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  1. Article: TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species.

    Ali, Eunus S / Rychkov, Grigori Y / Barritt, Greg J

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: TRPM2 channels admit ... ...

    Abstract TRPM2 channels admit Ca
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10081243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Molecular dynamics simulations reveal the hidden EF-hand of EF-SAM as a possible key thermal sensor for STIM1 activation by temperature.

    Neamtu, Andrei / Serban, Dragomir N / Barritt, Greg J / Isac, Dragos Lucian / Vasiliu, Tudor / Laaksonen, Aatto / Serban, Ionela Lacramioara

    The Journal of biological chemistry

    2023  Volume 299, Issue 8, Page(s) 104970

    Abstract: Intracellular calcium signaling is essential for many cellular processes, including store-operated ... ...

    Abstract Intracellular calcium signaling is essential for many cellular processes, including store-operated Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling ; Endoplasmic Reticulum/metabolism ; Molecular Dynamics Simulation ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 1/metabolism ; Temperature ; Humans
    Chemical Substances Calcium (SY7Q814VUP) ; ORAI1 Protein ; Stromal Interaction Molecule 1 ; STIM1 protein, human
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.104970
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  3. Article: Targeting Ca

    Ali, Eunus S / Rychkov, Grigori Y / Barritt, Greg J

    Cancers

    2020  Volume 12, Issue 10

    Abstract: Hepatocellular carcinoma (HCC) is a considerable health burden worldwide and a major contributor to cancer-related deaths. HCC is often not noticed until at an advanced stage where treatment options are limited and current systemic drugs can usually only ...

    Abstract Hepatocellular carcinoma (HCC) is a considerable health burden worldwide and a major contributor to cancer-related deaths. HCC is often not noticed until at an advanced stage where treatment options are limited and current systemic drugs can usually only prolong survival for a short time. Understanding the biology and pathology of HCC is a challenge, due to the cellular and anatomic complexities of the liver. While not yet fully understood, liver cancer stem cells play a central role in the initiation and progression of HCC and in resistance to drugs. There are approximately twenty Ca
    Language English
    Publishing date 2020-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12102755
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  4. Book: Communication within animal cells

    Barritt, Greg J.

    (Oxford science publications)

    1992  

    Author's details Greg J. Barritt
    Series title Oxford science publications
    Keywords Tiere ; Zellkommunikation
    Subject Zelle ; Interzelluläre Kommunikation ; Zell-Zell-Interaktion ; Zellinteraktion ; Cell-to-Cell Interaction ; Cell-to-Cell communication ; Fauna ; Tier ; Tierwelt ; Animals
    Language English
    Size XIV, 343 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003777827
    ISBN 0-19-854727-7 ; 0-19-854726-9 ; 978-0-19-854727-3 ; 978-0-19-854726-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1992 A 2678 order for loan Magazin

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  5. Article ; Online: Deranged hepatocyte intracellular Ca

    Ali, Eunus S / Rychkov, Grigori Y / Barritt, Greg J

    Cell calcium

    2019  Volume 82, Page(s) 102057

    Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the major risk factors for HCC. NAFLD, which involves the accumulation of excess ... ...

    Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the major risk factors for HCC. NAFLD, which involves the accumulation of excess lipid in cytoplasmic lipid droplets in hepatocytes, can progress to non-alcoholic steatosis, fibrosis, and HCC. Changes in intracellular Ca
    MeSH term(s) Animals ; Calcium Signaling/physiology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Homeostasis ; Humans ; Intracellular Space ; Lipid Metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2019-07-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.102057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca

    Ali, Eunüs S / Rychkov, Grigori Y / Barritt, Greg J

    Advances in experimental medicine and biology

    2017  Volume 993, Page(s) 595–621

    Abstract: In steatotic hepatocytes, intracellular ... ...

    Abstract In steatotic hepatocytes, intracellular Ca
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-57732-6_30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Orai1- and Orai2-, but not Orai3-mediated I

    Rychkov, Grigori Y / Zhou, Fiona H / Adams, Melissa K / Brierley, Stuart M / Ma, Linlin / Barritt, Greg J

    The Journal of physiology

    2021  Volume 600, Issue 3, Page(s) 623–643

    Abstract: Three Orai (Orai1, Orai2, and Orai3) and two stromal interaction molecule (STIM1 and STIM2) mammalian protein homologues constitute major components of the store-operated ... ...

    Abstract Three Orai (Orai1, Orai2, and Orai3) and two stromal interaction molecule (STIM1 and STIM2) mammalian protein homologues constitute major components of the store-operated Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Release Activated Calcium Channels ; Calcium Signaling ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; ORAI1 Protein/genetics ; ORAI2 Protein/metabolism ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances Calcium Channels ; Calcium Release Activated Calcium Channels ; ORAI1 Protein ; ORAI1 protein, human ; ORAI2 Protein ; ORAI2 protein, human ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-12-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP282502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes.

