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Article ; Online: AAV6 mediated Gsx1 expression in neural stem progenitor cells promotes neurogenesis and restores locomotor function after contusion spinal cord injury.

Finkel, Zachary / Esteban, Fatima / Rodriguez, Brianna / Clifford, Tanner / Joseph, Adelina / Alostaz, Hani / Dalmia, Mridul / Gutierrez, Juan / Tamasi, Matthew J / Zhang, Samuel Ming / Simone, Jonah / Petekci, Hafize / Nath, Susmita / Escott, Miriam / Garg, Shivam Kumar / Gormley, Adam J / Kumar, Suneel / Gulati, Sonia / Cai, Li

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2024 , Page(s) e00362

Abstract: Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required for the generation of excitatory and inhibitory interneurons during spinal cord development. In the adult, lentivirus (LV) mediated Gsx1 expression promotes neural ... ...

Abstract	Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required for the generation of excitatory and inhibitory interneurons during spinal cord development. In the adult, lentivirus (LV) mediated Gsx1 expression promotes neural regeneration and functional locomotor recovery in a mouse model of lateral hemisection spinal cord injury (SCI). The LV delivery method is clinically unsafe due to insertional mutations to the host DNA. In addition, the most common clinical case of SCI is contusion/compression. In this study, we identify that adeno-associated virus serotype 6 (AAV6) preferentially infects neural stem/progenitor cells (NSPCs) in the injured spinal cord. Using a rat model of contusion SCI, we demonstrate that AAV6 mediated Gsx1 expression promotes neurogenesis, increases the number of neuroblasts/immature neurons, restores excitatory/inhibitory neuron balance and serotonergic neuronal activity through the lesion core, and promotes locomotor functional recovery. Our findings support that AAV6 preferentially targets NSPCs for gene delivery and confirmed Gsx1 efficacy in clinically relevant rat model of contusion SCI.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1016/j.neurot.2024.e00362
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Article ; Online: Are Hindfoot Procedures More Painful than Forefoot Procedures? A Prospective Observational Study in Elective Foot and Ankle Surgery.

Makvana, Sonia / Faroug, Radwane / Venturini, Sara / Alcorn, Edward / Gulati, Aashish / Gaur, Atul / Mangwani, Jitendra

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2021 Volume 61, Issue 1, Page(s) 23–26

Abstract: Pain after lower limb orthopedic surgery can be severe. Poorly controlled pain is associated with adverse outcomes. Peripheral nerve blocks (PNB) have become popular in foot and ankle surgery for their effective pain control and low complication rates. ... ...

Abstract	Pain after lower limb orthopedic surgery can be severe. Poorly controlled pain is associated with adverse outcomes. Peripheral nerve blocks (PNB) have become popular in foot and ankle surgery for their effective pain control and low complication rates. It has always been assumed that hindfoot procedures are more painful than midfoot/forefoot procedures often requiring inpatient stay for pain relief. There are no published studies evaluating this assumption. To investigate whether hindfoot procedures are more painful than forefoot/midfoot procedures by measuring pain scores, assessing effectiveness of PNBs and patient satisfaction. One hundred forty patients undergoing elective foot and ankle surgery were prospectively studied. Inclusion criteria: Adults undergoing elective foot and ankle surgery. Exclusion criteria: Patients 16 years or under, those with alternate sources of pain, peripheral neuropathy, known substance abuse, psychiatric illness and incomplete pain scores. Pain was measured via the Visual Analog Scale at 3 time intervals: immediately, 6 hours and at 24 hours postoperatively. Analysis was via t-test. A p value of <.05 demonstrated a statistical significance. Forefoot/midfoot versus hindfoot surgery pain scores showed that there was no significant difference at any postoperative interval. PNB versus no PNB pain scores showed there was no significant difference, except at 24 hours postoperatively (p value .024). Patients who had a PNB experienced rebound pain at 24 hours. Hindfoot surgery is not more painful than forefoot/midfoot surgery. Patients who had a PNB experienced rebound pain at 24 hours postoperatively, a finding that requires further research.
MeSH term(s)	Adult ; Ankle/surgery ; Humans ; Lower Extremity ; Nerve Block ; Orthopedic Procedures/adverse effects ; Pain
Language	English
Publishing date	2021-06-11
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2021.04.024
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Article ; Online: Pathological Effects of Apalutamide in Lower-risk Prostate Cancer: Results From a Phase II Clinical Trial.

