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  1. Article ; Online: Serum Albumin Still of Interest to Predict Outcomes in Membranous Nephropathy in the Era of Phospholipase A2 Receptor.

    Delafosse, Marion / Ponlot, Eléonore / Hanset, Nicolas / Estève, Emmanuel / Boffa, Jean-Jaques / Dahan, Karine

    Kidney international reports

    2020  Volume 5, Issue 9, Page(s) 1611–1612

    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.06.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Personalized phospholipase A2 receptor antibody-driven rituximab treatment strategy in membranous nephropathy.

    Delafosse, Marion / Ponlot, Eléonore / Esteve, Emmanuel / Ghislain, Louise / Hanset, Nicolas / Boffa, Jean-Jacques / Johanet, Catherine / Dahan, Karine

    Kidney international

    2021  Volume 99, Issue 4, Page(s) 1023–1024

    MeSH term(s) Adrenal Cortex Hormones ; Cyclophosphamide ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Humans ; Receptors, Phospholipase A2 ; Rituximab ; Tacrolimus
    Chemical Substances Adrenal Cortex Hormones ; Receptors, Phospholipase A2 ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Modélisation de la barrière de filtration glomérulaire - Nouvelles avancées.

    Dembele, Mahamadou / Delafosse, Marion / Yousfi, Nadhir / Debiec, Hanna / Ngo, Kieu / Plaisier, Emmanuelle / Ronco, Pierre / Perry, Guillaume

    Medecine sciences : M/S

    2021  Volume 37, Issue 3, Page(s) 242–248

    Abstract: In this article, we present the latest innovations to generate in vitro models of the glomerular filtration barrier. There is currently a growing interest for such model systems that allow to reduce the use of animal models. Methodologies to improve ... ...

    Title translation Models of glomerular filtration barrier : New developments.
    Abstract In this article, we present the latest innovations to generate in vitro models of the glomerular filtration barrier. There is currently a growing interest for such model systems that allow to reduce the use of animal models. Methodologies to improve their physiological relevance have taken advantage of the development of induced pluripotent stem cells and of bioengineering, particularly tissue engineering. Here, we first introduce the methods to overcome the limitations of the currently used glomerular cells based on the use of stem cells. The different approaches to obtain podocytes, the most important cells in the glomerulus, are presented. Finally, we emphasize the importance of the glomerular microenvironment in maintaining the glomerular cell phenotype, which can be achieved by co-culturing different glomerular cells, integration of biomaterials mimicking the extracellular matrix and introduction of flows with microfluidics.
    MeSH term(s) Animals ; Glomerular Filtration Barrier ; Humans ; Models, Biological ; Podocytes
    Language French
    Publishing date 2021-03-19
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2872: Show issues Location:
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  4. Article: Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma.

    Delafosse, Marion / Teuma, Cécile / Miailhes, Patrick / Nouvier, Mathilde / Rabeyrin, Maud / Fouque, Denis

    Clinical kidney journal

    2018  Volume 11, Issue 5, Page(s) 667–669

    Abstract: Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. ...

    Abstract Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial nephritis without granulomas in an HIV-negative patient. Since all laboratory tests failed to isolate
    Language English
    Publishing date 2018-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfx157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6587: Show issues Location:
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  5. Article ; Online: Steroids: A Therapeutic Option for COVID-19 Pneumonia Patients With ESRD?

    Delafosse, Marion / Saint-Jaques, Camille / Petit-Hoang, Camille / François, Hélène / Peltier, Julie / Nicolet, Laurence / Verney, Charles / Viguier, Martin / Letavernier, Emmanuel / Dahan, Karine

    Kidney international reports

    2020  Volume 5, Issue 8, Page(s) 1375

    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.05.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients.

    Charmetant, Xavier / Espi, Maxime / Benotmane, Ilies / Barateau, Véronique / Heibel, Francoise / Buron, Fanny / Gautier-Vargas, Gabriela / Delafosse, Marion / Perrin, Peggy / Koenig, Alice / Cognard, Noëlle / Levi, Charlène / Gallais, Floriane / Manière, Louis / Rossolillo, Paola / Soulier, Eric / Pierre, Florian / Ovize, Anne / Morelon, Emmanuel /
    Defrance, Thierry / Fafi-Kremer, Samira / Caillard, Sophie / Thaunat, Olivier

    Science translational medicine

    2022  Volume 14, Issue 636, Page(s) eabl6141

    Abstract: Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response to vaccines. We observed that previous infection with ... ...

