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  1. Article ; Online: The reliability of intraoperative electrocorticography in magnetic resonance imaging-negative temporal lobe epilepsy: spikes mark the spot.

    Quigg, Mark

    JAMA neurology

    2014  Volume 71, Issue 6, Page(s) 681–682

    MeSH term(s) Electroencephalography ; Epilepsy, Temporal Lobe/surgery ; Female ; Humans ; Male
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2014.584
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    Ui II Zs.191: Show issues Location:
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  2. Article ; Online: The Wada test: the best steam engine on the tracks.

    Quigg, Mark

    Epilepsy research

    2019  Volume 156, Page(s) 106157

    MeSH term(s) Epilepsy/physiopathology ; Functional Laterality ; Humans ; Language ; Physician's Role ; Risk
    Language English
    Publishing date 2019-06-18
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2019.106157
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    Zs.A 2193: Show issues Location:
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  3. Article ; Online: Improvement in non-24-h sleep-wake rhythm disorder in a sighted individual treated with a melatonin receptor agonist.

    Connolly, Patrick J / Quigg, Mark / Davis, Eric M

    Sleep medicine

    2024  Volume 116, Page(s) 41–42

    Abstract: ... sleepy). Follow-up actigraphy showed marked resolution of phase delay with an average of five hours ...

    Abstract Non-24-hour sleep-wake rhythm disorder (N24SWD) typically presents in patients with visual impairments that disrupt the ability to entrain to the 24 hour solar cycle. We discuss a 43 year old sighted man who presented with periodic daytime hypersomnia and nighttime insomnia, occasionally leading to <3 hours of sleep per day. Previous polysomnography showed an apnea hypopnea index of 6.2 events per hour. A sleep log of 3 months showed irregular time of sleep onset, and an average of 3 hours of sleep per day. Wrist actigraphy confirmed N24SWD. A trial of tasimelteon 20 mg/day resulting in improved daytime hypersomnia (pre-Epworth Sleepiness Scale (ESS) = 21/24, post-ESS = 5/24; a score of > 10/24 is considered sleepy). Follow-up actigraphy showed marked resolution of phase delay with an average of five hours of sleep. The case demonstrates that tasimelteon is a possible treatment for N24SWD in sighted individuals.
    MeSH term(s) Male ; Humans ; Adult ; Receptors, Melatonin ; Sleep ; Benzofurans/pharmacology ; Sleep Disorders, Circadian Rhythm/drug therapy ; Sleep Wake Disorders/therapy ; Kleine-Levin Syndrome ; Melatonin/therapeutic use ; Melatonin/pharmacology ; Circadian Rhythm ; Cyclopropanes
    Chemical Substances tasimelteon (SHS4PU80D9) ; Receptors, Melatonin ; Benzofurans ; Melatonin (JL5DK93RCL) ; Cyclopropanes
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2023.10.041
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    Zs.A 5315: Show issues Location:
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    Zs.MO 635: Show issues

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  4. Article ; Online: Dynamic FDG-PET demonstration of functional brain abnormalities.

    Quigg, Mark / Kundu, Bijoy

    Annals of clinical and translational neurology

    2022  Volume 9, Issue 9, Page(s) 1487–1497

    Abstract: Positron emission tomography with fluorine-18 fluorodeoxyglucose ( ...

    Abstract Positron emission tomography with fluorine-18 fluorodeoxyglucose (
    MeSH term(s) Brain/diagnostic imaging ; Brain/metabolism ; Epilepsy/diagnostic imaging ; Fluorodeoxyglucose F18/metabolism ; Glucose/metabolism ; Humans ; Nervous System Malformations ; Positron-Emission Tomography/methods
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.51546
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  5. Article ; Online: Exploding Head Syndrome Associated with Central Hypoventilatory Hypopnea.

    Swingle, Nicholas / Davis, Eric M / Quigg, Mark

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 7, Page(s) 1061–1065

    MeSH term(s) Humans ; Respiratory Rate ; Central Nervous System Diseases ; Sleep Apnea Syndromes
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202209-771CC
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    Zs.A 5828: Show issues Location:
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  6. Article ; Online: Sleep-EEG in comorbid pain and insomnia: implications for the treatment of pain disorders.

    Reid, Matthew J / Quigg, Mark / Finan, Patrick H

    Pain reports

    2023  Volume 8, Issue 6, Page(s) e1101

    Abstract: Introduction: Patients with chronic pain experience a high prevalence of comorbid insomnia, which is associated with functional impairment. Recent advances in sleep electroencephalography (sleep-EEG) may clarify the mechanisms that link sleep and ... ...

    Abstract Introduction: Patients with chronic pain experience a high prevalence of comorbid insomnia, which is associated with functional impairment. Recent advances in sleep electroencephalography (sleep-EEG) may clarify the mechanisms that link sleep and chronic pain. In this clinical update, we outline current advancements in sleep-EEG assessments for pain and provide research recommendations.
    Results: Promising preliminary work suggests that sleep-EEG spectral bands, particularly beta, gamma, alpha, and delta power, may create candidate neurophysiological signatures of pain, and macro-architectural parameters (e.g., total sleep time, arousals, and sleep continuity) may facilitate EEG-derived sleep phenotyping and may enable future stratification in the treatment of pain.
    Conclusion: Integration of measures obtained through sleep-EEG represent feasible and scalable approaches that could be adopted in the future. We provide research recommendations to progress the field towards a deeper understanding of their utility and potential future applications in clinical practice.
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ISSN 2471-2531
    ISSN (online) 2471-2531
    DOI 10.1097/PR9.0000000000001101
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  7. Article ; Online: The female Tourette patient: Sex differences in Tourette Disorder.

