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  1. Article ; Online: Reply to Guglielmo Mantica, Nazareno Suardi, and Carlo Terrone's Letter to the Editor re: Ming-Chun Chan, Sharon E.K. Yeo, Yew-Lam Chong, Yee-Mun Lee. Stepping Forward: Urologists' Efforts During the COVID-19 Outbreak in Singapore. Eur Urol 2020;78:e38?9.

    Chan, Ming-Chun / Yeo, Sharon E K / Chong, Yew-Lam / Lee, Yee-Mun

    European urology

    2020  Volume 78, Issue 4, Page(s) e167–e168

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Singapore ; Urologists
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.04.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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  2. Article: Reply to Guglielmo Mantica, Nazareno Suardi, and Carlo Terrone's Letter to the Editor re: Ming-Chun Chan, Sharon E.K. Yeo, Yew-Lam Chong, Yee-Mun Lee. Stepping Forward: Urologists' Efforts During the COVID-19 Outbreak in Singapore. Eur Urol 2020;78:e38?9

    Chan, Ming-Chun / Yeo, Sharon E K / Chong, Yew-Lam / Lee, Yee-Mun

    Eur Urol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #209810
    Database COVID19

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  3. Article ; Online: Reply to Guglielmo Mantica, Nazareno Suardi, and Carlo Terrone’s Letter to the Editor re: Ming-Chun Chan, Sharon E.K. Yeo, Yew-Lam Chong, Yee-Mun Lee. Stepping Forward: Urologists’ Efforts During the COVID-19 Outbreak in Singapore. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.004

    Chan, Ming-Chun / Yeo, Sharon E.K. / Chong, Yew-Lam / Lee, Yee-Mun

    European Urology

    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.eururo.2020.04.071
    Database COVID19

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  4. Article ; Online: Effect of isotemporal substitution of sedentary behavior with different intensities of physical activity on the muscle function of older adults in the context of a medical center.

    Lai, Ting-Fu / Liao, Yung / Hsueh, Ming-Chun / Lin, Kun-Pei / Chan, Ding-Cheng / Chen, Yung-Ming / Wen, Chiung-Jung

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 130

    Abstract: Background: Engaging in physical activity and reducing sedentary time in daily life may enable older individuals to maintain muscle mass. This study aimed to investigate the effects of replacing sedentary behavior with light physical activity (LPA) or ... ...

    Abstract Background: Engaging in physical activity and reducing sedentary time in daily life may enable older individuals to maintain muscle mass. This study aimed to investigate the effects of replacing sedentary behavior with light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on the muscle function of older adults at a medical center in Taiwan.
    Methods: We recruited 141 older adults (51.1% men; 81.1 ± 6.9 years old) and asked them to wear a triaxial accelerometer on the waist to measure their sedentary behavior and physical activity. Functional performance was assessed based on handgrip strength, Timed Up and Go (TUG) test, gait speed, and five-times-sit-to-stand test (5XSST). Isotemporal substitution analysis was performed to examine the effect of substituting 60 min of sedentary time with 60 min of LPA, MVPA, and combined LPA and MVPA in different proportions.
    Results: Reallocating 60 min of sedentary behavior per day to LPA was associated with better handgrip strength (Beta [B] = 1.587, 95% confidence interval [CI] = 0.706, 2.468), TUG test findings (B = -1.415, 95% CI = -2.186, -0.643), and gait speed (B = 0.042, 95% CI = 0.007, 0.078). Reallocating 60 min of sedentary behavior per day to MVPA was associated with better gait speed (B = 0.105, 95% CI = 0.018, 0.193) and 5XSST findings (B = -0.060, 95% CI = -0.117, -0.003). In addition, each 5-min increment in MVPA in the total physical activity replacing 60 min of sedentary behavior per day resulted in greater gait speed. Replacing 60 min of sedentary behavior with 30-min of LPA and 30-min of MVPA per day significantly decreased the 5XSST test time.
    Conclusion: Our study indicates that introducing LPA and a combination of LPA and MVPA to specifically replace sedentary behavior may help maintain muscle function in older adults.
    MeSH term(s) Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Sedentary Behavior ; Hand Strength ; Exercise ; Hospitals ; Muscles
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-03819-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ZEB1 Fuels Serine Metabolism to Promote HCC Metastasis.

    Chan, For-Fan / Wong, Chun-Ming

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 4, Page(s) 646–647

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Transformation, Neoplastic/pathology ; Cell Line, Tumor ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism
    Chemical Substances ZEB1 protein, human ; Zinc Finger E-box-Binding Homeobox 1
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.07.002
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  6. Article ; Online: Physiologically-based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID-19.

    Ng, Tat Ming / Wang, Ziteng / Chan, Eric Chun Yong

    British journal of clinical pharmacology

    2024  

    Abstract: We aimed to address factors contributing to the pharmacokinetic changes of nirmatrelvir/ritonavir in renal impaired (RI) patients and recommend dosing adjustment via a physiologically-based pharmacokinetic (PBPK) modelling approach. A PBPK model of ... ...

    Abstract We aimed to address factors contributing to the pharmacokinetic changes of nirmatrelvir/ritonavir in renal impaired (RI) patients and recommend dosing adjustment via a physiologically-based pharmacokinetic (PBPK) modelling approach. A PBPK model of nirmatrelvir/ritonavir was developed via Simcyp® Simulator. Sensitivity analysis of the influence of hepatic CYP3A4 intrinsic clearance and abundance, as well as hepatic non-CYP3A4 metabolism (other human liver microsomes [HLM] CL
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16074
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
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  7. Article ; Online: Trialkylphosphonium Oxoborate as C(sp

    Leung, Vincent Ming-Yau / Pook, Chun-Man / Chan, Tsz-Chun / Yeung, Ying-Yeung

    Chemistry, an Asian journal

    2024  Volume 19, Issue 4, Page(s) e202300981

    Abstract: We have developed a catalytic protocol for Diels-Alder reaction using trialkylphosphonium oxoborates as oxyanion hole catalysts. The reaction can be operated under ambient conditions. Dienes could easily polymerize under acidic condition. Nonetheless, ... ...

