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  1. Article: Cheong-sang-bang-pung-san alleviated hepatic lipid accumulation by regulating lipid metabolism

    Kang, Yun-Mi / Kim, Kwang-Youn / Kim, Tae In / Kim, Yeon-Ji / Kim, Han-Hae / Kim, Kyungho

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1223534

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1223534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan's Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation.

    Park, Sa-Yoon / Kim, Kang-Sub / Lee, Won-Yung / Kim, Chang-Eop / Lee, Sullim

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 17

    Abstract: Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various ... by analyzing the mRNA expression levels of biomarkers (IL-1β and TNF-α for inflammation; GSTP1, GSTM1, and PTEN ...

    Abstract Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various chronic respiratory diseases. To investigate the system-level treatment mechanisms of CSBHH in respiratory tract diseases, we identified 56 active ingredients of CSBHH and evaluated the degree of overlap between their targets and respiratory tract disease-associated proteins. We then investigated the respiratory tract disease-related signaling pathways associated with CSBHH targets. Enrichment analysis showed that the CSBHH targets were significantly associated with various signaling pathways related to inflammation, alveolar structure, and tissue fibrosis. Experimental validation was conducted using phorbol-12-myristate-13-acetate (PMA)-stimulated NCI-H292 cells by analyzing the mRNA expression levels of biomarkers (IL-1β and TNF-α for inflammation; GSTP1, GSTM1, and PTEN for apoptosis) derived from network pharmacological analysis, in addition to the mucin genes MUC5AC and MUC2, to investigate the phlegm-expelling effect of CSBHH. The mRNA expression levels of these genes were consistent with network pharmacological predictions in a concentration-dependent manner. These results suggest that the therapeutic mechanisms of CSBHH in respiratory tract diseases could be attributed to the simultaneous action of multiple active ingredients in the herbal prescription.
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12173024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Gwan-sang

    Gim, Dong-hyeog / Kim, Tong-hyŏk

    2014  

    Title variant Sinario puk
    Institution Ju-pi-teo pil-leum
    Mi-di-eo peul-leg-seu
    Syo-bag-seu (Firm)
    미디어 플렉스
    쇼박스 (Firm)
    주피터 필름
    Author's details Syo-bag-seu (ju) Mi-di-eo peul-leg-seu, (ju) Ju-pi-teo pil-leum
    Language Korean
    Size 103 S.
    Publisher Ke-i-di mi-di-eo
    Publishing place Seo-ul
    Document type Book
    Note Based on the novel written by Paek Kum-nam
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Gwan-sang

    Gim, Dong-hyeog / Kim, Tong-hyŏk

    2014  

    Title variant K'ont'ibuk
    Institution Ju-pi-teo pil-leum
    Mi-di-eo peul-leg-seu
    Syo-bag-seu (Firm)
    미디어 플렉스
    쇼박스 (Firm)
    주피터 필름
    Author's details Syo-bag-seu (ju) Mi-di-eo peul-leg-seu, (ju) Ju-pi-teo pil-leum
    Language Korean
    Size 490 S., Ill.
    Publisher Ke-i-di mi-di-eo
    Publishing place Seo-ul
    Document type Book
    Note Based on the novel written by Paek Kum-nam
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Audio / Video: Gwan-sang

    Baeg, Geum-nam / Gim, Dong-hyeog / Kim, Tong-hyŏk / Paek, Kŭm-nam

    2014  

    Title variant Kwansang ; The face reader
    Institution Ju-pi-teo pil-leum
    Mi-di-eo peul-leg-seu
    Syo-bag-seu (Firm)
    미디어 플렉스
    쇼박스 (Firm)
    주피터 필름
    Author's details Syo-bag-seu (ju) Mi-di-eo peul-leg-seu, (ju) Ju-pi-teo pil-leum
    Keywords Physiognomy ; Korea
    Language Korean
    Size 2 DVD-Videos
    Publisher Ke-i-di mi-di-eo
    Publishing place Seo-ul
    Document type Book ; Audio / Video
    Accompanying material 2 Beihefte
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book ; Audio / Video: Gwan-sang

    Baeg, Geum-nam / Han, Jae-lim / Gim, Dong-hyeog / Song, Gang-ho / I, Jeong-jae / Han, Chae-rim / Kim, Tong-hyŏk / Paek, Kŭm-nam

    2014  

    Abstract: ... Because of his abilities, he gets involved in a power struggle between Prince Sooyang and Kim Jong-Seo ...