    Kheradpezhouh, Ehsan / Zhou, Fiona H / Barritt, Greg J / Rychkov, Grigori Y

    Biochemical and biophysical research communications

    2018  Volume 503, Issue 3, Page(s) 1891–1896

    Abstract: Transient Receptor Potential Melastatin (TRPM) 2 is a non-selective ... ...

    Abstract Transient Receptor Potential Melastatin (TRPM) 2 is a non-selective Ca
    MeSH term(s) Acetaminophen/pharmacology ; Animals ; Calcium/metabolism ; Cell Membrane/metabolism ; Cells, Cultured ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hydrogen Peroxide/pharmacology ; Male ; Oxidative Stress ; Rats ; Rats, Wistar ; TRPM Cation Channels/metabolism
    Chemical Substances TRPM Cation Channels ; TRPM2 protein, mouse ; Acetaminophen (362O9ITL9D) ; Hydrogen Peroxide (BBX060AN9V) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2018.07.132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  9. Article: TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

    Ali, Eunus S. / Rychkov, Grigori Y. / Barritt, Greg J.

    Antioxidants. 2021 Aug. 03, v. 10, no. 8

    2021  

    Abstract: TRPM2 channels admit Ca²⁺ and Na⁺ across the plasma membrane and release Ca²⁺ and Zn²⁺ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS), leading to a subsequent increase in ADP-ribose and the binding of ADP-ribose to an ... ...

    Abstract TRPM2 channels admit Ca²⁺ and Na⁺ across the plasma membrane and release Ca²⁺ and Zn²⁺ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS), leading to a subsequent increase in ADP-ribose and the binding of ADP-ribose to an allosteric site in the cytosolic NUDT9 homology domain. In many animal cell types, Ca²⁺ entry via TRPM2 channels mediates ROS-initiated cell injury and death. The aim of this review is to summarise the current knowledge of the roles of TRPM2 and Ca²⁺ in the initiation and progression of chronic liver diseases and acute liver injury. Studies to date provide evidence that TRPM2-mediated Ca²⁺ entry contributes to drug-induced liver toxicity, ischemia–reperfusion injury, and the progression of non-alcoholic fatty liver disease to cirrhosis, fibrosis, and hepatocellular carcinoma. Of particular current interest are the steps involved in the activation of TRPM2 in hepatocytes following an increase in ROS, the downstream pathways activated by the resultant increase in intracellular Ca²⁺, and the chronology of these events. An apparent contradiction exists between these roles of TRPM2 and the role identified for ROS-activated TRPM2 in heart muscle and in some other cell types in promoting Ca²⁺-activated mitochondrial ATP synthesis and cell survival. Inhibition of TRPM2 by curcumin and other “natural” compounds offers an attractive strategy for inhibiting ROS-induced liver cell injury. In conclusion, while it has been established that ROS-initiated activation of TRPM2 contributes to both acute and chronic liver injury, considerable further research is needed to elucidate the mechanisms involved, and the conditions under which pharmacological inhibition of TRPM2 can be an effective clinical strategy to reduce ROS-initiated liver injury.
    Keywords calcium ; cations ; cell viability ; curcumin ; death ; fatty liver ; fibrosis ; hepatocytes ; hepatoma ; hepatotoxicity ; liver ; lysosomes ; mitochondria ; myocardium ; plasma membrane ; reactive oxygen species ; sequence homology
    Language English
    Dates of publication 2021-0803
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10081243
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells.

    Tam, Ka Cheung / Ali, Eunus / Hua, Jin / Chataway, Tim / Barritt, Greg J

    Cell calcium

    2018  Volume 74, Page(s) 14–28

    Abstract: ... ...

    Abstract Ca
    MeSH term(s) Animals ; Endoplasmic Reticulum, Rough/chemistry ; Endoplasmic Reticulum, Rough/metabolism ; Hepatocytes/chemistry ; Hepatocytes/metabolism ; Male ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; ORAI1 Protein/analysis ; ORAI1 Protein/metabolism ; Peroxiredoxins/analysis ; Peroxiredoxins/metabolism ; Protein Binding/physiology ; Rats ; Rats, Wistar ; Stromal Interaction Molecule 1/analysis ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances ORAI1 Protein ; Orai1 protein, rat ; Stim1 protein, rat ; Stromal Interaction Molecule 1 ; Peroxiredoxins (EC 1.11.1.15) ; Prdx4 protein, rat (EC 1.11.1.15)
    Language English
    Publishing date 2018-05-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2018.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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