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  1. Article: Analysis of Psychological and Gut Microbiome Characteristics in Patients With Non-erosive Reflux Disease.

    Yang, Fan / Xie, Xin-Hui / Li, Xi / Liao, Hui-Na / Zou, Bing

    Frontiers in psychiatry

    2022  Volume 12, Page(s) 741049

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.741049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electroconvulsive Therapy in a Young Adult Patient With Bipolar Depression and Dysembryoplastic Neuroepithelial Tumor: A Case Report.

    Xu, Shu-Xian / Xie, Xin-Hui / Su, Dezhen / Liu, Zhongchun

    The journal of ECT

    2022  Volume 39, Issue 1, Page(s) 61–62

    MeSH term(s) Child ; Humans ; Young Adult ; Bipolar Disorder ; Electroconvulsive Therapy ; Brain Neoplasms ; Neoplasms, Neuroepithelial ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1426385-3
    ISSN 1533-4112 ; 1095-0680
    ISSN (online) 1533-4112
    ISSN 1095-0680
    DOI 10.1097/YCT.0000000000000876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2089: Show issues Location:
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  3. Article: Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress.

    Wang, Chao / Li, Ningyuan / Feng, Yuqi / Sun, Siqi / Rong, Jingtong / Xie, Xin-Hui / Xu, Shuxian / Liu, Zhongchun

    Neurobiology of stress

    2024  Volume 30, Page(s) 100632

    Abstract: The involvement of lipids in the mechanism of depression has triggered extensive discussions. Earlier studies have identified diminished levels of lysophosphatidic acid (LPA) and autotaxin (ATX) in individuals experiencing depression. However, the exact ... ...

    Abstract The involvement of lipids in the mechanism of depression has triggered extensive discussions. Earlier studies have identified diminished levels of lysophosphatidic acid (LPA) and autotaxin (ATX) in individuals experiencing depression. However, the exact significance of this phenomenon in relation to depression remains inconclusive. This study seeks to explore the deeper implications of these observations. We assessed alterations in ATX and LPA in both the control group and the chronic unpredictable mild stress (CUMS) model group. Additionally, the impact of ATX adeno-associated virus (AAV-ATX) injection into the hippocampus was validated through behavioral tests in CUMS-exposed mice. Furthermore, we probed the effects of LPA on synapse-associated proteins both in HT22 cells and within the mouse hippocampus. The mechanisms underpinning the LPA-triggered shifts in protein expression were further scrutinized. Hippocampal tissues were augmented with ATX to assess its potential to alleviate depression-like behavior by modulating synaptic-related proteins. Our findings suggest that the decrement in ATX and LPA levels alters the expression of proteins associated with synaptic plasticity
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2816500-7
    ISSN 2352-2895
    ISSN 2352-2895
    DOI 10.1016/j.ynstr.2024.100632
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  4. Article ; Online: The Neuroprotective Effects of BMSC-Derived Exosomes against Glutamate-Induced HT22 Cell Cytotoxicity.

    Rong, Jingtong / Sun, Siqi / Xu, Shu-Xian / Xie, Xin-Hui / Wang, Chao / Chen, Guopeng / Kang, Lijun / Xiang, Dan / Liu, Zhongchun

    Neuroscience

    2024  Volume 542, Page(s) 1–10

    Abstract: Many central nervous system diseases are closely related to nerve damage caused by dysregulation of the endogenous neurotransmitter glutamate. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) play an important role in improving injury ...

    Abstract Many central nervous system diseases are closely related to nerve damage caused by dysregulation of the endogenous neurotransmitter glutamate. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) play an important role in improving injury and regeneration functions. However, its mechanism remains unknown. Therefore, the aim of this study is to investigate whether and how BMSC-Exos improve neurotoxicity caused by glutamate and to fill the gap in the literature. In this study, glutamate-treated HT22 cells were first exposed to mouse-derived BMSC-Exos at different concentrations to observe their effects on HT22 apoptosis. Next, we treated glutamate-treated HT22 cells with mouse-derived BMSC-Exos. We then inhibited the PI3K/Akt/mTOR signaling pathways using the PI3K/Akt inhibitor and the mTOR inhibitor, respectively, and observed the protective effect of mouse-derived BMSC-Exos on HT22 cells treated with glutamate. Our results show that BMSC-Exos reduced apoptosis triggered by glutamate stimulation, increased cell vitality, and decreased the levels of proapoptotic proteins while increasing the levels of anti-apoptotic proteins. The protective effect of BMSC-Exos was weakened when PI3K/Akt inhibitor and mTOR inhibitor were added. To sum up, we draw the following conclusions: BMSC-Exos can reduce neuronal apoptosis and apoptosis-related protein expression after glutamate stimulation by regulating the PI3K/Akt/mTOR signaling pathway.
    MeSH term(s) Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Glutamic Acid/toxicity ; Glutamic Acid/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/metabolism ; Exosomes/metabolism ; TOR Serine-Threonine Kinases/metabolism ; MicroRNAs/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Glutamic Acid (3KX376GY7L) ; Neuroprotective Agents ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; MicroRNAs
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2024.01.023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: High throughput screening of pure silica zeolites for CF

