LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 849

Search options

  1. Article: Optimized recombinant production of the bacteriocin garvicin Q by

    Desiderato, Christian K / Müller, Carolin / Schretzmeier, Alexander / Hasenauer, Katharina M / Gnannt, Bruno / Süpple, Bastian / Reiter, Alexander / Steier, Valentin / Oldiges, Marco / Eikmanns, Bernhard J / Riedel, Christian U

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1254882

    Abstract: Bacteriocins are antimicrobial peptides applied in food preservation and are interesting candidates as alternatives to conventional antibiotics or as microbiome modulators. Recently, we ... ...

    Abstract Bacteriocins are antimicrobial peptides applied in food preservation and are interesting candidates as alternatives to conventional antibiotics or as microbiome modulators. Recently, we established
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1254882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Automed 2018

    Müller, Knut / Schauer, Thomas / Simanski, Olaf / Laufer, Bernhard / Krüger-Ziolek, Sabine

    Automatisierungstechnische Verfahren für die Medizin

    2018  

    Abstract: ... ...

    Abstract Tagungsband
    Keywords Simulation ; Medizintechnik ; optische Technologien ; Messtechnik ; Sensorik ; Intensivversorgung ; Beatmungs- und Überwachungstechnik ; Robotik ; Biosignal- und Bildverarbeitung
    Language German
    Size 91 p.
    Edition 1
    Publisher Pabst Science Publishers
    Document type Book
    Note PDA Manuell_1
    Format 154 x 216
    ISBN 9783958533844 ; 3958533841
    Database PDA

    Kategorien

    Order for free: Patron-Driven-Acquisition (PDA)

    This title is not yet in the ZB MED collection, but may be ordered for free via the ZB MED acquisition service PDA. The ordered item will be available in approximately one week.

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model.

    Mokady, Daphna / Charish, Jason / Barretto-Burns, Patrick / Grisé, Kenneth N / Coles, Brenda L K / Raab, Susanne / Ortin-Martinez, Arturo / Müller, Alex / Fasching, Bernhard / Jain, Payal / Drukker, Micha / van der Kooy, Derek / Steger, Matthias

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with ... ...

    Abstract Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with proliferative effects on retinal stem/progenitor cells, as assessed in vitro in a neurosphere assay and in vivo by measuring Msx1-positive ciliary body cell proliferation. The compound was identified as having kinase inhibitory activity and was subjected to cellular pathway analysis in non-retinal human primary cell systems. When tested in a disease-relevant murine model of adult retinal degeneration (MNU-induced retinal degeneration), we observed that four repeat intravitreal injections of the compound improved the thickness of the outer nuclear layer along with the regeneration of the visual function, as measured with ERG, visual acuity, and contrast sensitivity tests. This serves as a proof of concept for the use of a small molecule to promote endogenous regeneration in the eye.
    MeSH term(s) Humans ; Mice ; Animals ; Retinal Degeneration/metabolism ; Methylnitrosourea ; Retina/metabolism ; Photoreceptor Cells ; Regeneration ; Disease Models, Animal ; Mammals
    Chemical Substances Methylnitrosourea (684-93-5)
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031521
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Comparison of IGLV2-14 light chain sequences of patients with AL amyloidosis or multiple myeloma.

    Berghaus, Natalie / Schreiner, Sarah / Poos, Alexandra M / Raab, Marc S / Goldschmidt, Hartmut / Mai, Elias K / Salwender, Hans-Jürgen / Bernhard, Helga / Thurner, Lorenz / Müller-Tidow, Carsten / Weinhold, Niels / Hegenbart, Ute / Schönland, Stefan O / Huhn, Stefanie

    The FEBS journal

    2023  Volume 290, Issue 17, Page(s) 4256–4267

    Abstract: Light chain amyloidosis (AL) is one of the most common forms of systemic amyloidosis and is caused by the deposition of insoluble fibrils derived from misfolded and aggregated immunoglobulin light chains (LC). To uncover the causes leading to this ... ...

