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Article ; Online: Ventricular catheter exchange using a peel-away outer catheter.

Omahen, David A / Hentschel, Stephen J / Cameron, G Stuart

2011 Volume 115, Issue 3, Page(s) 633–635

Abstract: Ventricular catheter replacement can be challenging, especially in patients with small ventricles. Shunt malfunction due to ventricular catheter obstruction can occur without ventricular enlargement, such as in the setting of slit-ventricle syndrome or ... ...

Abstract	Ventricular catheter replacement can be challenging, especially in patients with small ventricles. Shunt malfunction due to ventricular catheter obstruction can occur without ventricular enlargement, such as in the setting of slit-ventricle syndrome or benign intracranial hypertension. The authors describe a simple technique for ventricular catheter exchange using a peel-away catheter. In the limited initial experience of the senior author (G.S.C.), this technique appears to be safe and effective. To the authors' knowledge, this method has not been described in the neurosurgical literature before.
MeSH term(s)	Adult ; Cerebral Ventricles/surgery ; Equipment Failure ; Humans ; Hydrocephalus/surgery ; Reoperation ; Ventriculoperitoneal Shunt/methods
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2011.4.JNS091879
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Article ; Online: Surgical resection of intrinsic insular tumors.

Hentschel, Stephen J / Lang, Frederick F

Neurosurgery

2005 Volume 57, Issue 1 Suppl, Page(s) 176–83; discussion 176–83

Abstract: This report, with an accompanying videotape, details the authors' technique for performing radical resections of tumors intrinsic to the insular lobe. The resection technique takes advantage of the fact that many intrinsic insular tumors grow within the ... ...

Abstract	This report, with an accompanying videotape, details the authors' technique for performing radical resections of tumors intrinsic to the insular lobe. The resection technique takes advantage of the fact that many intrinsic insular tumors grow within the confines of the insula, usually without violating pial borders or invading the medial structures. The method described is based on an anatomic dissection of the insula that uses the internal boundaries of the region, particularly the peri-insular sulci, as guides for resection. The videotape provides a visual description of this method.
MeSH term(s)	Adult ; Aged ; Brain Neoplasms/surgery ; Cerebral Cortex/surgery ; Child, Preschool ; Female ; Humans ; Male ; Microsurgery/methods ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Neurosurgical Procedures/methods ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2005-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/01.neu.0000163603.70972.ab
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Article: Optimizing outcomes with maximal surgical resection of malignant gliomas.

Hentschel, Stephen J / Sawaya, Raymond

Cancer control : journal of the Moffitt Cancer Center

2003 Volume 10, Issue 2, Page(s) 109–114

Abstract: Background: Aggressive surgical resection of malignant gliomas is a controversial issue in neurosurgery. Studies with rigorous methodology that fully address this issue have only recently become available.: Methods: The controversy regarding the role ...

Abstract	Background: Aggressive surgical resection of malignant gliomas is a controversial issue in neurosurgery. Studies with rigorous methodology that fully address this issue have only recently become available. Methods: The controversy regarding the role of maximal surgical resection of malignant gliomas is reviewed. The authors discuss surgical techniques and adjunctive technologies that can be utilized to assist in resection of these lesions. Results: Using current microneurosurgical techniques, it is possible to resect malignant gliomas in gross total fashion. An aggressive approach in which 98% or more of the tumor mass is resected results in a statistically significant survival advantage. Conclusions: An aggressive surgical procedure for malignant gliomas can result in increased survival duration for selected groups of patients.
MeSH term(s)	Brain Neoplasms/diagnosis ; Brain Neoplasms/mortality ; Brain Neoplasms/surgery ; Glioma/diagnosis ; Glioma/mortality ; Glioma/surgery ; Humans ; Magnetic Resonance Imaging ; Neurosurgical Procedures ; Treatment Outcome
Language	English
Publishing date	2003-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
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Article: Current surgical management of glioblastoma.

Hentschel, Stephen J / Lang, Frederick F

Cancer journal (Sudbury, Mass.)

2003 Volume 9, Issue 2, Page(s) 113–125

Abstract: Surgical resection is a critical aspect of the management of a patient with a glioblastoma (GBM). An intimate knowledge of the anatomy of a GBM, as well as familiarity with particular surgical techniques and adjunctive technologies is required for safe ... ...

