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  1. Article: Guest editorial: A dialogue with William J. Baumol

    Baumol, William J / Bacq, Sophie / Griffiths, Mark D / Kickul, Jill / Terjesen, Siri

    Entrepreneurship, theory and practice : ET & P Vol. 36, No. 4 , p. 611-625

    insights on entrepreneurship theory and education

    2012  Volume 36, Issue 4, Page(s) 611–625

    Title variant A dialogue with William J. Baumol : insights on entrepreneurship theory and education
    Author's details Mark Griffiths; Jill Kickul; Sophie Bacq; Siri Terjesen
    Keywords Entrepreneurship ; Bibliometrie
    Language English
    Publisher Wiley Subscription Servives, Inc
    Publishing place Hoboken, NJ
    Document type Article
    ZDB-ID 645949-3
    ISSN 0363-9428
    Database ECONomics Information System

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  2. Article ; Online: 11th ENOR meeting: Oxysterols in human health and diseases.

    Poirot, Marc / Iuliano, Luigi / Griffiths, William J / Lizard, Gerard

    The Journal of steroid biochemistry and molecular biology

    2024  Volume 239, Page(s) 106495

    MeSH term(s) Humans ; Oxysterols
    Chemical Substances Oxysterols
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2024.106495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Metabolomics, metabonomics and metabolite profiling

    Griffiths, William J.

    (RSC biomolecular sciences ; [9])

    2008  

    Author's details ed. by William J. Griffiths
    Series title RSC biomolecular sciences ; [9]
    Collection
    Keywords Metabolites ; Proteomics ; Molecular diagnosis
    Subject code 572.84
    Language English
    Size XI, 323 S. : Ill., graph. Darst.
    Publisher RSC Publ
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index ; Bandzählung einer Auflistung in Bd. 21 entnommen
    HBZ-ID HT015539756
    ISBN 978-0-85404-299-9 ; 0-85404-299-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 3362 order for loan Magazin

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  4. Article ; Online: Satisfactory outcomes in orthotopic liver transplantation for hepatic sarcoidosis: The UK experience.

    Sinharay, Ricky / Griffiths, William J H

    Transplant immunology

    2021  Volume 68, Page(s) 101442

    MeSH term(s) Humans ; Liver Transplantation ; Sarcoidosis/therapy ; United Kingdom
    Language English
    Publishing date 2021-07-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2021.101442
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  5. Article: Mass Spectrometry Imaging of Cholesterol and Oxysterols.

    Griffiths, William J / Yutuc, Eylan / Wang, Yuqin

    Advances in experimental medicine and biology

    2023  Volume 1440, Page(s) 73–87

    Abstract: Mass spectrometry imaging (MSI) is a new technique in the toolbox of the analytical biochemist. It allows the generation of a compound-specific image from a tissue slice where a measure of compound abundance is given pixel by pixel, usually displayed on ... ...

    Abstract Mass spectrometry imaging (MSI) is a new technique in the toolbox of the analytical biochemist. It allows the generation of a compound-specific image from a tissue slice where a measure of compound abundance is given pixel by pixel, usually displayed on a color scale. As mass spectra are recorded at each pixel, the data can be interrogated to generate images of multiple different compounds all in the same experiment. Mass spectrometry (MS) requires the ionization of analytes, but cholesterol and other neutral sterols tend to be poorly ionized by the techniques employed in most MSI experiments, so despite their high abundance in mammalian tissues, cholesterol is poorly represented in the MSI literature. In this chapter, we discuss some of the MSI studies where cholesterol has been imaged and introduce newer methods for its analysis by MSI. Disturbed cholesterol metabolism is linked to many disorders, and the potential of MSI to study cholesterol, its precursors, and its metabolites in animal models and from human biopsies will be discussed.
    MeSH term(s) Animals ; Humans ; Oxysterols ; Cholesterol/metabolism ; Mass Spectrometry/methods ; Sterols ; Models, Animal ; Mammals/metabolism
    Chemical Substances Oxysterols ; Cholesterol (97C5T2UQ7J) ; Sterols
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-43883-7_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development.

    Griffiths, William J / Wang, Yuqin

    Frontiers in physiology

    2021  Volume 12, Page(s) 723224

    Abstract: In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma ... ...

    Abstract In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol.
    Language English
    Publishing date 2021-10-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.723224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Estimating the Effects of a Hurricane on Carbon Storage in Mangrove Wetlands in Southwest Florida.

    Griffiths, Lauren N / Mitsch, William J

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: Tropical and subtropical mangrove swamps, under normal conditions, can sequester large amounts of carbon in their soils but as coastal wetlands, they are prone to hurricane disturbances. This study adds to the understanding of carbon storage capabilities ...