    Title variant English title known as: Face reader
    Institution Ju-pi-teo pil-leum
    Mi-di-eo peul-leg-seu
    Syo-bag-seu (Firm)
    미디어 플렉스
    쇼박스 (Firm)
    주피터 필름
    Author's details Syo-bag-seu (ju) Mi-di-eo peul-leg-seu, (ju) Ju-pi-teo pil-leum
    Abstract Set during the seizure of the throne by Sejo of Joseon in the year 1455, the movie follows the life of Nae-Kyung. Nae-Kyung, the son of a ruined noble family, goes all around Joseon and studies physiognomy. He is able to assess the personality, mental state and habits of a person by looking at someone's face. Because of his abilities, he gets involved in a power struggle between Prince Sooyang and Kim Jong-Seo
    Language Korean ; English
    Size 1 DVD-Video (Region: 3), 139 Min., sound, color, 4 3/4 in.
    Publisher Ke-i-di mi-di-eo
    Publishing place Seo-ul
    Document type Book ; Audio / Video
    Note In Korean, with optional Korean or English subtitles ; 500-06/$1 ; Anamorphic widescreen 2.35:1 ; Based on the novel written by Paek Kum-nam ; Director Han Chae-rim ; screenwriter Kim Tong-hyŏk ; producer Kim U-jae ; Originally released as a motion picture in 2013 ; disc 2: Special features
    Accompanying material 1 supplement disc (sound, color ; 4 3/4 in.)
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article ; Online: Suppression of lung inflammation by the ethanol extract of Chung-Sang and the possible role of Nrf2.

    Han, Jin-Woo / Kim, Kyun Ha / Kwun, Min-Jung / Choi, Jun-Yong / Kim, Sang-Jun / Jeong, Seung-Il / Lee, Beom-Joon / Kim, Kwan-Il / Won, Ran / Jung, Ji Hoon / Jung, Hee Jae / Joo, Myungsoo

    BMC complementary and alternative medicine

    2019  Volume 19, Issue 1, Page(s) 15

    Abstract: ... Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory ...

    Abstract Background: Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the efficacy of the major herb, resulting in a suboptimal therapeutic effect of an herbal remedy. Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory diseases, and tested whether an experimental formula composed of only major herbs is effective in suppressing inflammation without significant side effects.
    Methods: The 50% ethanol extract of CS (eCS) was fingerprinted by HPLC. Cytotoxicity to RAW 264.7 cells was determined by an MTT assay and a flow cytometer. Nuclear NF-κB and Nrf2 were analyzed by western blot. Ubiquitinated Nrf2 was similarly analyzed following immunoprecipitation of Nrf2. Acute lung inflammation and sepsis were induced in C57BL/6 mice. The effects of eCS on lung disease were measured by HE staining of lung sections, a differential cell counting of bronchoalveolar lavage fluid, a myeloperoxidase (MPO) assay, a real-time qPCR, and Kaplan-Meier survival of mice.
    Results: eCS neither elicited cytotoxicity nor reactive oxygen species. While not suppressing NF-κB, eCS activated Nrf2, reduced the ubiquitination of Nrf2, and consequently induced the expression of Nrf2-dependent genes. In an acute lung inflammation mouse model, an intratracheal (i.t.) eCS suppressed neutrophil infiltration, the expression of inflammatory cytokine genes, and MPO activity. In a sepsis mouse model, a single i.t. eCS was sufficient to significantly decrease mouse mortality.
    Conclusions: eCS could suppress severe lung inflammation in mice. This effect seemed to associate with eCS activating Nrf2. Our findings suggest that herbal remedies consisting of only major herbs are worth considering.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/isolation & purification ; Drug Compounding ; Humans ; Lung/drug effects ; Lung/immunology ; Mice ; Mice, Inbred C57BL ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/immunology ; NF-kappa B/genetics ; NF-kappa B/immunology ; Neutrophil Infiltration/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Pneumonia/drug therapy ; Pneumonia/genetics ; Pneumonia/immunology ; RAW 264.7 Cells
    Chemical Substances Anti-Inflammatory Agents ; NF-E2-Related Factor 2 ; NF-kappa B ; Plant Extracts
    Language English
    Publishing date 2019-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-018-2422-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The complete chloroplast genome of a new candidate cultivar, Sang Jae, of

    Min, Juhyeon / Kim, Yongsung / Xi, Hong / Jang, Taewon / Kim, Gwanho / Park, Jongsun / Park, Jae-Ho

    Mitochondrial DNA. Part B, Resources

    2019  Volume 4, Issue 2, Page(s) 3716–3718

    Abstract: Chloroplast genome of Sang Jae, new candidate cultivar of ...