Abstract	Surgical resection is a critical aspect of the management of a patient with a glioblastoma (GBM). An intimate knowledge of the anatomy of a GBM, as well as familiarity with particular surgical techniques and adjunctive technologies is required for safe surgical resection. The goals of resection include diagnosis, relief of mass effect, and cytoreduction. A recent study showed that resection of 98% or more of the tumor mass can result in a statistically significant survival advantage. Even in functionally critical areas, "gross total" resections are possible if proper techniques are employed. It is recommended that a "gross total" resection of the enhancing portion of a GBM be performed whenever possible. With this philosophy, the mortality rate is 3% and the rate of major neurologic morbidity is less than 10%.
MeSH term(s)	Brain Mapping ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Glioblastoma/pathology ; Glioblastoma/surgery ; Humans ; Neurosurgical Procedures/methods ; Patient Selection ; Surgery, Computer-Assisted/methods ; Survival Analysis
Language	English
Publishing date	2003-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2018400-1
ISSN	1528-9117 ; 1081-4442
ISSN	1528-9117 ; 1081-4442
DOI	10.1097/00130404-200303000-00007
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Zs.A 4470: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Health related Quality of Life over time in German sarcoma patients. An analysis of associated factors - results of the PROSa study.

Eichler, Martin / Hentschel, Leopold / Singer, Susanne / Hornemann, Beate / Richter, Stephan / Hofbauer, Christine / Hohenberger, Peter / Kasper, Bernd / Andreou, Dimosthenis / Pink, Daniel / Jakob, Jens / Grützmann, Robert / Fung, Stephen / Wardelmann, Eva / Arndt, Karin / Hermes-Moll, Kerstin / Schoffer, Olaf / Fried, Marius / Jambor, Helena K /

Weitz, Jürgen / Schaser, Klaus-Dieter / Bornhäuser, Martin / Schmitt, Jochen / Schuler, Markus K

Frontiers in endocrinology

2023 Volume 14, Page(s) 1166838

Abstract: Introduction: Sarcomas are rare cancers and very heterogeneous in their location, histological subtype, and treatment. Health-Related Quality of Life (HRQoL) of sarcoma patients has rarely been investigated in longitudinal studies.: Methods: Here, we ...

Abstract	Introduction: Sarcomas are rare cancers and very heterogeneous in their location, histological subtype, and treatment. Health-Related Quality of Life (HRQoL) of sarcoma patients has rarely been investigated in longitudinal studies. Methods: Here, we assessed adult sarcoma patients and survivors between September 2017 and February 2020, and followed-up for one year in 39 study centers in Germany. Follow-up time points were 6 (t1) and 12 months (t2) after inclusion. We used a standardized, validated questionnaire (the European Organisation for Research and Treatment of Cancer Quality of Life Core Instrument (EORTC QLQ-C30) and explored predictors of HRQoL in two populations (all patients (Analysis 1), patients in ongoing complete remission (Analysis 2)) using generalized linear mixed models. Results: In total we included up to 1111 patients at baseline (915 at t1, and 847 at t2), thereof 387 participants were in complete remission at baseline (334 at t1, and 200 at t2). When analyzing all patients, HRQoL differed with regard to tumor locations: patients with sarcoma in lower extremities reported lower HRQoL values than patients with sarcomas in the upper extremities. Treatment which included radiotherapy and/or systemic therapy was associated with lower HRQoL. For patients in complete remission, smoking was associated with worse HRQoL-outcomes. In both analyses, bone sarcomas were associated with the worst HRQoL values. Being female, in the age group 55-<65 years, having lower socioeconomic status, and comorbidities were all associated with a lower HRQoL, in both analyses. Discussion: HRQoL increased partially over time since treatment and with sporting activities. HRQoL improved with time since treatment, although not in all domains, and was associated with lifestyle and socioeconomic factors. Bone sarcomas were the most affected subgroup. Methods to preserve and improve HRQoL should be developed for sarcoma patients.
MeSH term(s)	Adult ; Humans ; Female ; Aged ; Male ; Quality of Life ; Sarcoma/therapy ; Soft Tissue Neoplasms/epidemiology ; Soft Tissue Neoplasms/therapy ; Osteosarcoma ; Bone Neoplasms/therapy
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1166838
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Article ; Online: Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis.

Cheong, Sek-Shir / Hentschel, Lisa / Davidson, Alice E / Gerrelli, Dianne / Davie, Rebecca / Rizzo, Roberta / Pontikos, Nikolas / Plagnol, Vincent / Moore, Anthony T / Sowden, Jane C / Michaelides, Michel / Snead, Martin / Tuft, Stephen J / Hardcastle, Alison J

American journal of human genetics

2016 Volume 99, Issue 6, Page(s) 1338–1352

Abstract: Anterior segment dysgeneses (ASDs) comprise a spectrum of developmental disorders affecting the anterior segment of the eye. Here, we describe three unrelated families affected by a previously unclassified form of ASD. Shared ocular manifestations ... ...

