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  1. Article ; Online: Suivi après transplantation d’organes.

    Rostaing, Lionel

    La Revue du praticien

    2024  Volume 73, Issue 9, Page(s) 976–979

    Abstract: MEDICAL FOLLOW-UP AFTER ORGAN TRANSPLANTATION. The role of the general practitioner is essential in the follow-up of solid organ transplant patients, both in the first year and over the long term, particularly beyond the first year, in relation to the ... ...

    Title translation Medical follow-up after organ transplantation.
    Abstract MEDICAL FOLLOW-UP AFTER ORGAN TRANSPLANTATION. The role of the general practitioner is essential in the follow-up of solid organ transplant patients, both in the first year and over the long term, particularly beyond the first year, in relation to the organ transplant specialist. Within the first-year post-transplant the patient can present very specific complications related to the transplanted organ itself (acute rejection) or to the immunosuppressive drugs (toxicities) such as opportunistic infections. In every organ transplant center, there is a hotline or a shared application where the patient will be able to expose to a paramedic his problems to solve them as soon as possible. Beyond the first-year post-transplant most of the situations that arise can be managed by the general practioner in coordination with the transplant center. This includes the trough levels of immunosuppressive drugs, an increase in serum creatinine, in glycemia or in LDL cholesterol. Immunosuppressive drugs increase the risk of viral- induced cancers, particularly of the skin and cervix; screening is therefore essential, with the help of the general practitioner. When the general practitioner has identified a potential serious problem he will have to contact the reference transplant center.
    MeSH term(s) Female ; Male ; Humans ; Follow-Up Studies ; Organ Transplantation ; Cholesterol, LDL ; General Practitioners ; Immunosuppressive Agents/adverse effects
    Chemical Substances Cholesterol, LDL ; Immunosuppressive Agents
    Language French
    Publishing date 2024-01-31
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suivi médical réglementaire du donneur après le don.

    Rostaing, Lionel

    La Revue du praticien

    2021  Volume 71, Issue 6, Page(s) 635

    Title translation Life-long mandatory follow-up of living kidney donor.
    MeSH term(s) Follow-Up Studies ; Humans ; Kidney ; Kidney Transplantation ; Living Donors
    Language French
    Publishing date 2021-09-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Donneur vivant en transplantation rénale.

    Rostaing, Lionel

    La Revue du praticien

    2021  Volume 71, Issue 6, Page(s) 615–616

    Title translation Living donor in kidney transplant.
    MeSH term(s) Graft Rejection ; Humans ; Kidney Transplantation ; Living Donors ; Transplant Recipients
    Language French
    Publishing date 2021-09-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immunosuppression après greffe rénale avec donneur vivant.

    Rostaing, Lionel

    La Revue du praticien

    2021  Volume 71, Issue 6, Page(s) 636–637

    Title translation Immunosuppression after kidney transplant with living donor.
    MeSH term(s) Graft Rejection/prevention & control ; Humans ; Immunosuppression/adverse effects ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Living Donors
    Chemical Substances Immunosuppressive Agents
    Language French
    Publishing date 2021-09-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Donneur vivant en transplantation rénale : 10 messages clés.

    Rostaing, Lionel

    La Revue du praticien

    2021  Volume 71, Issue 6, Page(s) 640

    Title translation Living donor in kidney transplant: 10 key messages.
    MeSH term(s) Graft Rejection ; Humans ; Kidney Transplantation ; Living Donors ; Transplant Recipients
    Language French
    Publishing date 2021-09-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A first small step toward personalized immunosuppression.

    Budde, Klemens / Rostaing, Lionel

    Kidney international

    2023  Volume 104, Issue 4, Page(s) 652–654

    Abstract: Lloberas et al. provide further evidence for the benefits of an individualized tacrolimus dosing algorithm based on population pharmacokinetics and pharmacogenetics. Better tacrolimus dosing could prevent underexposure and overexposure and potentially ... ...

    Abstract Lloberas et al. provide further evidence for the benefits of an individualized tacrolimus dosing algorithm based on population pharmacokinetics and pharmacogenetics. Better tacrolimus dosing could prevent underexposure and overexposure and potentially save costs. Most important, this could be the start of precision medicine in kidney transplantation, incorporating improved immunologic and donor quality assessments, advanced biopsy readouts, innovative pharmacogenomics for drug safety, and novel diagnostic and outcome algorithms to guide a truly personalized therapy.
    MeSH term(s) Tacrolimus/adverse effects ; Immunosuppression Therapy ; Algorithms ; Biopsy ; Kidney Transplantation/adverse effects
    Chemical Substances Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.06.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Parcours médical du donneur vivant de rein.

    Rostaing, Lionel

    La Revue du praticien

    2020  Volume 71, Issue 6, Page(s) 626–627

    Abstract: Care course of a potential living kidney donor. Care course of a potential living kidney donor is quite long (about 1-3 months) and sometimes cumbersome. During the first visit we evaluate the donor's motivations, and we look for potential medical ... ...

