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Artikel: Strangulation and Hanging.

Templeman, Charles

Transactions. Medico-Chirurgical Society of Edinburgh

2018 Band 12, Seite(n) 240–249

Sprache	Englisch
Erscheinungsdatum	2018-03-19
Erscheinungsland	Scotland
Dokumenttyp	Journal Article
ISSN	0267-2790
ISSN	0267-2790
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Two Hundred and Fifty-Eight Cases of Suffocation of Infants.

Templeman, Charles

Transactions. Medico-Chirurgical Society of Edinburgh

2018 Band 11, Seite(n) 210–217

Sprache	Englisch
Erscheinungsdatum	2018-03-19
Erscheinungsland	Scotland
Dokumenttyp	Journal Article
ISSN	0267-2790
ISSN	0267-2790
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Artikel: Two Rare Cases of Sudden Death in Medico-Legal Practice.

Templeman, Charles

Transactions. Medico-Chirurgical Society of Edinburgh

2018 Band 12, Seite(n) 20–28

Sprache	Englisch
Erscheinungsdatum	2018-03-19
Erscheinungsland	Scotland
Dokumenttyp	Journal Article
ISSN	0267-2790
ISSN	0267-2790
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Evidence Against Carbonization of the Thin-Film Filters of the

Tarrio, Charles / Berg, Robert F / Lucatorto, Thomas B / Eparvier, Francis G / Jones, Andrew R / Templeman, Brian / Woodraska, Donald L / Dominique, Marie

Solar physics

2021 Band 296, Heft 3

Abstract: In spite of strict limits on outgassing from organic materials, some spacecraft instruments making long-term measurements of solar extreme ultraviolet (EUV) radiation still suffer significant degradation. While such measures have reduced the rate of ... ...

Abstract	In spite of strict limits on outgassing from organic materials, some spacecraft instruments making long-term measurements of solar extreme ultraviolet (EUV) radiation still suffer significant degradation. While such measures have reduced the rate of degradation, they have not completely eliminated it in some cases. For example, in five years, the aluminum filters used in the
Sprache	Englisch
Erscheinungsdatum	2021-11-19
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1473830-2
ISSN	1573-093X ; 0038-0938
ISSN (online)	1573-093X
ISSN	0038-0938
DOI	10.1007/s11207-021-01806-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: ASHP Guidelines on Adverse Drug Reaction Monitoring and Reporting.

Lee, Lynne M / Carias, Delia Charest / Gosser, Rena / Hannah, Ambra / Stephens, Sarah / Templeman, William A

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2021 Band 79, Heft 1, Seite(n) e83–e89

Sprache	Englisch
Erscheinungsdatum	2021-09-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxab324
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers.

McIntyre, Alexander J / Angel, Charlotte Z / Smith, James S / Templeman, Amy / Beattie, Katherine / Beattie, Shannon / Ormrod, Alice / Devlin, Eadaoin / McGreevy, Charles / Bothwell, Chloe / Eddie, Sharon L / Buckley, Niamh E / Williams, Rich / Mullan, Paul B

Nucleic acids research

2022 Band 50, Heft 11, Seite(n) 6154–6173

Abstract: Chromosome 17q23 amplification occurs in 20% of primary breast tumours and is associated with poor outcome. The TBX2 gene is located on 17q23 and is often over-expressed in this breast tumour subset. TBX2 is an anti-senescence gene, promoting cell growth ...

Abstract	Chromosome 17q23 amplification occurs in 20% of primary breast tumours and is associated with poor outcome. The TBX2 gene is located on 17q23 and is often over-expressed in this breast tumour subset. TBX2 is an anti-senescence gene, promoting cell growth and survival through repression of Tumour Suppressor Genes (TSGs), such as NDRG1 and CST6. Previously we found that TBX2 cooperates with the PRC2 complex to repress several TSGs, and that PRC2 inhibition restored NDRG1 expression to impede cellular proliferation. Here, we now identify CoREST proteins, LSD1 and ZNF217, as novel interactors of TBX2. Genetic or pharmacological targeting of CoREST emulated TBX2 loss, inducing NDRG1 expression and abolishing breast cancer growth in vitro and in vivo. Furthermore, we uncover that TBX2/CoREST targeting of NDRG1 is achieved by recruitment of TBX2 to the NDRG1 promoter by Sp1, the abolishment of which resulted in NDRG1 upregulation and diminished cancer cell proliferation. Through ChIP-seq we reveal that 30% of TBX2-bound promoters are shared with ZNF217 and identify novel targets repressed by TBX2/CoREST; of these targets a lncRNA, LINC00111, behaves as a negative regulator of cell proliferation. Overall, these data indicate that inhibition of CoREST proteins represents a promising therapeutic intervention for TBX2-addicted breast tumours.
Mesh-Begriff(e)	Breast Neoplasms/genetics ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Genes, Tumor Suppressor ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; Promoter Regions, Genetic ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism
Chemische Substanzen	T-Box Domain Protein 2 ; T-Box Domain Proteins ; Trans-Activators ; ZNF217 protein, human ; Histone Demethylases (EC 1.14.11.-) ; KDM1A protein, human (EC 1.5.-)
Sprache	Englisch
Erscheinungsdatum	2022-06-10
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac494
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Mortality beyond emergency threshold in a silent crisis- results from a population-based mortality survey in Ouaka prefecture, Central African Republic, 2020.