Abstract	Anterior segment dysgeneses (ASDs) comprise a spectrum of developmental disorders affecting the anterior segment of the eye. Here, we describe three unrelated families affected by a previously unclassified form of ASD. Shared ocular manifestations include bilateral iris hypoplasia, ectopia lentis, corectopia, ectropion uveae, and cataracts. Whole-exome sequencing and targeted Sanger sequencing identified mutations in CPAMD8 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8) as the cause of recessive ASD in all three families. A homozygous missense mutation in the evolutionarily conserved alpha-2-macroglobulin (A2M) domain of CPAMD8, c.4351T>C (p. Ser1451Pro), was identified in family 1. In family 2, compound heterozygous frameshift, c.2352_2353insC (p.Arg785Glnfs
MeSH term(s)	Adolescent ; Adult ; Amino Acid Sequence ; Anterior Eye Segment/abnormalities ; Anterior Eye Segment/metabolism ; Child ; Child, Preschool ; Complement C3/chemistry ; Complement C3/genetics ; Eye Abnormalities/genetics ; Female ; Genes, Recessive/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Trypsin Inhibitor, Kazal Pancreatic/chemistry ; Trypsin Inhibitor, Kazal Pancreatic/genetics ; Young Adult ; alpha-Macroglobulins/chemistry ; alpha-Macroglobulins/genetics
Chemical Substances	CPAMD8 protein, human ; Complement C3 ; alpha-Macroglobulins ; Trypsin Inhibitor, Kazal Pancreatic (50936-63-5)
Language	English
Publishing date	2016-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2016.09.022
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Article: Chiari I malformation and acute acquired comitant esotropia: case report and review of the literature.

Hentschel, Stephen J / Yen, Kimberly G / Lang, Frederick F

Journal of neurosurgery

2005 Volume 102, Issue 4 Suppl, Page(s) 407–412

Abstract: The authors describe a rare case of a Chiari I malformation presenting with acute acquired comitant esotropia (AACE) in a 5-year-old boy. A posterior fossa decompression with duraplasty and a C1-2 laminectomy were performed. There was an immediate ... ...

Abstract	The authors describe a rare case of a Chiari I malformation presenting with acute acquired comitant esotropia (AACE) in a 5-year-old boy. A posterior fossa decompression with duraplasty and a C1-2 laminectomy were performed. There was an immediate postoperative improvement in the esotropia, which completely resolved by 7 months following surgery. The pertinent literature is discussed and reasons are presented for recommending posterior fossa decompression in certain patients, rather than strabismus surgery, as the initial treatment for esotropia. The authors suggest that in patients with AACE, even subtle symptoms and signs of Chiari I malformation should prompt imaging of the posterior fossa. Strong consideration should be given to performing posterior fossa decompression in patients with Chiari I malformation and AACE before strabismus surgery because the esotropia may completely resolve with decompression.
MeSH term(s)	Acute Disease ; Arnold-Chiari Malformation/complications ; Arnold-Chiari Malformation/surgery ; Child, Preschool ; Decompression, Surgical ; Dura Mater/surgery ; Esotropia/etiology ; Humans ; Laminectomy ; Male
Language	English
Publishing date	2005-05
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/ped.2005.102.4.0407
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Article ; Online: The association of Health-Related Quality of Life and 1-year-survival in sarcoma patients-results of a Nationwide Observational Study (PROSa).

British journal of cancer

2022 Volume 126, Issue 9, Page(s) 1346–1354

Abstract: Background: Sarcomas are rare cancers of high heterogeneity. Health-Related Quality of Life (HRQoL) has been shown to be a prognostic factor for survival in other cancer entities but it is unclear whether this applies to sarcoma patients.: Patients ... ...

Abstract	Background: Sarcomas are rare cancers of high heterogeneity. Health-Related Quality of Life (HRQoL) has been shown to be a prognostic factor for survival in other cancer entities but it is unclear whether this applies to sarcoma patients. Patients and methods: HRQoL was prospectively assessed in adult sarcoma patients from 2017 to 2020 in 39 German recruiting sites using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Vital status was ascertained over the course of 1 year. HRQoL domains were analysed by multivariable cox-regressions including clinical and socio-economic risk factors. Results: Of 1102 patients, 126 (11.4%) died during follow-up. The hazard ratio (HR) for global health was 0.73 per 10-point increase (95% confidence interval (CI) 0.64-0.85). HR for the HRQoL-summary score was 0.74 (CI 0.64-0.85) and for physical functioning 0.82 (CI 0.74-0.89). There was also evidence that fatigue (HR 1.17, CI 1.10-1.25), appetite loss (HR 1.15, CI 1.09-1.21) and pain (HR 1.14, CI 1.08-1.20) are prognostic factors for survival. Conclusion: Our study adds sarcoma-specific evidence to the existing data about cancer survival in general. Clinicians and care-givers should be aware of the relations between HRQoL and survival probability and include HRQoL in routine assessment.
MeSH term(s)	Adult ; Humans ; Prognosis ; Quality of Life ; Sarcoma ; Soft Tissue Neoplasms ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-022-01702-z
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Article ; Online: Stereotactic radiosurgery for Cushing disease.