Schweizer, Michael T / True, Lawrence / Gulati, Roman / Zhao, Yibai / Ellis, William / Schade, George / Montgomery, Bruce / Goyal, Sonia / Nega, Katie / Hakansson, Alexander K / Liu, Yang / Davicioni, Elai / Pienta, Kenneth / Nelson, Peter S / Lin, Daniel / Wright, Jonathan

The Journal of urology

2023 Volume 209, Issue 2, Page(s) 354–363

Abstract: Purpose: Active surveillance is a safe and effective strategy for men with lower-risk prostate cancer who want to avoid local therapy; however, many patients on active surveillance progress to active treatment (eg, prostatectomy or radiation). We ... ...

Abstract	Purpose: Active surveillance is a safe and effective strategy for men with lower-risk prostate cancer who want to avoid local therapy; however, many patients on active surveillance progress to active treatment (eg, prostatectomy or radiation). We hypothesized that apalutamide would decrease active surveillance attrition rates through downstaging low-grade tumors. Materials and methods: This was an open-label, single-arm, phase II study testing 90 days of oral apalutamide 240 mg daily in men with low- to intermediate-risk prostate cancer on active surveillance. The primary objective was to determine the percentage of patients with a negative biopsy immediately following treatment. Secondary objectives were to assess long-term clinical outcomes, quality of life, safety, and biomarkers of response/resistance. Results: Twenty-three patients enrolled and 22 completed 90 days of apalutamide with post-treatment biopsy. Fifteen (65%) had Grade Group 1 disease, and all others had Grade Group 2 disease. Seven (30%) had favorable- to intermediate-risk disease. Of 22 evaluable patients, 13 (59%) had no residual cancer on post-treatment biopsy. The median time to first positive biopsy was 364 days (95% CI: 91-742 days). The impact of apalutamide on quality of life was minimal and transient. Decipher risk classifier revealed a greater number of negative post-treatment biopsies in those with higher baseline genomic risk score ( Conclusions: The negative repeat biopsy rate following 90 days of apalutamide was high in men with prostate cancer followed on active surveillance. Apalutamide was safe, well tolerated, and had minimal impact on quality of life. Randomized studies evaluating the effects of apalutamide in men enrolled on active surveillance are warranted.
MeSH term(s)	Male ; Humans ; Quality of Life ; Prostatic Neoplasms/pathology ; Thiohydantoins ; Androgen Receptor Antagonists/adverse effects ; Watchful Waiting
Chemical Substances	apalutamide ; Thiohydantoins ; Androgen Receptor Antagonists
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000003038
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Article ; Online: Exploring the use of tablets (iPads) with children and young adults with disabilities in Trinidad.

Wiley, Brittney / Cameron, Deb / Gulati, Sonia / Hogg, Alison

Disability and rehabilitation. Assistive technology

2016 Volume 11, Issue 1, Page(s) 32–37

Abstract: Purpose: This study was conducted to review data gathered during a pilot project which trialed the use of a tablet computer, the iPad.: Methods: Students from a segregated special education school and pre-vocational centre, with a wide range of ... ...