    Abstract Chloroplast genome of Sang Jae, new candidate cultivar of
    Language English
    Publishing date 2019-10-23
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2019.1679678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Suppression of lung inflammation by the ethanol extract of Chung-Sang and the possible role of Nrf2

    Han, Jin-Woo / Kim, Kyun Ha / Kwun, Min-Jung / Choi, Jun-Yong / Kim, Sang-jun / Jeong, Seung-il / Lee, Beom-Joon / Kim, Kwan-Il / Won, Ran / Jung, Ji Hoon / Jung, Hee Jae / Joo, Myungsoo

    BMC Complement Altern Med. 2019 Dec., v. 19, no. 1 p.15-15

    2019  

    Abstract: ... Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory ...

    Abstract BACKGROUND: Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the efficacy of the major herb, resulting in a suboptimal therapeutic effect of an herbal remedy. Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory diseases, and tested whether an experimental formula composed of only major herbs is effective in suppressing inflammation without significant side effects. METHODS: The 50% ethanol extract of CS (eCS) was fingerprinted by HPLC. Cytotoxicity to RAW 264.7 cells was determined by an MTT assay and a flow cytometer. Nuclear NF-κB and Nrf2 were analyzed by western blot. Ubiquitinated Nrf2 was similarly analyzed following immunoprecipitation of Nrf2. Acute lung inflammation and sepsis were induced in C57BL/6 mice. The effects of eCS on lung disease were measured by HE staining of lung sections, a differential cell counting of bronchoalveolar lavage fluid, a myeloperoxidase (MPO) assay, a real-time qPCR, and Kaplan-Meier survival of mice. RESULTS: eCS neither elicited cytotoxicity nor reactive oxygen species. While not suppressing NF-κB, eCS activated Nrf2, reduced the ubiquitination of Nrf2, and consequently induced the expression of Nrf2-dependent genes. In an acute lung inflammation mouse model, an intratracheal (i.t.) eCS suppressed neutrophil infiltration, the expression of inflammatory cytokine genes, and MPO activity. In a sepsis mouse model, a single i.t. eCS was sufficient to significantly decrease mouse mortality. CONCLUSIONS: eCS could suppress severe lung inflammation in mice. This effect seemed to associate with eCS activating Nrf2. Our findings suggest that herbal remedies consisting of only major herbs are worth considering.
    Keywords Western blotting ; adverse effects ; complement ; cytokines ; cytotoxicity ; ethanol ; flow cytometry ; inflammation ; lungs ; mice ; models ; mortality ; myeloperoxidase ; neutrophils ; precipitin tests ; reactive oxygen species ; respiratory tract diseases ; therapeutics ; toxicity testing ; traditional medicine ; ubiquitination
    Language English
    Dates of publication 2019-12
    Size p. 15.
    Publishing place BioMed Central
    Document type Article ; Online
    Note Resource is Open Access
    ZDB-ID 2050429-9
    ISSN 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-018-2422-3
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Suppression of lung inflammation by the ethanol extract of Chung-Sang and the possible role of Nrf2

    Jin-Woo Han / Kyun Ha Kim / Min-Jung Kwun / Jun-Yong Choi / Sang-Jun Kim / Seung-Il Jeong / Beom-Joon Lee / Kwan-Il Kim / Ran Won / Ji Hoon Jung / Hee Jae Jung / Myungsoo Joo

    BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: ... Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory ...

    Abstract Abstract Background Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the efficacy of the major herb, resulting in a suboptimal therapeutic effect of an herbal remedy. Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory diseases, and tested whether an experimental formula composed of only major herbs is effective in suppressing inflammation without significant side effects. Methods The 50% ethanol extract of CS (eCS) was fingerprinted by HPLC. Cytotoxicity to RAW 264.7 cells was determined by an MTT assay and a flow cytometer. Nuclear NF-κB and Nrf2 were analyzed by western blot. Ubiquitinated Nrf2 was similarly analyzed following immunoprecipitation of Nrf2. Acute lung inflammation and sepsis were induced in C57BL/6 mice. The effects of eCS on lung disease were measured by HE staining of lung sections, a differential cell counting of bronchoalveolar lavage fluid, a myeloperoxidase (MPO) assay, a real-time qPCR, and Kaplan-Meier survival of mice. Results eCS neither elicited cytotoxicity nor reactive oxygen species. While not suppressing NF-κB, eCS activated Nrf2, reduced the ubiquitination of Nrf2, and consequently induced the expression of Nrf2-dependent genes. In an acute lung inflammation mouse model, an intratracheal (i.t.) eCS suppressed neutrophil infiltration, the expression of inflammatory cytokine genes, and MPO activity. In a sepsis mouse model, a single i.t. eCS was sufficient to significantly decrease mouse mortality. Conclusions eCS could suppress severe lung inflammation in mice. This effect seemed to associate with eCS activating Nrf2. Our findings suggest that herbal remedies consisting of only major herbs are worth considering.
    Keywords Formulation of herbal remedies ; Asian traditional medicine ; Lung inflammation ; Nrf2 ; NF-κB ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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