Robinson, Eve / Lee, Lawrence / Roberts, Leslie F / Poelhekke, Aurelie / Charles, Xavier / Ouabo, Adelaide / Vyncke, Jorieke / Ariti, Cono / Gbanzi, Mariette Claudia Adame / Ouakouma, Martial Tanguy / Gray, Nell / Daly, Maura / White, Kate / Templeman, Sam / Hejdenberg, Mia / Hersevoort, Maaike / Pena, Sibyl Jade / Kuehne, Anna

Conflict and health

2021 Band 15, Heft 1, Seite(n) 50

Abstract: Background: The Central African Republic (CAR) suffers a protracted conflict and has the second lowest human development index in the world. Available mortality estimates vary and differ in methodology. We undertook a retrospective mortality study in ... ...

Abstract	Background: The Central African Republic (CAR) suffers a protracted conflict and has the second lowest human development index in the world. Available mortality estimates vary and differ in methodology. We undertook a retrospective mortality study in the Ouaka prefecture to obtain reliable mortality data. Methods: We conducted a population-based two-stage cluster survey from 9 March to 9 April, 2020 in Ouaka prefecture. We aimed to include 64 clusters of 12 households for a required sample size of 3636 persons. We assigned clusters to communes proportional to population size and then used systematic random sampling to identify cluster starting points from a dataset of buildings in each commune. In addition to the mortality survey questions, we included an open question on challenges faced by the household. Results: We completed 50 clusters with 591 participating households including 4000 household members on the interview day. The median household size was 7 (interquartile range (IQR): 4-9). The median age was 12 (IQR: 5-27). The birth rate was 59.0/1000 population (95% confidence interval (95%-CI): 51.7-67.4). The crude and under-five mortality rates (CMR & U5MR) were 1.33 (95%-CI: 1.09-1.61) and 1.87 (95%-CI: 1.37-2.54) deaths/10,000 persons/day, respectively. The most common specified causes of death were malaria/fever (16.0%; 95%-CI: 11.0-22.7), violence (13.2%; 95%-CI: 6.3-25.5), diarrhoea/vomiting (10.6%; 95%-CI: 6.2-17.5), and respiratory infections (8.4%; 95%-CI: 4.6-14.8). The maternal mortality ratio (MMR) was 2525/100,000 live births (95%-CI: 825-5794). Challenges reported by households included health problems and access to healthcare, high number of deaths, lack of potable water, insufficient means of subsistence, food insecurity and violence. Conclusions: The CMR, U5MR and MMR exceed previous estimates, and the CMR exceeds the humanitarian emergency threshold. Violence is a major threat to life, and to physical and mental wellbeing. Other causes of death speak to poor living conditions and poor access to healthcare and preventive measures, corroborated by the challenges reported by households. Many areas of CAR face similar challenges to Ouaka. If these results were generalisable across CAR, the country would suffer one of the highest mortality rates in the world, a reminder that the longstanding "silent crisis" continues.
Sprache	Englisch
Erscheinungsdatum	2021-06-30
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2273783-2
ISSN	1752-1505
ISSN	1752-1505
DOI	10.1186/s13031-021-00385-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A systematic global stocktake of evidence on human adaptation to climate change

