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  1. Book ; Thesis: Gene therapy for ischemia-reperfusion injury-induced acute renal failure in the rat

    Dragun, Duska

    1998  

    Author's details Duska Dragun
    Language English
    Size 82 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT011076531
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 MB 972 order for loan Magazin

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  2. Article ; Online: Tempest in a sugar-coated lab vial.

    Dragun, Duska / Philippe, Aurélie

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2018  Volume 18, Issue 11, Page(s) 2622–2623

    MeSH term(s) Antibodies ; Fibrin ; Graft Rejection ; Heart Transplantation ; Sugars
    Chemical Substances Antibodies ; Sugars ; Fibrin (9001-31-4)
    Language English
    Publishing date 2018-07-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.14980
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  3. Article ; Online: The detection of antibodies to the Angiotensin II-type 1 receptor in transplantation.

    Dragun, Duska

    Methods in molecular biology (Clifton, N.J.)

    2013  Volume 1034, Page(s) 331–333

    Abstract: The detection of auto-antibodies detection is a major aspect of patient's immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney ... ...

    Abstract The detection of auto-antibodies detection is a major aspect of patient's immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney transplantation and in obliterative vasculopathy of autoimmune diseases. Here, a sandwich enzyme-linked immunosorbent assay (ELISA) is the reliable tool for the detection of auto-antibodies targeting AT1R.
    MeSH term(s) Angiotensin II/immunology ; Autoantibodies/immunology ; Autoantibodies/isolation & purification ; Enzyme-Linked Immunosorbent Assay/methods ; Graft Rejection/immunology ; Heart Transplantation ; Humans ; Kidney Transplantation ; Molecular Biology/methods ; Receptor, Angiotensin, Type 1/immunology
    Chemical Substances Autoantibodies ; Receptor, Angiotensin, Type 1 ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-62703-493-7_19
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  4. Article ; Online: Publisher Correction: mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells.

    Schaub, Theres / Gürgen, Dennis / Maus, Deborah / Lange, Claudia / Tarabykin, Victor / Dragun, Duska / Hegner, Björn

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 3740

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-02-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-59865-9
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  5. Article ; Online: Humoral responses directed against non-human leukocyte antigens in solid-organ transplantation.

    Dragun, Duska

    Transplantation

    2008  Volume 86, Issue 8, Page(s) 1019–1025

    Abstract: Antibody-mediated mechanisms have a major impact on allograft function and survival. During the last decade, improved immunohistochemical and serologic diagnostic procedures have been developed to monitor antibody responses against human leukocyte ... ...

    Abstract Antibody-mediated mechanisms have a major impact on allograft function and survival. During the last decade, improved immunohistochemical and serologic diagnostic procedures have been developed to monitor antibody responses against human leukocyte antigens (HLA). Acute and chronic allograft rejection can occur in HLA-identical sibling transplants implicating the importance of immune response against non-HLA targets. Non-HLA, complement and noncomplement-fixing antibodies may be responsible for a variety of allograft injuries, reflecting the complexity of their acute and chronic actions. Non-HLA antibodies may occur as alloantibodies or autoantibodies. Their antigenic targets described, thus, far include various minor histocompatibility antigens, vascular receptors, adhesion molecules, and intermediate filaments. An analysis of the subtle mechanistic differences in the individual antibody responses directed against non-HLA may help to identify patients at particular risk for irreversible acute or chronic allograft injuries and improve overall outcomes. This review summarizes the current state of research, development in diagnostic and therapeutic strategies, discusses some emerging problems, and provides perspectives in the area of humoral response against non-HLA in solid-organ transplantation.
    MeSH term(s) Antibody Formation/genetics ; Autoantibodies/metabolism ; Complement System Proteins/immunology ; Endothelial Cells/immunology ; Genes, MHC Class I/immunology ; Graft Rejection/genetics ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/genetics ; Graft Survival/immunology ; HLA Antigens/immunology ; Humans ; Isoantibodies/metabolism ; Organ Transplantation ; Receptor, Angiotensin, Type 1/immunology ; Thromboplastin/immunology ; Transplantation Immunology/genetics ; Transplantation, Homologous/immunology ; Vimentin/immunology
    Chemical Substances Autoantibodies ; HLA Antigens ; Isoantibodies ; Receptor, Angiotensin, Type 1 ; Vimentin ; Complement System Proteins (9007-36-7) ; Thromboplastin (9035-58-9)
    Language English
    Publishing date 2008-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0b013e3181889748
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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  6. Article: Agonistic antibody-triggered stimulation of Angiotensin II type 1 receptor and renal allograft vascular pathology.

    Dragun, Duska

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2007  Volume 22, Issue 7, Page(s) 1819–1822

    MeSH term(s) Antibodies/immunology ; Graft Rejection/diagnosis ; Graft Rejection/immunology ; Graft Rejection/pathology ; Graft Rejection/therapy ; Humans ; Kidney Transplantation/immunology ; Receptor, Angiotensin, Type 1/immunology ; Renal Circulation/immunology ; Transplantation, Homologous ; Vascular Diseases/immunology
    Chemical Substances Antibodies ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfm072
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  7. Article ; Online: Publisher Correction

    Theres Schaub / Dennis Gürgen / Deborah Maus / Claudia Lange / Victor Tarabykin / Duska Dragun / Björn Hegner

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Complement-ary matching: A definite maybe.

