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  1. Article ; Online: "And it was the worst possible result, because it actually worked:" An interview with Richard Harland.

    Harland, Richard M / Wallingford, John B

    Cells & development

    2024  , Page(s) 203910

    Abstract: One hundred years ago, Hilde Mangold and Hans Spemann published their seminal paper on what came to be known as The Organizer, but seven decades would pass before the molecular basis of this remarkable phenomenon was revealed. Richard Harland and his ... ...

    Abstract One hundred years ago, Hilde Mangold and Hans Spemann published their seminal paper on what came to be known as The Organizer, but seven decades would pass before the molecular basis of this remarkable phenomenon was revealed. Richard Harland and his laboratory played a key role in that discovery, and in this interview he discusses not just the science and the people but also other important factors like mental health and luck.
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2901
    ISSN (online) 2667-2901
    DOI 10.1016/j.cdev.2024.203910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aristotle, Buddhist scripture and embryology in ancient Mexico: building inclusion by re-thinking what counts as the history of developmental biology.

    Wallingford, John B

    Development (Cambridge, England)

    2021  Volume 148, Issue 3

    Abstract: It has not gone unnoticed in recent times that historical writing about science is heavily Eurocentric. A striking example can be found in the history of developmental biology: textbooks and popular science writing frequently trace an intellectual thread ...

    Abstract It has not gone unnoticed in recent times that historical writing about science is heavily Eurocentric. A striking example can be found in the history of developmental biology: textbooks and popular science writing frequently trace an intellectual thread from the Greek philosopher Aristotle through 19th century embryology to 20th century genetics. Few in our field are aware of the depth and breadth of early embryological thinking outside of Europe. Here, I provide a series of vignettes highlighting the rich history of embryological thinking in Asia and Latin America. My goal is to provide an entertaining, even provocative, synopsis of this important but under-studied topic. It is my hope that this work will spur others to carry out more thorough investigations, with the ultimate goal of building a more inclusive discipline.
    MeSH term(s) Asia ; Developmental Biology/history ; Embryology/history ; Europe ; Greece ; History, 19th Century ; History, 20th Century ; Humans ; Latin America ; Mexico
    Language English
    Publishing date 2021-02-01
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.192062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: We have seen the gatekeepers, and they are us.

    Cleaver, Ondine / Prince, Victoria E / Wallingford, John B

    Developmental biology

    2023  Volume 501, Page(s) A15–A17

    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2023.06.016
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  4. Article ; Online: Paradigms Lost Perspectives: revisiting well-worn models and concepts.

    Yap, Alpha S / Wallingford, John B / Bement, William M

    Molecular biology of the cell

    2023  Volume 34, Issue 5, Page(s) ed1

    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E23-01-0001
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  5. Article ; Online: Dishevelled controls bulk cadherin dynamics and the stability of individual cadherin clusters during convergent extension.

    Huebner, Robert J / Wallingford, John B

    Molecular biology of the cell

    2022  Volume 33, Issue 14, Page(s) br26

    Abstract: Animals are shaped through the movement of large cellular collectives. Such morphogenetic processes require cadherin-based cell adhesion to maintain tissue cohesion and planar cell polarity to coordinate movement. Despite a vast literature surrounding ... ...

    Abstract Animals are shaped through the movement of large cellular collectives. Such morphogenetic processes require cadherin-based cell adhesion to maintain tissue cohesion and planar cell polarity to coordinate movement. Despite a vast literature surrounding cadherin-based adhesion and planar cell polarity, it is unclear how these molecular networks interface. Here we investigate the relationship between cadherins and planar cell polarity during gastrulation cell movements in
    MeSH term(s) Animals ; Cadherins/metabolism ; Morphogenesis ; Gastrulation/physiology ; Xenopus laevis/metabolism ; Cell Adhesion/physiology
    Chemical Substances Cadherins
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E22-06-0194
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  6. Article ; Online: The 200-year effort to see the embryo.

    Wallingford, John B

    Science (New York, N.Y.)

    2019  Volume 365, Issue 6455, Page(s) 758–759

    MeSH term(s) Animals ; Embryology/history ; Embryology/trends ; Embryonic Development ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Microscopy/history ; Microscopy/methods
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaw7565
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    Zs.MG 77: Show issues

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  7. Article ; Online: We Are All Developmental Biologists.

    Wallingford, John B

    Developmental cell

    2019  Volume 50, Issue 2, Page(s) 132–137

    Abstract: Humans have sought to understand the embryo for millennia. Paradoxically, even as technical and intellectual innovations bring us ever closer to a transformative understanding of developmental biology, our discipline faces an "image problem." We should ... ...