    Garris, Jordan / Quigg, Mark

    Neuroscience and biobehavioral reviews

    2021  Volume 129, Page(s) 261–268

    Abstract: Tourette Disorder (TD) is a male predominant neurodevelopmental disorder characterized by tics and frequent psychiatric comorbidities. Girls with TD have later peak symptoms, less remission with age, and worse impairment from tics, particularly in ... ...

    Abstract Tourette Disorder (TD) is a male predominant neurodevelopmental disorder characterized by tics and frequent psychiatric comorbidities. Girls with TD have later peak symptoms, less remission with age, and worse impairment from tics, particularly in adulthood. Female TD patients are less likely to have Attention Deficit Hyperactivity Disorder and more likely to have anxiety and mood disorders. Hyperandrogenism is associated with TD in both sexes, and neuroanatomic sexual dimorphism is reduced in adult TD patients. Some women report catamenial tics, which may relate to estrogen withdrawal or rises in allopregnanolone. Limited data suggest that several neuroanatomic alterations present in boys with TD are not present in girls with TD. Female sex predicts better response to haloperidol. Further research into female tic pathophysiology may influence sex-specific treatment development.
    MeSH term(s) Adult ; Attention Deficit Disorder with Hyperactivity ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder ; Sex Characteristics ; Tic Disorders ; Tics ; Tourette Syndrome
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.08.001
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    Zs.A 1371: Show issues Location:
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  8. Article ; Online: Analysis of seizure-cluster circadian periodicity from a long-term, open-label safety study of diazepam nasal spray.

    Fountain, Nathan B / Quigg, Mark / Murchison, Charles F / Carrazana, Enrique / Rabinowicz, Adrian L

    Epilepsia

    2024  Volume 65, Issue 4, Page(s) 920–928

    Abstract: Objective: Seizure clusters require prompt medical treatment to minimize possible progression to status epilepticus, increased health care use, and disruptions to daily life. Isolated seizures may exhibit cyclical patterns, including circadian and ... ...

    Abstract Objective: Seizure clusters require prompt medical treatment to minimize possible progression to status epilepticus, increased health care use, and disruptions to daily life. Isolated seizures may exhibit cyclical patterns, including circadian and longer rhythms. However, little is known about the cyclical patterns in seizure clusters. This post hoc analysis of data from a long-term, phase 3, open-label, repeat-dose safety study of diazepam nasal spray modeled the periodicity of treated seizure clusters.
    Methods: Mixed-effects cosinor analysis evaluated circadian rhythmicity, and single component cosinors using 12 and 24 h were used to calculate cosinor parameters (e.g., midline statistic of rhythm, wave ampitude, and acrophase [peak]). Analysis was completed for the full cohort and a consistent cohort of participants with two or more seizure clusters in each of four, 3-month periods. The influence of epilepsy type on cosinor parameters was also analyzed.
    Results: Seizure-cluster events plotted across 24 h showed a bimodal distribution with acrophases (peaks) at ~06:30 and ~18:30. A 12-h plot showed a single peak at ~06:30. Cosinor analyses of the full and consistent cohort aligned, with acrophases for both models predicting peak seizure activity at ~23:30 on a 24-h scale and ~07:30 on a 12-h scale. The consistent cohort was associated with increases in baseline and peak seizure-cluster activity. Analysis by epilepsy type identified distinct trends. Seizure clusters in the focal epilepsy group peaked in the evening (acrophase 19:19), whereas events in the generalized epilepsy group peaked in the morning (acrophase 04:46). Together they compose the bimodal clustering observed over 24 h.
    Significance: This analysis of seizure clusters treated with diazepam nasal spray demonstrated that seizure clusters occur cyclically in 12- and 24-h time frames similar to that reported with isolated seizures. Further elucidation of these patterns may provide important information for patient care, ranging from improved patient-centered outcomes to seizure-cluster prediction.
    MeSH term(s) Humans ; Anticonvulsants/adverse effects ; Circadian Rhythm ; Diazepam/adverse effects ; Epilepsy/drug therapy ; Epilepsy, Generalized/drug therapy ; Nasal Sprays ; Seizures/drug therapy
    Chemical Substances Anticonvulsants ; Diazepam (Q3JTX2Q7TU) ; Nasal Sprays
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17911
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    Zs.MO 475: Show issues

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  9. Article ; Online: Recurrent Dissociative Fugue Episodes in a Child With Autism Spectrum Disorder.

    Libdeh, Amal Abu / Brenner, Laurie / Quigg, Mark

    Clinical pediatrics

    2022  Volume 61, Issue 3, Page(s) 253–255

    MeSH term(s) Adolescent ; Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/psychology ; Dissociative Disorders/etiology ; Dissociative Disorders/psychology ; Humans ; Male
    Language English
    Publishing date 2022-01-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228211069724
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  10. Article ; Online: Acetazolamide as an Adjunct to Positive Airway Pressure Therapy in the Treatment of Combined Central and Obstructive Sleep Apnea.

    Scherping, Steven C / Quigg, Mark / Davis, Eric M

    Annals of the American Thoracic Society

    2022  Volume 20, Issue 1, Page(s) 131–135

    MeSH term(s) Humans ; Acetazolamide/therapeutic use ; Sleep Apnea, Obstructive/therapy ; Carbonic Anhydrase Inhibitors/therapeutic use ; Continuous Positive Airway Pressure
    Chemical Substances Acetazolamide (O3FX965V0I) ; Carbonic Anhydrase Inhibitors
    Language English
    Publishing date 2022-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202204-366CC
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