    Abstract We have developed a catalytic protocol for Diels-Alder reaction using trialkylphosphonium oxoborates as oxyanion hole catalysts. The reaction can be operated under ambient conditions. Dienes could easily polymerize under acidic condition. Nonetheless, these acid-sensitive substrates are compatible with the catalytic protocol and the reaction scope covers a wide range of substrates.
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300981
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  8. Article: Diurnal pattern of breaks in sedentary time and the physical function of older adults.

    Lai, Ting-Fu / Liao, Yung / Lin, Chien-Yu / Hsueh, Ming-Chun / Koohsari, Mohammad Javad / Shibata, Ai / Oka, Koichiro / Chan, Ding-Cheng

    Archives of public health = Archives belges de sante publique

    2023  Volume 81, Issue 1, Page(s) 35

    Abstract: Background: The association of breaks in sedentary time with outcomes of physical function can vary according to the time of day. We examined the association of the diurnal pattern of breaks in sedentary time with physical function outcomes in older ... ...

    Abstract Background: The association of breaks in sedentary time with outcomes of physical function can vary according to the time of day. We examined the association of the diurnal pattern of breaks in sedentary time with physical function outcomes in older adults.
    Methods: A cross-sectional analysis was conducted among 115 older adults (≥60 years). The overall and time-specific breaks (morning: 06:00-12:00; afternoon: 12:00-18:00; evening: 18:00-24:00) in sedentary time were assessed using a triaxial accelerometer (Actigraph GT3X+). A break in sedentary time was defined as at least 1 min where the accelerometer registered ≥100 cpm following a sedentary period. Five physical function outcomes were assessed: handgrip strength (dynamometer), balance ability (single leg stance), gait speed (11-m walking), basic functional mobility (time up and go), and lower-limb strength (five times sit-to-stand). Generalized linear models were used to examine the associations of the overall and time-specific breaks in sedentary time with the physical function outcomes.
    Results: Participants showed an average of 69.4 breaks in sedentary time during the day. Less frequent breaks in the evening (19.3) were found than that in the morning (24.3) and the afternoon (25.3) (p < 0.05). Breaks in sedentary time during the day were associated with less time on gait speed in older adults (exp (β) = 0.92, 95% confidence interval [CI] 0.86-0.98; p < 0.01). Time-specific analysis showed that breaks in sedentary time were associated with less time on gait speed (exp (β) = 0.94, 95% CI 0.91-0.97; p < 0.01), basic functional mobility (exp (β) = 0.93, 95% CI 0.89-0.97; p < 0.01), and lower-limb strength (exp (β) = 0.92, 95% CI 0.87-0.97; p < 0.01) in the evening only.
    Conclusion: A break in sedentary time, particularly during the evening, was associated with better lower extremity strength in older adults. Further strategies to interrupt sedentary time with frequent breaks, with an emphasis on evening hours, can be helpful to maintain and improve physical function in older adults.
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1117688-x
    ISSN 2049-3258 ; 0778-7367 ; 0003-9578
    ISSN (online) 2049-3258
    ISSN 0778-7367 ; 0003-9578
    DOI 10.1186/s13690-023-01050-1
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    Zs.A 147: Show issues Location:
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  9. Article ; Online: Baricitinib Treatment for Palisaded Neutrophilic Granulomatous Dermatitis: A New Paradoxical Reaction to Tocilizumab.

    Chung, Wen-Hung / Chen, Chun-Bing / Chan, Tien-Ming

    Dermatitis : contact, atopic, occupational, drug

    2023  Volume 34, Issue 5, Page(s) 466–467

    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000879
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    Zs.A 3680: Show issues Location:
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  10. Article ; Online: REDfold: accurate RNA secondary structure prediction using residual encoder-decoder network.

    Chen, Chun-Chi / Chan, Yi-Ming

    BMC bioinformatics

    2023  Volume 24, Issue 1, Page(s) 122

    Abstract: Background: As the RNA secondary structure is highly related to its stability and functions, the structure prediction is of great value to biological research. The traditional computational prediction for RNA secondary prediction is mainly based on the ... ...

    Abstract Background: As the RNA secondary structure is highly related to its stability and functions, the structure prediction is of great value to biological research. The traditional computational prediction for RNA secondary prediction is mainly based on the thermodynamic model with dynamic programming to find the optimal structure. However, the prediction performance based on the traditional approach is unsatisfactory for further research. Besides, the computational complexity of the structure prediction using dynamic programming is [Formula: see text]; it becomes [Formula: see text] for RNA structure with pseudoknots, which is computationally impractical for large-scale analysis.
    Results: In this paper, we propose REDfold, a novel deep learning-based method for RNA secondary prediction. REDfold utilizes an encoder-decoder network based on CNN to learn the short and long range dependencies among the RNA sequence, and the network is further integrated with symmetric skip connections to efficiently propagate activation information across layers. Moreover, the network output is post-processed with constrained optimization to yield favorable predictions even for RNAs with pseudoknots. Experimental results based on the ncRNA database demonstrate that REDfold achieves better performance in terms of efficiency and accuracy, outperforming the contemporary state-of-the-art methods.
    MeSH term(s) RNA/chemistry ; RNA, Untranslated ; Base Sequence ; Protein Structure, Secondary ; Databases, Factual
    Chemical Substances RNA (63231-63-0) ; RNA, Untranslated
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-023-05238-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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