    Abstract Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response to vaccines. We observed that previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but not the standard two-dose regimen of vaccination, provided protection against symptomatic COVID-19 in kidney transplant recipients. We therefore compared the cellular and humoral immune responses of these two groups of patients. Neutralizing anti-receptor-binding domain (RBD) immunoglobulin G (IgG) antibodies were identified as the primary correlate of protection for transplant recipients. Analysis of virus-specific B and T cell responses suggested that the generation of neutralizing anti-RBD IgG may have depended on cognate T-B cell interactions that took place in germinal center, potentially acting as a limiting checkpoint. High-dose mycophenolate mofetil, an immunosuppressive drug, was associated with fewer antigen-specific B and T follicular helper (T
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; Prospective Studies ; SARS-CoV-2 ; Transplant Recipients ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abl6141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  7. Article: Steroids: A Therapeutic Option for COVID-19 Pneumonia Patients With ESRD?

    Delafosse, Marion / Saint-Jaques, Camille / Petit-Hoang, Camille / François, Hélène / Peltier, Julie / Nicolet, Laurence / Verney, Charles / Viguier, Martin / Letavernier, Emmanuel / Dahan, Karine

    Kidney Intl. Rep.

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #600957
    Database COVID19

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  8. Article ; Online: Steroids

    Delafosse, Marion / Saint-Jaques, Camille / Petit-Hoang, Camille / François, Hélène / Peltier, Julie / Nicolet, Laurence / Verney, Charles / Viguier, Martin / Letavernier, Emmanuel / Dahan, Karine

    Kidney International Reports

    A Therapeutic Option for COVID-19 Pneumonia Patients With ESRD?

    2020  Volume 5, Issue 8, Page(s) 1375

    Keywords Nephrology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2468-0249
    DOI 10.1016/j.ekir.2020.05.031
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Comparison of infected and vaccinated transplant recipients highlights the role of Tfh and neutralizing IgG in COVID-19 protection

    Charmetant, Xavier / ESPI, Maxime / Benotmane, Ilies / Heibel, Francoise / Buron, Fanny / Gautier-Vargas, Gabriela / Delafosse, Marion / Perrin, Peggy / Koenig, Alice / Cognard, Noelle / Levi, Charlene / Gallais, Floriane / Maniere, Louis / Rossolillo, Paola / Soulier, Eric / Pierre, Florian / Ovize, Anne / Morelon, Emmanuel / Defrance, Thierry /
    Fafi-Kremer, Samira / Caillard, Sophie / Thaunat, Olivier

    medRxiv

    Abstract: Transplant recipients, which receive therapeutic immunosuppression to prevent graft rejection, are characterized by high COVID-19-related mortality and defective response to vaccines. Having observed that previous infection by SARS-CoV-2 but not the ... ...

    Abstract Transplant recipients, which receive therapeutic immunosuppression to prevent graft rejection, are characterized by high COVID-19-related mortality and defective response to vaccines. Having observed that previous infection by SARS-CoV-2 but not the standard 2 doses scheme of vaccination, provided complete protection against COVID-19 to transplant recipients, we undertook this translational study to compare the cellular and humoral immune responses of these 2 groups of patients. Neutralizing anti-Receptor Binding Domain (RBD) IgG were identified as the critical immune effectors associated with protection. Generation of anti-RBD IgG was dependent upon spike-specific T follicular helper (Tfh) CD4+ T cells, which acted as limiting checkpoint. Tfh generation was impeded by high dose mycophenolate mofetil in non-responders to vaccine but not in infected patients, suggesting that increasing immunogenicity of vaccine could improve response rate to mRNA vaccine. This theory was validated in two independent prospective cohorts, in which administration of a 3rd dose of vaccine resulted in the generation of anti-RBD IgG in half of non-responders to 2 doses.
    Keywords covid19
    Language English
    Publishing date 2021-07-24
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.07.22.21260852
    Database COVID19

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