    Zhang, Hui-Dong / Li, Xiao-Dong / Xie, Yan-Yu / Yang, Peng-Hui / Yu, Jing-Xin

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 15, Page(s) 11570–11581

    Abstract: The capture and separation of ... ...

    Abstract The capture and separation of CF
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d4cp00171k
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  6. Article ; Online: Crown ether-like octanuclear molybdenum(V) clusters for cation binding and gas adsorption.

    Dai, Ru-Dan / Xie, Zhen-Lang / Liu, Cheng / Xin, Dong / Zhou, Zhao-Hui

    Dalton transactions (Cambridge, England : 2003)

    2024  

    Abstract: Octanuclear polyoxomolybdenum-based porous materials, ... ...

    Abstract Octanuclear polyoxomolybdenum-based porous materials, Na
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d4dt00825a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Violent behavior and the network properties of psychopathological symptoms and real-life functioning in patients with schizophrenia.

    Chen, Li-Chang / Tan, Wen-Yan / Xi, Jun-Yan / Xie, Xin-Hui / Lin, Hai-Cheng / Wang, Shi-Bin / Wu, Gong-Hua / Liu, Yu / Gu, Jing / Jia, Fu-Jun / Du, Zhi-Cheng / Hao, Yuan-Tao

    Frontiers in psychiatry

    2024  Volume 14, Page(s) 1324911

    Abstract: Objective: To assess the interplay among psychopathological symptoms and real-life functioning, and to further detect their influence with violent behavior in patient with schizophrenia.: Methods: A sample of 1,664 patients with post-violence ... ...

    Abstract Objective: To assess the interplay among psychopathological symptoms and real-life functioning, and to further detect their influence with violent behavior in patient with schizophrenia.
    Methods: A sample of 1,664 patients with post-violence assessments and their propensity score-matched controls without violence from a disease registration report system of community mental health service in Guangdong, China, were studied by network analysis.
    Results: Some nodes in the same domain were highly positive interrelations, while psychopathological symptoms were negatively related to real-life functioning in all networks. Many symptom-symptom connections and symptom-functioning connections were disconnected after the violence. The network density decreased from 23.53% to 12.42% without statistical significance (
    Conclusion: The decreasing connectivity may indicate an increased risk of violence and early warning for detecting violence. Interventions and improving health state based on nodes with high strength might prevent violence in schizophrenia patients.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1324911
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  8. Article ; Online: Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy.

    Xie, Xin-Hui / Xu, Shu-Xian / Yao, Lihua / Chen, Mian-Mian / Zhang, Honghan / Wang, Chao / Nagy, Corina / Liu, Zhongchun

    Brain stimulation

    2023  Volume 17, Issue 1, Page(s) 19–28

    Abstract: Background: The neurogenesis hypothesis is a promising candidate etiologic hypothesis for depression, and it is associated with electroconvulsive therapy (ECT). However, human in vivo molecular-level evidence is lacking.: Objective: We used neuron- ... ...