    Title translation Care course of a potential living kidney donor.
    Abstract Care course of a potential living kidney donor. Care course of a potential living kidney donor is quite long (about 1-3 months) and sometimes cumbersome. During the first visit we evaluate the donor's motivations, and we look for potential medical contraindications such as recent neoplasia treatment, chronic viral infections (hepatitis B, C or HIV), and uncontrolled hypertension despite 2 hypotensive drugs. At the end of that consultation some lab tests are performed: serum creatinine (and eGFR), microalbuminuria, ABO and HLA typings. At the same time the recipient will be ABO and HLA typed as well as being tested for anti-HLA antibodies. The second step within the donor will be to perform renal angioCT scan in order to detect potential surgical contraindications. At this point the donor will meet the surgeon, and if it is fine he will undergo specific exams such as measurement of glomerular filtration rate (iohexol clearance), echocardiography and ambulatory blood pressure monitoring (if indicated). Females will undergo mammography, cervical smear and pelvic echography, whereas males will be tested for PSA. At this point a multidisciplinary team will validate (or not) the medical project. If it is the case the medical files are transmitted to the Agence de la biomédecine, which will then send them to the expert committee (5 members). The latter will give an unmotivated answer.
    MeSH term(s) Blood Pressure Monitoring, Ambulatory ; Female ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Transplantation ; Living Donors ; Male
    Language French
    Publishing date 2020-12-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Adverse Drug Events after Kidney Transplantation.

    Rostaing, Lionel / Jouve, Thomas / Terrec, Florian / Malvezzi, Paolo / Noble, Johan

    Journal of personalized medicine

    2023  Volume 13, Issue 12

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13121706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Is There a Place for Apheresis in the Management of Idiopathic Membranous Nephropathy? A Report of Three Cases and Literature Review.

    Naciri Bennani, Hamza / Banza, Augustin Twite / Giovannini, Diane / Motte, Lionel / Noble, Johan / Corbu, Alexandra / Malvezzi, Paolo / Jouve, Thomas / Rostaing, Lionel

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Membranous nephropathy constitutes approximately 20% of adult nephrotic syndrome cases. In approximately 80% of cases, membranous nephropathy is primary, mediated by IgG autoantibodies primarily targeting podocyte antigens (PLA2R, THSD7A, etc.). The ... ...

    Abstract Membranous nephropathy constitutes approximately 20% of adult nephrotic syndrome cases. In approximately 80% of cases, membranous nephropathy is primary, mediated by IgG autoantibodies primarily targeting podocyte antigens (PLA2R, THSD7A, etc.). The treatment involves a combination of corticosteroids and cyclophosphamide or anti-CD20-based therapies, e.g., rituximab. In the event of significant proteinuria and in order to avoid the urinary elimination of rituximab, therapeutic apheresis, in particular semi-specific immunoadsorption, may be an option allowing for a reduction in proteinuria and autoantibodies before initiating treatment with rituximab. We present the preliminary experience of three patients treated with semi-specific immunoadsorption for primary membranous nephropathy between January 2021 and March 2023. Two patients were anti-PLA2R-autoantibody-positive and one was seronegative. The average age was 59 ± 17 years. Semi-specific immunoadsorption did not reduce albuminuria, but it, nevertheless, led to an increase in serum albumin, contributing to the regression of edema. It effectively eliminated anti-PLA2R autoantibodies in the two anti-PLA2R-positive patients. Consequently, apheresis may not induce a rapid reduction in proteinuria, but could contribute to a more accelerated remission when combined with the anti-CD20 treatment.
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030249
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  10. Article ; Online: Impact of donor-specific antibody with low mean fluorescence intensity on allograft outcomes in kidney transplant.

    Kitpermkiat, Rungthiwa / Kantachuvesiri, Surasak / Thotsiri, Sansanee / Thammanichanond, Duangtawan / Rostaing, Lionel / Wiwattanathum, Punlop

    Transplant immunology

    2024  , Page(s) 102054

    Abstract: Background: Immune-mediated rejection is the most common cause of allograft failure in kidney transplant (KT) patients. Exposure to alloantigen, including human leukocyte antigen (HLA), results in the production of donor-specific antibodies (DSA). There ...

    Abstract Background: Immune-mediated rejection is the most common cause of allograft failure in kidney transplant (KT) patients. Exposure to alloantigen, including human leukocyte antigen (HLA), results in the production of donor-specific antibodies (DSA). There are limited data about low levels of mean fluorescence intensity (MFI) DSA, especially post-transplantation. This study evaluated allograft outcomes in KT patients with low MFI DSA.
    Methods: From January 2007 to December 2021, KT patients who were tested for post-transplant DSA at Ramathibodi Hospital, Bangkok, Thailand, with the DSA MFI ≤ 1000 were evaluated. These KT patients were categorized into two groups: very low DSA (VLL; MFI = 1-500) and low DSA (LL; MFI = 501-1000). All KT patients were evaluated for the primary outcomes, such as the incidence of acute rejection, serum creatinine levels at one and five years after transplantation as well as allograft and patient survivals.
    Results: Among 36 KT patients 25 were included as those with VLL and 11 as those with LL. The LL group had significantly higher T-cell mediated allograft rejection (TCMR) than the VLL group (45% vs. 12%, P = 0.04). In addition, 10 patients, 5 in the VLL group and 5 in the LL group developed antibody-mediated allograft rejection (ABMR). Both TCMR and ABMR were confirmed by biopsy results. There was a trend toward higher MFI in KT patients with ABMR than without ABMR (P = 0.22). At 5 post-transplant years, serum creatinine, allograft and patient survivals were comparable between these two groups. Furthermore, the univariate and multivariate analyzes revealed that the LL group was a high risk for rejection.
    Conclusion: Low MFI DSA values after transplantation may be associated with a higher incidence of rejection, but this finding did not show differences in allograft and patient survival in this study's analysis.
    Language English
    Publishing date 2024-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2024.102054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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