    Abstract Humans have sought to understand the embryo for millennia. Paradoxically, even as technical and intellectual innovations bring us ever closer to a transformative understanding of developmental biology, our discipline faces an "image problem." We should face this problem by acknowledging that developmental biology is fundamental to the human experience.
    MeSH term(s) Developmental Biology/methods ; Developmental Biology/trends ; Embryo, Mammalian/cytology ; Genetic Diseases, Inborn ; Humans ; Regeneration ; Stem Cells/cytology
    Language English
    Publishing date 2019-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2019.07.006
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  8. Article ; Online: PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension.

    Devitt, Caitlin C / Weng, Shinuo / Bejar-Padilla, Vidal D / Alvarado, José / Wallingford, John B

    Current biology : CB

    2024  Volume 34, Issue 3, Page(s) 615–622.e4

    Abstract: Convergent extension (CE) requires the coordinated action of the planar cell polarity (PCP) ... ...

    Abstract Convergent extension (CE) requires the coordinated action of the planar cell polarity (PCP) proteins
    MeSH term(s) Mice ; Animals ; Septins/metabolism ; Actins/metabolism ; Actomyosin/metabolism ; Actin Cytoskeleton/metabolism ; Cell Movement/physiology ; Cell Polarity/physiology ; Membrane Proteins/metabolism ; LIM Domain Proteins/metabolism
    Chemical Substances Septins (EC 3.6.1.-) ; Actins ; Actomyosin (9013-26-7) ; Prickle2 protein, mouse ; Membrane Proteins ; LIM Domain Proteins
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.12.025
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  9. Article ; Online: Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.

    Takagishi, Maki / Yue, Yang / Gray, Ryan S / Verhey, Kristen J / Wallingford, John B

    Disease models & mechanisms

    2024  Volume 17, Issue 2

    Abstract: Motile cilia on ependymal cells that line brain ventricular walls beat in concert to generate a flow of laminar cerebrospinal fluid (CSF). Dyneins and kinesins are ATPase microtubule motor proteins that promote the rhythmic beating of cilia axonemes. ... ...

    Abstract Motile cilia on ependymal cells that line brain ventricular walls beat in concert to generate a flow of laminar cerebrospinal fluid (CSF). Dyneins and kinesins are ATPase microtubule motor proteins that promote the rhythmic beating of cilia axonemes. Despite common consensus about the importance of axonemal dynein motor proteins, little is known about how kinesin motors contribute to cilia motility. Here, we show that Kif6 is a slow processive motor (12.2±2.0 nm/s) on microtubules in vitro and localizes to both the apical cytoplasm and the axoneme in ependymal cells, although it does not display processive movement in vivo. Using a mouse mutant that models a human Kif6 mutation in a proband displaying macrocephaly, hypotonia and seizures, we found that loss of Kif6 function causes decreased ependymal cilia motility and, subsequently, decreases fluid flow on the surface of brain ventricular walls. Disruption of Kif6 also disrupts orientation of cilia, formation of robust apical actin networks and stabilization of basal bodies at the apical surface. This suggests a role for the Kif6 motor protein in the maintenance of ciliary homeostasis within ependymal cells.
    MeSH term(s) Humans ; Brain/metabolism ; Cilia/metabolism ; Dyneins/metabolism ; Ependyma ; Kinesins/metabolism
    Chemical Substances Dyneins (EC 3.6.4.2) ; Kinesins (EC 3.6.4.4) ; KIF6 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050137
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  10. Article ; Online: Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells.

    Lee, Chanjae / Ma, Yun / Tu, Fan / Wallingford, John B

    Differentiation; research in biological diversity

    2023  Volume 131, Page(s) 49–58

    Abstract: The beating of motile cilia requires the coordinated action of diverse machineries that include not only the axonemal dynein arms, but also the central apparatus, the radial spokes, and the microtubule inner proteins. These machines exhibit complex ... ...

    Abstract The beating of motile cilia requires the coordinated action of diverse machineries that include not only the axonemal dynein arms, but also the central apparatus, the radial spokes, and the microtubule inner proteins. These machines exhibit complex radial and proximodistal patterns in mature axonemes, but little is known about the interplay between them during motile ciliogenesis. Here, we describe and quantify the relative rates of axonemal deployment for these diverse cilia beating machineries during the final stages of differentiation of Xenopus epidermal multiciliated cells.
    MeSH term(s) Animals ; Axoneme/metabolism ; Dyneins/metabolism ; Cilia/metabolism ; Vertebrates/metabolism
    Chemical Substances Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 184540-8
    ISSN 1432-0436 ; 0301-4681
    ISSN (online) 1432-0436
    ISSN 0301-4681
    DOI 10.1016/j.diff.2023.03.001
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