Abstract	Purpose: This study was conducted to review data gathered during a pilot project which trialed the use of a tablet computer, the iPad. Methods: Students from a segregated special education school and pre-vocational centre, with a wide range of intellectual and physical disabilities, were previously observed participating in 5-10-min introductory learning sessions with the iPad. This study reviewed quantitative and qualitative data collected during these sessions which included data regarding students' level of engagement and overall ability to learn how to operate the iPad and its applications. Results: Results were positive for level of engagement and ease of use with cause and effect applications. For lower functioning students or students not previously exposed to tablet technology, scores were lower but overall remained high based on the 5-point scaling used in this study. Conclusion: Regular use of tablet technology in the classroom with applications appropriate to the level of ability of the student has the potential to enhance engagement in learning as well as maximise independence in the classroom. Implications for Rehabilitation The iPad has the capacity to be used with learners of all different ability levels if applications are selected appropriately and learners are given equal opportunity to access this type of technology. Enjoyment when using the iPad was high overall and this type of technology has the potential to promote more engagement in the learning process. Many applications are easy to use and progress students through step by step increasing the potential for independent learning in the classroom.
MeSH term(s)	Adolescent ; Adult ; Attitude to Computers ; Child ; Child, Preschool ; Computer User Training/methods ; Computers, Handheld/utilization ; Disabled Persons/psychology ; Disabled Persons/statistics & numerical data ; Female ; Humans ; Learning ; Male ; Patient Satisfaction ; Pilot Projects ; Schools ; Students/psychology ; Trinidad and Tobago ; Young Adult
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.3109/17483107.2014.914251
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Zs.A 6301: Show issues

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Article ; Online: In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery.

Ramzan, Mohhammad / Gourion-Arsiquaud, Samuel / Hussain, Afzal / Gulati, Jaspreet Singh / Zhang, Qihong / Trehan, Sonia / Puri, Vinam / Michniak-Kohn, Bozena / Kaur, Indu Pal

Drug delivery and translational research

2022 Volume 12, Issue 7, Page(s) 1659–1683

Abstract: The study focused to evaluate and investigate optimized (using QbD) and novel ketoconazole (KTZ)-loaded solid lipid nanoparticles (KTZ-SLNs; 2% w/v KTZ) for enhanced permeation across skin. KTZ-SLNs were evaluated for size, distribution, zeta potential ( ... ...

Abstract	The study focused to evaluate and investigate optimized (using QbD) and novel ketoconazole (KTZ)-loaded solid lipid nanoparticles (KTZ-SLNs; 2% w/v KTZ) for enhanced permeation across skin. KTZ-SLNs were evaluated for size, distribution, zeta potential (ZP), percent entrapment efficiency (%EE), drug release, morphology (HRTEM and FESEM), thermal behaviour (DSC), spectroscopic (FTIR), and solid-state/diffraction characterization (X-ray diffraction, XRD). Moreover, ex vivo permeation and drug deposition into rat skin were conducted using Franz diffusion cell. The same was confirmed using human dermatome skin and fluorescence, confocal Raman, and vibrational ATR-FTIR microscopic methods. An in vivo dermatokinetics study was performed in rats to assess the extent of KTZ permeation into the skin. Stability including accelerated and photostability studies were conducted at different temperatures (2-8, 30, and 40 °C) for 12 months. The spherical, optimized KTZ-SLN formulation (KOF1) showed particle size of 293 nm and high EE of 88.5%. Results of FTIR, DSC, and XRD confirmed formation of KTZ-SLNs and their amorphous nature due to presence of KTZ in a dissolved state in the lipid matrix. In vitro release was slow and sustained whereas ex vivo permeation parameters were significantly high in KTZ-SLNs as compared to free drug suspension (KTZ-SUS) and marketed product (Nizral®; 2% KTZ w/v). Drug retention was 10- and five-fold higher than KTZ-SUS and marketed product, respectively. In vivo dermatokinetics parameters improved significantly with SLN formulation (410-900% enhanced). Confocal Raman spectroscopy experiment showed that KTZ-SLNs could penetrate beyond the human stratum corneum into viable epidermis. Fluorescent microscopy also indicated improved penetration of KTZ-SLNs. KTZ-SLNs were photostable and showed long-term stability over 12 months under set conditions.
MeSH term(s)	Animals ; Drug Carriers/chemistry ; Ketoconazole ; Liposomes ; Nanoparticles/chemistry ; Particle Size ; Rats ; Suspensions
Chemical Substances	Drug Carriers ; Lipid Nanoparticles ; Liposomes ; Suspensions ; Ketoconazole (R9400W927I)
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-021-01058-6
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Article ; Online: Diagnosis and treatment of tuberculosis of the foot and ankle-A literature review.