    Abstract Light chain amyloidosis (AL) is one of the most common forms of systemic amyloidosis and is caused by the deposition of insoluble fibrils derived from misfolded and aggregated immunoglobulin light chains (LC). To uncover the causes leading to this aggregation, we compared AL LC sequences with those of patients with the related disease multiple myeloma (MM), which do not aggregate in insoluble fibrils in vivo. IGLV2-14 is one of the most common AL-associated IGLV subfamilies. Here, we analysed IGLV2-14 LC sequences of 13 AL and eight MM patients in detail. We found that AL-associated LCs presented a lower median mutation count (7.0 vs. 11.5 in MM; P = 0.045), as well as an overall composition of less charged amino acids than MM LCs. However, we did not find a mutation that was present in ≥ 50% of the AL and not in the MM sequences. Furthermore, we did not find a significant difference in the isoelectric point (pI) in general, suggesting similar stability of the LCs in AL and MM. However, the subgroup of patients without a detectable heavy chain stood out. Surprisingly, they are characterized by an increase in mutation count (median 7.0 vs. 5.5) and pI (median 7.82 vs. 6.44, P = 0.043). In conclusion, our data suggest that the amount of mutations and the introduction of charges play a crucial role in AL fibril formation, as well as the absence or presence of a potential heavy chain binding partner.
    MeSH term(s) Humans ; Immunoglobulin Light-chain Amyloidosis/genetics ; Multiple Myeloma/genetics ; Amyloidosis/genetics ; Amyloidosis/metabolism ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Light Chains/metabolism ; Mutation ; Amyloid/chemistry
    Chemical Substances Immunoglobulin Light Chains ; Amyloid
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16805
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Hypothermie: Strategien in der Präklinik

    Dahlmann, Philipp / Adamek, Katharina / Müller, Bernhard / Bliemsrieder, Bernhard

    retten!

    2024  Volume 13, Issue 01, Page(s) 37–45

    Keywords Hypothermie ; Notfallpatient ; Unterkühlung ; Wärmeerhalt ; Rettungsdienst
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2193-2395 ; 2193-2387
    ISSN (online) 2193-2395
    ISSN 2193-2387
    DOI 10.1055/a-1875-1211
    Database Thieme publisher's database

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography.

    Krämer, Robert M / Moissl, Angela P / Lorkowski, Stefan / Krämer, Bernhard K / Lehtimäki, Terho / Mishra, Binisha H / Mishra, Pashupati P / Leipe, Jan / März, Winfried / Kleber, Marcus E / Müller-Myhsok, Bertram / Delgado, Graciela E

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1125151

    Abstract: Background: Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet.: Aims: The aim of our study was to investigate ... ...

    Abstract Background: Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet.
    Aims: The aim of our study was to investigate the association of a genetic depression risk score (GDRS) with mortality [all-cause and cardiovascular (CV)] and markers of depression (including intake of antidepressants and a history of depression) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study involving 3,316 patients who had been referred for coronary angiography.
    Methods and results: The GDRS was calculated in 3,061 LURIC participants according to a previously published method and was found to be associated with all-cause (
    Conclusion: A genetic predisposition for depression estimated by a GDRS was independently associated with all-cause and CV mortality in our cohort of patients who had been referred for coronary angiography. No biomarker correlating with the GDRS could be identified.
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1125151
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants.

    Furrer, Thierry / Müller, Benedikt / Hasler, Christoph / Berger, Bernhard / Levis, Michael K / Zogg, Andreas

    Chimia

    2021  Volume 75, Issue 11, Page(s) 948–956

    Abstract: The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational ... ...

