure by means of the WATCHMAN
MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Humans ; Stroke/etiology ; Stroke/prevention & control ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2019-0086
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Zs.A 6836: Show issues

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Book ; Online ; Thesis: Die endovaskuläre Implantation von Stentgrafts bei Typ B-Aortendissektion unter prognostischen Gesichtspunkten

Kische, Stephan [Verfasser]

2008

Author's details	vorgelegt von Stephan Kische
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Treatment of pure aortic insufficiency after aortic stentless valve implantation: increasing safety with a transcatheter inflatable fully repositionable valve.

Kische, Stephan / D'Ancona, Giuseppe / Ortak, Jasmin / Ince, Hüseyin

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2015 Volume 11, Issue 5, Page(s) e1–2

MeSH term(s)	Aged ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/surgery ; Heart Valve Prosthesis ; Humans ; Prosthesis Failure ; Transcatheter Aortic Valve Replacement/methods ; Ultrasonography
Language	English
Publishing date	2015-09
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJV11I5A117
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: Left atrial appendage closure with the watchman device reduces atrial fibrillation management costs.

D Ancona, Giuseppe / Safak, Erdal / Weber, Denise / Arslan, Fatih / Kische, Stephan / Darius, Harald / Behrens, Steffen / Zohlenhöfer-Momm, Dietlind / Ortak, Jasmin / Kugler, Joachim / Ince, Hüseyin

Clinical research in cardiology : official journal of the German Cardiac Society

2021 Volume 111, Issue 1, Page(s) 105–113

Abstract: Aims: To report hospitalization costs of patients with non-valvular atrial fibrillation (AF) submitted to percutaneous left atrial appendage closure (LAAC) with the Watchman device.: Methods: Pre- and post-procedural hospitalization AF-related costs ... ...

Abstract	Aims: To report hospitalization costs of patients with non-valvular atrial fibrillation (AF) submitted to percutaneous left atrial appendage closure (LAAC) with the Watchman device. Methods: Pre- and post-procedural hospitalization AF-related costs were calculated using the DRG system (diagnosis-related groups) and compared. Results: Between 2012 and 2016, 677 non-valvular AF patients underwent LAAC. Median time from first cardiac hospitalization to LAAC was 5.9 years (IQR 1.6-9.1) and median follow-up after LAAC was 4.8 years (IQR 3.6-5.6). LAAC mortality was 1.3% and follow-up mortality 16.9%. Median pre-LAAC hospitalization cost was € 17,867 (IQR € 7512-35,08) and post-LAAC € 8772 (IQR € 1183-25,159) (p < 0.0001). Annualized cost pre-LAAC was 3773 € (IQR € 1644-8,493) and post-LAAC 2,001 € (IQR € 260-6913) (p < 0.0001). Follow-up survivors had significantly lower post-LAAC costs (p < 0.0001) and after a survival cut-off time of 4.6 years LAAC procedural and post-procedural hospitalization costs achieved parity with pre-LACC costs (AUC 0.64; p = 0.02). CHA2DS2-VASc score (B = 0.04; p = 0.02; 95% CI 0.006-0.08), and HAS-BLED score (B = 0.08; p = 0.004; 95% CI 0.02-0.14) were independent determinants for annualized hospitalization costs post-LAAC. At Cox-regression analysis the DRG mean clinical complexity level (CCL) was the only independent determinant for follow-up mortality (OR = 2.2; p < 0.0001; 95% CI 1.6-2.8) with a cut-off value of 2.25 to predict follow-up mortality (AUC 0.72; p < 0.0001; Spec. 70%; Sens. 70%). Conclusion: Hospitalization costs pre-LAAC are consistent, and after LAAC, they are significantly reduced. Costs seem related to the patient's risk profile at the time of the procedure. With the increase in post-LAAC survival time, the procedure becomes economically more profitable.
MeSH term(s)	Aged ; Atrial Appendage/surgery ; Atrial Fibrillation/mortality ; Atrial Fibrillation/surgery ; Cardiac Catheterization ; Costs and Cost Analysis ; Female ; Germany ; Hospitalization/economics ; Humans ; Male ; Prostheses and Implants/economics
Language	English
Publishing date	2021-10-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-021-01943-7
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