Faroug, Radwane / Psyllakis, Panagiotis / Gulati, Aashish / Makvana, Sonia / Pareek, Manish / Mangwani, Jitendra

Foot (Edinburgh, Scotland)

2018 Volume 37, Page(s) 105–112

Abstract: Foot osteoarticular tuberculosis is uncommon. Late diagnosis and sub-optimal management can lead to significant morbidity, deformity and even death. Preservation of life, limb and function can be achieved with prompt diagnosis and treatment. In 1882, ... ...

Abstract	Foot osteoarticular tuberculosis is uncommon. Late diagnosis and sub-optimal management can lead to significant morbidity, deformity and even death. Preservation of life, limb and function can be achieved with prompt diagnosis and treatment. In 1882, Robert Koch published his discovery of mycobacterium tuberculosis as the causative agent of tuberculosis (TB), and showed the disease was infectious rather than inherited. Over two centuries later, TB remains one of the top 10 causes of death worldwide. Whilst in 90% of cases TB infects the respiratory system, in 10% it is extrapulmonary and can infect the skeletal, nervous, lymphatic and genitourinary systems. The spine is the most frequently affected site in the musculoskeletal system and this is known as Pott's disease. The foot and ankle is affected in only 0.13% cases of extrapulmonary TB. A high index of suspicion is thus required. This infrequency in incidence, heterogeneity of its presentation along with the difficulty in early diagnosis often causes significant delays in its treatment and hence results in a considerable disability. The medical treatment is well established but the role of surgery, its usefulness and its correct timing remain controversial. The main diagnostic issues include imaging being non-specific. Plain radiographs remain the first line imaging modality. MRI and CT scans provide greater detail and capture the disease at an earlier stage. Microbiological testing has low sensitivity and specificity becasue TB lesions are paucibacillary. Bone biopsy is of significant diagnostic value as it not only allows histological examination to detect granulomas but enables sensitivity and resistance testing of anti-tuberculous therapy (ATT). Issues relating to treatment include timing, duration, combination of chemotherapy and the challenge of multi drug resistant tuberculosis MDR-TB. The selection and timing of appropriate surgical techniques and optimal duration of follow-up are further points to consider. In this article we aim to review the literature on diagnosis and treatment of foot and ankle TB.
MeSH term(s)	Foot Bones ; Humans ; Tuberculosis, Osteoarticular/diagnosis ; Tuberculosis, Osteoarticular/etiology ; Tuberculosis, Osteoarticular/therapy
Language	English
Publishing date	2018-07-25
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	1070358-5
ISSN	1532-2963 ; 0958-2592
ISSN (online)	1532-2963
ISSN	0958-2592
DOI	10.1016/j.foot.2018.07.005
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Article: Disturbed laterality of non-rapid eye movement sleep oscillations in post-stroke human sleep: a pilot study.

Simpson, Benjamin K / Rangwani, Rohit / Abbasi, Aamir / Chung, Jeffrey M / Reed, Chrystal M / Gulati, Tanuj

Frontiers in neurology

2023 Volume 14, Page(s) 1243575

Abstract: Sleep is known to promote recovery post-stroke. However, there is a paucity of data profiling sleep oscillations in the post-stroke human brain. Recent rodent work showed that resurgence of physiologic spindles coupled to sleep slow oscillations (SOs) ... ...

Abstract	Sleep is known to promote recovery post-stroke. However, there is a paucity of data profiling sleep oscillations in the post-stroke human brain. Recent rodent work showed that resurgence of physiologic spindles coupled to sleep slow oscillations (SOs) and concomitant decrease in pathological delta (
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1243575
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Article: Disturbed laterality of non-rapid eye movement sleep oscillations in post-stroke human sleep: a pilot study.

Simpson, Benjamin K / Rangwani, Rohit / Abbasi, Aamir / Chung, Jeffrey M / Reed, Chrystal M / Gulati, Tanuj

medRxiv : the preprint server for health sciences

2023

Abstract: Sleep is known to promote recovery post-stroke. However, there is a paucity of data profiling sleep oscillations post-stroke in the human brain. Recent rodent work showed that resurgence of physiologic spindles coupled to sleep slow oscillations(SOs) and ...