Hentschel, Stephen J / McCutcheon, Ian E

Neurosurgical focus

2004 Volume 16, Issue 4, Page(s) E5

Abstract: The most common cause of Cushing syndrome is Cushing disease, in which hypercortisolism is produced by a functional adrenocorticotropic hormone-producing adenoma of the anterior pituitary gland. The common therapies available include microsurgical ... ...

Abstract	The most common cause of Cushing syndrome is Cushing disease, in which hypercortisolism is produced by a functional adrenocorticotropic hormone-producing adenoma of the anterior pituitary gland. The common therapies available include microsurgical resection, conventional fractionated radiotherapy, and stereotactic radiosurgery (SRS). In this article the authors review the indications, results, and complications associated with SRS in the treatment of Cushing disease. In as many as 90% of patients SRS results in disease remission, which is defined as a normal 24-hour urinary free cortisol level and a normal or subnormal morning serum cortisol level. Although in most patients who are subsequently cured a marked decrease in the serum cortisol level is demonstrated within 3 months after treatment, a biochemical cure may be delayed up to 3 years in some cases. Complications following SRS for pituitary adenomas are uncommon, particularly in patients with microadenomas, which are most commonly seen in Cushing disease. The most common complication is hypopituitarism, which occurs in up to 50% of patients with a mean latency period of 5 years. Radiation-induced optic neuropathy has been reported in less than 2% of cases and induction of a secondary neoplasm in less than 1% of cases. For patients with Cushing disease, the rate of endocrinological cure following SRS appears to be similar to that attained using microsurgical resection. In contrast to surgery, SRS has the benefit of being noninvasive and associated with a very low incidence of diabetes insipidus, although hypopituitarism may be more common with SRS. With continued follow-up patient reviews and additional experience with SRS, it may become possible to make more definitive statements regarding SRS as the initial treatment for patients with Cushing disease.
MeSH term(s)	Cushing Syndrome/diagnosis ; Cushing Syndrome/surgery ; Humans ; Magnetic Resonance Imaging ; Radiosurgery/adverse effects ; Remission Induction
Language	English
Publishing date	2004-04-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/foc.2004.16.4.6
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Article: Jugular bulb oximetry for prediction of vasospasm following subarachnoid hemorrhage.

Heran, Navraj S / Hentschel, Stephen J / Toyota, Brian D

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2004 Volume 31, Issue 1, Page(s) 80–86

Abstract: Background: Cerebral vasospasm adversely impacts the outcome of those suffering aneurysmal subarachnoid hemorrhage (SAH). Prediction of vasospasm could improve outcomes. We hypothesized that preclinical vasospasm would be heralded by an increase in ... ...

Abstract	Background: Cerebral vasospasm adversely impacts the outcome of those suffering aneurysmal subarachnoid hemorrhage (SAH). Prediction of vasospasm could improve outcomes. We hypothesized that preclinical vasospasm would be heralded by an increase in cerebral oxygen extractions (AVDO2) which could be detected by jugular bulb oximetry. A pilot study was conducted to address this hypothesis. Methods: Fourteen consenting patients with aneurysmal SAH, undergoing early surgery, were entered into the study. Four patients were withdrawn from the study secondary to failure of catheters or religious belief. At the time of craniotomy, a jugular bulb catheter was placed. Post-operatively, arterial and jugular bulb blood samples were taken every 12 hours to calculate AVDO2. As this was an observational study, no change in management occurred based on measurements. Results: Four of 10 patients had clinical vasospasm. These patients had a significant rise in AVDO2 approximately one day prior to the onset of neurologic deficits (P<0.001). Symptoms resolved along with a significant improvement in AVDO2 on instituting hypertensive, hemo-dilutional, and hypervolemic therapy in these patients. The six patients who did not exhibit clinical vasospasm did not demonstrate significant rise in AVDO2. Conclusions: Jugular bulb oximetry is simple and cost effective. Increases in AVDO2 using this technique were predictive of clinically evident vasospasm in the subsequent hours to days. This investigation supports a larger study to assess the utility of jugular bulb oximetry in predicting vasospasm in aneurysmal SAH.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Jugular Veins/metabolism ; Male ; Middle Aged ; Oximetry/methods ; Oximetry/statistics & numerical data ; Pilot Projects ; Predictive Value of Tests ; Prospective Studies ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/metabolism ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/metabolism
Language	English
Publishing date	2004-05-01
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/s0317167100002870
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