    Abstract Tropical and subtropical mangrove swamps, under normal conditions, can sequester large amounts of carbon in their soils but as coastal wetlands, they are prone to hurricane disturbances. This study adds to the understanding of carbon storage capabilities of mangrove wetlands and explores how these capacities might change within the scope of a changing storm climate. In September 2017, Naples Bay, FL, USA (28°5' N, 81°47' W) encountered a direct hit from hurricane Irma, a Saffir-Simpson category 3 storm. By comparing carbon storage, forest community structure, and aboveground productivity collected in 2013 and in 2019, we estimated the effects of hurricane Irma on mangrove functions. Aboveground biomass increased during the study period at a rate of approximately 0.72 kg m
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10081749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cholesterol metabolism: from lipidomics to immunology.

    Griffiths, William J / Wang, Yuqin

    Journal of lipid research

    2021  Volume 63, Issue 2, Page(s) 100165

    Abstract: Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo, ... ...

    Abstract Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo, other than as intermediates in bile acid biosynthesis, has long been debated. However, in the first quarter of this century, a role for side-chain oxysterols and their C-7 oxidized metabolites has been convincingly established in the immune system. 25-Hydroxycholesterol has been shown to be synthesized by macrophages in response to the activation of Toll-like receptors and to offer protection against microbial pathogens, whereas 7α,25-dihydroxycholesterol has been shown to act as a chemoattractant to lymphocytes expressing the G protein-coupled receptor Epstein-Barr virus-induced gene 2 and to be important in coordinating the action of B cells, T cells, and dendritic cells in secondary lymphoid tissue. There is a growing body of evidence that not only these two oxysterols but also many of their isomers are of importance to the proper function of the immune system. Here, we review recent findings related to the roles of oxysterols in immunology.
    MeSH term(s) Lipidomics
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2021.100165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

    Berger, Joel I / Billig, Alexander J / Sedley, William / Kumar, Sukhbinder / Griffiths, Timothy D / Gander, Phillip E

    Human brain mapping

    2024  Volume 45, Issue 3, Page(s) e26627

    Abstract: The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by a number of studies. These structures are usually considered in the context of a "limbic system," a concept typically invoked to explain the emotional ... ...

    Abstract The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by a number of studies. These structures are usually considered in the context of a "limbic system," a concept typically invoked to explain the emotional response to tinnitus. Despite this common framing, it is not apparent from current literature that this is necessarily the main functional role of these structures in persistent tinnitus. Here, we highlight a different role that encompasses their most commonly implicated functional position within the brain-that is, as a memory system. We consider tinnitus as an auditory object that is held in memory, which may be made persistent by associated activity from the hippocampus and parahippocampal gyrus. Evidence from animal and human studies implicating these structures in tinnitus is reviewed and used as an anchor for this hypothesis. We highlight the potential for the hippocampus/parahippocampal gyrus to facilitate maintenance of the memory of the tinnitus percept via communication with auditory cortex, rather than (or in addition to) mediating emotional responses to this percept.
    MeSH term(s) Animals ; Humans ; Tinnitus/diagnostic imaging ; Hippocampus/diagnostic imaging ; Parahippocampal Gyrus/diagnostic imaging ; Limbic System ; Auditory Cortex
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: First report of post-transplant autoimmune hepatitis recurrence following SARS-CoV-2 mRNA vaccination.

    Mahalingham, Aarani / Duckworth, Adam / Griffiths, William J H

    Transplant immunology

    2022  Volume 72, Page(s) 101600

    Abstract: Whilst vaccination for the SARS-CoV-2 virus has been successful in reducing the severity and burden of the COVID-19 pandemic, there have been recent reports of mRNA vaccines triggering autoimmune hepatitis in the native liver. There have been no ... ...

    Abstract Whilst vaccination for the SARS-CoV-2 virus has been successful in reducing the severity and burden of the COVID-19 pandemic, there have been recent reports of mRNA vaccines triggering autoimmune hepatitis in the native liver. There have been no descriptions thus far of recurrent 'autoimmune hepatitis' after liver transplantation in the context of SARS-CoV-2 vaccination. We describe a patient transplanted for autoimmune hepatitis who was stable for many years until they had immune-mediated flares coinciding with Pfizer-BioNTech mRNA vaccination. Intravenous steroid treatment was required to suppress histologically evident interface hepatitis. We firmly believe that mRNA vaccination was responsible for this 'recurrence' and that clinicians should be vigilant for this reaction in patients transplanted for autoimmune hepatitis.
    MeSH term(s) BNT162 Vaccine ; COVID-19/diagnosis ; COVID-19 Vaccines/adverse effects ; Hepatitis, Autoimmune/etiology ; Humans ; Pandemics ; RNA, Messenger ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-04-04
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2022.101600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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