Abstract	Sleep is known to promote recovery post-stroke. However, there is a paucity of data profiling sleep oscillations post-stroke in the human brain. Recent rodent work showed that resurgence of physiologic spindles coupled to sleep slow oscillations(SOs) and concomitant decrease in pathological delta(
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.01.23289359
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Article ; Online: A global comparison of implementation and effectiveness of materiovigilance program: overview of regulations.

Joshi, Deeksha / Sharma, Ishita / Gupta, Saurabh / Singh, Thakur Gurjeet / Dhiman, Sonia / Prashar, Abhimanyu / Gulati, Monica / Kumar, Bimlesh / Vishwas, Sukriti / Chellappan, Dinesh Kumar / Gupta, Gaurav / Jha, Niraj Kumar / Gupta, Piyush Kumar / Negi, Poonam / Dua, Kamal / Singh, Sachin Kumar

Environmental science and pollution research international

2021 Volume 28, Issue 42, Page(s) 59608–59629

Abstract: Medical devices, being life-saving tools, are considered to be a boon for healthcare system. However, in addition to their therapeutic effects, there are several ill consequences that are caused by these devices. An effective cohort vigilant system was ... ...

Abstract	Medical devices, being life-saving tools, are considered to be a boon for healthcare system. However, in addition to their therapeutic effects, there are several ill consequences that are caused by these devices. An effective cohort vigilant system was needed to manage such adverse effects. This had led to the introduction of materiovigilance. Materiovigilance is the study and follow-up of occurrences that arise as a result from the usage of the medical equipment. It not only manages adverse events (AE) but also creates harmonization among countries. Keeping these objectives in focus, the principles, perspectives, and practices with regard to materiovigilance that are followed in the USA, Europe, China, Japan, Australia, Canada, and India are being compared. Such a comparison is essential, which will help us to understand the gaps in the current regulatory systems in the above-mentioned countries and furthermore will provide a comprehensive picture to the regulatory authorities to amend any existing laws if required. These amendments may ensure optimal patient safety by providing them a benign experience from the use of medical devices.
MeSH term(s)	Australia ; Canada ; China ; Delivery of Health Care ; Europe ; Government Regulation ; Humans ; India ; Japan ; United States
Language	English
Publishing date	2021-09-13
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-16345-5
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Article ; Online: Health care providers' perspectives about working with parents of children with cancer: a qualitative study.

Klassen, Anne / Gulati, Sonia / Dix, David

Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

2012 Volume 29, Issue 2, Page(s) 92–97

Abstract: Research to understand the sources of stress and job satisfaction in pediatric oncology staff is limited. The aim of the authors' qualitative study was to describe the key work-related demands and rewards in relation to working closely with parents from ... ...

Abstract	Research to understand the sources of stress and job satisfaction in pediatric oncology staff is limited. The aim of the authors' qualitative study was to describe the key work-related demands and rewards in relation to working closely with parents from the perspective of health care providers (HCPs). Semistructured interviews were conducted with 13 doctors, 9 nurses, 5 social workers, and 6 child life specialists. Line-by-line, focused, and theoretical coding was used to establish categories and themes. Constant comparisons were used to examine the relationships within and across codes and categories. Interviewing continued until no new themes emerged. HCPs found it rewarding when they established close or long-term relationships with parents and to helped families through the entire cancer journey, including palliative care. HCPs found it challenging to work with complex families; with parents who are demanding, rude, or angry; with parents who have differing views about the treatments and palliative care; and with having to relay bad news to parents. Future research could explore the relationship between the factors that the authors have identified and burnout syndrome.
MeSH term(s)	Adaptation, Psychological ; Adult ; Attitude of Health Personnel ; Child ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Interview, Psychological ; Job Satisfaction ; Male ; Middle Aged ; Neoplasms/nursing ; Neoplasms/psychology ; Oncology Nursing ; Palliative Care/psychology ; Pediatrics ; Perception ; Practice Patterns, Physicians' ; Professional-Patient Relations ; Qualitative Research ; Stress, Psychological/complications ; Stress, Psychological/psychology ; Terminal Care/psychology
Language	English
Publishing date	2012-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1038107-7
ISSN	1532-8457 ; 1043-4542
ISSN (online)	1532-8457
ISSN	1043-4542
DOI	10.1177/1043454212438405
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