Berrang-Ford, Lea / Siders, A.R / Lesnikowski, Alexandra / Fischer, Alexandra Paige / Callaghan, Max W. / Haddaway, Neal R. / Mach, Katharine J / Araos, Malcolm / Shah, Mohammad Aminur Rahman / Wannewitz, Mia / Doshi, Deepal / Leiter, Timo / Matavel, Custodio / Musah-Surugu, Justice Issah / Wong-Parodi, Gabrielle / Antwi-Agyei, Philip / Ajibade, Idowu / Chauhan, Neha / Kakenmaster, William /

Grady, Caitlin / Chalastani, Vasiliki I / Jagannathan, Kripa / Galappaththi, Eranga K. / Sitati, Asha / Scarpa, Giulia / Totin, Edmond / Davis, Katy / Hamilton, Nikita Charles / Kirchhoff, Christine J. / Kumar, Praveen / Pentz, Brian / Simpson, . Nicholas P. / Theokritoff, Emily / Deryng, Delphine / Reckien, Diana / Zavaleta-Cortijo, Carol / Ulibarri, Nicola / Segnon, Alcade C. / Khavhagali, Vhalinavho / Shang, Yuanyuan / Zvobgo, Luckson / Zommers, Zinta / Xu, Jiren / Williams, Portia Adade / Canosa, Ivan Villaverde / van Maanen, Nicole / Bavel, Bianca van / Aalst, Maarten van / Turek-Hankins, Lynée L / Trivedi, Hasti / Trisos, Christopher H. / Thomas, Adelle / Thakur, Shinny / Templeman, Sienna / Stringer, Lindsay C. / Sotnik, Garry / Sjostrom, Kathryn Dana / Singh, Chandni / Siña, Mariella Z. / Shukla, Roopam / Sardans, Jordi / Salubi, Eunice A. / Safaee Chalkasra, Lolita Shaila / Ruiz-Díaz, Raquel / Richards, Carys / Pokharel, Pratik / Petzold, Jan / Penuelas, Josep / Pelaez Avila, Julia / Murillo, Julia B. Pazmino / Ouni, Souha / Niemann, Jennifer / Nielsen, Miriam / New, Mark G. / Nayna Schwerdtle, Patricia / Nagle Alverio, Gabriela / Mullin, Cristina A / Mullenite, Joshua / Mosurska, Anuszka / Morecroft, Mike D. / Minx, Jan C. / Maskell, Gina / Nunbogu, Abraham Marshall / Magnan, Alexandre K / Lwasa, Shuaib / Lukas-Sithole, Megan / Lissner, Tabea / Lilford, Oliver / Koller, Steven F. / Jurjonas, Matthew / Joe, Elphin Tom / Huynh, Lam T.M. / Hill, Avery / Hernandez, Rebecca R. / Hegde, Greeshma / Hawxwell, Tom / Harper, Sherilee / Harden, Alexandra / Haasnoot, Marjolijn / Gilmore, Elisabeth A / Gichuki, Leah / Gatt, Alyssa / Garschagen, Matthias / Ford, James D / Forbes, Andrew / Farrell, Aidan D / Enquist, Carolyn A. F / Elliott, Susan / Duncan, Emily / Coughlan de Perez, Erin / Coggins, Shaugn / Chen, Tara / Campbell, Donovan / Browne, Katherine E / Bowen, Kathryn J / Biesbroek, Robbert / Bhatt, Indra D. / Bezner Kerr, Rachel / Barr, Stephanie L / Baker, Emily / Austin, Stephanie E / Arotoma-Rojas, Ingrid / Anderson, Christa / Ajaz, Warda / Thelma Zulfawu / Agrawal, Tanvi / Abu, Thelma Zulfawu

2021

Abstract: Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48, ...

Abstract	Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48,000 articles using machine learning methods and a global network of 126 researchers. Our synthesis of the resulting 1,682 articles presents a systematic and comprehensive global stocktake of implemented human adaptation to climate change. Documented adaptations were largely fragmented, local and incremental, with limited evidence of transformational adaptation and negligible evidence of risk reduction outcomes. We identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses.
Schlagwörter	climate change ; adaptation ; agriculture
Sprache	Englisch
Erscheinungsdatum	2021-11-18T14:15:49Z
Verlag	Springer
Erscheinungsland	fr
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: A systematic global stocktake of evidence on human adaptation to climate change

Berrang-Ford, Lea / Siders, A.R. / Lesnikowski, Alexandra / Fischer, Alexandra Paige / Callaghan, Max W. / Haddaway, Neal R. / Mach, Katharine J. / Araos, Malcolm / Shah, Mohammad Aminur Rahman / Wannewitz, Mia / Doshi, Deepal / Leiter, Timo / Matavel, Custodio / Musah-Surugu, Justice Issah / Wong-Parodi, Gabrielle / Antwi-Agyei, Philip / Ajibade, Idowu / Chauhan, Neha / Kakenmaster, William /