    Abstract Background: The neurogenesis hypothesis is a promising candidate etiologic hypothesis for depression, and it is associated with electroconvulsive therapy (ECT). However, human in vivo molecular-level evidence is lacking.
    Objective: We used neuron-derived extracellular vesicles (NDEVs) as a "window to the neurons" to explore the in vivo neurogenesis status associated with ECT in patients with treatment-resistant depression (TRD).
    Methods: In this study, we enrolled 40 patients with TRD and 35 healthy controls (HCs). We isolated NDEVs from the plasma of each participant to test the levels of doublecortin (DCX), a marker of neurogenesis, and cluster of differentiation (CD) 81, a marker of EVs. We also assessed the plasma levels of brain-derived neurotrophic factor (BDNF), a protein that is known to be associated with ECT and neuroplastic processes.
    Results: Our findings indicated that both the levels of DCX in NDEVs and BDNF in plasma were significantly lower in TRD patients compared to HCs at baseline, but increased following ECTs. Conversely, levels of CD81 in NDEVs were found higher in TRD patients at baseline, but did not change after the ECT treatments. Exploratory analyses revealed that lower levels of BDNF in plasma and DCX in NDEVs, along with higher CD81 levels in NDEVs, were associated with more severe depressive symptoms and reduced cognitive function at baseline. Furthermore, higher baseline CD81 concentrations in NDEVs were correlated with greater decreases in depression symptoms.
    Conclusions: We first present human in vivo evidence of early neurogenesis using DCX through NDEVs: decreased in TRD patients, increased after ECTs.
    MeSH term(s) Humans ; Electroconvulsive Therapy ; Brain-Derived Neurotrophic Factor ; Depression/therapy ; Treatment Outcome ; Depressive Disorder, Treatment-Resistant/therapy
    Chemical Substances Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2023.12.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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  9. Article: Machine Learning Prediction Model and Risk Factor Analysis of Reoperation in Recurrent Lumbar Disc Herniation Patients After Percutaneous Endoscopic Lumbar Discectomy.

    Shan, Zheng-Ming / Ren, Xue-Song / Shi, Hang / Zheng, Shi-Jie / Zhang, Cong / Zhuang, Su-Yang / Wu, Xiao-Tao / Xie, Xin-Hui

    Global spine journal

    2023  , Page(s) 21925682231173353

    Abstract: Objective: To investigate the risk factors of reoperation after percutaneous endoscopic lumbar discectomy (PELD) due to recurrent lumbar disc herniation (rLDH) and to establish a set of individualized prediction models.: Methods: Patients who ... ...

    Abstract Objective: To investigate the risk factors of reoperation after percutaneous endoscopic lumbar discectomy (PELD) due to recurrent lumbar disc herniation (rLDH) and to establish a set of individualized prediction models.
    Methods: Patients who underwent PELD successfully from January 2016 to February 2022 in a single institution were enrolled in this study. Six methods of machine learning (ML) were used to establish an individualized prediction model for reoperation in rLDH patients after PELD, and these models were compared with logistics regression model to select optimal model.
    Results: A total of 2603 patients were enrolled in this study. 57 patients had repeated operation due to rLDH and 114 patients were selected from the remaining 2546 nonrecurrent patients as matched controls. Multivariate logistic regression analysis showed that disc herniation type (
    Conclusion: This study showed that disc herniation type (extrusion, sequestration), Modic changes (type II), a large sROM, a large FO and high FI were independent risk factors for reoperation in LDH patients after PELD. The prediction efficiency of XGBoost model was higher than traditional Logistic regression analysis model.
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682231173353
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  10. Article: Trajectories of Efficacy and Cognitive Function During Electroconvulsive Therapy Course in Young Adults with Treatment-Resistant Depression.

    Xu, Shu-Xian / Xie, Xin-Hui / Yao, Lihua / Chen, Li-Chang / Wan, Qirong / Chen, Zhen-Hua / Liu, Zhongchun

    Neuropsychiatric disease and treatment

    2023  Volume 19, Page(s) 267–281

    Abstract: Objective: Little is known about the effectiveness and cognitive side-effects of electroconvulsive therapy (ECT) in young adults with treatment-resistant depression (TRD). The primary aim of this prospective longitudinal observational trial was to ... ...

    Abstract Objective: Little is known about the effectiveness and cognitive side-effects of electroconvulsive therapy (ECT) in young adults with treatment-resistant depression (TRD). The primary aim of this prospective longitudinal observational trial was to examine the clinical features and cognitive outcomes of young adults with TRD undergoing ECT.
    Methods: Changes in depressive symptoms and objective and subjective cognitive function were assessed using repeated evaluation at baseline, after each ECT session, and at one-month follow-up using the Montgomery-Äsberg Depression Rating Scale (MADRS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Forward Digital Span Test (FDST), and part of the Columbia Subjective Side Effects Schedule.
    Results: Of 41 inpatients, 35 (85.4%) and 12 (29.3%) met the criteria for response and remission after ECT, respectively. The greatest clinical improvements occurred during the first 3-4 ECT sessions. While 34 patients reported subjective cognitive impairment increased with ECT, immediate and delayed memory (RBANS) significantly increased after ECT, consistent with FDST results. Objective cognition significantly improved during follow-up, but subjective cognition remained impaired.
    Conclusion: ECT is effective in young adults with TRD. Although subjective cognitive impairment increased during treatment, objective cognitive impairments were not observed.
    Language English
    Publishing date 2023-01-29
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S394155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6068: Show issues Location:
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