    Dragun, Duska

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2006  Volume 21, Issue 12, Page(s) 3371–3373

    MeSH term(s) Complement Activation ; Complement C3/immunology ; Humans ; Kidney Transplantation/immunology
    Chemical Substances Complement C3
    Language English
    Publishing date 2006-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfl480
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  9. Article ; Online: Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke-PROSCIS-B.

    Liman, Thomas G / Siegerink, Bob / Piper, Sophie / Catar, Rusan / Moll, Guido / Riemekasten, Gabriela / Heidecke, Harald / Heuschmann, Peter U / Elkind, Mitchell S V / Dragun, Duska / Endres, Matthias

    Journal of the American Heart Association

    2023  Volume 12, Issue 23, Page(s) e032441

    Abstract: Background: Vasoregulatory autoantibodies including autoantibodies targeting G-protein-coupled receptors might play a functional role in vascular diseases. We investigated the impact of vasoregulatory autoantibodies on clinical outcome after ischemic ... ...

    Abstract Background: Vasoregulatory autoantibodies including autoantibodies targeting G-protein-coupled receptors might play a functional role in vascular diseases. We investigated the impact of vasoregulatory autoantibodies on clinical outcome after ischemic stroke.
    Methods and results: Data were used from the PROSCIS-B (Prospective Cohort With Incident Stroke-Berlin). Autoantibody-targeting receptors such as angiotensin II type 1 receptor (AT1R), endothelin-1 type A receptor, complement factor-3 and -5 receptors, vascular endothelial growth factor receptor-1 and -2, vascular endothelial growth factor A and factor B were measured. We explored associations of high antibody levels with (1) poor functional outcome defined as modified Rankin Scale >2 or Barthel Index <60 at 1 year after stroke, (2) Barthel Index scores over time using general estimating equations, and (3) secondary vascular events (recurrent stroke, myocardial infarction) or death up to 3 years using Cox proportional hazard models. We included 491 patients with ischemic stroke with data on autoantibody levels and outcome. In models adjusted for demographics and vascular risk factors, high autoantibody concentrations (quartile 4) targeting complement factor C3a receptor, vascular endothelial growth factor receptor-2, and vascular endothelial growth factor B were associated with poor functional outcome at 1 year: (odds ratio, 2.0 [95% CI, 1.1-3.6]; odds ratio, 1.8 [95% CI, 1.1-3.2]; and odds ratio, 2.1 [95% CI, 1.2-3.6], respectively) and with lower Barthel Index scores over 3 years (complement factor C3a receptor: adjusted β=-3.3 [95% CI, -5.7 to -0.5]; VEGF-B: adjusted β=-2.4 [95% CI, -4.8 to -0.06]). Patients with high autoantibody levels were not at higher risk for secondary vascular events or death.
    Conclusions: High levels of autoantibodies against vascular endothelial growth factor receptor-2, vascular endothelial growth factor B, and complement factor C3a receptor measured are associated with poor functional outcome after stroke but not with recurrent vascular events or death.
    Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01363856.
    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor B ; Ischemic Stroke/complications ; Vascular Endothelial Growth Factor Receptor-2 ; Prospective Studies ; Autoantibodies ; Stroke/diagnosis ; Stroke/complications
    Chemical Substances Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor B ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Autoantibodies
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032441
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  10. Article: The role of angiotensin II type 1 receptor-activating antibodies in renal allograft vascular rejection.

    Dragun, Duska

    Pediatric nephrology (Berlin, Germany)

    2007  Volume 22, Issue 7, Page(s) 911–914

    Abstract: Acute rejection with vascular involvement remains a challenging problem in renal allotransplantation. Fibrinoid necrosis of the arteries with secondary thrombotic occlusions is C4d negative in 50% of cases and has the worst prognosis among all allograft ... ...

    Abstract Acute rejection with vascular involvement remains a challenging problem in renal allotransplantation. Fibrinoid necrosis of the arteries with secondary thrombotic occlusions is C4d negative in 50% of cases and has the worst prognosis among all allograft vascular lesions. Nonhuman leukocyte antigen (HLA) non-complement-fixing antibodies reacting to artery-specific antigens have been speculated to be responsible for causing severe vascular injury. We recently reported the presence of agonistic antibodies against the angiotensin II type 1 receptor (AT(1)R-AA) in 16 recipients of renal allografts who had severe vascular rejection and malignant hypertension but who did not have anti-HLA antibodies. AT(1)R-AA stimulate AT(1)R and induce mediators of inflammation and thrombosis. Removal of AT(1)R-AA by plasmapheresis in combination with pharmacologic AT(1)R blockade leads to improved renal function and graft survival in AT(1)R-AA-positive patients. We have shown that the analysis of the subtle diagnostic and mechanistic differences may help to identify patients at particular risk and improve outcome of rejections with vascular pathology.
    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Antibodies/blood ; Graft Rejection/immunology ; Graft Rejection/pathology ; Graft Rejection/therapy ; Humans ; Kidney Transplantation ; Models, Immunological ; Plasmapheresis ; Receptor, Angiotensin, Type 1/immunology ; Transplantation, Homologous
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Antibodies ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2007-07
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-007-0452-z
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