    Abstract The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
    MeSH term(s) Hydrogenation ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1516-7
    ISSN 0009-4293
    ISSN 0009-4293
    DOI 10.2533/chimia.2021.948
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4.5: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants

    Thierry Furrer / Benedikt Müller / Christoph Hasler / Bernhard Berger / Michael K. Levis / Andreas Zogg

    CHIMIA, Vol 75, Iss 11, Pp 948-

    2021  Volume 956

    Abstract: The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational ... ...

    Abstract The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
    Keywords agitated vessel ; hydrogenation ; process modelling ; quality by design (qbd) ; scale-up / scale-down ; Chemistry ; QD1-999
    Subject code 660
    Language German
    Publishing date 2021-11-01T00:00:00Z
    Publisher Swiss Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Hybrid

    Meixner, Christian R / Eisen, Christian K / Schmitter, Sebastian / Müller, Max / Herrler, Jürgen / Hensel, Bernhard / Dörfler, Arnd / Uder, Michael / Nagel, Armin M

    Magnetic resonance in medicine

    2021  Volume 87, Issue 1, Page(s) 207–219

    Abstract: Purpose: To improve pseudo-continuous arterial spin labeling (pcASL) at 7T by exploiting a hybrid homogeneity- and efficiency-optimized : Methods: The following three experiments were performed at 7T, each employing five volunteers: (1) A hybrid (ie, ...

    Abstract Purpose: To improve pseudo-continuous arterial spin labeling (pcASL) at 7T by exploiting a hybrid homogeneity- and efficiency-optimized
    Methods: The following three experiments were performed at 7T, each employing five volunteers: (1) A hybrid (ie, homogeneity-efficiency optimized)
    Results: The
    Conclusion: The combination of the proposed hybrid
    MeSH term(s) Arteries ; Brain/diagnostic imaging ; Cerebrovascular Circulation ; Gray Matter/diagnostic imaging ; Signal-To-Noise Ratio ; Spin Labels
    Chemical Substances Spin Labels
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28982
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity.

    Wang, Xue Fan / Vigouroux, Robin / Syonov, Michal / Baglaenko, Yuriy / Nikolakopoulou, Angeliki M / Ringuette, Dene / Rus, Horea / DiStefano, Peter V / Dufour, Suzie / Shabanzadeh, Alireza P / Lee, Seunggi / Mueller, Bernhard K / Charish, Jason / Harada, Hidekiyo / Fish, Jason E / Wither, Joan / Wälchli, Thomas / Cloutier, Jean-François / Zlokovic, Berislav V /
    Carlen, Peter L / Monnier, Philippe P

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1037

    Abstract: Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver influences BCB-integrity remain elusive. One possibility is that the liver secretes an as-yet ... ...

    Abstract Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver influences BCB-integrity remain elusive. One possibility is that the liver secretes an as-yet to be identified molecule(s) that circulate in the serum to directly promote BCB-integrity. To study BCB-integrity, we developed light-sheet imaging for three-dimensional analysis. We show that liver- or muscle-specific knockout of Hfe2/Rgmc induces BCB-breakdown, leading to accumulation of toxic-blood-derived fibrinogen in the brain, lower cortical neuron numbers, and behavioral deficits in mice. Soluble HFE2 competes with its homologue RGMa for binding to Neogenin, thereby blocking RGMa-induced downregulation of PDGF-B and Claudin-5 in endothelial cells, triggering BCB-disruption. HFE2 administration in female mice with experimental autoimmune encephalomyelitis, a model for multiple sclerosis, prevented paralysis and immune cell infiltration by inhibiting RGMa-mediated BCB alteration. This study has implications for the pathogenesis and potential treatment of diseases associated with BCB-dysfunction.
    MeSH term(s) Animals ; Female ; Mice ; Blood-Brain Barrier/metabolism ; Central Nervous System/metabolism ; Encephalomyelitis, Autoimmune, Experimental ; Endothelial Cells/metabolism ; Liver/metabolism ; Muscles/metabolism
    Chemical Substances HJV protein, mouse
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45303-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top