Grady, Caitlin / Chalastani, Vasiliki I. / Jagannathan, Kripa / Galappaththi, Eranga K. / Sitati, Asha / Scarpa, Giulia / Totin, Edmond / Davis, Katy / Hamilton, Nikita Charles / Kirchhoff, Christine J. / Kumar, Praveen / Pentz, Brian / Simpson, Nicholas P. / Theokritoff, Emily / Deryng, Delphine / Reckien, Diana / Zavaleta-Cortijo, Carol / Ulibarri, Nicola / Segnon, Alcade C. / Khavhagali, Vhalinavho / Shang, Yuanyuan / Zvobgo, Luckson / Zommers, Zinta / Xu, Jiren / Williams, Portia Adade / Canosa, Ivan Villaverde / van Maanen, Nicole / van Bavel, Bianca / van Aalst, Maarten / Turek-Hankins, Lynée L. / Trivedi, Hasti / Trisos, Christopher H. / Thomas, Adelle / Thakur, Shinny / Templeman, Sienna / Stringer, Lindsay C. / Sotnik, Garry / Sjostrom, Kathryn Dana / Singh, Chandni / Siña, Mariella Z. / Shukla, Roopam / Sardans, Jordi / Salubi, Eunice A. / Safaee Chalkasra, Lolita S. / Ruiz-Díaz, Raquel / Richards, Carys / Pokharel, Pratik / Petzold, Jan / Penuelas, Josep / Pelaez Avila, Julia / Pazmino Murillo, Julia B. / Ouni, Souha / Niemann, Jennifer / Nielsen, Miriam / New, Mark / Schwerdtle, Patricia N. / Nagle Alverio, Gabriela / Mullin, Cristina A. / Mullenite, Joshua / Mosurska, Anuszka / Morecroft, Mike D. / Minx, Jan C. / Maskell, Gina / Nunbogu, Abraham Marshall / Magnan, Alexandre K. / Lwasa, Shuaib / Lukas-Sithole, Megan / Lissner, Tabea / Lilford, Oliver / Koller, Steven F. / Jurjonas, Matthew / Joe, Elphin T. / Huynh, Lam T.M. / Hill, Avery / Hernandez, Rebecca R. / Hegde, Greeshma / Hawxwell, Tom / Harper, Sherilee / Harden, Alexandra / Haasnoot, Marjolijn / Gilmore, Elisabeth A. / Gichuki, Leah / Gatt, Alyssa / Garschagen, Matthias / Ford, James D. / Forbes, Andrew / Farrell, Aidan D. / Enquist, Carolyn A.F. / Elliott, Susan / Duncan, Emily / Coughlan de Perez, Erin / Coggins, Shaugn / Chen, Tara / Campbell, Donovan / Browne, Katherine E. / Bowen, Kathryn J. / Biesbroek, Robbert / Bhatt, Indra D. / Bezner Kerr, Rachel / Barr, Stephanie L. / Baker, Emily / Austin, Stephanie E. / Arotoma-Rojas, Ingrid / Anderson, Christa / Ajaz, Warda / Agrawal, Tanvi / Abu, Thelma Zulfawu

Nature Climate Change

2021 Band 11, Heft 11

Abstract	Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48,000 articles using machine learning methods and a global network of 126 researchers. Our synthesis of the resulting 1,682 articles presents a systematic and comprehensive global stocktake of implemented human adaptation to climate change. Documented adaptations were largely fragmented, local and incremental, with limited evidence of transformational adaptation and negligible evidence of risk reduction outcomes. We identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses.
Schlagwörter	Life Science
Thema/Rubrik (Code)	306
Sprache	Englisch
Erscheinungsland	nl
Dokumenttyp	Artikel ; Online
ZDB-ID	2614383-5
ISSN	1758-6798 ; 1758-678X
ISSN (online)	1758-6798
ISSN	1758-678X
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Buch: The education of the South African native

Loram, Charles Templeman

1927

Verfasserangabe	By Charles Templeman Loram
Umfang	XX, 340 S
Verlag	Longmans, Green
Erscheinungsort	London usw.
Dokumenttyp	Buch
Datenquelle	ECONomics Information System

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